Hub : Genes

ANKS1A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1540 0.0380 1.0e-10 0.121 0.118 0.116 0.115 0.119 1.7e-14 3.1e-14 5.5e-14 7.4e-14 2.5e-14
2 GTEx Artery Aorta 0.0990 0.0440 6.4e-03 0.097 NA 0.062 NA 0.083 5.2e-06 NA 2.5e-04 NA 2.4e-05
3 GTEx Artery Coronary 0.2250 0.0930 8.7e-03 0.089 NA 0.016 NA 0.090 6.3e-04 NA 9.4e-02 NA 5.8e-04
4 ROSMAP Brain Pre-frontal Cortex 0.1783 0.0389 2.2e-16 0.177 0.133 0.158 0.142 0.164 3.4e-22 8.7e-17 9.2e-20 7.1e-18 1.3e-20
5 YFS Blood 0.0422 0.0133 1.9e-07 0.000 0.018 0.016 0.019 0.009 3.5e-01 8.1e-07 4.3e-06 6.8e-07 4.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.5 0.7 2.2 0.2 -0.9 -1.5 0.1 0.8
Bipolar Disorder or Schizophrenia 0.3 0.7 3.2 -0.2 0.0 0.6 -0.2 1.8
Depressed Affect (Nagel 2018) 1.7 3.7 11.6 -1.2 -1.9 -0.1 -1.2 -3.4
Depression (Nagel 2018) 1.1 1.7 4.1 0.9 2.0 -0.1 1.1 -1.5
Intelligence (Savage-Jansen 2018) 0.9 2.7 5.8 -2.3 -1.2 -0.8 -2.4 -0.0
Neuroticism (Nagel 2018) 2.0 4.7 22.7 0.1 -0.6 -0.7 0.2 -4.8
Schizophrenia (2018) 0.8 1.7 4.1 -0.3 0.8 2.0 -0.3 2.0
Schizophrenia vs Biploar Disorder 0.1 0.1 0.3 0.0 0.5 0.5 0.0 0.4
Worry (Nagel 2018) 2.4 5.1 9.5 2.5 1.7 -0.6 2.6 -3.1
Alzheimer’s Disease (in mother) 0.6 0.7 1.3 -1.1 -0.0 -0.5 -1.1 -1.0
Alzheimer’s Disease (in father) 0.4 0.5 1.4 -0.6 1.2 -0.1 -0.7 0.1
Alzheimer’s Disease (including proxy) 0.5 0.8 0.9 -1.0 0.9 -0.9 -0.9 -0.7
Crohns Disease (2017) 0.4 0.8 2.4 -0.9 -0.4 -0.0 -0.7 -1.6
Irritable Bowel Disease (IBD) 0.8 1.9 4.4 -1.6 -0.5 -0.3 -1.5 -2.1
Ulcerative Colitis (UC) 0.7 1.3 2.2 -1.5 -0.2 -0.5 -1.4 -1.4
Major Depression (MDD) 0.6 0.7 1.3 0.9 0.8 1.2 0.8 -0.4
Reaction Time 0.7 1.4 4.4 -1.0 -2.1 0.7 -1.0 -0.2
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.5 -1.2 0.8 0.0 -1.2 -0.4
Breast Cancer 0.1 0.2 0.4 -0.4 -0.3 -0.6 -0.4 0.0
Ovarian Cancer 0.1 0.1 0.3 -0.6 0.3 0.1 -0.5 -0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 2.5 3.7 5.6 2.4 2.0 0.7 2.4 -1.7
Bipolar Disorder (2011) 1.0 0.9 3.2 0.7 -0.5 -0.5 0.8 1.8
Body Mass Index (BMI) (2010) 0.5 0.6 2.0 -0.2 -1.4 -1.0 -0.2 -0.3
Coronary Artery Disease (CAD) 8.8 10.5 22.5 -3.5 -4.7 -1.3 -3.5 -1.8
Crohns Disease (2012) 0.8 1.2 5.1 -0.7 -0.1 -0.3 -0.6 -2.3
Mean Putamen Volume 1.0 1.1 2.6 1.6 0.5 0.1 1.6 -0.6
Fasting Glucose 0.9 1.1 4.0 -0.5 -0.5 -2.0 -0.5 0.7
HbA1C 1.8 2.0 2.7 -1.6 -1.6 1.1 -1.5 -1.2
HDL Cholesterol 2.5 4.1 9.5 1.5 3.1 0.0 1.5 2.6
LDL Cholesterol 0.2 0.4 0.8 0.7 -0.2 -0.9 0.6 0.2
Lupus 0.3 0.4 1.2 0.2 -1.1 -0.8 0.3 -0.2
Neuroticism (2016) 1.1 1.6 3.1 1.3 0.6 -0.9 1.3 -1.8
