Hub : Genes

WDR20

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1360 0.0350 5.6e-17 0.182 0.164 0.170 0.172 0.175 1.3e-21 1.6e-19 3.3e-20 2.0e-20 9.0e-21
2 METSIM Adipose 0.0314 0.0138 3.6e-04 0.037 0.021 0.036 0.023 0.039 2.3e-06 3.4e-04 3.7e-06 1.9e-04 1.6e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.2 0.3 0.5 -0.7 0.1
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 -0.5 -0.1
Depressed Affect (Nagel 2018) 2.2 4.6 5.0 -2.1 2.2
Depression (Nagel 2018) 0.6 0.8 1.0 -1.0 0.8
Intelligence (Savage-Jansen 2018) 0.4 1.3 1.6 -1.3 1.0
Neuroticism (Nagel 2018) 4.2 9.9 10.6 -3.0 3.3
Schizophrenia (2018) 0.0 0.0 0.0 -0.0 -0.1
Schizophrenia vs Biploar Disorder 0.7 1.0 1.2 1.1 -0.9
Worry (Nagel 2018) 0.9 1.9 2.4 -1.2 1.5
Alzheimer’s Disease (in mother) 1.1 1.3 1.9 -1.4 0.9
Alzheimer’s Disease (in father) 0.3 0.4 0.6 -0.4 0.7
Alzheimer’s Disease (including proxy) 1.9 2.8 3.0 -1.6 1.7
Crohns Disease (2017) 0.1 0.2 0.2 0.3 -0.5
Irritable Bowel Disease (IBD) 0.2 0.4 0.4 -0.6 0.6
Ulcerative Colitis (UC) 0.6 1.1 1.3 -1.0 1.1
Major Depression (MDD) 0.2 0.2 0.3 -0.4 0.6
Reaction Time 2.8 5.3 6.2 -2.1 2.5
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.5 -0.6 0.7
Breast Cancer 1.8 4.3 4.8 -1.9 2.2
Ovarian Cancer 0.3 0.3 0.5 0.4 -0.7
Prostate Cancer 0.0 0.0 0.0 -0.1 -0.1
Age at First Birth 0.1 0.1 0.2 0.4 -0.3
Bipolar Disorder (2011) 0.3 0.3 0.3 0.5 -0.5
Body Mass Index (BMI) (2010) 0.7 1.0 1.3 1.1 -0.8
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 -0.1
Crohns Disease (2012) 0.5 0.9 1.6 -1.3 0.4
Mean Putamen Volume 6.5 7.4 9.0 3.0 -2.4
Fasting Glucose 3.8 4.5 5.3 2.3 -1.9
HbA1C 0.8 0.9 1.5 1.2 -0.4
HDL Cholesterol 0.7 1.1 1.1 -1.1 1.1
LDL Cholesterol 0.1 0.1 0.3 0.5 0.0
Lupus 3.5 5.3 6.1 2.5 -2.1
Neuroticism (2016) 0.1 0.2 0.2 -0.3 0.5
Primary Biliary Cirrhosis 1.1 1.6 1.9 1.1 -1.4
Rheumatoid Arthritis 1.9 2.6 3.0 1.7 -1.5
Schizophrenia (2014) 0.7 1.4 1.6 1.1 -1.3
Triglycerides 0.5 0.8 1.0 0.7 -1.0
Type 2 Diabetes (T2D) (2012) 2.7 3.1 3.3 1.8 -1.7
Ulcerative Colitis 0.9 1.3 1.4 -1.1 1.2
Blood Eosinophil Count 1.6 12.2 13.6 3.3 -3.7
Blood Platelet Count 1.2 14.1 20.1 -2.9 4.5
Blood Red Count 0.6 5.9 7.7 -2.8 2.0
Blood White Count 0.1 1.1 1.5 -1.2 0.8
Heel T-Score 1.0 7.8 8.8 3.0 -2.6
BMI 1.3 7.7 8.8 2.6 -3.0
Height 0.1 2.6 3.7 -1.2 1.9
Waist Hip Ratio (WHR) 0.0 0.2 0.2 0.3 0.5
Systolic Blood Pressure 0.0 0.0 0.0 -0.2 0.1
Smoking Status 0.0 0.1 0.2 0.4 -0.1
Allergy or Eczema 0.0 0.0 0.0 -0.1 -0.1
Cardiovascular Disease 0.0 0.2 0.3 0.5 -0.2
Hypothyroidism (self reported) 0.1 0.2 0.2 0.5 -0.3
Respiratory disease 0.0 0.1 0.2 0.1 0.4
Type 2 Diabetes (T2D) (2018) 1.1 2.0 2.3 1.3 -1.5
Lung FEV1/FVC ratio 1.4 7.2 7.6 2.8 -2.6
Lung FVC 1.9 9.6 11.8 2.7 -3.4
Neuroticism 3.4 8.3 9.8 -2.6 3.1
Chronotype (morning person) 1.2 2.7 3.2 1.8 -1.5
Hair Pigment 0.0 1.2 1.9 0.7 -1.4
Tanning 0.3 4.1 4.6 -2.1 1.9
Hand grip strength (left) 0.1 0.3 0.3 -0.5 0.6
