TWAS hub - EIF2B4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0112	0.0102	0.0350	0.000	0.000	0.002	0.001	0.000	0.52000	0.29	0.084	0.097	0.27
2	TCGA	Breast Invasive Carcinoma	0.0767	0.0448	0.0061	0.013	-0.001	0.004	NA	0.007	0.00073	0.53	0.035	NA	0.01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Triglycerides	68.0	111.4	116.6	-10.8	-10.3
Fasting Glucose	23.9	28.6	36.5	6.0	4.6
High cholesterol (Self-reported)	18.6	33.1	39.2	-6.3	-5.2
Alcohol intake frequency.	16.5	38.5	48.3	-7.0	-5.3
Gout (self-reported)	14.4	19.7	30.6	-5.5	-3.0
Blood Platelet Count	12.0	139.4	225.0	-15.0	-7.3
Medication: Allopurinol	10.1	13.5	23.5	-4.8	-1.9
Medication: Cholesterol lowering	10.0	15.6	19.3	-4.4	-3.4
Medication: Atorvastatin	9.3	11.5	12.0	-3.5	-3.3
Medication: Simvastatin	8.2	12.0	14.9	-3.9	-3.0
Blood White Count	7.4	54.6	66.7	-8.2	-6.5
Pulse rate, automated reading	6.7	21.6	30.0	-5.5	-3.6
Cholesterol lowering medication	6.6	9.7	11.9	-3.5	-2.7
Medication for cholesterol	5.7	8.6	17.1	4.1	0.4
Trunk predicted mass	5.3	30.1	39.2	6.3	4.6
Diabetes (self-reported)	5.2	8.0	14.3	1.3	3.8
Trunk fat-free mass	5.2	29.9	39.6	6.3	4.5
Illnesses of mother	5.2	6.5	10.7	3.3	1.5
High blood pressure (siblings)	5.0	7.1	14.2	-3.8	-0.3
Medication for cholesterol, blood pressure or diabetes	4.9	8.1	14.5	3.8	1.3
Whole body fat-free mass	4.9	27.9	34.2	5.8	4.7
Commuting to job workplace: Car/motor vehicle	4.8	5.5	11.1	-3.3	0.1
Whole body water mass	4.8	27.5	34.0	5.8	4.6
Ever taken oral contraceptive pill	4.8	5.3	9.8	0.9	3.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.7	5.5	8.6	-2.9	-1.5
Number of self-reported non-cancer illnesses	4.7	8.1	11.8	-3.4	-2.1
Impedance of whole body	4.7	23.7	28.5	-5.3	-4.3
Arm predicted mass (right)	4.6	23.6	29.9	5.5	4.2
Arm fat-free mass (right)	4.5	22.9	29.9	5.5	4.0
Diabetes diagnosed by doctor	4.5	7.4	11.2	1.9	3.3
Impedance of arm (left)	4.4	20.6	27.0	-5.2	-3.8
Illnesses of father: Heart disease	4.4	6.0	6.9	-2.6	-2.3
Had menopause	4.2	5.3	10.4	3.2	0.3
Alcohol intake versus 10 years previously	4.1	6.1	10.9	-3.3	-1.1
Medication for pain relief, constipation, heartburn	4.1	7.0	13.4	3.7	0.8
Arm fat-free mass (left)	4.1	20.9	27.1	5.2	3.8
Cardiovascular Disease	4.0	13.2	23.1	-4.8	-1.8
Type 2 Diabetes (T2D) (2018)	4.0	7.5	8.9	2.5	3.0
Number of treatments/medications taken	4.0	7.2	11.4	-3.4	-1.7
Vitamin and mineral supplements	4.0	5.4	10.7	3.3	0.2
Impedance of arm (right)	4.0	18.9	26.9	-5.2	-3.3
Arm predicted mass (left)	4.0	20.3	25.6	5.1	3.9
Basal metabolic rate	3.9	21.9	25.4	5.0	4.3
Leg fat-free mass (left)	3.8	20.0	20.7	4.5	4.4
Average weekly spirits intake	3.7	4.5	8.4	-2.9	-0.9
Leg predicted mass (left)	3.7	19.8	20.6	4.5	4.4
Leg predicted mass (right)	3.7	19.7	20.9	4.6	4.3
Multivitamins +/- minerals	3.6	4.6	7.9	-2.8	-1.2
Impedance of leg (left)	3.6	17.4	18.3	-4.1	-4.3
Leg fat-free mass (right)	3.6	19.1	19.9	4.5	4.3
High blood pressure (mother)	3.4	4.8	9.0	-3.0	-0.7
