TWAS hub - CCDC33

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Lung Adenocarcinoma	0.0479	0.0212	4.2e-05	0.021	0.036	0.033	NA	0.031	0.0016	0.00004	8.6e-05	NA	1.5e-04
2	TCGA	Pancreatic Adenocarcinoma	0.2030	0.0750	1.9e-04	0.059	0.077	0.088	NA	0.111	0.0018	0.00040	1.5e-04	NA	2.3e-05
3	TCGA	Rectum Adenocarcinoma	0.2020	0.0970	8.0e-03	0.066	0.038	0.040	NA	0.050	0.0120	0.04500	4.2e-02	NA	2.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Blood pressure	7.9	15.0	23.2	4.8	1.5	4.4
Commuting to job workplace: Walk	7.4	8.0	9.2	2.5	3.0	3.0
Ever taken oral contraceptive pill	7.3	8.1	11.2	-2.5	-2.6	-3.4
Frequency of tiredness / lethargy in last 2 weeks	6.8	11.0	14.5	-3.8	-2.1	-3.8
Number of operations (self-reported)	6.3	9.4	11.4	-2.9	-2.9	-3.4
Had major operations	5.8	6.8	10.2	-3.2	-1.6	-2.8
Cardiovascular Disease	5.7	18.9	32.0	5.7	2.1	4.5
Mouth/teeth dental problems: Loose teeth	5.7	6.8	10.3	-3.1	-0.7	-3.2
Hypertension (Self-reported)	5.6	15.6	31.6	5.6	0.7	3.8
Pain experienced in last month	5.4	9.1	15.7	2.7	2.1	4.0
High blood pressure	5.3	14.7	30.9	5.6	0.5	3.6
Knee pain experienced in last month	5.3	8.2	10.9	-3.3	-2.0	-3.1
Medication: Paracetamol	5.1	7.9	9.4	-3.1	-2.2	-3.1
Vascular/heart problems diagnosed by doctor	5.0	13.6	26.8	-5.2	-0.8	-3.7
Eye problems/disorders: Diabetes related eye disease	4.9	5.4	8.2	1.5	2.9	2.4
Medication: Ramipril	4.5	5.7	8.8	3.0	1.2	2.6
Medication: Aspirin	4.5	5.9	8.2	2.9	1.6	2.6
Medication: Aspirin	4.3	5.6	8.5	2.9	1.3	2.5
Had other major operations	4.1	5.0	5.9	-2.1	-2.2	-2.4
Alzheimer’s Disease (in father)	4.0	4.3	9.8	-3.1	-0.2	-1.8
Ulcerative Colitis	4.0	5.8	9.3	-2.5	-1.4	-3.0
Loud music exposure frequency	3.9	4.3	5.6	-1.6	-2.2	-2.4
Illnesses of siblings: Diabetes	3.8	4.7	5.8	2.4	1.8	2.3
Impedance of arm (right)	3.7	17.5	40.4	6.4	-1.0	3.3
Impedance of arm (left)	3.4	15.8	33.5	5.8	-0.2	3.7
Medication: Paracetamol	3.3	5.5	5.7	-2.4	-2.3	-2.4
Overall health rating	3.3	7.0	8.7	-2.8	-2.1	-2.9
Osteoarthritis (self-reported)	3.3	4.3	9.1	-3.0	-0.6	-1.8
Pain type(s) experienced in last month: Hip pain	3.3	4.2	5.2	-2.2	-1.6	-2.3
Chronic bronchitis/emphysema (father)	3.1	3.7	6.1	-2.5	-0.7	-2.1
High cholesterol (Self-reported)	3.1	5.5	11.2	3.3	0.5	2.3
Diabetes (father)	3.0	3.7	4.3	2.1	2.0	1.6
Ever unenthusiastic/disinterested for a whole week	3.0	3.7	8.0	-2.8	-0.4	-1.7
Diverticular disease/diverticulitis (self-reported)	2.9	3.4	4.6	-1.4	-2.1	-1.9
