[Hub]/) : Traits : Impedance of arm (left) : ← →

chr4:119,408,351-121,242,474

Best TWAS P=4.3e-11 · Best GWAS P=8.3e-11 conditioned to 0.036

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	GTEx	Brain Caudate basal ganglia	PDE5A	0.13	0.02	enet	12	0.06	6.4e-03	-5.6	6.6	4.3e-11	-0.79	0.10	0.70	TRUE
50	GTEx	Thyroid	RP11-33B1.4	0.07	0.07	lasso	3	0.05	1.8e-04	-6.5	6.4	1.3e-10	-0.99	0.02	0.98	FALSE
37	GTEx	Liver	RP11-33B1.4	0.18	0.14	lasso	6	0.12	3.2e-04	-6.5	6.4	1.4e-10	-0.99	0.04	0.95	FALSE
48	GTEx	Testis	RP11-33B1.4	0.23	0.31	enet	16	0.37	1.5e-17	-5.5	6.4	1.7e-10	-0.97	0.04	0.96	FALSE
15	GTEx	Brain Caudate basal ganglia	RP11-33B1.4	0.12	0.16	lasso	4	0.15	5.7e-05	-5.9	6.3	3.6e-10	-0.97	0.05	0.91	FALSE
42	GTEx	Pancreas	RP11-33B1.1	0.13	0.18	lasso	5	0.18	4.7e-08	-5.6	6.1	1.1e-09	-0.88	0.44	0.56	FALSE
35	GTEx	Heart Atrial Appendage	RP11-33B1.4	0.12	0.10	lasso	4	0.05	2.0e-03	-5.5	-6.1	1.3e-09	0.85	0.28	0.39	FALSE
26	GTEx	Cells EBV-transformed lymphocytes	PDE5A	0.25	0.20	lasso	27	0.20	5.1e-07	-5.5	6.1	1.4e-09	-0.95	0.09	0.91	FALSE
43	GTEx	Pancreas	RP11-33B1.4	0.20	0.05	lasso	16	0.05	3.8e-03	-6.1	6.1	1.4e-09	-0.96	0.02	0.97	FALSE
40	GTEx	Ovary	RP11-33B1.1	0.26	0.07	enet	33	0.16	1.2e-04	3.8	6.0	1.8e-09	-0.63	0.14	0.50	FALSE
19	GTEx	Brain Cerebellum	RP11-33B1.4	0.14	-0.01	enet	18	-0.01	7.4e-01	-5.4	-5.9	3.5e-09	0.82	0.12	0.29	FALSE
56	NTR	Blood	PDE5A	0.03	0.05	lasso	6	0.04	2.0e-13	-5.5	5.9	3.7e-09	-0.91	0.64	0.36	FALSE
52	GTEx	Vagina	RP11-33B1.1	0.32	0.25	lasso	10	0.27	5.3e-07	-5.5	5.9	4.1e-09	-0.90	0.28	0.69	FALSE
46	GTEx	Stomach	RP11-33B1.1	0.11	0.08	lasso	3	0.09	4.3e-05	-5.6	5.8	5.4e-09	-0.91	0.11	0.88	FALSE
3	CommonMind	Brain Pre-frontal Cortex	USP53	0.16	0.13	lasso	11	0.20	3.5e-23	3.7	5.8	5.9e-09	-0.69	0.99	0.01	FALSE
41	GTEx	Ovary	RP11-33B1.4	0.13	0.07	lasso	3	0.02	1.2e-01	-5.3	-5.8	6.5e-09	0.86	0.09	0.32	FALSE
25	GTEx	Breast Mammary Tissue	RP11-33B1.1	0.19	0.08	lasso	4	0.15	3.7e-08	4.8	5.8	7.7e-09	-0.68	0.67	0.32	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	USP53	0.11	0.03	blup	88	0.07	5.8e-07	3.9	5.7	9.6e-09	-0.58	0.82	0.07	FALSE
59	The Cancer Genome Atlas	Colon Adenocarcinoma	FABP2	0.24	0.20	lasso	9	0.25	1.8e-14	4.2	-5.7	9.7e-09	0.86	0.06	0.94	FALSE
