[Hub]/) : Traits : Leg fat percentage (right) : ← →

chr6:33,745,071-36,804,187

Best TWAS P=3.55e-25 · Best GWAS P=4.15e-20 conditioned to 0.0268

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
57	GTEx	Uterus	UHRF1BP1	0.20	0.03	lasso	4	0.07	1.8e-02	9.1	10.4	3.6e-25	0.86	0.04	0.67	TRUE
10	GTEx	Artery Aorta	ANKS1A	0.10	0.10	lasso	2	0.08	2.4e-05	-7.1	-7.3	2.6e-13	-0.32	0.30	0.24	TRUE
37	GTEx	Heart Atrial Appendage	MAPK13	0.12	0.00	lasso	5	0.00	3.1e-01	5.3	-5.4	7.4e-08	-0.17	0.03	0.57	TRUE
54	GTEx	Stomach	UHRF1BP1	0.24	0.22	enet	20	0.23	2.2e-11	9.0	10.1	4.4e-24	0.92	0.03	0.97	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	SNRPC	0.05	0.05	blup	31	0.05	2.9e-05	9.1	-9.7	3.0e-22	-0.94	0.02	0.98	FALSE
16	GTEx	Brain Caudate basal ganglia	SNRPC	0.19	0.15	lasso	3	0.06	7.7e-03	9.1	-9.6	9.9e-22	-0.98	0.03	0.93	FALSE
34	GTEx	Esophagus Muscularis	UHRF1BP1	0.42	0.35	enet	48	0.33	1.0e-20	9.1	9.5	1.8e-21	0.93	0.03	0.97	FALSE
42	GTEx	Muscle Skeletal	SNRPC	0.03	0.02	lasso	3	0.02	8.3e-03	9.1	-9.5	2.0e-21	-0.98	0.03	0.91	FALSE
29	GTEx	Colon Transverse	UHRF1BP1	0.42	0.28	lasso	4	0.28	1.6e-13	9.0	9.5	2.3e-21	0.97	0.03	0.97	FALSE
40	GTEx	Lung	UHRF1BP1	0.17	0.20	enet	22	0.18	4.3e-14	9.1	9.5	2.3e-21	0.99	0.03	0.97	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SNRPC	0.10	0.16	lasso	4	0.15	3.6e-18	9.1	-9.5	2.5e-21	-0.99	0.03	0.97	FALSE
80	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UHRF1BP1	0.08	0.09	blup	71	0.10	2.0e-06	9.1	9.5	2.5e-21	0.91	0.02	0.98	FALSE
52	GTEx	Small Intestine Terminal Ileum	UHRF1BP1	0.20	0.03	lasso	5	0.00	3.4e-01	9.1	9.4	3.5e-21	0.94	0.04	0.75	FALSE
90	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UHRF1BP1	0.20	0.23	lasso	16	0.25	8.3e-11	9.1	9.4	4.2e-21	0.98	0.01	0.99	FALSE
27	GTEx	Cells Transformed fibroblasts	UHRF1BP1	0.34	0.32	enet	44	0.31	2.4e-23	9.1	9.4	4.5e-21	0.96	0.03	0.97	FALSE
5	GTEx	Adipose Subcutaneous	UHRF1BP1	0.30	0.35	enet	28	0.36	1.6e-30	9.1	9.4	4.6e-21	0.98	0.03	0.97	FALSE
59	GTEx	Whole Blood	UHRF1BP1	0.14	0.14	lasso	7	0.14	2.9e-13	9.1	9.4	6.9e-21	0.96	0.03	0.97	FALSE
71	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNRPC	0.01	0.01	blup	31	0.00	3.0e-02	5.7	-9.4	7.6e-21	-0.97	0.01	0.64	FALSE
32	GTEx	Esophagus Mucosa	UHRF1BP1	0.14	0.15	enet	28	0.17	1.3e-11	8.9	9.3	9.3e-21	0.99	0.03	0.97	FALSE
44	GTEx	Nerve Tibial	UHRF1BP1	0.31	0.31	lasso	6	0.31	3.9e-22	9.1	9.3	1.9e-20	0.98	0.03	0.97	FALSE
93	The Cancer Genome Atlas	Soft Tissue Sarcoma	UHRF1BP1	0.08	0.09	blup	71	0.08	1.0e-05	9.1	9.3	1.9e-20	0.93	0.01	0.98	FALSE
11	GTEx	Artery Aorta	UHRF1BP1	0.35	0.32	lasso	10	0.30	7.7e-17	9.2	9.2	2.8e-20	1.00	0.02	0.98	FALSE
79	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UHRF1BP1	0.18	0.28	lasso	5	0.27	1.0e-30	9.1	9.2	4.5e-20	0.99	0.01	0.99	FALSE