Number of treatments/medications taken 0.2 0.4 0.6 -0.5 0.7
Average weekly spirits intake 0.6 0.7 1.1 0.5 -1.1
Sensitivity / hurt feelings 3.7 6.4 6.9 -2.4 2.6
Frequency of depressed mood in last 2 weeks 2.5 3.5 4.3 -1.6 2.1
Hearing difficulty/problems: Yes 0.9 1.4 2.1 -0.9 1.4
Relative age of first facial hair 0.5 1.1 1.4 -0.9 1.2
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.0 0.1 0.1
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.5 0.5 -1.2
Ever had hysterectomy (womb removed) 0.0 0.0 0.0 -0.1 0.1
Systolic blood pressure, automated reading 0.5 1.5 2.0 1.0 -1.4
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.1 0.1 -0.4
Angina 0.2 0.3 0.5 -0.2 0.7
Medication for hormone replacement therapy 3.5 3.9 5.2 1.7 -2.3
Vitamin and mineral supplements 5.9 8.0 10.4 2.4 -3.2
Supplements: Zinc 0.1 0.1 0.3 -0.1 0.5
Medication: Co-codamol 0.1 0.2 0.3 0.6 -0.1
Medication: Metformin 1.6 2.2 2.3 1.5 -1.5
Diabetes (father) 1.6 1.9 2.4 -1.2 1.6
Diabetes (mother) 0.1 0.1 0.1 -0.4 0.3
Severe depression (siblings) 8.7 9.7 10.8 -3.3 2.9
Pack years adult smoking proportion 0.4 0.6 0.7 0.8 -0.8
Impedance of leg (right) 2.3 11.3 14.2 -2.9 3.8
Leg fat-free mass (left) 0.5 2.7 2.7 1.6 -1.6
Trunk fat percentage 1.7 6.8 8.1 -2.4 2.8
Hand grip strength (right) 0.0 0.1 0.1 0.4 -0.1
Townsend deprivation index at recruitment 1.5 2.1 2.5 -1.3 1.6
Current tobacco smoking 0.2 0.4 0.5 0.7 -0.6
Average weekly fortified wine intake 1.6 1.9 1.9 1.4 -1.4
Maternal smoking around birth 6.8 9.8 11.9 -2.8 3.4
Fed-up feelings 1.7 3.1 4.4 -1.4 2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.0 -0.8 1.4
Relative age voice broke 0.5 0.7 0.8 0.9 -0.8
Taking other prescription medications 0.1 0.2 0.3 0.5 -0.3
Age when periods started (menarche) 0.2 0.4 0.5 0.6 -0.7
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 1.5 1.0 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.6 -0.8 0.3
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 1.9 1.4 -0.8
Qualifications: CSEs or equivalent 0.1 0.1 0.1 0.4 -0.1
Serious illness, injury or assault to yourself 0.2 0.2 0.4 0.7 -0.2
High blood pressure 0.0 0.0 0.0 0.0 0.1
Hayfever, allergic rhinitis or eczema 0.2 0.5 0.7 -0.8 0.6
Multivitamins +/- minerals 4.1 5.2 6.4 -2.0 2.5
Stomach or abdominal pain in last month 0.4 0.5 0.8 -0.5 0.9
Supplements: Glucosamine 0.6 0.7 1.4 1.2 -0.3
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.4 -0.2 0.6
Medication: Atenolol 0.1 0.1 0.2 0.5 -0.2
Medication: Levothyroxine sodium 5.8 9.8 11.4 3.4 -2.9
Sitting height 0.3 2.3 3.1 1.8 -1.3
Chronic bronchitis/emphysema (father) 0.4 0.4 0.5 -0.7 0.6
High blood pressure (mother) 2.0 2.8 3.6 1.9 -1.4
Body mass index (BMI) 0.6 2.7 2.9 1.6 -1.7
Impedance of leg (left) 2.8 13.7 16.9 -3.2 4.1
Leg predicted mass (left) 0.5 2.7 2.7 1.6 -1.6
Trunk fat mass 0.4 1.7 2.2 -1.1 1.5
Waist circumference 0.3 1.0 1.4 1.2 -0.8
Number of incorrect matches in round 2.1 3.5 4.1 2.0 -1.7