Frequency of tenseness / restlessness in last 2 weeks	2.9	4.5	6.3	-1.7	-2.5	-2.1
Medication: Cholesterol lowering	2.9	4.5	8.4	2.9	0.8	2.1
Qualifications: O levels/GCSEs or equivalent	2.8	4.5	6.8	-2.6	-2.2	-1.3
Pulse rate, automated reading	2.8	9.1	14.2	-3.8	-1.7	-3.2
Eye problems/disorders: Glaucoma	2.8	3.3	4.5	-2.1	-0.9	-2.1
Irritable Bowel Disease (IBD)	2.7	6.3	9.5	-2.1	-2.3	-3.1
Systolic Blood Pressure	2.7	13.4	22.9	4.8	1.5	3.9
Multivitamins +/- minerals	2.7	3.4	4.7	-0.9	-2.2	-2.2
Eye problems/disorders: None of the above	2.7	3.1	5.4	2.3	0.4	1.9
Breast Cancer	2.5	6.0	8.3	2.4	1.9	2.9
Medication: Simvastatin	2.5	3.7	6.1	2.5	0.9	2.1
Diabetes diagnosed by doctor	2.5	4.1	5.9	2.0	2.4	1.5
Medication: Lisinopril	2.5	3.2	4.0	1.9	2.0	1.5
Risk taking	2.5	3.7	6.9	-1.3	-1.6	-2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	5.5	-1.1	-2.4	-1.7
Pulse wave peak to peak time	2.4	2.8	4.0	1.6	1.4	2.0
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	4.0	-1.8	-0.6	-2.0
Ulcerative Colitis (UC)	2.3	4.4	6.1	-1.7	-2.0	-2.5
Noisy workplace	2.3	2.9	3.5	-1.6	-1.6	-1.9
Impedance of whole body	2.3	11.6	24.0	4.9	-0.9	3.1
Frequency of depressed mood in last 2 weeks	2.2	3.1	5.8	-0.9	-2.4	-1.6
Pack years adult smoking proportion	2.2	3.3	5.5	-2.4	-0.1	-2.1
Townsend deprivation index at recruitment	2.2	3.1	4.7	-0.4	-2.2	-2.1
Fluid intelligence score	2.2	4.7	6.6	2.3	1.5	2.6
Long-standing illness, disability or infirmity	2.2	3.3	4.0	-1.9	-1.5	-2.0
Alzheimer’s Disease (including proxy)	2.1	3.0	5.4	-2.3	-0.4	-1.9
Diabetes (self-reported)	2.1	3.2	4.6	1.5	2.2	1.7
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	7.6	-2.8	-0.7	-1.5
Commuting to job workplace: Cycle	2.1	2.5	5.6	1.3	0.5	2.4
Pack years of smoking	2.1	3.1	4.9	-2.2	-0.1	-2.1
Medication: Atenolol	2.0	2.5	4.0	1.2	1.5	2.0
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.5	7.8	2.8	1.6	1.8
Heart attack	2.0	2.6	5.8	-0.5	-2.4	-1.3
Alcohol intake versus 10 years previously	2.0	3.0	8.2	0.7	-2.9	-0.4
Glaucoma (self-reported)	2.0	2.3	3.6	-1.4	-1.1	-1.9
Exposure to tobacco smoke outside home	2.0	2.7	3.8	-1.9	-0.7	-1.9
Medication: Ibuprofen	2.0	2.3	3.3	-1.8	-0.9	-1.7
Heart attack/myocardial infarction (self-reported)	2.0	2.6	5.6	-0.4	-2.4	-1.4
LDL Cholesterol	1.9	3.0	5.1	-2.2	-0.9	-1.7
Medication: Co-codamol	1.9	2.2	3.6	-1.9	-1.1	-1.3
Hearing difficulty/problems with background noise	1.9	3.0	4.5	-2.1	-0.6	-2.0
Had menopause	1.9	2.4	3.7	1.9	1.1	1.5