Migraine (self-reported)	3.4	4.2	5.1	-1.8	-2.3
Illnesses of siblings: Diabetes	3.4	4.1	4.8	1.9	2.2
Medication: Paracetamol	3.3	5.5	10.7	-3.3	-0.6
Diabetes (father)	3.2	3.9	4.3	1.9	2.1
Impedance of leg (right)	3.1	14.9	16.6	-3.6	-4.1
Age when periods started (menarche)	3.0	7.2	11.8	1.6	-3.4
Medication: Metformin	2.9	4.1	4.3	2.1	2.0
Relative age of first facial hair	2.8	5.8	11.1	-0.7	-3.3
Angina	2.8	3.6	6.6	-0.8	-2.6
Stomach or abdominal pain in last month	2.8	3.5	5.1	-1.4	-2.3
Loneliness, isolation	2.8	3.9	7.6	-0.5	-2.8
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.4	6.4	-2.5	0.7
Medication: Amlodipine	2.7	3.8	4.9	-2.2	1.6
Health satisfaction	2.7	3.5	6.0	-2.4	-1.0
Angina (self-reported)	2.7	3.5	6.8	-0.4	-2.6
Alzheimer’s Disease (in mother)	2.6	3.1	3.7	-1.9	-1.6
Illnesses of siblings	2.6	3.6	7.2	2.7	-0.2
Number of operations (self-reported)	2.6	3.8	6.6	-2.6	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	3.6	-1.9	-1.4
Medication: Paracetamol	2.5	3.8	6.7	-2.6	-1.0
Type 2 Diabetes (T2D) (2012)	2.4	2.8	4.2	1.2	2.1
Alcohol usually taken with meals	2.4	4.0	7.4	-2.7	0.7
Ever unenthusiastic/disinterested for a whole week	2.4	2.9	3.4	-1.6	-1.8
Number of children fathered	2.4	2.7	4.7	0.9	-2.2
Eye problems/disorders: None of the above	2.4	2.8	4.4	1.1	2.1
Mouth/teeth dental problems: Loose teeth	2.4	2.8	4.7	-2.2	-1.0
Vascular/heart problems diagnosed by doctor	2.4	6.5	12.2	3.5	0.9
Supplements: Zinc	2.3	2.6	4.1	-1.0	2.0
Sitting height	2.3	16.4	22.1	4.7	3.3
Heart disease (mother)	2.3	2.8	5.2	-2.3	-0.6
Eye problems/disorders: Cataract	2.3	2.7	2.8	-1.6	-1.7
Osteoarthritis (self-reported)	2.3	2.9	4.1	-2.0	1.3
Medication: Gliclazide	2.3	2.6	4.0	1.1	2.0
Depression (Nagel 2018)	2.2	3.3	4.7	-2.2	-1.3
Systolic Blood Pressure	2.2	11.3	22.0	-4.7	-0.7
High blood pressure	2.2	6.2	12.2	-3.5	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	3.0	1.4	1.7
Overall health rating	2.2	4.8	5.5	-2.0	-2.3
Alcohol drinker status: Never	2.2	2.6	5.3	0.2	-2.3
Neuroticism	2.1	5.2	5.9	-2.4	-2.1
Pulse rate	2.1	3.6	5.2	-2.3	-1.4
Glaucoma (self-reported)	2.1	2.4	3.8	1.0	-2.0
Hypertension (Self-reported)	2.1	5.7	11.5	-3.4	0.1
Smoking status: Previous	2.1	3.2	4.6	-1.3	2.1
Eye problems/disorders: Glaucoma	2.1	2.5	3.4	1.3	-1.8
Heart disease (siblings)	2.1	2.5	4.3	-0.9	-2.1
Schizophrenia vs Biploar Disorder	2.0	2.6	4.2	1.0	2.0
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	2.9	-1.7	-1.5
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	4.2	0.9	2.0
Mood swings	2.0	3.6	4.9	-1.5	-2.2
Commuting to job workplace: Public transport	2.0	2.4	4.5	2.1	-0.5
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	3.5	-1.9	-0.9
Pain all over the body in last month	1.9	2.0	3.8	-2.0	-0.4
Medication: Ibuprofen	1.9	2.3	4.5	-2.1	0.1
Qualifications: nursing, teaching	1.9	2.9	4.0	-1.4	2.0
Osteoporosis (self-reported)	1.9	2.4	2.5	-1.5	-1.6
Miserableness	1.9	3.3	6.2	-0.6	-2.5
Ulcerative Colitis	1.8	2.6	5.2	-2.3	-0.3