Primary Biliary Cirrhosis 2.4 3.4 5.4 -2.2 -2.3 -0.2 -2.3 1.1
Rheumatoid Arthritis 0.3 0.4 1.6 -0.5 -0.3 -0.1 -0.5 1.3
Schizophrenia (2014) 0.9 1.9 3.9 -1.2 -0.5 1.6 -1.2 2.0
Triglycerides 1.7 2.8 7.4 -1.6 -2.7 -1.1 -1.6 0.5
Type 2 Diabetes (T2D) (2012) 2.3 2.6 4.8 -2.2 -0.9 1.3 -2.1 -1.2
Ulcerative Colitis 2.3 3.3 5.9 -2.4 -1.6 -1.2 -2.4 -1.0
Blood Eosinophil Count 4.3 32.9 55.9 -7.5 -6.8 1.9 -7.4 -2.1
Blood Platelet Count 1.9 21.5 67.7 -2.5 1.6 8.2 -2.4 -5.0
Blood Red Count 0.6 5.4 8.8 1.7 2.7 2.2 1.7 -3.0
Blood White Count 2.3 16.8 45.1 0.2 2.9 5.5 0.3 -6.7
Heel T-Score 0.9 7.4 15.1 -2.9 1.1 2.0 -2.9 -3.9
BMI 4.6 26.9 75.7 -5.2 -8.7 -0.5 -5.2 -2.2
Height 2.7 51.7 94.1 6.1 7.4 -5.4 6.7 9.7
Waist Hip Ratio (WHR) 1.4 6.3 13.5 -1.6 1.9 3.7 -1.4 -3.1
Systolic Blood Pressure 0.4 2.2 3.5 1.7 1.7 1.2 1.9 -0.6
Smoking Status 3.1 7.5 12.9 -3.3 -3.6 0.9 -3.4 -0.8
Allergy or Eczema 0.2 0.6 1.1 -1.0 -0.8 -0.1 -1.0 -0.2
Cardiovascular Disease 1.9 6.3 17.2 -2.4 -4.2 -0.0 -2.4 -1.8
Hypothyroidism (self reported) 2.0 4.5 10.4 -1.2 -3.0 -0.0 -1.2 -3.2
Respiratory disease 0.9 2.1 9.1 -0.6 -0.8 0.1 -0.5 3.0
Type 2 Diabetes (T2D) (2018) 2.1 3.8 8.1 -2.0 -1.3 1.2 -1.9 -2.8
Lung FEV1/FVC ratio 0.4 2.1 3.6 -1.7 -0.9 0.4 -1.8 -1.9
Lung FVC 1.4 6.9 13.8 3.1 3.7 0.7 3.1 -1.2
Neuroticism 1.3 3.2 14.6 0.7 -0.1 -0.8 0.7 -3.8
Chronotype (morning person) 0.6 1.3 2.1 1.5 1.3 0.6 1.4 -0.5
Hair Pigment 0.1 2.6 8.7 -0.7 -0.3 -1.9 -0.6 -3.0
Tanning 0.1 0.7 2.3 -0.3 0.8 1.5 -0.3 -0.6
Hand grip strength (left) 3.4 8.9 18.5 3.3 4.3 -1.3 3.4 1.2
Number of treatments/medications taken 4.7 8.5 17.2 -3.5 -4.2 0.2 -3.4 -1.2
Average weekly spirits intake 2.3 2.9 6.6 -1.6 -2.6 -0.5 -1.5 -1.6
Sensitivity / hurt feelings 1.5 2.6 11.4 -0.7 0.0 -0.9 -0.6 -3.4
Frequency of depressed mood in last 2 weeks 2.2 3.1 6.0 2.0 2.4 -0.8 2.0 -1.0
Hearing difficulty/problems: Yes 1.5 2.3 4.0 -1.4 -1.4 1.3 -1.4 -2.0
Relative age of first facial hair 0.6 1.2 4.0 -0.5 0.7 -1.0 -0.4 2.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.7 0.1 -1.3 -0.7 0.1 0.3
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.6 -1.2 -0.2 -0.1 -1.2 1.1
Ever had hysterectomy (womb removed) 2.8 3.1 4.4 -1.9 -1.9 -0.6 -1.9 2.1
Systolic blood pressure, automated reading 0.0 0.0 0.1 0.1 0.0 -0.2 0.2 -0.3
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 0.8 0.9 0.7 -0.8 0.9 0.1
Angina 1.9 2.5 8.4 -1.3 -2.9 -0.4 -1.4 -0.4
Medication for hormone replacement therapy 1.4 1.6 5.6 1.0 2.4 0.4 1.0 0.5
Vitamin and mineral supplements 0.4 0.5 0.9 0.9 0.5 -0.2 0.9 0.8
Supplements: Zinc 1.1 1.2 5.8 -0.3 0.1 -0.4 -0.3 2.4