Pulse wave Arterial Stiffness index	1.9	2.2	3.6	-1.4	-1.0	-1.9
Number of full brothers	1.9	2.3	4.2	-1.6	0.5	-2.0
Commuting to job workplace: Car/motor vehicle	1.9	2.2	4.0	-1.5	-0.6	-2.0
Medication: Atorvastatin	1.9	2.4	4.1	2.0	0.3	1.7
Serious illness, injury or assault to yourself	1.8	2.2	4.9	-2.2	-0.2	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	3.0	-1.7	-1.0	-1.7
Medication: Amlodipine	1.8	2.5	3.3	1.8	1.4	1.4
Medication: Blood pressure	1.8	3.3	6.1	2.5	1.2	1.5
Alcohol intake frequency.	1.8	4.2	8.1	2.8	0.8	2.0
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	4.3	-2.1	0.1	-1.4
Handedness (chirality/laterality): Left-handed	1.8	2.2	3.1	-0.9	-1.8	-1.6
Medication for cholesterol	1.8	2.7	5.0	-2.2	0.1	-1.7
Type 2 Diabetes (T2D) (2018)	1.7	3.1	5.3	1.4	2.3	1.4
Ever had hysterectomy (womb removed)	1.7	1.9	4.4	1.1	-2.1	0.1
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	4.1	-0.1	-2.0	-1.3
Mouth/teeth dental problems	1.7	2.7	4.6	1.4	1.3	2.1
Miserableness	1.7	3.0	3.8	-1.6	-2.0	-1.6
Irritability	1.7	2.9	4.5	-1.8	-1.0	-2.1
Heart disease (siblings)	1.7	2.1	3.7	1.9	-1.4	0.7
Blood Red Count	1.6	15.2	27.8	5.3	0.9	4.1
Stomach or abdominal pain in last month	1.6	2.0	3.6	-1.5	-0.4	-1.9
Pulse wave reflection index	1.6	1.9	3.0	-1.0	-1.3	-1.7
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	3.2	-1.8	-0.7	-1.5
Supplements: Calcium	1.6	1.7	3.0	1.7	0.6	1.4
Type 2 Diabetes (T2D) (2012)	1.5	1.7	4.9	-0.1	-2.2	-0.4
Supplements: Glucosamine	1.5	1.9	3.5	-1.9	-0.4	-1.4
High blood pressure (mother)	1.5	2.0	3.5	1.9	1.1	1.2
Illnesses of mother	1.5	1.9	3.2	-1.8	-0.4	-1.5
Peak expiratory flow (PEF)	1.5	3.4	7.4	2.7	-1.4	0.8
Leg pain on walking	1.5	1.8	2.7	-1.7	0.8	-1.5
Financial situation satisfaction	1.5	1.9	4.4	-2.1	-0.4	-1.1
Prostate Cancer	1.4	2.0	5.5	-2.3	-0.3	-0.6
Bipolar Disorder (2011)	1.4	1.4	2.9	-1.7	-1.1	0.0
Average weekly spirits intake	1.4	1.7	2.7	-1.4	-0.6	-1.7
Falls in the last year	1.4	1.9	3.6	-1.2	-0.8	-1.9
Hair/balding pattern: Pattern 3	1.4	2.1	3.4	1.8	0.8	1.5
Standing height	1.4	13.4	22.9	2.9	4.8	3.0
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.7	0.8	1.6	1.3
Back pain experienced in last month	1.4	2.0	3.5	-1.6	-0.2	-1.9
Ever depressed for a whole week	1.4	1.8	2.8	-1.7	1.3	-0.9
Financial difficulties in last 2 years	1.3	1.8	2.2	-1.3	-1.2	-1.5
Time employed in main current job	1.3	1.4	2.6	-1.3	-0.2	-1.6