Number of incorrect matches in round	1.8	3.1	4.5	-1.3	2.1
Comparative height size at age 10	1.8	10.2	11.7	3.4	2.9
Average weekly champagne plus white wine intake	1.8	2.5	3.8	1.9	1.1
Medication: Blood pressure	1.8	3.4	6.7	-2.6	-0.2
Other serious medical condition/disability diagnosed by doctor	1.7	2.3	4.1	-0.6	-2.0
Neuroticism score	1.7	3.5	6.7	-0.6	-2.6
Weight	1.7	8.2	8.4	2.8	2.9
Qualifications: A levels/AS levels or equivalent	1.7	3.7	5.2	2.3	1.5
Average weekly beer plus cider intake	1.7	2.4	3.1	1.3	-1.8
Systolic blood pressure, automated reading	1.6	4.5	8.9	-3.0	-0.4
Had other major operations	1.6	1.9	3.8	-2.0	-0.2
Medication: Ramipril	1.6	2.1	2.7	-1.6	1.2
Happiness	1.6	2.0	3.9	-2.0	-0.1
Pulse wave reflection index	1.6	2.0	3.1	1.8	-0.9
Medication: Bendroflumethiazide	1.6	2.5	3.7	-1.9	-1.1
Bipolar Disorder (2011)	1.5	1.4	1.7	-1.3	-1.0
Neuroticism (2016)	1.5	2.2	2.8	-1.3	-1.7
Hand grip strength (left)	1.5	3.9	7.1	2.7	0.9
Townsend deprivation index at recruitment	1.5	2.1	3.8	2.0	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	5.1	1.2	2.2
Falls in the last year	1.5	2.1	4.2	-2.0	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.2	4.0	-2.0	-0.6
Birth weight of first child	1.5	2.7	3.8	1.3	1.9
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.6	-0.2	-1.9
Supplements: Vitamin C	1.5	1.8	2.4	-1.1	1.6
Illnesses of father: High blood pressure	1.5	1.9	3.1	-1.8	0.8
Depressed Affect (Nagel 2018)	1.4	2.8	4.0	-1.3	-2.0
Irritable Bowel Disease (IBD)	1.4	3.3	6.1	-2.5	-0.8
Fluid intelligence score	1.4	2.8	4.7	2.2	1.0
Standing height	1.4	13.5	19.3	4.4	2.8
Exposure to tobacco smoke at home	1.4	1.5	2.9	-0.4	1.7
Breastfed as a baby	1.4	1.8	3.0	-0.7	1.7
Ever smoked	1.4	2.4	3.0	-1.7	1.4
Height	1.3	24.8	27.6	5.2	4.7
Chronotype (morning person)	1.3	2.9	5.4	0.6	-2.3
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	1.7	1.0	1.3
Medication for hormone replacement therapy	1.3	1.5	3.0	-1.7	0.1
Hayfever, allergic rhinitis or eczema	1.3	2.9	5.8	-2.4	-0.3
Past tobacco smoking	1.3	2.3	2.7	1.4	-1.6
Hair/balding pattern: Pattern 2	1.3	1.7	2.2	-1.1	-1.5
Tense / ‘highly strung’	1.3	2.2	4.3	-0.3	-2.1
Waist Hip Ratio (WHR)	1.2	5.4	10.8	-0.0	-3.3
Severe depression (siblings)	1.2	1.3	2.1	0.8	1.4
Peak expiratory flow (PEF)	1.2	2.8	4.7	1.0	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	3.0	0.4	-1.7
Medication: Aspirin	1.2	1.6	2.7	-1.6	-0.8
LDL Cholesterol	1.1	1.8	3.5	-0.2	-1.9
Allergy or Eczema	1.1	3.0	5.8	-2.4	-0.4
Tanning	1.1	13.0	17.0	3.0	4.1
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.1	1.5	-0.8
Hand grip strength (right)	1.1	3.1	4.7	2.2	1.2
Hearing difficulty/problems with background noise	1.1	1.7	1.9	-1.4	1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	4.6	0.6	2.1
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	1.9	-1.4	0.9
Hair/balding pattern: Pattern 4	1.1	2.6	2.9	1.5	1.7
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.2	-0.4	1.8
Headache pain in last month	1.1	1.8	2.1	-1.2	-1.5