28	GTEx	Cells Transformed fibroblasts	RP11-33B1.1	0.23	0.44	lasso	11	0.45	1.8e-37	-5.6	5.7	9.9e-09	-0.91	0.79	0.21	FALSE
4	GTEx	Adipose Subcutaneous	RP11-33B1.1	0.23	0.10	lasso	12	0.18	4.7e-15	3.4	5.7	1.0e-08	-0.72	0.16	0.84	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PDE5A	0.05	0.04	lasso	2	0.03	8.1e-05	-5.5	5.7	1.2e-08	-0.89	0.18	0.81	FALSE
23	GTEx	Brain Nucleus accumbens basal ganglia	RP11-33B1.1	0.42	0.36	lasso	11	0.33	9.5e-10	-5.6	5.7	1.2e-08	-0.90	0.18	0.82	FALSE
8	GTEx	Artery Aorta	RP11-33B1.1	0.12	0.10	lasso	8	0.13	2.0e-07	-5.0	5.7	1.3e-08	-0.88	0.76	0.24	FALSE
24	GTEx	Brain Putamen basal ganglia	RP11-33B1.1	0.32	0.16	lasso	7	0.16	9.9e-05	-5.5	5.7	1.4e-08	-0.75	0.21	0.42	FALSE
44	GTEx	Small Intestine Terminal Ileum	RP11-33B1.1	0.15	0.10	lasso	19	0.09	5.4e-03	-5.5	5.7	1.6e-08	-0.88	0.11	0.55	FALSE
32	GTEx	Esophagus Muscularis	RP11-33B1.1	0.10	0.14	lasso	3	0.12	1.4e-07	-5.5	5.6	1.7e-08	-0.89	0.52	0.48	FALSE
34	GTEx	Heart Atrial Appendage	RP11-33B1.1	0.15	0.08	lasso	3	0.10	4.0e-05	-5.6	5.6	1.7e-08	-0.76	0.58	0.37	FALSE
53	GTEx	Whole Blood	C4orf3	0.11	0.16	lasso	6	0.16	3.0e-14	-5.9	-5.6	1.8e-08	0.91	0.17	0.83	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LOC645513	0.27	0.50	enet	50	0.51	2.1e-72	-5.5	5.6	1.9e-08	-0.89	0.79	0.21	FALSE
16	GTEx	Brain Cerebellar Hemisphere	RP11-33B1.1	0.35	0.34	lasso	8	0.33	2.5e-09	-5.5	5.6	2.1e-08	-0.82	0.23	0.73	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-33B1.1	0.23	0.10	lasso	7	0.17	5.2e-09	-5.0	5.6	2.3e-08	-0.72	0.25	0.74	FALSE
6	GTEx	Adrenal Gland	RP11-33B1.1	0.13	0.07	enet	25	0.09	5.5e-04	-5.6	5.6	2.3e-08	-0.78	0.18	0.76	FALSE
14	GTEx	Brain Caudate basal ganglia	RP11-33B1.1	0.27	0.34	lasso	2	0.29	5.9e-09	-5.5	5.6	2.3e-08	-0.85	0.24	0.75	FALSE
31	GTEx	Esophagus Mucosa	RP11-33B1.1	0.25	0.29	lasso	12	0.36	3.3e-25	-5.5	5.6	2.3e-08	-0.78	0.78	0.22	FALSE
17	GTEx	Brain Cerebellar Hemisphere	RP11-33B1.4	0.13	0.05	lasso	4	0.01	1.6e-01	-5.4	-5.6	2.5e-08	0.90	0.10	0.58	FALSE
27	GTEx	Cells EBV-transformed lymphocytes	RP11-33B1.1	0.33	0.46	lasso	8	0.44	4.3e-16	-5.5	5.6	2.8e-08	-0.91	0.62	0.38	FALSE
47	GTEx	Testis	RP11-33B1.1	0.37	0.46	lasso	6	0.47	2.2e-23	-5.5	5.5	3.0e-08	-0.89	0.80	0.20	FALSE
33	GTEx	Heart Atrial Appendage	MYOZ2	0.17	0.01	enet	16	0.02	5.7e-02	-5.7	-5.5	3.2e-08	0.71	0.08	0.62	FALSE