Illnesses of father: None of the above (group 1)	1.3	1.6	3.0	1.7	0.2	1.3
Sensitivity / hurt feelings	1.2	2.0	2.7	-1.1	-1.5	-1.6
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.0	1.3	-1.7	0.0
Fed-up feelings	1.2	2.2	3.8	-1.0	-1.9	-1.3
Number of live births	1.2	1.7	2.9	1.0	1.7	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.2	1.8	0.7	0.6
Medication: Ventolin 100micrograms inhaler	1.2	1.6	3.5	-0.5	1.9	1.0
Arm fat-free mass (right)	1.2	6.2	10.2	-2.8	3.2	-0.8
Wheeze or whistling in the chest in last year	1.2	2.1	3.2	-1.8	0.2	-1.8
Bipolar Disorder (2018)	1.1	1.7	2.0	1.2	1.2	1.4
Verbal and Numeric Reasoning (VNR)	1.1	2.7	4.2	2.1	0.3	1.9
Relative age voice broke	1.1	1.6	4.3	2.1	-0.7	0.2
Chronic bronchitis/emphysema (mother)	1.1	1.2	3.0	-1.7	-0.4	-0.7
Medication for pain relief, constipation, heartburn	1.1	2.0	3.3	0.8	1.8	1.4
Neck or shoulder pain in last month	1.1	1.6	2.8	-1.2	-0.8	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.8	1.7	0.1	1.0
Average weekly red wine intake	1.1	1.6	1.9	-1.4	1.0	-1.3
Age started oral contraceptive pill	1.1	1.4	3.0	1.7	0.2	1.0
Crohns Disease (2012)	1.0	1.6	2.5	-1.4	-0.7	-1.6
HbA1C	1.0	1.1	1.2	1.1	0.9	1.1
Height	1.0	20.2	26.8	4.2	5.2	4.0
Illnesses of siblings	1.0	1.4	2.4	-1.6	-0.8	-1.0
Qualifications: A levels/AS levels or equivalent	1.0	2.3	4.9	-2.2	-0.1	-1.4
Blood clot in the leg (DVT)	1.0	1.3	2.1	-1.1	-0.7	-1.5
Arm predicted mass (right)	1.0	5.4	10.2	-2.4	3.2	-0.5
Mood swings	1.0	1.9	3.0	-0.8	-1.7	-1.4
Average weekly beer plus cider intake	1.0	1.5	4.4	0.0	-2.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.3	-1.0	-0.7	-1.5
Depressed Affect (Nagel 2018)	0.9	1.9	3.4	-0.5	-1.9	-1.4
Crohns Disease (2017)	0.9	2.1	3.3	-1.4	-1.0	-1.8
Lupus	0.9	1.4	2.4	1.6	-0.1	1.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.8	-0.9	-0.1	-1.7
Maternal smoking around birth	0.9	1.3	2.6	-1.6	-0.2	-1.1
Body mass index (BMI)	0.9	4.0	7.4	-2.7	-0.1	-2.2
Trunk fat-free mass	0.9	5.4	12.7	-1.9	3.6	-0.2
Trunk predicted mass	0.9	5.3	12.8	-1.8	3.6	-0.2
Length of working week for main job	0.9	1.0	1.5	-0.7	-1.2	-1.1
Health satisfaction	0.9	1.2	2.5	-1.6	0.4	-0.9
Comparative height size at age 10	0.9	4.9	9.1	1.6	3.0	1.7
Whole body fat-free mass	0.9	5.4	13.1	-1.8	3.6	-0.2
Whole body water mass	0.9	5.3	12.8	-1.7	3.6	-0.2
Arm fat-free mass (left)	0.9	4.7	8.8	-2.3	3.0	-0.6
Cholesterol lowering medication	0.9	1.4	2.7	1.6	0.2	1.2
Depression (Nagel 2018)	0.8	1.1	2.2	-0.3	-1.5	-1.1
