Best TWAS P=1.95e-10 · Best GWAS P=1.71e-09 conditioned to 0.0191
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | BAIAP2L2 | 0.11 | 0.03 | lasso | 5 | 0.04 | 1.8e-04 | 4.7 | -6.1 | 9.4e-10 | -0.75 | 0.03 | 0.87 | FALSE |
| 2 | GTEx | Artery Aorta | C22orf23 | 0.10 | 0.01 | enet | 24 | 0.02 | 1.6e-02 | 3.2 | 5.7 | 1.0e-08 | 0.34 | 0.25 | 0.10 | FALSE |
| 3 | GTEx | Artery Aorta | PLA2G6 | 0.10 | 0.02 | enet | 9 | 0.02 | 4.5e-02 | 3.2 | 5.6 | 1.9e-08 | 0.67 | 0.07 | 0.60 | FALSE |
| 4 | GTEx | Artery Aorta | TMEM184B | 0.17 | 0.07 | enet | 34 | 0.03 | 1.2e-02 | 5.3 | -5.4 | 5.1e-08 | -0.67 | 0.06 | 0.74 | FALSE |
| 5 | GTEx | Artery Aorta | AL021977.1 | 0.13 | 0.00 | enet | 17 | 0.01 | 8.7e-02 | 5.6 | -6.4 | 1.9e-10 | -0.73 | 0.03 | 0.76 | TRUE |
| 6 | GTEx | Brain Cortex | TMEM184B | 0.29 | 0.12 | lasso | 7 | 0.09 | 1.6e-03 | 5.3 | -5.6 | 2.0e-08 | -0.90 | 0.01 | 0.89 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | ANKRD54 | 0.11 | 0.09 | lasso | 4 | 0.09 | 5.3e-07 | -5.0 | -5.1 | 3.0e-07 | -0.20 | 0.56 | 0.32 | FALSE |
| 8 | GTEx | Nerve Tibial | MAFF | 0.14 | 0.06 | lasso | 3 | 0.05 | 1.2e-04 | 6.0 | -5.9 | 3.8e-09 | -0.99 | 0.01 | 0.99 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | ANKRD54 | 0.03 | 0.00 | blup | 397 | 0.01 | 2.2e-02 | 2.3 | -5.7 | 1.1e-08 | -0.27 | 0.18 | 0.06 | TRUE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLA2G6 | 0.05 | 0.01 | blup | 76 | 0.01 | 7.7e-02 | 6.0 | 6.1 | 1.4e-09 | 0.85 | 0.01 | 0.84 | FALSE |