[Hub]/) : Traits : Leg fat percentage (right) :

chr6:33,745,071-36,804,187

Best TWAS P=3.55e-25 · Best GWAS P=4.15e-20 conditioned to 0.0268

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C6orf106 0.29 0.21 bslmm 382 0.23 6.9e-28 7.9 5.9 4.5e-09 0.32 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex PACSIN1 0.07 0.01 lasso 6 0.02 1.1e-03 8.1 6.5 9.0e-11 0.49 0.32 0.04 FALSE
3 CommonMind Brain Pre-frontal Cortex SNRPC 0.10 0.16 lasso 4 0.15 3.6e-18 9.1 -9.5 2.5e-21 -0.99 0.03 0.97 FALSE
4 CommonMind Brain Pre-frontal Cortex UHRF1BP1 0.17 0.23 lasso 19 0.22 5.8e-27 9.1 9.2 5.5e-20 1.00 0.03 0.97 FALSE
5 GTEx Adipose Subcutaneous UHRF1BP1 0.30 0.35 enet 28 0.36 1.6e-30 9.1 9.4 4.6e-21 0.98 0.03 0.97 FALSE
6 GTEx Adipose Subcutaneous SNRPC 0.13 0.13 enet 21 0.13 1.2e-10 9.1 -8.5 1.6e-17 -0.89 0.03 0.97 FALSE
7 GTEx Adipose Visceral Omentum UHRF1BP1 0.30 0.34 lasso 3 0.34 3.0e-18 9.0 9.1 1.3e-19 0.99 0.03 0.97 FALSE
8 GTEx Adrenal Gland UHRF1BP1 0.32 0.26 enet 33 0.33 1.3e-12 9.1 6.6 4.5e-11 0.89 0.03 0.97 FALSE
9 GTEx Adrenal Gland SNRPC 0.13 0.04 lasso 6 0.03 2.7e-02 8.9 -8.6 5.6e-18 -0.75 0.05 0.81 FALSE
10 GTEx Artery Aorta ANKS1A 0.10 0.10 lasso 2 0.08 2.4e-05 -7.1 -7.3 2.6e-13 -0.32 0.30 0.24 TRUE
11 GTEx Artery Aorta UHRF1BP1 0.35 0.32 lasso 10 0.30 7.7e-17 9.2 9.2 2.8e-20 1.00 0.02 0.98 FALSE
12 GTEx Artery Coronary UHRF1BP1 0.33 0.36 lasso 2 0.35 1.6e-12 9.1 9.1 1.1e-19 0.99 0.03 0.97 FALSE
13 GTEx Artery Tibial UHRF1BP1 0.31 0.43 lasso 11 0.43 4.0e-36 9.1 8.8 1.7e-18 0.99 0.03 0.97 FALSE
14 GTEx Artery Tibial SNRPC 0.06 0.06 lasso 4 0.05 1.3e-04 9.1 -9.1 9.4e-20 -0.99 0.03 0.97 FALSE
15 GTEx Brain Caudate basal ganglia UHRF1BP1 0.19 0.14 lasso 7 0.12 3.1e-04 9.1 8.6 6.3e-18 0.98 0.04 0.92 FALSE
16 GTEx Brain Caudate basal ganglia SNRPC 0.19 0.15 lasso 3 0.06 7.7e-03 9.1 -9.6 9.9e-22 -0.98 0.03 0.93 FALSE
17 GTEx Brain Cerebellar Hemisphere UHRF1BP1 0.22 0.16 lasso 12 0.15 1.0e-04 9.1 8.9 8.1e-19 0.96 0.04 0.92 FALSE
18 GTEx Brain Cerebellum UHRF1BP1 0.14 0.09 enet 23 0.12 1.5e-04 9.1 8.3 1.2e-16 0.88 0.03 0.85 FALSE
19 GTEx Brain Cortex C6orf106 0.22 0.07 enet 16 0.10 1.1e-03 8.1 5.2 1.9e-07 0.42 0.45 0.13 FALSE