Intelligence (Savage-Jansen 2018)	0.8	2.6	6.9	0.9	0.3	2.6
Coronary Artery Disease (CAD)	0.8	0.9	1.8	-1.3	-0.8	-0.6
Mean Putamen Volume	0.8	0.9	1.5	1.0	-0.4	1.2
Blood Platelet Count	0.8	9.0	21.4	-4.6	-1.1	-2.1
Medication for hormone replacement therapy	0.8	0.9	2.2	-0.1	-1.5	-0.7
Supplements: Zinc	0.8	0.8	1.4	0.8	-0.6	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	2.4	1.5	1.3	1.0
Medication: Levothyroxine sodium	0.8	1.4	2.6	-1.1	-0.5	-1.6
Leg predicted mass (left)	0.8	4.0	11.1	-1.0	3.3	0.1
Waist circumference	0.8	3.1	4.8	-2.2	0.3	-2.1
Pulse rate	0.8	1.3	3.1	-1.8	-0.1	-0.9
Birth weight of first child	0.8	1.5	2.4	-1.2	-0.7	-1.6
Leg fat percentage (right)	0.8	2.7	3.6	-1.9	-1.3	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.1	-1.4	-0.7	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.4	1.2	-1.1	0.4
Shortness of breath walking on level ground	0.8	0.9	1.3	0.7	1.0	1.2
Supplements: Vitamin C	0.8	0.9	1.3	1.0	1.1	0.7
Leg fat-free mass (right)	0.8	4.3	11.7	-1.1	3.4	-0.1
Ever had bowel cancer screening	0.8	1.0	1.3	1.1	-0.8	-1.0
Mineral and other dietary supplements	0.8	1.1	2.4	0.4	0.8	1.5
Leg predicted mass (right)	0.8	4.3	11.7	-1.1	3.4	-0.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.6	1.1	-1.3	-0.0
Basal metabolic rate	0.8	4.6	11.0	-1.6	3.3	-0.3
Leg fat percentage (left)	0.8	2.9	3.8	-1.9	-1.3	-1.8
Arm predicted mass (left)	0.8	4.1	9.0	-1.8	3.0	-0.5
Medication: Metformin	0.7	0.9	1.9	1.4	0.7	0.6
Impedance of leg (right)	0.7	3.5	5.3	2.3	-1.4	1.8
Leg fat-free mass (left)	0.7	3.9	10.7	-1.0	3.3	0.0
Age when periods started (menarche)	0.7	1.7	2.1	-1.5	-1.4	-1.0
Impedance of leg (left)	0.7	3.6	5.9	2.4	-1.4	1.7
Father’s age at death	0.7	0.9	2.7	0.1	1.6	0.1
Smoking status: Previous	0.7	1.1	2.4	-0.7	-0.6	-1.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	1.4	1.1	1.2	1.0
Wears glasses or contact lenses	0.7	0.9	1.9	0.3	1.4	0.8
Fractured/broken bones in last 5 years	0.7	0.9	1.4	-0.7	-0.9	-1.2
Alcohol drinker status: Previous	0.7	0.8	2.3	0.2	1.5	0.3
Bipolar Disorder or Schizophrenia	0.6	1.6	2.3	1.4	0.6	1.5
Worry (Nagel 2018)	0.6	1.2	2.4	1.5	0.1	1.2
Ovarian Cancer	0.6	0.8	1.4	0.9	-1.2	-0.5
Age at First Birth	0.6	0.9	2.5	0.3	-1.6	-0.3
HDL Cholesterol	0.6	1.1	1.6	-1.3	-0.9	-0.9
Rheumatoid Arthritis	0.6	0.8	1.6	-1.3	-0.9	-0.3
Heel T-Score	0.6	4.4	10.0	3.2	-0.2	1.8
Waist Hip Ratio (WHR)	0.6	2.6	4.3	-1.4	-1.2	-2.1
Relative age of first facial hair	0.6	1.2	2.2	1.5	-1.2	-0.1