Medication: Blood pressure	1.1	2.0	4.0	-2.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.0	-1.4	-0.8
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.2	-1.5	-0.8
Diastolic blood pressure, automated reading	1.1	3.5	6.0	-2.4	1.0
Myopia	1.1	1.5	3.0	-1.7	0.3
Crohns Disease (2017)	1.0	2.3	3.5	-1.9	-1.0
Coronary Artery Disease (CAD)	1.0	1.2	1.6	-1.3	0.8
Frequency of depressed mood in last 2 weeks	1.0	1.4	1.8	-1.0	-1.3
Diabetes (mother)	1.0	1.3	1.7	1.0	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	2.8	-0.8	-1.7
Medication: Seretide 50 evohaler	1.0	1.2	2.0	0.6	1.4
Suffer from ‘nerves’	1.0	1.5	3.0	0.3	-1.7
Chest pain or discomfort	1.0	1.4	2.8	0.2	-1.7
Mother’s age at death	1.0	1.3	2.4	-0.3	1.6
Alzheimer’s Disease (in father)	0.9	1.0	2.0	0.2	1.4
Ulcerative Colitis (UC)	0.9	1.8	3.4	-1.8	-0.4
BMI	0.9	5.2	6.4	2.0	2.5
Mouth/teeth dental problems	0.9	1.4	2.1	0.8	1.5
Average weekly red wine intake	0.9	1.3	2.4	0.5	1.6
Medication: Aspirin	0.9	1.2	2.1	-1.5	-0.6
Guilty feelings	0.9	1.4	2.1	0.8	-1.5
Ovarian Cancer	0.8	1.0	1.3	0.9	-1.1
Fed-up feelings	0.8	1.5	3.0	0.1	-1.7
Serious illness, injury or assault to yourself	0.8	0.9	1.4	-1.2	-0.7
Chronic bronchitis/emphysema (father)	0.8	1.0	1.2	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	3.2	1.5	-1.8
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.8	-1.3	0.2
Exposure to tobacco smoke outside home	0.8	1.0	2.0	-0.2	-1.4
Worry too long after embarrassment	0.8	1.4	1.4	1.2	-1.2
Had major operations	0.8	0.9	1.3	-1.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	2.5	0.9	1.6
Alzheimer’s Disease (including proxy)	0.7	1.1	2.1	-1.4	-0.3
Age at First Birth	0.7	1.1	1.5	-1.2	0.8
Body Mass Index (BMI) (2010)	0.7	0.9	1.5	-0.6	1.2
Ever had hysterectomy (womb removed)	0.7	0.8	1.2	-1.1	-0.7
Medication: Co-codamol	0.7	0.8	0.9	-1.0	-0.8
Relative age voice broke	0.7	1.1	1.8	0.7	-1.3
Allergy	0.7	1.7	3.3	1.8	0.1
Time employed in main current job	0.7	0.8	1.6	-0.4	1.2
Prospective memory result	0.7	0.9	1.0	-1.0	0.9
Birth weight	0.7	1.4	2.0	-1.4	0.9
Comparative body size at age 10	0.7	2.1	3.7	-1.9	-0.7
Pulse wave peak to peak time	0.7	0.9	1.7	0.1	1.3
Leg pain on walking	0.7	0.9	1.8	-0.3	-1.3
Irritability	0.7	1.2	2.5	0.0	-1.6
Fractured/broken bones in last 5 years	0.7	0.9	1.0	-1.0	0.9
Ever depressed for a whole week	0.7	0.9	1.5	-0.6	-1.2
Pain experienced in last month	0.7	1.1	2.1	1.5	0.3
Supplements: Calcium	0.7	0.8	1.6	-1.3	-0.2
Neuroticism (Nagel 2018)	0.6	1.3	2.6	-0.0	-1.6
Reaction Time	0.6	1.1	2.1	0.3	1.4
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.7	1.6	0.5
Lupus	0.6	1.0	1.6	-1.2	0.6
Lung FEV1/FVC ratio	0.6	3.1	3.2	1.7	-1.8
Trunk fat percentage	0.6	2.3	4.6	-2.1	-0.1
Current tobacco smoking	0.6	0.9	1.9	-0.0	-1.4
Lung cancer (father)	0.6	0.7	0.8	0.7	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	2.2	1.5	-1.3
Mean time to correctly identify matches	0.6	1.2	2.2	-0.3	1.5
Ever had bowel cancer screening	0.6	0.7	0.8	-0.8	0.9