Medication: Co-codamol 1.1 1.3 2.2 1.4 0.6 1.5 1.3 0.2
Medication: Metformin 1.3 1.8 2.5 -1.6 -1.3 -0.4 -1.5 -1.6
Diabetes (father) 2.1 2.6 3.6 1.7 1.8 0.5 1.8 1.9
Diabetes (mother) 0.5 0.6 1.2 1.0 1.1 0.1 1.0 0.1
Severe depression (siblings) 1.4 1.5 2.3 1.2 0.2 1.5 1.3 -1.4
Pack years adult smoking proportion 0.9 1.4 2.8 -1.2 -1.1 0.1 -1.2 -1.7
Impedance of leg (right) 0.5 2.7 5.7 0.5 2.4 1.2 0.5 2.4
Leg fat-free mass (left) 0.6 3.4 8.2 -0.4 -2.7 -2.9 -0.3 1.3
Trunk fat percentage 4.6 18.3 52.6 -4.2 -7.2 -0.5 -4.2 2.0
Hand grip strength (right) 2.0 5.4 10.3 2.3 3.2 -2.1 2.4 1.0
Townsend deprivation index at recruitment 0.4 0.5 1.2 0.6 -1.1 -0.9 0.6 -0.4
Current tobacco smoking 3.8 6.3 11.3 -3.0 -3.4 -1.4 -3.0 0.1
Average weekly fortified wine intake 1.4 1.6 4.1 -0.9 -0.4 -1.4 -0.9 2.0
Maternal smoking around birth 2.7 3.9 6.8 -2.6 -2.3 -0.2 -2.6 -0.6
Fed-up feelings 1.4 2.6 9.5 -0.4 -1.6 -0.8 -0.4 -3.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.5 -0.3 1.2 0.3 -0.2 -1.2
Relative age voice broke 0.9 1.4 3.4 0.5 0.3 -1.7 0.5 1.9
Taking other prescription medications 3.8 5.9 11.7 -2.6 -3.4 1.4 -2.5 -1.7
Age when periods started (menarche) 0.4 1.0 1.9 -1.3 -0.0 1.0 -1.4 -0.6
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.1 -0.7 -0.5 -1.0 -0.7 0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.3 2.9 9.1 -1.4 -0.5 0.9 -1.5 -3.0
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 3.1 1.3 1.8 0.4 1.3 1.4
Qualifications: CSEs or equivalent 0.5 0.7 1.3 1.1 -0.9 -0.3 1.1 0.2
Serious illness, injury or assault to yourself 2.9 3.5 6.4 -2.5 -1.9 0.7 -2.5 -0.7
High blood pressure 1.6 4.5 8.3 -2.2 -2.9 -0.8 -2.2 -1.9
Hayfever, allergic rhinitis or eczema 0.6 1.3 1.7 -1.3 -0.9 1.2 -1.3 -0.9
Multivitamins +/- minerals 0.2 0.2 0.8 -0.2 -0.5 0.0 -0.2 -0.9
Stomach or abdominal pain in last month 0.3 0.4 0.8 0.9 -0.6 -0.1 0.9 -0.1
Supplements: Glucosamine 1.1 1.4 5.8 -0.4 0.8 -0.5 -0.3 2.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 1.1 0.1 1.1 -0.0 0.1 0.6
Medication: Atenolol 5.4 6.7 13.7 -2.9 -3.7 0.0 -2.9 -1.7
Medication: Levothyroxine sodium 5.1 8.6 18.3 -1.9 -4.1 -0.5 -1.9 -4.3
Sitting height 0.8 5.5 16.8 1.7 0.2 -4.1 2.0 2.0
Chronic bronchitis/emphysema (father) 1.8 2.1 4.8 -0.9 -2.2 0.5 -0.9 -1.9
High blood pressure (mother) 2.1 2.9 5.8 2.4 0.5 0.3 2.4 -1.7
Body mass index (BMI) 3.9 16.5 52.1 -3.7 -7.2 -1.1 -3.8 -1.2
Impedance of leg (left) 0.5 2.6 8.0 0.2 1.9 1.1 0.2 2.8
Leg predicted mass (left) 0.7 3.5 8.1 -0.4 -2.7 -2.8 -0.3 1.2
Trunk fat mass 3.6 15.3 42.9 -3.8 -6.5 -1.2 -3.7 2.0