20 GTEx Brain Putamen basal ganglia UHRF1BP1 0.20 0.17 lasso 2 0.16 1.5e-04 9.0 9.1 9.6e-20 0.99 0.03 0.88 FALSE
21 GTEx Breast Mammary Tissue UHRF1BP1 0.34 0.28 enet 46 0.29 4.7e-15 9.0 8.6 1.3e-17 0.87 0.03 0.97 FALSE
22 GTEx Breast Mammary Tissue (Male) UHRF1BP1 0.19 0.16 enet 24 0.08 5.6e-03 9.0 9.2 4.8e-20 0.99 0.03 0.93 FALSE
23 GTEx Breast Mammary Tissue (Female) UHRF1BP1 0.23 0.21 lasso 3 0.20 1.0e-06 9.1 8.8 1.2e-18 0.95 0.03 0.96 FALSE
24 GTEx Cells EBV-transformed lymphocytes UHRF1BP1 0.37 0.08 enet 46 0.11 1.7e-04 9.1 6.0 1.8e-09 0.72 0.04 0.92 FALSE
25 GTEx Cells EBV-transformed lymphocytes C6orf106 0.20 0.00 lasso 5 0.00 2.7e-01 8.2 7.2 7.2e-13 0.48 0.07 0.10 FALSE
26 GTEx Cells Transformed fibroblasts DEF6 0.14 0.03 enet 35 0.04 9.7e-04 4.3 -6.7 1.9e-11 -0.27 0.60 0.03 FALSE
27 GTEx Cells Transformed fibroblasts UHRF1BP1 0.34 0.32 enet 44 0.31 2.4e-23 9.1 9.4 4.5e-21 0.96 0.03 0.97 FALSE
28 GTEx Colon Sigmoid UHRF1BP1 0.44 0.36 lasso 12 0.38 1.8e-14 9.1 8.7 4.3e-18 0.92 0.03 0.97 FALSE
29 GTEx Colon Transverse UHRF1BP1 0.42 0.28 lasso 4 0.28 1.6e-13 9.0 9.5 2.3e-21 0.97 0.03 0.97 FALSE
30 GTEx Colon Transverse C6orf106 0.15 0.05 lasso 1 0.03 1.5e-02 6.5 6.5 6.4e-11 0.33 0.16 0.12 FALSE
31 GTEx Esophagus Gastroesophageal Junction UHRF1BP1 0.47 0.38 enet 22 0.43 7.3e-17 7.9 7.6 3.3e-14 0.89 0.04 0.96 FALSE
32 GTEx Esophagus Mucosa UHRF1BP1 0.14 0.15 enet 28 0.17 1.3e-11 8.9 9.3 9.3e-21 0.99 0.03 0.97 FALSE
33 GTEx Esophagus Mucosa SNRPC 0.12 0.10 lasso 2 0.08 4.8e-06 9.1 -9.1 7.7e-20 -1.00 0.03 0.97 FALSE
34 GTEx Esophagus Muscularis UHRF1BP1 0.42 0.35 enet 48 0.33 1.0e-20 9.1 9.5 1.8e-21 0.93 0.03 0.97 FALSE
35 GTEx Esophagus Muscularis SNRPC 0.09 0.11 lasso 3 0.07 3.8e-05 9.1 -8.7 2.5e-18 -0.97 0.03 0.97 FALSE
36 GTEx Heart Atrial Appendage UHRF1BP1 0.13 0.07 enet 17 0.05 1.9e-03 9.1 8.8 1.7e-18 0.65 0.03 0.95 FALSE
37 GTEx Heart Atrial Appendage MAPK13 0.12 0.00 lasso 5 0.00 3.1e-01 5.3 -5.4 7.4e-08 -0.17 0.03 0.57 TRUE
38 GTEx Heart Left Ventricle UHRF1BP1 0.23 0.12 lasso 7 0.22 1.2e-11 9.0 6.8 1.1e-11 0.91 0.03 0.97 FALSE
39 GTEx Liver UHRF1BP1 0.13 0.04 lasso 3 0.05 1.8e-02 9.1 8.9 7.0e-19 0.85 0.03 0.82 FALSE
40 GTEx Lung UHRF1BP1 0.17 0.20 enet 22 0.18 4.3e-14 9.1 9.5 2.3e-21 0.99 0.03 0.97 FALSE