Past tobacco smoking 1.1 2.0 2.2 1.3 -1.5
Alcohol usually taken with meals 0.2 0.4 0.5 -0.7 0.5
Nervous feelings 3.5 6.5 7.7 -2.3 2.8
Frequency of tenseness / restlessness in last 2 weeks 7.3 11.3 13.0 -3.1 3.6
Hearing difficulty/problems with background noise 2.1 3.4 3.6 -1.8 1.9
Hair/balding pattern: Pattern 2 2.9 3.7 3.7 -1.9 1.9
Had menopause 3.1 3.8 4.5 2.1 -1.8
Had other major operations 4.8 5.9 5.9 2.4 -2.4
Forced vital capacity (FVC) 0.4 1.5 1.7 1.1 -1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.4 -0.6 0.2
Ever unenthusiastic/disinterested for a whole week 2.2 2.7 3.0 -1.5 1.7
Qualifications: None of the above 0.8 1.6 1.9 1.4 -1.2
Financial difficulties in last 2 years 1.9 2.5 3.2 -1.3 1.8
Mouth/teeth dental problems 0.2 0.2 0.4 -0.2 0.6
Heart attack 0.5 0.6 0.7 -0.8 0.7
Allergy 0.1 0.3 0.3 0.6 -0.4
Pain all over the body in last month 0.2 0.2 0.4 -0.1 0.6
Diabetes (self-reported) 0.6 0.9 1.4 0.7 -1.2
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.1 -0.1 0.4
Medication: Ramipril 0.3 0.4 0.5 0.5 -0.7
Medication: Simvastatin 0.0 0.0 0.0 0.1 -0.2
Fluid intelligence score 0.1 0.3 0.3 0.6 -0.5
Illnesses of siblings 1.2 1.7 1.9 -1.2 1.4
Neuroticism score 4.9 10.3 12.2 -2.9 3.5
Weight 0.4 1.9 2.1 1.5 -1.3
Impedance of arm (right) 8.6 40.2 43.2 -6.1 6.6
Arm fat percentage (right) 0.2 0.7 0.8 -0.8 0.9
Trunk fat-free mass 2.4 14.0 14.2 3.8 -3.7
Hip circumference 0.1 0.5 0.5 0.7 -0.7
Time employed in main current job 0.0 0.0 0.0 -0.0 0.2
Alcohol intake versus 10 years previously 0.1 0.1 0.1 -0.4 0.3
Father’s age at death 0.1 0.1 0.2 0.0 0.5
Worrier / anxious feelings 1.5 2.8 3.9 -1.3 2.0
Frequency of tiredness / lethargy in last 2 weeks 7.7 12.4 16.0 -3.0 4.0
Falls in the last year 0.0 0.0 0.1 0.2 0.1
Hair/balding pattern: Pattern 3 3.7 5.4 5.9 2.2 -2.4
Number of live births 0.1 0.1 0.2 0.4 0.0
Forced expiratory volume in 1-second (FEV1) 0.9 3.0 3.0 1.7 -1.7
Pulse rate 0.2 0.4 0.7 0.8 -0.2
Happiness 1.2 1.4 1.6 -1.3 1.1
Noisy workplace 1.4 1.8 1.8 1.3 -1.3
Qualifications: A levels/AS levels or equivalent 1.8 3.9 4.2 -1.9 2.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.5 -0.7 0.1
Mouth/teeth dental problems: Dentures 2.4 4.1 4.7 1.9 -2.2
Asthma 0.0 0.0 0.1 0.0 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.6 0.5 -0.8
Medication: Cholesterol lowering 0.1 0.2 0.4 0.1 -0.6
Depression (self-reported) 0.4 0.5 0.9 -0.4 1.0
Medication: Lansoprazole 0.1 0.1 0.1 0.3 -0.2
Prospective memory result 0.4 0.5 0.9 0.9 -0.4
Lung cancer (father) 0.3 0.3 0.4 -0.5 0.6
Illnesses of mother 0.3 0.3 0.4 -0.6 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 2.1 1.1 -1.4
Pulse wave Arterial Stiffness index 3.5 4.1 4.3 2.0 -2.1
Impedance of arm (left) 10.0 46.1 48.5 -6.6 7.0
Arm fat mass (right) 0.1 0.2 0.3 0.5 -0.5
Trunk predicted mass 2.5 14.3 14.4 3.8 -3.8
Standing height 0.0 0.3 0.6 -0.1 0.8
Length of working week for main job 1.6 1.7 2.4 1.1 -1.5
