Best TWAS P=4.25e-30 · Best GWAS P=4.82e-27 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Female) | AC074117.10 | 0.06 | 0.01 | lasso | 2 | 0.04 | 2.7e-02 | -7.94 | -8.7 | 5.4e-18 | -0.23 | 0.04 | 0.05 | FALSE |
| 2 | GTEx | Esophagus Muscularis | NRBP1 | 0.07 | 0.04 | lasso | 6 | 0.04 | 1.3e-03 | -3.23 | 5.4 | 5.4e-08 | 0.82 | 0.02 | 0.97 | FALSE |
| 3 | GTEx | Lung | RP11-373D23.3 | 0.08 | 0.00 | enet | 21 | 0.02 | 2.3e-02 | -6.07 | 5.5 | 5.1e-08 | 0.23 | 0.20 | 0.11 | FALSE |
| 4 | GTEx | Ovary | AC074117.10 | 0.16 | 0.04 | enet | 9 | 0.05 | 2.0e-02 | -2.15 | 5.2 | 2.4e-07 | 0.77 | 0.04 | 0.79 | FALSE |
| 5 | GTEx | Stomach | AC074117.10 | 0.06 | 0.01 | lasso | 7 | 0.01 | 7.8e-02 | -3.23 | -9.3 | 8.6e-21 | -0.36 | 0.20 | 0.08 | FALSE |
| 6 | GTEx | Testis | NRBP1 | 0.16 | 0.09 | lasso | 3 | 0.06 | 1.8e-03 | -3.23 | 5.7 | 1.3e-08 | 0.80 | 0.03 | 0.96 | FALSE |
| 7 | GTEx | Testis | AC074117.10 | 0.14 | 0.08 | lasso | 6 | 0.12 | 4.5e-06 | -2.18 | 6.7 | 2.6e-11 | 0.85 | 0.05 | 0.95 | FALSE |
| 8 | GTEx | Thyroid | FNDC4 | 0.24 | 0.10 | enet | 23 | 0.16 | 2.2e-12 | -8.69 | -10.5 | 9.3e-26 | -0.69 | 0.66 | 0.34 | FALSE |
| 9 | METSIM | Adipose | BRE | 0.03 | 0.00 | blup | 534 | 0.00 | 1.3e-01 | -0.75 | 7.0 | 3.3e-12 | 0.30 | 0.10 | 0.05 | FALSE |
| 10 | YFS | Blood | EIF2B4 | 0.01 | 0.00 | enet | 9 | 0.00 | 8.5e-02 | -0.66 | -5.2 | 2.1e-07 | -0.52 | 0.04 | 0.03 | FALSE |
| 11 | YFS | Blood | MRPL33 | 0.02 | 0.01 | blup | 385 | 0.01 | 6.4e-05 | -7.39 | 6.8 | 1.0e-11 | 0.22 | 0.97 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GPN1 | 0.06 | 0.02 | lasso | 6 | 0.02 | 7.2e-05 | 8.60 | 7.0 | 3.1e-12 | 0.54 | 0.02 | 0.89 | FALSE |
| 13 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SUPT7L | 0.06 | 0.03 | blup | 29 | 0.05 | 2.0e-03 | -8.45 | -6.5 | 1.0e-10 | -0.04 | 0.01 | 0.82 | TRUE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SUPT7L | 0.05 | 0.02 | blup | 28 | 0.04 | 5.2e-05 | -8.45 | -10.3 | 6.9e-25 | -0.40 | 0.00 | 0.98 | TRUE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FNDC4 | 0.13 | 0.06 | lasso | 2 | 0.05 | 1.1e-03 | 10.77 | -11.4 | 4.2e-30 | -0.99 | 0.00 | 0.95 | TRUE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | FNDC4 | 0.24 | 0.09 | enet | 9 | 0.17 | 1.9e-16 | -8.80 | -10.2 | 1.6e-24 | -0.70 | 0.42 | 0.58 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | GCKR | 0.18 | 0.08 | enet | 5 | 0.13 | 1.7e-12 | -8.69 | -10.1 | 4.3e-24 | -0.64 | 0.90 | 0.10 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | IFT172 | 0.08 | 0.01 | blup | 43 | 0.02 | 6.1e-03 | -8.70 | -10.5 | 5.2e-26 | -0.54 | 0.02 | 0.28 | FALSE |