Vitamin and mineral supplements	0.6	0.9	1.3	-0.9	1.1	0.8
Hand grip strength (right)	0.6	1.5	4.5	-0.2	2.1	0.1
Neuroticism score	0.6	1.2	1.8	-0.6	-1.4	-1.2
Lung cancer (father)	0.6	0.6	1.0	1.0	-0.5	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.9	-0.8	1.4	0.0
Worry too long after embarrassment	0.6	1.0	2.2	-1.5	0.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.4	0.9	1.6	0.5
Qualifications: nursing, teaching	0.6	0.9	2.1	-0.8	0.3	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.4	0.0	-1.6	-1.0
Average weekly champagne plus white wine intake	0.6	0.8	1.0	-1.0	-0.8	-0.9
Commuting to job workplace: Public transport	0.6	0.7	0.9	0.9	0.6	0.8
Neuroticism (2016)	0.5	0.7	1.3	-0.6	-0.8	-1.1
Lung FEV1/FVC ratio	0.5	2.4	4.2	2.0	-1.4	1.1
Lung FVC	0.5	2.8	3.4	-1.8	-1.4	-1.7
Neuroticism	0.5	1.2	2.5	-0.2	-1.6	-1.1
Hearing difficulty/problems: Yes	0.5	0.8	0.9	-1.0	0.8	-0.9
Systolic blood pressure, automated reading	0.5	1.5	3.3	1.8	0.3	1.0
Angina	0.5	0.6	1.2	-0.5	1.1	0.7
Nervous feelings	0.5	1.0	1.3	0.9	-1.1	0.9
Exposure to tobacco smoke at home	0.5	0.6	1.4	-0.0	0.5	1.2
Birth weight	0.5	1.0	2.0	-1.4	0.8	-0.5
Number of children fathered	0.5	0.6	1.5	-1.2	-0.3	-0.3
Medication: Allopurinol	0.5	0.6	1.0	1.0	0.2	0.9
Medication: Omeprazole	0.5	0.6	1.5	1.2	0.1	0.7
Mean time to correctly identify matches	0.5	0.9	2.4	1.6	-0.5	0.4
Leg fat mass (right)	0.5	2.0	3.3	-1.8	-0.1	-1.6
Suffer from ‘nerves’	0.5	0.8	2.1	1.4	-0.5	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	-0.6	-1.1	-0.2
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.0	0.3	-0.9	-1.0
Leg fat mass (left)	0.5	1.8	2.9	-1.7	0.1	-1.5
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	-0.0	-1.2	-0.3
Major Depression (MDD)	0.4	0.5	0.6	-0.8	0.7	-0.6
Fasting Glucose	0.4	0.5	0.7	0.8	-0.6	0.6
Triglycerides	0.4	0.6	1.0	0.4	-1.0	-0.8
Smoking Status	0.4	0.9	1.9	-1.4	0.2	-0.9
Allergy or Eczema	0.4	1.2	2.7	-0.8	1.6	-0.3
Chronotype (morning person)	0.4	1.0	2.7	0.4	1.7	-0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	1.0	0.3	0.3
Hair/balding pattern: Pattern 2	0.4	0.5	1.0	0.7	-0.0	1.0
Weight	0.4	2.1	4.1	-1.4	2.0	-0.7
Mouth/teeth dental problems: Dentures	0.4	0.7	1.3	0.3	-1.2	-0.9
Gout (self-reported)	0.4	0.5	1.0	1.0	0.4	0.7
Emphysema/chronic bronchitis	0.4	0.4	0.6	-0.8	0.8	0.2
Age at last live birth	0.4	0.6	1.0	-1.0	0.1	-0.9
Illnesses of father: Heart disease	0.4	0.5	1.1	-0.6	-1.0	-0.4