Waist circumference 2.5 9.3 27.4 -3.1 -5.2 -0.4 -3.0 -0.5
Number of incorrect matches in round 0.9 1.5 2.9 1.7 1.0 0.0 1.7 0.9
Past tobacco smoking 0.2 0.3 1.4 0.1 1.2 -0.4 0.2 -0.0
Alcohol usually taken with meals 1.0 1.5 3.6 1.8 0.7 -0.1 1.9 -0.5
Nervous feelings 2.9 5.3 10.0 3.1 1.8 -0.6 3.2 -1.9
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.6 0.9 1.3 0.5 0.9 -0.5
Hearing difficulty/problems with background noise 1.8 2.8 6.5 2.5 0.8 -0.6 2.5 0.2
Hair/balding pattern: Pattern 2 0.8 1.0 4.3 -0.1 -0.8 -2.1 -0.1 0.0
Had menopause 0.7 0.8 3.0 -0.6 -0.4 -0.5 -0.6 1.7
Had other major operations 0.5 0.7 1.3 1.1 0.3 -0.7 1.2 0.2
Forced vital capacity (FVC) 3.4 13.2 27.4 4.0 5.2 -1.0 4.1 2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 3.4 -0.8 0.5 1.1 -0.8 -1.9
Ever unenthusiastic/disinterested for a whole week 2.1 2.5 4.0 1.9 1.6 0.8 2.0 -1.4
Qualifications: None of the above 0.6 1.3 2.9 -0.9 -1.7 -1.3 -0.9 -0.1
Financial difficulties in last 2 years 1.3 1.8 3.0 -1.4 -1.7 0.7 -1.4 -1.3
Mouth/teeth dental problems 1.6 2.5 4.8 2.1 1.3 -0.6 2.2 0.8
Heart attack 3.0 3.8 6.6 -2.1 -2.6 -0.7 -2.1 1.8
Allergy 0.5 1.1 2.0 1.4 1.1 -0.5 1.4 -0.4
Pain all over the body in last month 4.6 5.0 9.0 -3.0 -2.3 -0.3 -3.0 -1.4
Diabetes (self-reported) 0.8 1.2 3.5 -1.0 -0.7 0.5 -0.9 -1.9
Hayfever/allergic rhinitis (self-reported) 0.3 0.3 1.1 -0.4 -0.3 -0.4 -0.4 -1.0
Medication: Ramipril 2.3 3.0 5.7 -2.4 -1.1 0.5 -2.4 -1.5
Medication: Simvastatin 1.3 2.0 3.0 -1.6 -1.7 0.9 -1.6 -1.0
Fluid intelligence score 0.3 0.7 1.2 -1.1 -0.1 0.5 -1.1 -0.9
Illnesses of siblings 2.2 3.1 6.4 2.5 1.6 -0.6 2.5 -0.1
Neuroticism score 1.5 3.2 12.5 0.9 -0.2 -1.4 0.9 -3.5
Weight 1.6 8.1 23.5 -2.2 -4.8 -2.3 -2.1 1.6
Impedance of arm (right) 0.9 4.1 10.6 0.4 1.7 2.6 0.5 3.3
Arm fat percentage (right) 4.3 17.0 54.5 -3.9 -7.4 0.2 -3.9 0.3
Trunk fat-free mass 0.6 3.4 12.5 1.1 0.5 -3.5 1.2 1.3
Hip circumference 1.6 7.0 24.9 -1.8 -5.0 -1.2 -1.9 1.4
Time employed in main current job 1.7 1.9 4.6 2.1 0.7 -0.4 2.1 0.4
Alcohol intake versus 10 years previously 1.1 1.6 7.6 -0.2 0.1 0.6 -0.0 -2.8
Father’s age at death 0.5 0.7 1.1 0.8 0.7 -1.1 0.9 0.7
Worrier / anxious feelings 1.2 2.3 7.0 1.3 0.1 -0.8 1.4 -2.6
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.6 2.7 -0.1 -0.1 -0.1 -0.1 -1.7
Falls in the last year 0.5 0.7 1.7 0.6 -0.6 0.8 0.7 1.3
Hair/balding pattern: Pattern 3 0.3 0.4 1.5 0.5 1.2 -0.1 0.5 0.0
Number of live births 0.6 0.9 2.6 -0.6 -0.9 -1.6 -0.6 -0.5
Forced expiratory volume in 1-second (FEV1) 2.5 8.5 18.2 3.3 4.3 -0.7 3.4 1.3
Pulse rate 0.6 1.0 3.5 0.5 0.6 1.9 0.6 -0.6
