[Hub]/) : Traits : Impedance of arm (left) : ← →

chr12:47,671,905-49,444,545

Best TWAS P=1.13e-15 · Best GWAS P=1.81e-16 conditioned to 0.000986

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
45	GTEx	Skin Sun Exposed Lower leg	RP1-228P16.1	0.29	0.24	enet	28	0.26	2.0e-21	6.9	-8.0	1.1e-15	-0.76	0.13	0.87	TRUE
18	GTEx	Brain Frontal Cortex BA9	TMEM106C	0.35	0.01	lasso	8	-0.01	6.8e-01	-3.4	7.7	1.5e-14	0.72	0.03	0.76	FALSE
49	GTEx	Testis	ASB8	0.17	0.15	lasso	3	0.13	1.8e-06	8.0	7.7	1.7e-14	0.84	0.01	0.98	FALSE
2	GTEx	Adipose Subcutaneous	RP1-228P16.1	0.20	0.20	lasso	8	0.22	4.7e-18	6.8	-7.6	2.6e-14	-0.83	0.18	0.82	FALSE
17	GTEx	Brain Cortex	ASB8	0.28	0.19	lasso	7	0.20	3.3e-06	7.1	7.6	2.7e-14	0.74	0.31	0.56	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	RP1-228P16.1	0.33	0.20	lasso	9	0.29	6.3e-10	6.5	-7.5	5.4e-14	-0.88	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ASB8	0.04	0.03	blup	69	0.03	4.1e-04	6.4	7.4	1.8e-13	0.66	0.02	0.92	FALSE
19	GTEx	Brain Frontal Cortex BA9	ASB8	0.24	0.16	lasso	6	0.07	7.1e-03	7.1	7.2	4.8e-13	0.69	0.17	0.55	FALSE
47	GTEx	Spleen	RP1-228P16.1	0.35	0.23	lasso	7	0.19	1.6e-05	6.8	-7.1	1.5e-12	-0.76	0.03	0.96	FALSE
36	GTEx	Muscle Skeletal	RP1-228P16.1	0.12	0.10	lasso	9	0.09	7.4e-09	7.0	-7.0	1.9e-12	-0.75	0.04	0.96	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	ASB8	0.20	0.04	lasso	4	0.02	7.7e-02	6.5	7.0	3.1e-12	0.65	0.10	0.38	FALSE
14	GTEx	Brain Caudate basal ganglia	RP1-228P16.1	0.14	0.12	lasso	4	0.11	5.7e-04	7.0	-7.0	3.3e-12	-0.72	0.06	0.78	FALSE
38	GTEx	Nerve Tibial	ASB8	0.09	0.08	lasso	4	0.07	1.8e-05	6.9	7.0	3.6e-12	0.73	0.17	0.80	FALSE
4	GTEx	Adipose Visceral Omentum	ASB8	0.10	0.00	lasso	6	0.00	6.8e-01	8.2	6.9	4.1e-12	0.86	0.02	0.93	FALSE
15	GTEx	Brain Cerebellar Hemisphere	RP1-228P16.1	0.30	0.21	lasso	7	0.28	6.5e-08	6.8	-6.9	4.2e-12	-0.73	0.38	0.61	FALSE
28	GTEx	Esophagus Mucosa	ZNF641	0.08	0.00	enet	23	0.01	1.0e-01	5.9	6.9	4.6e-12	0.56	0.11	0.78	FALSE
3	GTEx	Adipose Visceral Omentum	ZNF641	0.14	0.09	lasso	4	0.08	3.7e-05	5.9	6.9	7.3e-12	0.62	0.38	0.45	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	ASB8	0.04	0.03	lasso	3	0.03	2.3e-04	7.1	6.9	7.3e-12	0.68	0.01	0.98	FALSE
41	GTEx	Pituitary	RP1-228P16.1	0.20	0.15	lasso	6	0.16	1.1e-04	7.0	-6.8	1.0e-11	-0.73	0.18	0.59	FALSE