39	GTEx	Muscle Skeletal	RP11-33B1.1	0.04	0.03	lasso	3	0.02	8.1e-03	-5.5	5.5	3.2e-08	-0.86	0.32	0.64	FALSE
55	GTEx	Whole Blood	RP11-33B1.4	0.13	0.16	lasso	9	0.15	1.4e-13	-5.5	-5.5	3.3e-08	0.91	0.77	0.23	FALSE
49	GTEx	Thyroid	RP11-33B1.1	0.18	0.21	lasso	3	0.24	1.0e-18	-5.9	5.5	4.0e-08	-0.77	0.71	0.29	FALSE
45	GTEx	Spleen	RP11-33B1.1	0.22	0.03	enet	17	0.02	7.7e-02	3.7	5.5	4.1e-08	-0.71	0.10	0.44	FALSE
51	GTEx	Uterus	RP11-33B1.4	0.23	0.24	lasso	4	0.16	4.9e-04	-5.4	-5.5	4.9e-08	0.83	0.13	0.31	FALSE
10	GTEx	Artery Coronary	RP11-33B1.4	0.10	0.02	lasso	2	0.01	1.5e-01	-5.3	-5.4	5.1e-08	0.79	0.13	0.47	FALSE
12	GTEx	Artery Tibial	RP11-33B1.1	0.22	0.17	lasso	7	0.16	1.4e-12	-5.0	5.4	6.3e-08	-0.83	0.88	0.12	FALSE
29	GTEx	Colon Sigmoid	RP11-33B1.1	0.25	0.14	lasso	3	0.16	2.3e-06	-5.6	5.4	6.4e-08	-0.79	0.46	0.42	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	USP53	0.06	0.04	blup	470	0.05	5.7e-07	-5.8	5.4	6.4e-08	-0.83	0.15	0.85	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	RP11-33B1.1	0.22	0.42	lasso	5	0.42	1.4e-59	-5.0	5.4	7.4e-08	-0.87	0.98	0.02	FALSE
18	GTEx	Brain Cerebellum	RP11-33B1.1	0.31	0.30	lasso	11	0.32	2.9e-10	-5.5	5.4	8.5e-08	-0.78	0.66	0.33	FALSE
11	GTEx	Artery Tibial	C4orf3	0.04	0.00	enet	7	0.03	3.2e-03	-3.4	-5.3	9.2e-08	0.65	0.07	0.78	FALSE
38	GTEx	Lung	RP11-33B1.4	0.10	0.10	lasso	5	0.09	4.2e-07	-5.5	-5.3	9.4e-08	0.90	0.66	0.34	FALSE
7	GTEx	Adrenal Gland	RP11-33B1.4	0.11	0.10	enet	20	0.16	3.2e-06	-5.5	5.3	1.2e-07	-0.81	0.04	0.95	FALSE
22	GTEx	Brain Hypothalamus	RP11-33B1.1	0.40	0.24	lasso	6	0.23	4.5e-06	-5.5	5.3	1.3e-07	-0.74	0.25	0.58	FALSE
30	GTEx	Colon Transverse	RP11-33B1.1	0.25	0.31	lasso	10	0.39	7.1e-20	-5.6	5.3	1.3e-07	-0.77	0.77	0.23	FALSE
21	GTEx	Brain Hippocampus	RP11-33B1.1	0.18	0.02	enet	20	0.05	2.2e-02	-5.6	5.3	1.5e-07	-0.74	0.19	0.40	FALSE
54	GTEx	Whole Blood	RP11-33B1.1	0.06	0.06	lasso	4	0.05	2.3e-05	-5.4	5.2	1.5e-07	-0.90	0.33	0.67	FALSE
20	GTEx	Brain Frontal Cortex BA9	RP11-33B1.1	0.36	0.28	lasso	8	0.25	2.2e-07	-5.0	5.2	1.6e-07	-0.87	0.61	0.36	FALSE
36	GTEx	Liver	RP11-33B1.1	0.18	0.12	enet	31	0.17	1.6e-05	-5.5	5.2	1.6e-07	-0.81	0.23	0.74	FALSE
9	GTEx	Artery Coronary	RP11-33B1.1	0.21	0.16	lasso	10	0.22	7.4e-08	-5.5	5.2	2.5e-07	-0.75	0.53	0.45	FALSE