Mineral and other dietary supplements	0.6	0.8	0.9	1.0	0.8
Smoking status: Current	0.6	1.0	1.9	0.3	-1.4
Financial situation satisfaction	0.6	0.7	1.4	-1.2	0.0
Unable to work because of sickness or disability	0.6	0.8	1.5	0.2	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.3	0.4	-1.1
Primary Biliary Cirrhosis	0.5	0.7	1.0	-1.0	-0.7
Hair Pigment	0.5	14.2	23.5	-2.2	-4.8
Medication: Atenolol	0.5	0.6	1.0	0.5	-1.0
Financial difficulties in last 2 years	0.5	0.7	0.7	-0.8	-0.9
Hip circumference	0.5	2.0	4.1	0.1	2.0
Father’s age at death	0.5	0.6	0.6	0.8	0.8
Pulse wave Arterial Stiffness index	0.5	0.6	1.2	0.1	-1.1
Neck or shoulder pain in last month	0.5	0.7	0.7	-0.8	0.8
Number of full sisters	0.5	0.6	0.8	0.9	-0.6
Knee pain experienced in last month	0.5	0.7	1.3	-1.2	0.2
Back pain experienced in last month	0.5	0.8	1.5	-0.2	-1.2
Illnesses of father: None of the above (group 1)	0.5	0.6	0.7	0.8	0.7
Major Depression (MDD)	0.4	0.5	0.8	0.6	-0.9
Breast Cancer	0.4	0.8	1.7	-0.2	-1.3
Prostate Cancer	0.4	0.5	0.8	-0.5	-0.9
Crohns Disease (2012)	0.4	0.7	1.3	-1.1	-0.1
Heel T-Score	0.4	3.4	4.7	2.2	1.5
Supplements: Glucosamine	0.4	0.5	0.9	1.0	-0.1
Body mass index (BMI)	0.4	1.7	2.9	0.8	1.7
Nervous feelings	0.4	0.7	1.3	0.5	-1.1
Arm fat mass (right)	0.4	1.8	2.7	0.9	1.6
Body fat percentage	0.4	1.6	3.1	-1.8	-0.4
Medication: Omeprazole	0.4	0.4	0.7	0.3	-0.9
Long-standing illness, disability or infirmity	0.4	0.5	1.0	-0.3	-1.0
Arm fat mass (left)	0.4	1.5	2.3	0.9	1.5
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.6	-0.5	0.8
Commuting to job workplace: Cycle	0.4	0.4	0.8	0.2	-0.9
Leg fat mass (left)	0.4	1.6	2.1	1.0	1.5
Bipolar Disorder (2018)	0.3	0.5	1.0	-0.4	-1.0
Worry (Nagel 2018)	0.3	0.6	1.1	-0.4	-1.0
Blood Red Count	0.3	2.8	4.1	2.0	1.3
Smoking Status	0.3	0.7	0.9	-0.8	0.9
Lung FVC	0.3	1.3	2.3	-1.5	-0.5
Average weekly fortified wine intake	0.3	0.3	0.6	0.8	0.0
Maternal smoking around birth	0.3	0.5	0.9	0.9	0.3
Taking other prescription medications	0.3	0.5	0.6	-0.8	-0.6
Qualifications: CSEs or equivalent	0.3	0.4	0.7	-0.2	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.4	-0.6	0.5
Medication: Levothyroxine sodium	0.3	0.5	0.9	-0.2	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.5	-0.7	-0.6
Forced vital capacity (FVC)	0.3	1.1	2.0	1.4	-0.4
Noisy workplace	0.3	0.4	0.7	0.4	-0.8
Mouth/teeth dental problems: Dentures	0.3	0.5	0.5	0.7	-0.7
Medication: Lansoprazole	0.3	0.3	0.4	-0.4	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.0	1.9	1.4	-0.4
Leg fat mass (right)	0.3	1.3	1.6	1.0	1.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.9	-1.0	0.2
Hearing aid user	0.3	0.3	0.6	0.1	-0.8
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.5	0.5	0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	-0.4	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.9	1.0	-0.1
Schizophrenia (2018)	0.2	0.4	0.7	0.8	-0.1
Rheumatoid Arthritis	0.2	0.3	0.6	0.1	0.8
Pack years adult smoking proportion	0.2	0.3	0.7	0.1	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.3	-0.7
