Best TWAS P=2.48e-20 · Best GWAS P=1.79e-20 conditioned to 0.000276
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PACSIN1 | 0.07 | 0.01 | lasso | 6 | 0.02 | 1.1e-03 | -3.8 | -6.5 | 7.7e-11 | 0.26 | 0.32 | 0.04 | FALSE |
2 | GTEx | Brain Frontal Cortex BA9 | RPS10 | 0.21 | 0.08 | lasso | 3 | 0.06 | 8.6e-03 | -7.8 | -8.7 | 3.6e-18 | 0.87 | 0.07 | 0.47 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | C6orf106 | 0.20 | 0.00 | lasso | 5 | 0.00 | 2.7e-01 | -5.3 | -5.5 | 4.0e-08 | 0.09 | 0.07 | 0.06 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | RPS10 | 0.12 | 0.05 | lasso | 4 | 0.06 | 4.5e-05 | -8.8 | -9.2 | 2.5e-20 | 0.94 | 0.01 | 0.99 | TRUE |
5 | GTEx | Esophagus Muscularis | NUDT3 | 0.12 | 0.00 | lasso | 7 | 0.02 | 3.2e-02 | -8.8 | 8.5 | 1.4e-17 | -0.81 | 0.03 | 0.82 | FALSE |
6 | GTEx | Muscle Skeletal | C6orf106 | 0.08 | 0.06 | lasso | 4 | 0.06 | 7.1e-07 | -3.9 | 5.2 | 1.7e-07 | -0.10 | 0.98 | 0.00 | FALSE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | SNRPC | 0.18 | 0.04 | enet | 37 | 0.03 | 1.0e-02 | -4.2 | 5.4 | 7.8e-08 | -0.20 | 0.23 | 0.10 | TRUE |
8 | GTEx | Spleen | UHRF1BP1 | 0.34 | 0.21 | enet | 36 | 0.17 | 4.5e-05 | -4.3 | -5.6 | 2.6e-08 | 0.26 | 0.62 | 0.04 | FALSE |
9 | GTEx | Testis | RPS10 | 0.17 | 0.11 | lasso | 1 | 0.04 | 5.2e-03 | -7.5 | -7.5 | 4.7e-14 | 0.87 | 0.08 | 0.75 | FALSE |
10 | GTEx | Uterus | UHRF1BP1 | 0.20 | 0.03 | lasso | 4 | 0.07 | 1.8e-02 | -4.1 | -5.5 | 3.4e-08 | 0.10 | 0.10 | 0.08 | FALSE |
11 | METSIM | Adipose | C6orf106 | 0.04 | 0.02 | blup | 381 | 0.02 | 7.7e-04 | -4.7 | -5.4 | 5.3e-08 | 0.28 | 0.37 | 0.16 | FALSE |
12 | ROSMAP | Brain Pre-frontal Cortex | TEAD3 | 0.07 | 0.03 | bslmm | 421 | 0.04 | 5.6e-06 | -3.4 | 6.6 | 3.5e-11 | -0.11 | 0.15 | 0.81 | TRUE |
13 | YFS | Blood | NUDT3 | 0.12 | 0.12 | lasso | 9 | 0.13 | 2.5e-40 | -7.5 | -6.5 | 8.6e-11 | 0.83 | 1.00 | 0.00 | FALSE |
14 | YFS | Blood | SNRPC | 0.02 | 0.03 | lasso | 5 | 0.02 | 3.0e-08 | -5.3 | 5.3 | 1.2e-07 | -0.07 | 1.00 | 0.00 | FALSE |