41 GTEx Muscle Skeletal UHRF1BP1 0.34 0.34 enet 45 0.39 4.3e-40 9.1 8.1 7.4e-16 0.91 0.03 0.97 FALSE
42 GTEx Muscle Skeletal SNRPC 0.03 0.02 lasso 3 0.02 8.3e-03 9.1 -9.5 2.0e-21 -0.98 0.03 0.91 FALSE
43 GTEx Muscle Skeletal C6orf106 0.08 0.06 lasso 4 0.06 7.1e-07 8.8 -8.9 3.7e-19 -0.69 0.33 0.66 FALSE
44 GTEx Nerve Tibial UHRF1BP1 0.31 0.31 lasso 6 0.31 3.9e-22 9.1 9.3 1.9e-20 0.98 0.03 0.97 FALSE
45 GTEx Nerve Tibial SNRPC 0.12 0.10 lasso 4 0.08 1.5e-06 9.1 -9.1 1.0e-19 -0.99 0.03 0.97 FALSE
46 GTEx Nerve Tibial C6orf106 0.11 0.07 enet 17 0.07 1.3e-05 8.0 6.3 2.1e-10 0.33 0.70 0.02 FALSE
47 GTEx Pancreas C6orf106 0.14 0.11 enet 11 0.13 2.8e-06 8.9 8.3 1.2e-16 0.56 0.32 0.63 FALSE
48 GTEx Skin Not Sun Exposed Suprapubic UHRF1BP1 0.20 0.10 enet 30 0.15 2.1e-08 9.0 6.3 2.2e-10 0.85 0.04 0.96 FALSE
49 GTEx Skin Not Sun Exposed Suprapubic SNRPC 0.18 0.04 enet 37 0.03 1.0e-02 8.9 -5.6 1.7e-08 -0.50 0.04 0.86 FALSE
50 GTEx Skin Sun Exposed Lower leg UHRF1BP1 0.19 0.13 enet 33 0.14 2.7e-11 9.1 9.0 3.3e-19 0.90 0.03 0.97 FALSE
51 GTEx Skin Sun Exposed Lower leg SNRPC 0.03 0.04 lasso 2 0.03 1.9e-03 9.1 -9.1 9.0e-20 -0.99 0.03 0.95 FALSE
52 GTEx Small Intestine Terminal Ileum UHRF1BP1 0.20 0.03 lasso 5 0.00 3.4e-01 9.1 9.4 3.5e-21 0.94 0.04 0.75 FALSE
53 GTEx Spleen UHRF1BP1 0.34 0.21 enet 36 0.17 4.5e-05 9.1 8.8 2.0e-18 0.85 0.03 0.95 FALSE
54 GTEx Stomach UHRF1BP1 0.24 0.22 enet 20 0.23 2.2e-11 9.0 10.1 4.4e-24 0.92 0.03 0.97 FALSE
55 GTEx Thyroid UHRF1BP1 0.13 0.06 enet 37 0.08 5.9e-07 4.9 6.8 8.4e-12 0.65 0.18 0.82 FALSE
56 GTEx Thyroid SNRPC 0.07 0.04 lasso 6 0.05 1.6e-04 9.1 -9.1 8.1e-20 -0.99 0.03 0.96 FALSE
57 GTEx Uterus UHRF1BP1 0.20 0.03 lasso 4 0.07 1.8e-02 9.1 10.4 3.6e-25 0.86 0.04 0.67 TRUE
58 GTEx Vagina UHRF1BP1 0.31 0.05 lasso 8 0.04 5.0e-02 9.1 9.1 1.1e-19 0.95 0.04 0.79 FALSE
59 GTEx Whole Blood UHRF1BP1 0.14 0.14 lasso 7 0.14 2.9e-13 9.1 9.4 6.9e-21 0.96 0.03 0.97 FALSE
60 METSIM Adipose C6orf106 0.04 0.02 blup 381 0.02 7.7e-04 5.3 5.6 2.4e-08 0.34 0.35 0.21 FALSE
61 METSIM Adipose SNRPC 0.05 0.05 lasso 7 0.07 2.9e-11 9.2 -7.7 1.7e-14 -0.94 0.03 0.97 FALSE