22	GTEx	Breast Mammary Tissue (Male)	UHRF1BP1	0.19	0.16	enet	24	0.08	5.6e-03	9.0	9.2	4.8e-20	0.99	0.03	0.93	FALSE
4	CommonMind	Brain Pre-frontal Cortex	UHRF1BP1	0.17	0.23	lasso	19	0.22	5.8e-27	9.1	9.2	5.5e-20	1.00	0.03	0.97	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	SNRPC	0.15	0.27	lasso	4	0.27	4.0e-35	9.1	-9.1	6.1e-20	-0.99	0.03	0.97	FALSE
94	The Cancer Genome Atlas	Stomach Adenocarcinoma	UHRF1BP1	0.08	0.10	lasso	1	0.10	7.1e-08	9.1	9.1	6.7e-20	0.99	0.01	0.99	FALSE
33	GTEx	Esophagus Mucosa	SNRPC	0.12	0.10	lasso	2	0.08	4.8e-06	9.1	-9.1	7.7e-20	-1.00	0.03	0.97	FALSE
56	GTEx	Thyroid	SNRPC	0.07	0.04	lasso	6	0.05	1.6e-04	9.1	-9.1	8.1e-20	-0.99	0.03	0.96	FALSE
76	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SNRPC	0.06	0.07	lasso	2	0.07	6.7e-08	9.1	-9.1	8.2e-20	-0.99	0.02	0.98	FALSE
51	GTEx	Skin Sun Exposed Lower leg	SNRPC	0.03	0.04	lasso	2	0.03	1.9e-03	9.1	-9.1	9.0e-20	-0.99	0.03	0.95	FALSE
14	GTEx	Artery Tibial	SNRPC	0.06	0.06	lasso	4	0.05	1.3e-04	9.1	-9.1	9.4e-20	-0.99	0.03	0.97	FALSE
69	YFS	Blood	UHRF1BP1	0.18	0.34	enet	36	0.34	2.5e-117	9.1	9.1	9.4e-20	0.98	0.03	0.97	FALSE
20	GTEx	Brain Putamen basal ganglia	UHRF1BP1	0.20	0.17	lasso	2	0.16	1.5e-04	9.0	9.1	9.6e-20	0.99	0.03	0.88	FALSE
45	GTEx	Nerve Tibial	SNRPC	0.12	0.10	lasso	4	0.08	1.5e-06	9.1	-9.1	1.0e-19	-0.99	0.03	0.97	FALSE
70	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	UHRF1BP1	0.03	0.04	lasso	3	0.04	1.7e-04	9.1	9.1	1.0e-19	0.99	0.02	0.95	FALSE
97	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SNRPC	0.09	0.11	lasso	2	0.10	8.1e-04	9.1	-9.1	1.0e-19	-0.99	0.02	0.80	FALSE
12	GTEx	Artery Coronary	UHRF1BP1	0.33	0.36	lasso	2	0.35	1.6e-12	9.1	9.1	1.1e-19	0.99	0.03	0.97	FALSE
58	GTEx	Vagina	UHRF1BP1	0.31	0.05	lasso	8	0.04	5.0e-02	9.1	9.1	1.1e-19	0.95	0.04	0.79	FALSE
7	GTEx	Adipose Visceral Omentum	UHRF1BP1	0.30	0.34	lasso	3	0.34	3.0e-18	9.0	9.1	1.3e-19	0.99	0.03	0.97	FALSE
74	The Cancer Genome Atlas	Colon Adenocarcinoma	UHRF1BP1	0.08	0.11	lasso	12	0.10	2.3e-06	9.1	9.1	1.4e-19	0.99	0.01	0.99	FALSE
75	The Cancer Genome Atlas	Esophageal Carcinoma	UHRF1BP1	0.19	0.20	lasso	10	0.17	5.2e-06	9.0	9.0	1.5e-19	0.99	0.02	0.98	FALSE
72	The Cancer Genome Atlas	Breast Invasive Carcinoma	UHRF1BP1	0.04	0.05	lasso	3	0.04	8.4e-09	9.0	9.0	1.6e-19	1.00	0.02	0.98	FALSE
73	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	UHRF1BP1	0.07	0.11	lasso	3	0.07	2.6e-04	9.0	9.0	2.2e-19	0.99	0.02	0.97	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	UHRF1BP1	0.16	0.27	lasso	10	0.28	2.7e-36	8.9	9.0	3.0e-19	0.98	0.04	0.96	FALSE
50	GTEx	Skin Sun Exposed Lower leg	UHRF1BP1	0.19	0.13	enet	33	0.14	2.7e-11	9.1	9.0	3.3e-19	0.90	0.03	0.97	FALSE
43	GTEx	Muscle Skeletal	C6orf106	0.08	0.06	lasso	4	0.06	7.1e-07	8.8	-8.9	3.7e-19	-0.69	0.33	0.66	FALSE
86	The Cancer Genome Atlas	Lung Adenocarcinoma	UHRF1BP1	0.06	0.07	enet	20	0.08	6.4e-10	9.1	8.9	3.7e-19	0.98	0.01	0.99	FALSE