Osteoporosis (self-reported)	0.4	0.5	0.8	0.6	-0.9	0.6
Medication: Gliclazide	0.4	0.4	0.6	0.3	-0.8	-0.8
Mother’s age at death	0.4	0.5	0.7	0.8	0.6	0.8
Neuroticism (Nagel 2018)	0.3	0.7	1.4	0.2	-1.2	-0.8
Alzheimer’s Disease (in mother)	0.3	0.3	0.5	-0.6	-0.1	-0.7
Reaction Time	0.3	0.5	1.2	1.1	0.0	0.6
Schizophrenia (2014)	0.3	0.7	1.9	0.2	-1.4	-0.3
Blood Eosinophil Count	0.3	2.2	3.9	2.0	-0.5	1.6
Hypothyroidism (self reported)	0.3	0.7	1.3	-0.4	1.1	-0.9
Tanning	0.3	4.1	8.0	-2.8	0.7	-2.0
Hand grip strength (left)	0.3	0.8	1.7	-0.7	1.3	-0.5
Severe depression (siblings)	0.3	0.3	0.6	0.3	-0.8	0.5
Average weekly fortified wine intake	0.3	0.4	0.6	-0.8	0.7	-0.3
Taking other prescription medications	0.3	0.4	0.8	-0.3	-0.9	-0.7
Sitting height	0.3	2.3	6.2	-0.9	2.5	0.2
Past tobacco smoking	0.3	0.6	1.5	0.6	0.4	1.2
Alcohol usually taken with meals	0.3	0.5	0.9	0.7	0.9	0.3
Qualifications: None of the above	0.3	0.5	0.9	0.9	-0.1	0.9
Allergy	0.3	0.8	1.5	0.8	0.2	1.2
Hip circumference	0.3	1.4	3.5	-0.9	1.9	-0.2
Happiness	0.3	0.3	0.7	-0.5	0.8	-0.2
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	-0.5	-0.3	-0.8
Comparative body size at age 10	0.3	0.7	1.6	-1.3	-0.2	-0.7
Angina (self-reported)	0.3	0.4	0.7	-0.4	0.8	0.7
Migraine (self-reported)	0.3	0.4	0.8	0.9	-0.6	-0.2
Heart disease (mother)	0.3	0.4	0.5	0.4	0.6	0.7
Loneliness, isolation	0.3	0.5	0.8	0.9	-0.7	-0.4
Friendships satisfaction	0.3	0.3	0.5	0.7	-0.6	-0.2
Eye problems/disorders: Cataract	0.3	0.4	1.1	-0.0	1.0	0.1
Breast cancer (self-reported)	0.3	0.3	0.7	-0.5	0.8	0.2
Number of self-reported non-cancer illnesses	0.3	0.6	1.5	1.2	-0.3	0.4
Medication: Bendroflumethiazide	0.3	0.5	1.1	1.1	-0.2	0.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	0.8	0.4	0.5
Schizophrenia (2018)	0.2	0.5	0.8	0.9	-0.2	0.8
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.1	-0.1	-0.9
Respiratory disease	0.2	0.5	1.2	-1.1	0.1	0.5
Number of treatments/medications taken	0.2	0.3	0.9	0.1	-0.9	-0.3
Current tobacco smoking	0.2	0.3	0.8	-0.9	0.3	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.4	-0.5	0.6	-0.6
Number of incorrect matches in round	0.2	0.3	0.5	-0.7	0.7	-0.1
Forced vital capacity (FVC)	0.2	0.8	1.4	-1.2	0.0	-0.9
Pain all over the body in last month	0.2	0.2	0.3	-0.5	0.3	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	0.2	-0.6	-0.5
Arm fat percentage (right)	0.2	0.6	1.0	0.2	-1.0	-0.9
Worrier / anxious feelings	0.2	0.3	0.7	0.1	-0.9	0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.2	-1.0	-0.3	-1.1