62 METSIM Adipose UHRF1BP1 0.16 0.31 enet 30 0.32 1.0e-49 9.1 8.7 4.9e-18 0.98 0.03 0.97 FALSE
63 NTR Blood C6orf106 0.03 0.02 lasso 6 0.02 7.2e-07 8.0 7.7 1.7e-14 0.56 0.99 0.01 FALSE
64 NTR Blood UHRF1BP1 0.03 0.05 enet 19 0.05 7.4e-15 8.9 8.9 4.0e-19 0.98 0.03 0.97 FALSE
65 ROSMAP Brain Pre-frontal Cortex UHRF1BP1 0.16 0.27 lasso 10 0.28 2.7e-36 8.9 9.0 3.0e-19 0.98 0.04 0.96 FALSE
66 ROSMAP Brain Pre-frontal Cortex SNRPC 0.15 0.27 lasso 4 0.27 4.0e-35 9.1 -9.1 6.1e-20 -0.99 0.03 0.97 FALSE
67 ROSMAP Brain Pre-frontal Cortex C6orf106 0.30 0.26 bslmm 372 0.33 9.3e-44 8.0 5.8 6.3e-09 0.22 0.99 0.01 FALSE
68 YFS Blood SNRPC 0.02 0.03 lasso 5 0.02 3.0e-08 7.9 -7.8 6.6e-15 -0.86 0.22 0.78 FALSE
69 YFS Blood UHRF1BP1 0.18 0.34 enet 36 0.34 2.5e-117 9.1 9.1 9.4e-20 0.98 0.03 0.97 FALSE
70 The Cancer Genome Atlas Bladder Urothelial Carcinoma UHRF1BP1 0.03 0.04 lasso 3 0.04 1.7e-04 9.1 9.1 1.0e-19 0.99 0.02 0.95 FALSE
71 The Cancer Genome Atlas Breast Invasive Carcinoma SNRPC 0.01 0.01 blup 31 0.00 3.0e-02 5.7 -9.4 7.6e-21 -0.97 0.01 0.64 FALSE
72 The Cancer Genome Atlas Breast Invasive Carcinoma UHRF1BP1 0.04 0.05 lasso 3 0.04 8.4e-09 9.0 9.0 1.6e-19 1.00 0.02 0.98 FALSE
73 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma UHRF1BP1 0.07 0.11 lasso 3 0.07 2.6e-04 9.0 9.0 2.2e-19 0.99 0.02 0.97 FALSE
74 The Cancer Genome Atlas Colon Adenocarcinoma UHRF1BP1 0.08 0.11 lasso 12 0.10 2.3e-06 9.1 9.1 1.4e-19 0.99 0.01 0.99 FALSE
75 The Cancer Genome Atlas Esophageal Carcinoma UHRF1BP1 0.19 0.20 lasso 10 0.17 5.2e-06 9.0 9.0 1.5e-19 0.99 0.02 0.98 FALSE
76 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SNRPC 0.06 0.07 lasso 2 0.07 6.7e-08 9.1 -9.1 8.2e-20 -0.99 0.02 0.98 FALSE
77 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma UHRF1BP1 0.06 0.06 enet 8 0.06 1.3e-07 8.9 8.4 4.6e-17 0.86 0.02 0.98 FALSE
78 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C6orf106 0.04 0.01 blup 68 0.01 2.4e-02 8.1 6.1 9.8e-10 0.35 0.04 0.07 FALSE
79 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma UHRF1BP1 0.18 0.28 lasso 5 0.27 1.0e-30 9.1 9.2 4.5e-20 0.99 0.01 0.99 FALSE
80 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma UHRF1BP1 0.08 0.09 blup 71 0.10 2.0e-06 9.1 9.5 2.5e-21 0.91 0.02 0.98 FALSE