29	GTEx	Esophagus Mucosa	RP1-228P16.1	0.19	0.18	lasso	4	0.21	8.7e-14	7.0	-6.8	1.1e-11	-0.68	0.95	0.05	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	ASB8	0.08	0.01	blup	69	0.04	3.9e-05	7.1	6.8	1.1e-11	0.56	0.02	0.97	FALSE
55	METSIM	Adipose	ASB8	0.03	0.00	bslmm	526	0.01	3.8e-02	6.8	6.8	1.3e-11	0.70	0.04	0.80	FALSE
26	GTEx	Colon Transverse	RP1-228P16.1	0.24	0.18	lasso	5	0.18	4.9e-09	7.0	-6.7	1.7e-11	-0.67	0.62	0.38	FALSE
33	GTEx	Liver	RP1-228P16.1	0.19	0.08	lasso	7	0.06	7.1e-03	6.0	-6.7	1.7e-11	-0.77	0.04	0.84	FALSE
7	GTEx	Adrenal Gland	RP1-228P16.1	0.19	0.20	lasso	5	0.15	4.4e-06	6.9	-6.7	1.9e-11	-0.72	0.12	0.87	FALSE
10	GTEx	Artery Coronary	RP1-228P16.1	0.12	0.06	lasso	2	0.03	2.6e-02	6.9	-6.7	2.5e-11	-0.74	0.11	0.79	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	RP1-228P16.1	0.23	0.25	enet	17	0.23	6.8e-09	7.0	-6.7	2.7e-11	-0.73	0.41	0.58	FALSE
48	GTEx	Stomach	RP1-228P16.1	0.12	0.03	lasso	7	0.05	1.9e-03	7.0	-6.7	2.9e-11	-0.76	0.03	0.96	FALSE
53	GTEx	Uterus	RP1-228P16.1	0.32	0.09	lasso	15	0.01	2.1e-01	6.5	-6.6	3.5e-11	-0.65	0.09	0.38	FALSE
35	GTEx	Lung	RP1-228P16.1	0.18	0.20	enet	21	0.21	7.0e-16	6.5	-6.6	4.9e-11	-0.71	0.91	0.09	FALSE
21	GTEx	Brain Putamen basal ganglia	RP1-228P16.1	0.21	0.24	lasso	6	0.24	2.1e-06	5.9	-6.6	5.2e-11	-0.65	0.17	0.70	FALSE
51	GTEx	Thyroid	ZNF641	0.16	0.06	enet	26	0.13	2.0e-10	-3.5	6.5	5.8e-11	0.59	0.64	0.35	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	ZNF641	0.15	0.11	enet	30	0.10	3.1e-06	5.9	6.5	8.0e-11	0.72	0.32	0.67	FALSE
39	GTEx	Nerve Tibial	RP1-228P16.1	0.18	0.21	enet	22	0.21	4.9e-15	6.8	-6.5	8.1e-11	-0.72	0.10	0.90	FALSE
5	GTEx	Adipose Visceral Omentum	RP1-228P16.1	0.18	0.13	lasso	4	0.15	2.3e-08	7.0	-6.4	1.3e-10	-0.65	0.18	0.82	FALSE
12	GTEx	Artery Tibial	RP1-228P16.1	0.16	0.14	lasso	14	0.15	5.9e-12	6.9	-6.4	1.6e-10	-0.71	0.79	0.21	FALSE
23	GTEx	Breast Mammary Tissue (Female)	RP1-228P16.1	0.07	-0.01	enet	2	-0.01	5.9e-01	6.8	-6.4	1.9e-10	-0.66	0.05	0.35	FALSE
16	GTEx	Brain Cortex	TMEM106C	0.21	0.04	enet	20	0.10	1.0e-03	6.8	6.4	2.1e-10	0.64	0.04	0.76	FALSE
6	GTEx	Adrenal Gland	ZNF641	0.31	0.18	lasso	3	0.21	4.2e-08	5.0	6.3	2.6e-10	0.65	0.25	0.68	FALSE
11	GTEx	Artery Tibial	ZNF641	0.19	0.16	lasso	5	0.16	1.6e-12	5.9	6.3	3.2e-10	0.71	0.98	0.02	FALSE
44	GTEx	Skin Sun Exposed Lower leg	ZNF641	0.21	0.03	enet	17	0.08	6.5e-07	-3.3	6.3	3.8e-10	0.57	0.48	0.51	FALSE
