[Hub]/) : Traits : Impedance of arm (left) : ← →

chr4:102,852,939-104,815,937

Best TWAS P=1.96e-14 · Best GWAS P=2.22e-12 conditioned to 0.0453

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CENPE	0.04	0.01	enet	10	0.02	2.6e-03	6.05	-7.7	2.0e-14	-0.74	0.01	0.93	TRUE
20	GTEx	Colon Sigmoid	CISD2	0.20	0.24	enet	15	0.13	2.1e-05	6.91	-7.4	1.7e-13	-0.95	0.05	0.95	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	UBE2D3	0.05	0.06	blup	337	0.07	5.0e-09	6.62	-7.2	4.9e-13	-0.95	0.04	0.96	FALSE
61	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CISD2	0.05	0.01	blup	18	0.06	1.9e-03	6.89	-7.2	7.4e-13	-0.98	0.01	0.69	FALSE
7	GTEx	Adrenal Gland	CISD2	0.08	0.03	lasso	2	0.03	4.1e-02	6.89	-7.1	9.5e-13	-0.94	0.05	0.87	FALSE
10	GTEx	Artery Coronary	CISD2	0.14	0.15	lasso	8	0.12	7.4e-05	-6.21	-7.0	2.4e-12	-0.94	0.05	0.91	FALSE
4	CommonMind	Brain Pre-frontal Cortex	SLC9B1	0.13	0.23	enet	24	0.24	4.4e-29	7.02	-7.0	2.6e-12	-0.93	0.03	0.97	FALSE
15	GTEx	Breast Mammary Tissue (Male)	CISD2	0.15	0.02	lasso	3	-0.01	6.5e-01	7.00	-7.0	3.5e-12	-0.97	0.04	0.40	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBE2D3	0.03	0.04	enet	11	0.03	1.4e-04	6.86	-6.9	3.7e-12	-0.97	0.02	0.97	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	CISD2	0.15	0.34	lasso	9	0.34	1.2e-44	6.89	-6.9	3.8e-12	-0.98	0.06	0.94	FALSE
9	GTEx	Artery Aorta	CISD2	0.10	0.08	lasso	4	0.06	1.8e-04	6.94	-6.9	4.4e-12	-0.99	0.05	0.95	FALSE
5	GTEx	Adipose Subcutaneous	CISD2	0.06	0.09	enet	12	0.06	7.3e-06	6.92	-6.9	5.2e-12	-0.97	0.05	0.95	FALSE
13	GTEx	Brain Cerebellum	CISD2	0.13	0.18	lasso	3	0.17	1.1e-05	6.82	-6.9	5.7e-12	-0.98	0.05	0.94	FALSE
18	GTEx	Cells Transformed fibroblasts	UBE2D3	0.11	0.09	enet	13	0.08	2.3e-06	6.81	-6.9	6.1e-12	-0.99	0.05	0.95	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	CISD2	0.05	0.08	enet	5	0.06	1.9e-06	6.80	-6.9	6.3e-12	-0.97	0.01	0.99	FALSE
35	GTEx	Skin Sun Exposed Lower leg	CISD2	0.12	0.20	lasso	14	0.20	1.1e-16	6.97	-6.9	6.6e-12	-0.99	0.04	0.96	FALSE
24	GTEx	Esophagus Muscularis	CISD2	0.19	0.22	enet	25	0.21	6.2e-13	6.62	-6.8	8.3e-12	-0.94	0.06	0.94	FALSE
8	GTEx	Artery Aorta	UBE2D3	0.07	0.06	lasso	5	0.04	3.5e-03	6.82	-6.8	8.8e-12	-0.97	0.06	0.91	FALSE
11	GTEx	Artery Tibial	CISD2	0.11	0.12	lasso	4	0.10	3.1e-08	6.91	-6.8	9.2e-12	-0.98	0.05	0.95	FALSE
25	GTEx	Lung	CISD2	0.06	0.05	enet	10	0.04	5.4e-04	6.62	-6.8	1.4e-11	-0.89	0.05	0.95	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MANBA	0.03	0.03	blup	71	0.04	2.0e-05	5.57	6.8	1.4e-11	0.84	0.04	0.95	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	RP11-10L12.4	0.08	0.10	lasso	7	0.09	5.1e-12	6.97	-6.7	1.6e-11	-0.98	0.04	0.96	FALSE
