Best TWAS P=2.36e-09 · Best GWAS P=6.3e-08 conditioned to 0.056
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PPHLN1 | 0.11 | 0.11 | enet | 12 | 0.13 | 8.5e-11 | 4.9 | -6.0 | 2.4e-09 | 0.67 | 0.04 | 0.95 | TRUE |
2 | GTEx | Artery Tibial | PPHLN1 | 0.12 | 0.07 | lasso | 5 | 0.09 | 2.3e-07 | -4.4 | -5.2 | 2.6e-07 | 0.92 | 0.05 | 0.94 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | PPHLN1 | 0.17 | 0.10 | enet | 24 | 0.17 | 1.3e-12 | -4.1 | -5.7 | 9.9e-09 | 0.88 | 0.03 | 0.96 | FALSE |
4 | GTEx | Esophagus Muscularis | ZCRB1 | 0.13 | 0.10 | lasso | 2 | 0.08 | 2.4e-05 | -5.2 | -5.4 | 8.1e-08 | 0.97 | 0.00 | 0.99 | FALSE |
5 | GTEx | Lung | ZCRB1 | 0.10 | 0.14 | enet | 13 | 0.13 | 5.6e-10 | -5.2 | -5.3 | 1.3e-07 | 0.95 | 0.00 | 1.00 | FALSE |
6 | GTEx | Skin Sun Exposed Lower leg | PRICKLE1 | 0.13 | 0.01 | lasso | 7 | 0.00 | 1.7e-01 | 4.9 | 5.1 | 2.9e-07 | -0.08 | 0.07 | 0.49 | FALSE |
7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZCRB1 | 0.04 | 0.01 | blup | 34 | 0.01 | 1.8e-02 | -3.8 | -5.1 | 2.8e-07 | 0.93 | 0.01 | 0.33 | FALSE |