64	NTR	Blood	UHRF1BP1	0.03	0.05	enet	19	0.05	7.4e-15	8.9	8.9	4.0e-19	0.98	0.03	0.97	FALSE
89	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	UHRF1BP1	0.06	0.07	lasso	1	0.05	1.5e-04	8.9	8.9	5.5e-19	0.96	0.02	0.98	FALSE
92	The Cancer Genome Atlas	Prostate Adenocarcinoma	UHRF1BP1	0.10	0.20	lasso	5	0.19	1.6e-19	9.0	8.9	6.9e-19	0.99	0.02	0.98	FALSE
39	GTEx	Liver	UHRF1BP1	0.13	0.04	lasso	3	0.05	1.8e-02	9.1	8.9	7.0e-19	0.85	0.03	0.82	FALSE
17	GTEx	Brain Cerebellar Hemisphere	UHRF1BP1	0.22	0.16	lasso	12	0.15	1.0e-04	9.1	8.9	8.1e-19	0.96	0.04	0.92	FALSE
23	GTEx	Breast Mammary Tissue (Female)	UHRF1BP1	0.23	0.21	lasso	3	0.20	1.0e-06	9.1	8.8	1.2e-18	0.95	0.03	0.96	FALSE
13	GTEx	Artery Tibial	UHRF1BP1	0.31	0.43	lasso	11	0.43	4.0e-36	9.1	8.8	1.7e-18	0.99	0.03	0.97	FALSE
36	GTEx	Heart Atrial Appendage	UHRF1BP1	0.13	0.07	enet	17	0.05	1.9e-03	9.1	8.8	1.7e-18	0.65	0.03	0.95	FALSE
53	GTEx	Spleen	UHRF1BP1	0.34	0.21	enet	36	0.17	4.5e-05	9.1	8.8	2.0e-18	0.85	0.03	0.95	FALSE
35	GTEx	Esophagus Muscularis	SNRPC	0.09	0.11	lasso	3	0.07	3.8e-05	9.1	-8.7	2.5e-18	-0.97	0.03	0.97	FALSE
28	GTEx	Colon Sigmoid	UHRF1BP1	0.44	0.36	lasso	12	0.38	1.8e-14	9.1	8.7	4.3e-18	0.92	0.03	0.97	FALSE
62	METSIM	Adipose	UHRF1BP1	0.16	0.31	enet	30	0.32	1.0e-49	9.1	8.7	4.9e-18	0.98	0.03	0.97	FALSE
9	GTEx	Adrenal Gland	SNRPC	0.13	0.04	lasso	6	0.03	2.7e-02	8.9	-8.6	5.6e-18	-0.75	0.05	0.81	FALSE
15	GTEx	Brain Caudate basal ganglia	UHRF1BP1	0.19	0.14	lasso	7	0.12	3.1e-04	9.1	8.6	6.3e-18	0.98	0.04	0.92	FALSE
21	GTEx	Breast Mammary Tissue	UHRF1BP1	0.34	0.28	enet	46	0.29	4.7e-15	9.0	8.6	1.3e-17	0.87	0.03	0.97	FALSE
6	GTEx	Adipose Subcutaneous	SNRPC	0.13	0.13	enet	21	0.13	1.2e-10	9.1	-8.5	1.6e-17	-0.89	0.03	0.97	FALSE
77	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UHRF1BP1	0.06	0.06	enet	8	0.06	1.3e-07	8.9	8.4	4.6e-17	0.86	0.02	0.98	FALSE
18	GTEx	Brain Cerebellum	UHRF1BP1	0.14	0.09	enet	23	0.12	1.5e-04	9.1	8.3	1.2e-16	0.88	0.03	0.85	FALSE
47	GTEx	Pancreas	C6orf106	0.14	0.11	enet	11	0.13	2.8e-06	8.9	8.3	1.2e-16	0.56	0.32	0.63	FALSE
41	GTEx	Muscle Skeletal	UHRF1BP1	0.34	0.34	enet	45	0.39	4.3e-40	9.1	8.1	7.4e-16	0.91	0.03	0.97	FALSE
81	The Cancer Genome Atlas	Brain Lower Grade Glioma	C6orf106	0.04	0.05	lasso	4	0.03	8.1e-05	8.1	8.0	9.1e-16	0.59	0.95	0.04	FALSE
91	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	UHRF1BP1	0.13	0.09	enet	13	0.10	6.4e-05	9.1	7.8	4.1e-15	0.90	0.02	0.97	FALSE
68	YFS	Blood	SNRPC	0.02	0.03	lasso	5	0.02	3.0e-08	7.9	-7.8	6.6e-15	-0.86	0.22	0.78	FALSE
83	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	UHRF1BP1	0.12	0.09	blup	70	0.06	5.6e-04	9.1	7.7	1.0e-14	0.94	0.02	0.94	FALSE
61	METSIM	Adipose	SNRPC	0.05	0.05	lasso	7	0.07	2.9e-11	9.2	-7.7	1.7e-14	-0.94	0.03	0.97	FALSE