Trunk fat mass	0.2	0.8	1.5	0.2	1.2
Qualifications: None of the above	0.2	0.5	0.9	-0.4	-0.9
Arm fat percentage (right)	0.2	0.6	1.1	-1.1	0.3
Hair/balding pattern: Pattern 3	0.2	0.4	0.5	0.7	0.4
Number of live births	0.2	0.3	0.4	-0.5	0.6
Depression (self-reported)	0.2	0.2	0.2	-0.5	-0.4
Length of working week for main job	0.2	0.2	0.3	0.5	0.2
Loud music exposure frequency	0.2	0.2	0.3	-0.5	0.2
Shortness of breath walking on level ground	0.2	0.3	0.5	0.0	-0.7
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.6	-0.1
Whole body fat mass	0.2	1.0	1.7	0.4	1.3
Age at last live birth	0.2	0.2	0.3	-0.5	0.5
Family relationship satisfaction	0.2	0.2	0.4	0.2	0.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	-0.4	-0.6
Friendships satisfaction	0.2	0.3	0.3	-0.5	-0.5
Breast cancer (self-reported)	0.2	0.2	0.2	-0.5	-0.4
Asthma (self-reported)	0.2	0.3	0.7	-0.0	0.8
Wears glasses or contact lenses	0.2	0.2	0.3	-0.4	0.5
Age started oral contraceptive pill	0.2	0.3	0.4	0.5	-0.6
Bipolar Disorder or Schizophrenia	0.1	0.3	0.4	0.4	-0.7
Mean Putamen Volume	0.1	0.2	0.3	-0.0	-0.6
HbA1C	0.1	0.1	0.1	0.3	-0.2
HDL Cholesterol	0.1	0.2	0.4	-0.2	0.6
Schizophrenia (2014)	0.1	0.1	0.3	0.5	0.1
Blood Eosinophil Count	0.1	0.7	1.4	1.2	-0.2
Hypothyroidism (self reported)	0.1	0.3	0.5	0.3	0.7
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.3	-0.4
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.1	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.4	-0.2
Waist circumference	0.1	0.5	0.5	0.7	0.7
Asthma	0.1	0.3	0.5	0.1	0.7
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.4	0.2
Leg fat percentage (right)	0.1	0.5	0.8	-0.9	-0.4
Number of full brothers	0.1	0.1	0.2	-0.4	0.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	0.3	-0.4
Age at first live birth	0.1	0.2	0.3	-0.4	0.5
Qualifications: College or University degree	0.1	0.4	0.8	-0.1	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.3	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.1	-0.4
Arm fat percentage (left)	0.1	0.5	1.1	-1.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.3	0.6	-0.5
Medication: Lisinopril	0.1	0.1	0.2	-0.4	0.2
Leg fat percentage (left)	0.1	0.5	1.0	-1.0	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	0.1
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.3	0.4
Pack years of smoking	0.1	0.2	0.3	0.2	-0.6
Respiratory disease	0.0	0.1	0.1	0.4	-0.1
Heart attack	0.0	0.0	0.0	0.1	0.0
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.0	-0.0	0.0
Worrier / anxious feelings	0.0	0.1	0.2	-0.0	-0.4
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	0.1	0.4
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.1	0.3	0.1
Commuting to job workplace: Walk	0.0	0.0	0.0	0.1	0.1
Risk taking	0.0	0.1	0.1	-0.4	-0.1
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	-0.0	-0.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	0.1	0.0

Hub : Genes

EIF2B4

Models

Trait associations