81 The Cancer Genome Atlas Brain Lower Grade Glioma C6orf106 0.04 0.05 lasso 4 0.03 8.1e-05 8.1 8.0 9.1e-16 0.59 0.95 0.04 FALSE
82 The Cancer Genome Atlas Brain Lower Grade Glioma UHRF1BP1 0.06 0.05 blup 70 0.04 8.6e-06 5.7 7.5 4.9e-14 0.87 0.05 0.95 FALSE
83 The Cancer Genome Atlas Liver Hepatocellular Carcinoma UHRF1BP1 0.12 0.09 blup 70 0.06 5.6e-04 9.1 7.7 1.0e-14 0.94 0.02 0.94 FALSE
84 The Cancer Genome Atlas Lung Adenocarcinoma C6orf106 0.03 0.03 lasso 3 0.01 7.6e-03 5.3 6.6 5.4e-11 0.49 0.10 0.23 FALSE
85 The Cancer Genome Atlas Lung Adenocarcinoma FKBP5 0.04 0.05 lasso 2 0.04 5.4e-05 5.0 5.2 2.3e-07 0.21 0.15 0.74 FALSE
86 The Cancer Genome Atlas Lung Adenocarcinoma UHRF1BP1 0.06 0.07 enet 20 0.08 6.4e-10 9.1 8.9 3.7e-19 0.98 0.01 0.99 FALSE
87 The Cancer Genome Atlas Lung Squamous Cell Carcinoma UHRF1BP1 0.04 0.06 blup 70 0.06 1.5e-07 9.1 7.2 4.2e-13 0.90 0.02 0.98 FALSE
88 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C6orf106 0.14 0.07 enet 6 0.06 1.0e-04 8.0 5.2 2.6e-07 0.38 0.40 0.04 FALSE
89 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma UHRF1BP1 0.06 0.07 lasso 1 0.05 1.5e-04 8.9 8.9 5.5e-19 0.96 0.02 0.98 FALSE
90 The Cancer Genome Atlas Pancreatic Adenocarcinoma UHRF1BP1 0.20 0.23 lasso 16 0.25 8.3e-11 9.1 9.4 4.2e-21 0.98 0.01 0.99 FALSE
91 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma UHRF1BP1 0.13 0.09 enet 13 0.10 6.4e-05 9.1 7.8 4.1e-15 0.90 0.02 0.97 FALSE
92 The Cancer Genome Atlas Prostate Adenocarcinoma UHRF1BP1 0.10 0.20 lasso 5 0.19 1.6e-19 9.0 8.9 6.9e-19 0.99 0.02 0.98 FALSE
93 The Cancer Genome Atlas Soft Tissue Sarcoma UHRF1BP1 0.08 0.09 blup 71 0.08 1.0e-05 9.1 9.3 1.9e-20 0.93 0.01 0.98 FALSE
94 The Cancer Genome Atlas Stomach Adenocarcinoma UHRF1BP1 0.08 0.10 lasso 1 0.10 7.1e-08 9.1 9.1 6.7e-20 0.99 0.01 0.99 FALSE
95 The Cancer Genome Atlas Thyroid Carcinoma SNRPC 0.05 0.05 blup 31 0.05 2.9e-05 9.1 -9.7 3.0e-22 -0.94 0.02 0.98 FALSE
96 The Cancer Genome Atlas Thyroid Carcinoma UHRF1BP1 0.07 0.03 blup 71 0.05 2.8e-05 9.1 6.7 2.6e-11 0.87 0.02 0.98 FALSE
97 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma SNRPC 0.09 0.11 lasso 2 0.10 8.1e-04 9.1 -9.1 1.0e-19 -0.99 0.02 0.80 FALSE