Best TWAS P=6.93e-17 · Best GWAS P=3.4e-14 conditioned to 0.189
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SOX15 | 0.04 | 0.01 | lasso | 3 | 0.01 | 2.8e-02 | -6.32 | 5.2 | 2.1e-07 | 0.39 | 0.18 | 0.04 | FALSE |
2 | GTEx | Adipose Subcutaneous | SNORA48 | 0.12 | 0.04 | lasso | 2 | 0.04 | 4.0e-04 | -5.45 | -5.6 | 1.8e-08 | -0.27 | 0.38 | 0.03 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | TNFSF12 | 0.25 | 0.22 | lasso | 8 | 0.20 | 7.4e-15 | 7.47 | 7.7 | 9.9e-15 | 0.99 | 0.00 | 1.00 | FALSE |
4 | GTEx | Muscle Skeletal | CHRNB1 | 0.34 | 0.18 | enet | 35 | 0.24 | 4.9e-23 | 6.40 | -6.0 | 2.5e-09 | -0.63 | 0.91 | 0.09 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | ATP1B2 | 0.08 | 0.01 | lasso | 3 | 0.01 | 4.8e-02 | -5.31 | -6.8 | 1.5e-11 | -0.38 | 0.35 | 0.10 | FALSE |
6 | GTEx | Testis | ZBTB4 | 0.26 | 0.00 | enet | 35 | 0.06 | 1.6e-03 | -5.41 | 6.0 | 2.5e-09 | 0.29 | 0.05 | 0.14 | FALSE |
7 | GTEx | Whole Blood | TNFSF12 | 0.09 | 0.03 | enet | 24 | 0.04 | 1.9e-04 | 7.58 | 8.3 | 6.9e-17 | 0.82 | 0.00 | 1.00 | TRUE |
8 | METSIM | Adipose | ATP1B2 | 0.07 | 0.04 | bslmm | 494 | 0.03 | 1.2e-05 | -6.47 | -6.0 | 1.8e-09 | -0.28 | 0.81 | 0.17 | FALSE |
9 | METSIM | Adipose | CHD3 | 0.06 | 0.03 | blup | 509 | 0.02 | 6.7e-04 | 0.49 | 5.5 | 4.9e-08 | 0.28 | 0.26 | 0.08 | FALSE |
10 | METSIM | Adipose | SENP3 | 0.06 | 0.03 | lasso | 3 | 0.02 | 4.9e-04 | 6.87 | -6.5 | 5.8e-11 | -0.79 | 0.13 | 0.73 | FALSE |
11 | NTR | Blood | TNFSF12 | 0.06 | 0.07 | bslmm | 462 | 0.07 | 9.4e-23 | 7.42 | 6.6 | 3.6e-11 | 0.93 | 0.00 | 1.00 | FALSE |
12 | ROSMAP | Brain Pre-frontal Cortex | TNFSF12 | 0.10 | 0.04 | lasso | 6 | 0.06 | 9.2e-08 | 7.47 | 7.8 | 5.5e-15 | 0.90 | 0.00 | 1.00 | FALSE |
13 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ATP1B2 | 0.06 | 0.01 | blup | 39 | 0.02 | 4.3e-03 | -6.51 | -5.6 | 1.9e-08 | -0.34 | 0.07 | 0.24 | FALSE |
14 | The Cancer Genome Atlas | Colon Adenocarcinoma | TNFSF12-TNFSF13 | 0.07 | 0.05 | lasso | 3 | 0.02 | 1.9e-02 | 6.87 | 7.0 | 2.1e-12 | 0.82 | 0.01 | 0.91 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CHRNB1 | 0.04 | 0.03 | blup | 57 | 0.02 | 1.5e-03 | 6.40 | -5.7 | 9.7e-09 | -0.69 | 0.00 | 0.98 | FALSE |
16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TNFSF12 | 0.04 | 0.01 | enet | 9 | 0.01 | 4.3e-02 | 6.87 | -5.9 | 3.3e-09 | -0.74 | 0.01 | 0.86 | FALSE |
17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ATP1B2 | 0.04 | 0.02 | blup | 39 | 0.04 | 2.3e-05 | -6.51 | -6.5 | 9.3e-11 | -0.34 | 0.14 | 0.45 | FALSE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TNFSF12-TNFSF13 | 0.03 | 0.00 | lasso | 4 | 0.01 | 2.9e-02 | 7.47 | 7.0 | 2.1e-12 | 0.89 | 0.00 | 0.80 | FALSE |
19 | The Cancer Genome Atlas | Thyroid Carcinoma | ATP1B2 | 0.04 | 0.01 | blup | 40 | 0.01 | 1.4e-02 | -2.08 | -5.8 | 8.9e-09 | -0.24 | 0.01 | 0.08 | FALSE |
20 | The Cancer Genome Atlas | Thyroid Carcinoma | SHBG | 0.04 | 0.00 | blup | 59 | 0.02 | 4.4e-03 | 7.32 | 6.7 | 1.5e-11 | 0.65 | 0.01 | 0.78 | FALSE |