63	NTR	Blood	C6orf106	0.03	0.02	lasso	6	0.02	7.2e-07	8.0	7.7	1.7e-14	0.56	0.99	0.01	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	UHRF1BP1	0.47	0.38	enet	22	0.43	7.3e-17	7.9	7.6	3.3e-14	0.89	0.04	0.96	FALSE
82	The Cancer Genome Atlas	Brain Lower Grade Glioma	UHRF1BP1	0.06	0.05	blup	70	0.04	8.6e-06	5.7	7.5	4.9e-14	0.87	0.05	0.95	FALSE
87	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UHRF1BP1	0.04	0.06	blup	70	0.06	1.5e-07	9.1	7.2	4.2e-13	0.90	0.02	0.98	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	C6orf106	0.20	0.00	lasso	5	0.00	2.7e-01	8.2	7.2	7.2e-13	0.48	0.07	0.10	FALSE
55	GTEx	Thyroid	UHRF1BP1	0.13	0.06	enet	37	0.08	5.9e-07	4.9	6.8	8.4e-12	0.65	0.18	0.82	FALSE
38	GTEx	Heart Left Ventricle	UHRF1BP1	0.23	0.12	lasso	7	0.22	1.2e-11	9.0	6.8	1.1e-11	0.91	0.03	0.97	FALSE
26	GTEx	Cells Transformed fibroblasts	DEF6	0.14	0.03	enet	35	0.04	9.7e-04	4.3	-6.7	1.9e-11	-0.27	0.60	0.03	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	UHRF1BP1	0.07	0.03	blup	71	0.05	2.8e-05	9.1	6.7	2.6e-11	0.87	0.02	0.98	FALSE
8	GTEx	Adrenal Gland	UHRF1BP1	0.32	0.26	enet	33	0.33	1.3e-12	9.1	6.6	4.5e-11	0.89	0.03	0.97	FALSE
84	The Cancer Genome Atlas	Lung Adenocarcinoma	C6orf106	0.03	0.03	lasso	3	0.01	7.6e-03	5.3	6.6	5.4e-11	0.49	0.10	0.23	FALSE
30	GTEx	Colon Transverse	C6orf106	0.15	0.05	lasso	1	0.03	1.5e-02	6.5	6.5	6.4e-11	0.33	0.16	0.12	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PACSIN1	0.07	0.01	lasso	6	0.02	1.1e-03	8.1	6.5	9.0e-11	0.49	0.32	0.04	FALSE
46	GTEx	Nerve Tibial	C6orf106	0.11	0.07	enet	17	0.07	1.3e-05	8.0	6.3	2.1e-10	0.33	0.70	0.02	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	UHRF1BP1	0.20	0.10	enet	30	0.15	2.1e-08	9.0	6.3	2.2e-10	0.85	0.04	0.96	FALSE
78	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C6orf106	0.04	0.01	blup	68	0.01	2.4e-02	8.1	6.1	9.8e-10	0.35	0.04	0.07	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	UHRF1BP1	0.37	0.08	enet	46	0.11	1.7e-04	9.1	6.0	1.8e-09	0.72	0.04	0.92	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C6orf106	0.29	0.21	bslmm	382	0.23	6.9e-28	7.9	5.9	4.5e-09	0.32	1.00	0.00	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	C6orf106	0.30	0.26	bslmm	372	0.33	9.3e-44	8.0	5.8	6.3e-09	0.22	0.99	0.01	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	SNRPC	0.18	0.04	enet	37	0.03	1.0e-02	8.9	-5.6	1.7e-08	-0.50	0.04	0.86	FALSE
60	METSIM	Adipose	C6orf106	0.04	0.02	blup	381	0.02	7.7e-04	5.3	5.6	2.4e-08	0.34	0.35	0.21	FALSE
19	GTEx	Brain Cortex	C6orf106	0.22	0.07	enet	16	0.10	1.1e-03	8.1	5.2	1.9e-07	0.42	0.45	0.13	FALSE
85	The Cancer Genome Atlas	Lung Adenocarcinoma	FKBP5	0.04	0.05	lasso	2	0.04	5.4e-05	5.0	5.2	2.3e-07	0.21	0.15	0.74	FALSE
88	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C6orf106	0.14	0.07	enet	6	0.06	1.0e-04	8.0	5.2	2.6e-07	0.38	0.40	0.04	FALSE