41	GTEx	Uterus	CISD2	0.34	0.22	enet	25	0.19	8.9e-05	6.62	-6.7	1.8e-11	-0.92	0.05	0.90	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	CISD2	0.02	0.02	enet	7	0.02	1.3e-03	-6.08	6.7	2.5e-11	0.87	0.01	0.86	FALSE
36	GTEx	Small Intestine Terminal Ileum	CISD2	0.29	0.19	enet	34	0.15	3.2e-04	6.89	-6.6	3.0e-11	-0.92	0.06	0.83	FALSE
14	GTEx	Breast Mammary Tissue	CISD2	0.21	0.08	enet	13	0.08	6.0e-05	6.81	-6.6	4.0e-11	-0.89	0.06	0.94	FALSE
40	GTEx	Thyroid	CISD2	0.12	0.07	lasso	3	0.05	8.8e-05	6.62	-6.6	4.7e-11	-0.97	0.05	0.95	FALSE
60	The Cancer Genome Atlas	Lung Adenocarcinoma	MANBA	0.13	0.10	blup	69	0.10	4.5e-12	5.62	6.6	4.7e-11	0.79	0.38	0.62	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	CISD2	0.13	0.14	enet	18	0.10	6.0e-06	6.90	-6.6	4.8e-11	-0.96	0.04	0.96	FALSE
30	GTEx	Ovary	CISD2	0.12	0.12	lasso	4	0.07	6.9e-03	6.62	-6.6	5.2e-11	-0.96	0.05	0.77	FALSE
23	GTEx	Esophagus Mucosa	CISD2	0.12	0.06	enet	13	0.05	2.1e-04	6.96	-6.6	5.6e-11	-0.98	0.05	0.95	FALSE
32	GTEx	Pancreas	UBE2D3	0.13	0.09	enet	12	0.12	6.7e-06	5.45	-6.6	5.8e-11	-0.88	0.05	0.95	FALSE
17	GTEx	Cells Transformed fibroblasts	MANBA	0.26	0.22	lasso	9	0.27	1.9e-20	5.38	6.5	6.9e-11	0.74	0.98	0.02	FALSE
16	GTEx	Breast Mammary Tissue (Female)	CISD2	0.12	0.04	enet	12	0.07	5.0e-03	6.62	-6.5	7.0e-11	-0.83	0.06	0.77	FALSE
6	GTEx	Adipose Visceral Omentum	UBE2D3	0.07	0.00	enet	23	0.02	3.2e-02	6.82	-6.5	8.1e-11	-0.68	0.06	0.71	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	CISD2	0.10	0.05	enet	6	0.04	1.6e-02	-6.21	-6.5	1.0e-10	-0.98	0.05	0.83	FALSE
19	GTEx	Cells Transformed fibroblasts	CISD2	0.16	0.17	enet	12	0.13	9.7e-10	6.62	-6.4	1.3e-10	-0.96	0.06	0.94	FALSE
27	GTEx	Muscle Skeletal	CISD2	0.03	0.02	enet	15	0.03	7.9e-04	-5.81	-6.4	1.6e-10	-0.79	0.13	0.84	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBE2D3	0.02	0.02	enet	6	0.02	3.7e-03	6.86	-6.3	2.2e-10	-0.95	0.02	0.81	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	MANBA	0.20	0.30	enet	26	0.31	2.3e-40	6.08	-6.3	2.9e-10	-0.70	0.89	0.11	FALSE
44	NTR	Blood	MANBA	0.01	0.00	bslmm	390	0.01	3.1e-03	5.38	6.3	3.4e-10	0.64	0.09	0.12	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	UBE2D3	0.11	0.00	enet	17	0.00	2.5e-01	0.43	-6.2	5.7e-10	-0.67	0.06	0.78	FALSE