32	GTEx	Heart Left Ventricle	RP1-228P16.1	0.26	0.14	lasso	16	0.17	1.9e-09	7.0	-6.2	5.8e-10	-0.83	0.03	0.97	FALSE
34	GTEx	Lung	ZNF641	0.08	0.10	lasso	2	0.08	8.0e-07	6.2	6.1	1.1e-09	0.69	0.96	0.03	FALSE
56	METSIM	Adipose	ZNF641	0.07	0.03	blup	487	0.06	7.0e-09	-3.4	6.0	1.6e-09	0.58	0.98	0.02	FALSE
54	GTEx	Whole Blood	RP1-228P16.1	0.10	0.06	enet	20	0.09	4.7e-09	8.1	-6.0	2.1e-09	-0.78	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	ZNF641	0.10	0.10	lasso	4	0.10	2.8e-08	5.8	5.9	3.3e-09	0.69	0.99	0.01	FALSE
37	GTEx	Nerve Tibial	ZNF641	0.14	0.11	lasso	4	0.08	2.3e-06	5.9	5.9	4.4e-09	0.69	0.93	0.07	FALSE
13	GTEx	Brain Caudate basal ganglia	ASB8	0.18	0.02	lasso	4	0.04	2.1e-02	7.1	5.8	8.2e-09	0.67	0.08	0.41	FALSE
40	GTEx	Pancreas	RP1-228P16.1	0.12	0.05	enet	10	0.05	5.0e-03	3.9	-5.8	8.7e-09	-0.76	0.09	0.80	FALSE
30	GTEx	Esophagus Muscularis	RP1-228P16.1	0.20	0.17	enet	14	0.17	1.2e-10	7.0	-5.7	1.6e-08	-0.67	0.29	0.71	FALSE
50	GTEx	Testis	RP1-228P16.1	0.38	0.28	lasso	6	0.31	4.0e-14	6.8	-5.6	1.6e-08	-0.69	0.24	0.76	FALSE
31	GTEx	Heart Atrial Appendage	RP1-228P16.1	0.16	0.02	enet	14	0.02	3.2e-02	3.7	-5.6	1.9e-08	-0.64	0.13	0.58	FALSE
60	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SENP1	0.09	0.02	enet	10	0.06	1.1e-04	-4.2	-5.6	2.3e-08	-0.65	0.04	0.74	FALSE
46	GTEx	Spleen	ZNF641	0.42	0.21	lasso	11	0.28	5.4e-08	-3.8	5.5	2.9e-08	0.57	0.21	0.71	FALSE
61	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMEM106C	0.27	0.10	lasso	3	0.09	1.7e-04	-3.6	5.5	3.6e-08	0.39	0.08	0.51	FALSE
25	GTEx	Cells Transformed fibroblasts	RP1-228P16.1	0.09	0.03	lasso	3	0.04	8.1e-04	6.5	-5.4	5.2e-08	-0.63	0.26	0.64	FALSE
8	GTEx	Artery Aorta	ZNF641	0.22	0.13	enet	30	0.18	4.9e-10	6.4	5.4	5.3e-08	0.63	0.97	0.03	FALSE
9	GTEx	Artery Aorta	RP1-228P16.1	0.16	0.05	enet	28	0.11	1.7e-06	6.4	-5.4	5.5e-08	-0.59	0.77	0.22	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	SENP1	0.01	0.00	blup	87	0.01	1.8e-02	-4.2	-5.4	7.4e-08	-0.63	0.04	0.34	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	RP1-228P16.1	0.17	0.10	enet	23	0.16	4.1e-09	6.4	-5.3	9.9e-08	-0.71	0.06	0.94	FALSE
22	GTEx	Breast Mammary Tissue	RP1-228P16.1	0.22	0.14	lasso	8	0.20	1.3e-10	4.3	-5.3	1.2e-07	-0.61	0.79	0.21	FALSE
52	GTEx	Thyroid	RP1-228P16.1	0.30	0.30	enet	41	0.33	1.4e-25	6.9	-5.3	1.2e-07	-0.65	0.98	0.02	FALSE