Exposure to tobacco smoke at home 1.3 1.4 1.9 1.4 -1.0
Breastfed as a baby 2.5 3.1 3.5 1.9 -1.7
Tense / ‘highly strung’ 1.4 2.4 3.3 -1.2 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.7 3.8 -1.9 1.9
Hair/balding pattern: Pattern 4 0.6 1.4 1.6 -1.1 1.3
Birth weight of first child 0.5 0.8 1.0 1.0 -0.8
Peak expiratory flow (PEF) 0.5 1.2 1.3 1.1 -1.0
Pulse wave reflection index 0.3 0.3 0.5 0.5 -0.7
Ever highly irritable/argumentative for 2 days 1.9 2.2 3.0 -1.7 1.2
Loud music exposure frequency 6.2 6.7 8.0 -2.3 2.8
Qualifications: O levels/GCSEs or equivalent 0.7 1.0 1.1 -1.0 1.0
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 1.5 -1.1 1.2
Blood clot in the leg (DVT) 0.5 0.6 0.8 0.7 -0.9
Medication: Paracetamol 0.3 0.5 1.0 1.0 -0.2
Headache pain in last month 2.4 4.1 5.4 -1.6 2.3
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.3 -0.5 0.4
Glaucoma (self-reported) 1.2 1.4 1.6 -1.1 1.3
Gout (self-reported) 1.5 2.0 2.5 1.6 -1.3
Hypothyroidism/myxoedema (self-reported) 0.6 1.3 1.5 1.2 -1.0
Medication: Amlodipine 0.0 0.0 0.0 0.2 0.0
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.5 0.7 -0.3
Birth weight 0.0 0.0 0.0 0.2 0.1
Chronic bronchitis/emphysema (mother) 1.2 1.4 1.5 -1.1 1.2
High blood pressure (siblings) 3.0 4.3 4.7 2.0 -2.2
Forced vital capacity (FVC), Best measure 0.6 2.1 2.6 1.2 -1.6
Body fat percentage 0.6 2.3 2.7 -1.4 1.7
Leg fat percentage (right) 0.0 0.1 0.2 0.4 -0.2
Arm fat-free mass (right) 2.3 11.7 12.5 3.5 -3.3
Exposure to tobacco smoke outside home 1.6 2.2 2.5 -1.4 1.6
Comparative body size at age 10 0.4 1.1 1.5 0.9 -1.2
Number of full brothers 0.3 0.4 0.4 -0.6 0.7
Worry too long after embarrassment 8.6 14.4 14.9 -3.7 3.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.3 -0.4 0.5
Wheeze or whistling in the chest in last year 0.3 0.5 0.7 -0.6 0.8
Number of children fathered 3.7 4.1 4.6 1.9 -2.1
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 1.4 1.2 -0.8
Age at first live birth 0.9 1.6 2.1 -1.5 1.1
Pulse wave peak to peak time 3.5 4.1 4.3 -2.0 2.1
Health satisfaction 4.6 6.0 7.5 -2.1 2.7
Shortness of breath walking on level ground 0.2 0.2 0.2 -0.5 0.4
Qualifications: College or University degree 1.4 4.4 4.9 -2.0 2.2
Eye problems/disorders: None of the above 0.5 0.6 0.9 0.9 -0.6
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.0 0.0 0.0
Emphysema/chronic bronchitis 2.4 2.7 2.9 1.7 -1.6
Medication for pain relief, constipation, heartburn 0.6 1.1 1.5 0.9 -1.2
Neck or shoulder pain in last month 1.4 2.0 2.4 1.2 -1.6
Medication: Blood pressure 0.2 0.4 0.5 0.7 -0.5
Angina (self-reported) 0.1 0.1 0.3 -0.0 0.5
Migraine (self-reported) 0.5 0.6 1.2 1.1 -0.2
Medication: Ibuprofen 0.8 1.0 1.1 1.0 -0.9
Medication: Allopurinol 3.0 4.0 4.1 2.0 -2.0
Medication: Omeprazole 1.2 1.4 1.7 -1.1 1.3
Medication: Seretide 50 evohaler 0.2 0.2 0.3 -0.5 0.4
Mean time to correctly identify matches 2.3 4.4 4.8 -2.0 2.2