38	GTEx	Testis	CISD2	0.10	0.04	lasso	5	0.03	1.3e-02	6.96	-6.2	7.1e-10	-0.93	0.04	0.89	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	CENPE	0.06	0.07	lasso	15	0.06	9.4e-09	5.39	6.1	1.1e-09	0.54	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	MANBA	0.33	0.11	enet	13	0.21	2.0e-12	4.99	6.1	1.4e-09	0.78	0.02	0.98	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	MANBA	0.12	0.06	enet	5	0.06	1.9e-06	5.64	6.0	1.8e-09	0.67	0.27	0.72	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	MANBA	0.11	0.16	lasso	4	0.16	3.4e-32	5.62	6.0	2.1e-09	0.72	0.95	0.05	FALSE
12	GTEx	Brain Cerebellum	MANBA	0.18	0.03	enet	27	0.05	1.2e-02	5.64	-5.9	4.7e-09	-0.59	0.08	0.31	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MANBA	0.15	0.09	lasso	6	0.09	1.0e-10	5.49	5.8	5.8e-09	0.66	0.97	0.03	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	NHEDC2	0.03	0.03	lasso	2	0.01	1.8e-02	6.31	5.8	6.3e-09	0.49	0.04	0.17	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MANBA	0.10	0.13	lasso	4	0.11	1.8e-09	5.62	5.7	1.0e-08	0.73	0.73	0.27	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	MANBA	0.11	0.04	lasso	7	0.04	3.5e-05	5.62	5.7	1.2e-08	0.69	0.22	0.76	FALSE
37	GTEx	Spleen	MANBA	0.29	0.23	enet	11	0.30	2.3e-08	5.57	-5.7	1.3e-08	-0.59	0.72	0.17	FALSE
43	METSIM	Adipose	UBE2D3	0.04	0.02	bslmm	332	0.03	2.0e-05	6.91	-5.6	1.8e-08	-0.81	0.06	0.91	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CENPE	0.10	0.10	lasso	14	0.11	5.8e-13	5.39	5.6	2.8e-08	0.47	1.00	0.00	FALSE
21	GTEx	Colon Transverse	CISD2	0.12	0.09	enet	19	0.06	1.0e-03	6.62	-5.6	2.8e-08	-0.84	0.06	0.91	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CISD2	0.02	0.00	blup	322	0.00	2.7e-01	-5.93	5.5	2.9e-08	0.80	0.06	0.74	FALSE
26	GTEx	Muscle Skeletal	UBE2D3	0.03	0.00	enet	21	0.00	3.8e-01	6.62	-5.5	3.4e-08	-0.68	0.06	0.67	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	NHEDC1	0.01	0.01	blup	58	0.01	1.1e-03	-6.21	5.5	4.0e-08	0.91	0.03	0.74	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MANBA	0.08	0.04	bslmm	390	0.03	9.6e-05	-5.81	5.5	4.5e-08	0.62	0.62	0.34	FALSE
31	GTEx	Pancreas	MANBA	0.14	0.14	enet	5	0.06	1.8e-03	5.48	-5.5	5.0e-08	-0.52	0.60	0.03	FALSE
39	GTEx	Testis	RP11-10L12.4	0.13	0.05	enet	15	0.14	1.3e-06	1.38	-5.4	6.3e-08	-0.77	0.08	0.76	FALSE
50	YFS	Blood	MANBA	0.09	0.10	lasso	3	0.10	5.2e-30	5.40	5.4	6.7e-08	0.52	1.00	0.00	FALSE
28	GTEx	Nerve Tibial	UBE2D3	0.14	0.07	lasso	5	0.04	4.9e-04	5.62	-5.4	7.8e-08	-0.71	0.14	0.45	FALSE
29	GTEx	Nerve Tibial	CISD2	0.19	0.14	enet	43	0.14	7.5e-10	6.81	-5.4	7.8e-08	-0.78	0.05	0.95	FALSE
42	METSIM	Adipose	SLC9B1	0.02	0.03	lasso	8	0.02	1.2e-04	5.37	5.4	7.8e-08	0.52	0.55	0.21	FALSE