Depression (self-reported)	0.2	0.2	0.5	-0.7	-0.2	-0.4
Prospective memory result	0.2	0.2	0.3	0.5	-0.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.4	-0.4	-0.1	-1.2
Tense / ‘highly strung’	0.2	0.4	0.6	-0.1	-0.7	-0.7
Headache pain in last month	0.2	0.4	1.2	0.1	-0.2	-1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.6	-0.1	0.8	-0.6
Forced vital capacity (FVC), Best measure	0.2	0.7	1.3	-0.9	-0.1	-1.1
Age at first live birth	0.2	0.4	0.9	-0.3	0.9	-0.6
Medication: Seretide 50 evohaler	0.2	0.3	0.5	0.7	-0.1	0.6
Number of full sisters	0.2	0.3	0.3	0.6	-0.6	-0.5
Family relationship satisfaction	0.2	0.2	0.4	-0.5	0.2	-0.6
Smoking status: Current	0.2	0.3	0.7	-0.8	0.4	-0.1
Alcohol drinker status: Never	0.2	0.3	0.8	0.1	0.9	0.1
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.8	-0.1	0.0	-0.9
Diastolic blood pressure, automated reading	0.2	0.7	1.5	1.2	-0.8	0.2
Myopia	0.2	0.3	0.8	0.9	-0.1	0.2
Primary Biliary Cirrhosis	0.1	0.1	0.3	0.0	-0.5	-0.2
Blood White Count	0.1	0.5	1.1	-0.6	-1.1	-0.3
Hair Pigment	0.1	1.7	2.8	-1.7	-0.7	-1.3
Diabetes (mother)	0.1	0.1	0.3	-0.6	-0.0	0.1
Qualifications: CSEs or equivalent	0.1	0.2	0.4	-0.2	-0.6	-0.4
Trunk fat mass	0.1	0.2	0.3	-0.3	0.6	-0.6
Asthma	0.1	0.3	0.5	-0.7	-0.6	-0.2
Medication: Lansoprazole	0.1	0.1	0.2	-0.0	-0.3	0.4
Arm fat mass (right)	0.1	0.4	0.8	-0.7	0.2	-0.9
Breastfed as a baby	0.1	0.1	0.1	-0.3	0.0	-0.3
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	-0.5	-0.2	-0.8
High blood pressure (siblings)	0.1	0.2	0.3	0.4	0.2	0.5
Body fat percentage	0.1	0.3	0.5	-0.1	-0.6	-0.7
Whole body fat mass	0.1	0.3	0.4	-0.4	0.5	-0.6
Chest pain or discomfort	0.1	0.1	0.2	-0.3	-0.0	-0.4
Arm fat percentage (left)	0.1	0.5	0.8	-0.3	-0.8	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.5	-0.0	-0.7	0.1
Asthma (self-reported)	0.1	0.2	0.4	-0.6	-0.5	-0.1
Arm fat mass (left)	0.1	0.4	0.7	-0.7	0.3	-0.9
Guilty feelings	0.1	0.1	0.2	0.4	-0.4	-0.2
Hearing aid user	0.1	0.1	0.2	-0.3	0.4	-0.2
Illnesses of father: High blood pressure	0.1	0.2	0.4	-0.4	0.6	-0.1
Ever smoked	0.1	0.2	0.7	0.2	-0.1	-0.8
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.1	0.2	0.5
BMI	0.0	0.1	0.1	-0.0	0.4	-0.2
Trunk fat percentage	0.0	0.1	0.2	0.4	-0.2	-0.3
Qualifications: College or University degree	0.0	0.2	0.4	-0.7	0.1	-0.1
Unable to work because of sickness or disability	0.0	0.0	0.1	0.0	-0.1	-0.2

Hub : Genes

CCDC33

Models

Trait associations