Heart disease (mother) 0.2 0.3 0.3 0.5 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.7 1.8 1.3 -1.3
Whole body fat mass 0.0 0.1 0.2 -0.3 0.4
Leg fat mass (right) 0.2 0.7 0.9 0.9 -0.8
Arm predicted mass (right) 2.1 10.7 10.8 3.3 -3.3
Pulse rate, automated reading 7.2 23.2 25.0 5.0 -4.6
Alcohol intake frequency. 0.8 1.9 2.5 -1.2 1.6
Comparative height size at age 10 0.3 1.9 2.4 -1.2 1.5
Number of full sisters 0.7 0.8 1.0 -0.8 1.0
Suffer from ‘nerves’ 1.2 1.8 2.7 -1.0 1.7
Overall health rating 0.2 0.4 0.8 0.1 0.9
Chest pain or discomfort 1.1 1.6 1.7 -1.2 1.3
Had major operations 0.9 1.0 1.1 0.9 -1.1
Age at last live birth 0.5 0.7 0.7 -0.8 0.8
Family relationship satisfaction 0.0 0.0 0.0 -0.1 -0.0
Leg pain on walking 0.7 0.9 1.2 0.8 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 -0.4 0.0
Commuting to job workplace: Car/motor vehicle 2.7 3.0 3.3 -1.7 1.8
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.1 0.4 -0.1
Medication: Aspirin 0.6 0.8 0.8 -0.9 0.9
Supplements: Vitamin C 0.4 0.5 0.6 -0.6 0.8
Knee pain experienced in last month 0.0 0.0 0.0 0.1 -0.1
Hypertension (Self-reported) 0.0 0.0 0.0 0.0 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 -0.4 0.2
Illnesses of father: Heart disease 0.8 1.2 1.2 1.1 -1.1
Illnesses of siblings: Diabetes 0.6 0.7 0.7 -0.8 0.8
Smoking status: Previous 0.7 1.1 1.3 -1.1 1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.9 4.0 4.1 -2.0 2.0
Whole body fat-free mass 1.7 9.5 9.6 3.1 -3.1
Leg fat-free mass (right) 0.5 2.5 2.5 1.6 -1.6
Arm fat percentage (left) 0.4 1.7 1.7 -1.3 1.3
Average weekly red wine intake 0.7 1.1 1.2 1.0 -1.1
Handedness (chirality/laterality): Left-handed 1.4 1.7 1.9 1.4 -1.3
Mood swings 3.4 6.1 7.6 -2.1 2.8
Loneliness, isolation 0.5 0.6 0.9 -0.6 1.0
Long-standing illness, disability or infirmity 0.0 0.0 0.0 0.0 0.0
Ever had bowel cancer screening 1.7 1.9 2.1 1.4 -1.3
Diabetes diagnosed by doctor 0.4 0.6 1.1 0.5 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 0.5 0.5 -0.7
Friendships satisfaction 0.0 0.1 0.1 0.2 0.3
Qualifications: nursing, teaching 5.2 8.1 9.9 -2.5 3.1
Commuting to job workplace: Walk 0.2 0.2 0.3 -0.3 0.6
Eye problems/disorders: Cataract 0.0 0.0 0.0 -0.2 0.0
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 1.3 -1.1 1.0
Medication for cholesterol 0.2 0.3 0.3 -0.6 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.2 1.4 -1.0 1.2
Back pain experienced in last month 0.3 0.4 0.5 0.7 -0.6
Mineral and other dietary supplements 0.3 0.4 0.4 0.6 -0.7
Breast cancer (self-reported) 0.2 0.3 0.4 -0.3 0.7
Asthma (self-reported) 0.0 0.0 0.1 0.2 0.2
Osteoporosis (self-reported) 0.4 0.5 0.5 0.7 -0.7
Osteoarthritis (self-reported) 0.3 0.3 0.3 0.6 -0.6
Medication: Aspirin 0.5 0.7 0.8 -0.7 0.9
Medication: Gliclazide 0.4 0.4 0.6 0.8 -0.5
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 0.4 -0.3
Smoking status: Current 0.2 0.3 0.3 0.6 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.5 4.9 1.4 -2.2
Whole body water mass 1.8 10.1 10.3 3.2 -3.2
Leg predicted mass (right) 0.4 2.1 2.1 1.4 -1.4
Arm fat mass (left) 0.0 0.1 0.1 0.4 -0.2
Number of self-reported non-cancer illnesses 0.3 0.5 0.9 -0.3 0.9
Average weekly champagne plus white wine intake 0.0 0.1 0.1 0.4 -0.0
Miserableness 4.2 7.4 8.6 -2.5 2.9
Guilty feelings 2.8 4.2 5.4 -1.7 2.3
Wears glasses or contact lenses 0.3 0.4 0.7 -0.9 0.3
Ever taken oral contraceptive pill 1.0 1.1 1.3 -0.9 1.1
Hearing aid user 0.1 0.1 0.2 -0.5 0.0
Mother’s age at death 0.5 0.6 0.8 0.9 -0.6
Financial situation satisfaction 5.4 6.6 7.5 -2.4 2.7
Tinnitus: Yes, now most or all of the time 1.0 1.1 1.6 -0.8 1.3
Commuting to job workplace: Public transport 0.1 0.2 0.2 0.5 -0.4
Eye problems/disorders: Glaucoma 1.4 1.7 2.1 -1.1 1.5
Medication: Blood pressure 0.1 0.2 0.4 0.7 -0.2
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.2 0.5 -0.5
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.4 -0.6 0.7
High cholesterol (Self-reported) 0.2 0.3 0.5 0.7 -0.4
Medication: Bendroflumethiazide 0.6 1.0 1.9 -0.3 1.4
Medication: Paracetamol 0.9 1.4 2.3 1.5 -0.7
Medication: Lisinopril 0.5 0.6 1.0 -0.5 1.0
Medication: Atorvastatin 0.0 0.0 0.0 -0.2 -0.1
Illnesses of father: High blood pressure 0.1 0.1 0.2 -0.5 -0.1
Alcohol drinker status: Never 0.4 0.4 0.5 0.6 -0.7
Ever smoked 0.6 1.1 1.6 -0.8 1.3
Basal metabolic rate 1.1 6.0 6.2 2.5 -2.4
Leg fat percentage (left) 0.0 0.1 0.1 0.4 -0.1
Arm fat-free mass (left) 2.6 13.0 13.6 3.7 -3.5
Number of operations (self-reported) 3.6 5.3 5.8 2.2 -2.4
Average weekly beer plus cider intake 1.2 1.8 2.5 1.0 -1.6
Irritability 2.9 5.0 5.8 -2.4 2.0
Risk taking 0.0 0.0 0.1 -0.1 0.2
Ever had prostate specific antigen (PSA) test 1.0 1.1 1.5 0.8 -1.2
Fractured/broken bones in last 5 years 0.0 0.0 0.1 0.1 -0.3
Age started oral contraceptive pill 6.4 8.1 8.6 2.9 -2.7
Diastolic blood pressure, automated reading 0.5 1.5 1.6 1.3 -1.2
Ever depressed for a whole week 2.2 2.8 3.1 -1.6 1.8
Unable to work because of sickness or disability 0.2 0.3 0.5 0.3 0.7
Commuting to job workplace: Cycle 1.4 1.6 2.7 0.8 -1.6
Myopia 1.2 1.8 2.5 -1.0 1.6
Vascular/heart problems diagnosed by doctor 0.0 0.0 0.0 -0.2 0.1
Cholesterol lowering medication 1.1 1.6 2.2 -1.0 1.5
Medication: Omeprazole (e.g. Zanprol) 3.1 3.8 4.4 -2.1 1.8
Pain experienced in last month 0.3 0.5 0.7 0.5 -0.9
Supplements: Calcium 6.5 7.2 7.3 -2.6 2.7
Basal cell carcinoma (self-reported) 3.3 4.0 4.7 1.8 -2.2
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.6 -0.8 0.7
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 0.6 0.7 -0.8
Heart disease (siblings) 0.0 0.0 0.0 0.2 -0.2
Alcohol drinker status: Previous 0.2 0.2 0.2 -0.5 0.4
Pack years of smoking 1.0 1.4 1.5 1.2 -1.2
Impedance of whole body 7.2 36.5 41.3 -5.6 6.4
Leg fat mass (left) 0.2 0.8 1.0 1.0 -0.8
Arm predicted mass (left) 2.5 12.9 13.5 3.7 -3.5