Happiness 0.7 0.9 2.1 1.0 1.5 0.2 1.0 -0.4
Noisy workplace 0.9 1.1 3.4 -0.7 -0.1 1.1 -0.7 -1.8
Qualifications: A levels/AS levels or equivalent 0.7 1.6 6.9 0.7 2.6 -0.2 0.7 0.2
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.3 4.4 -0.4 1.4 2.1 -0.4 -0.1
Mouth/teeth dental problems: Dentures 1.7 2.9 4.4 -1.7 -2.0 0.0 -1.7 -2.1
Asthma 0.6 1.2 3.9 -0.8 -0.9 -0.1 -0.8 2.0
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.1 5.3 -0.6 -2.1 -2.3 -0.5 -0.3
Medication: Cholesterol lowering 2.0 3.1 7.3 -2.0 -2.7 -0.3 -2.0 0.2
Depression (self-reported) 1.1 1.3 2.5 1.5 0.1 -0.7 1.6 -1.0
Medication: Lansoprazole 0.9 1.1 1.9 -1.2 -1.4 0.1 -1.2 -0.7
Prospective memory result 0.4 0.5 1.1 0.4 -1.0 -0.9 0.4 0.2
Lung cancer (father) 1.2 1.4 3.2 -1.2 -1.8 -0.3 -1.2 -0.8
Illnesses of mother 0.4 0.5 1.5 0.3 1.2 0.8 0.4 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.5 14.1 2.8 3.8 -0.8 2.8 1.4
Pulse wave Arterial Stiffness index 0.7 0.8 2.0 -0.6 -0.5 1.4 -0.6 1.0
Impedance of arm (left) 0.9 4.0 11.6 1.0 1.6 1.9 1.1 3.4
Arm fat mass (right) 3.3 13.5 44.1 -3.3 -6.6 -1.1 -3.3 0.7
Trunk predicted mass 0.6 3.5 12.7 1.1 0.5 -3.6 1.2 1.3
Standing height 1.8 17.6 37.7 3.0 4.7 -2.8 3.4 6.1
Length of working week for main job 0.7 0.7 1.8 -0.2 -0.8 -1.3 -0.2 -1.0
Exposure to tobacco smoke at home 1.2 1.4 3.3 0.7 -1.6 -1.8 0.5 0.5
Breastfed as a baby 0.4 0.5 0.8 0.8 -0.2 -0.5 0.9 0.9
Tense / ‘highly strung’ 0.8 1.4 3.7 0.6 -0.2 -1.9 0.6 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 3.2 4.9 8.9 2.5 1.5 0.7 2.6 -3.0
Hair/balding pattern: Pattern 4 1.4 3.3 5.6 -1.9 -0.7 2.4 -1.9 -1.9
Birth weight of first child 3.5 6.3 11.3 2.7 3.4 1.4 2.9 -1.6
Peak expiratory flow (PEF) 1.8 4.1 7.1 2.5 2.7 -0.2 2.6 0.4
Pulse wave reflection index 0.9 1.1 2.8 -1.1 -1.7 -0.4 -1.2 0.4
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.0 -1.0 -0.6 -0.9 -1.0 -0.1
Loud music exposure frequency 0.3 0.4 1.4 0.3 0.1 1.2 0.4 0.4
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 3.4 0.4 1.8 0.0 0.4 -1.2
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.0 -1.4 -0.7 0.7 -1.4 -0.1
Blood clot in the leg (DVT) 0.2 0.3 0.6 -0.8 -0.6 0.1 -0.7 -0.1
Medication: Paracetamol 1.4 2.4 8.7 -0.9 -3.0 -1.1 -0.9 -0.7
Headache pain in last month 1.5 2.5 6.5 -0.2 -2.5 -1.0 -0.2 -2.2
Medication for cholesterol, blood pressure or diabetes 1.7 2.8 5.7 1.8 2.4 0.7 1.8 1.1
Glaucoma (self-reported) 0.7 0.8 1.6 -0.6 -1.3 0.7 -0.5 -1.1
Gout (self-reported) 2.9 3.9 6.0 -2.5 -2.4 0.6 -2.4 -1.3
Hypothyroidism/myxoedema (self-reported) 2.4 4.8 11.4 -1.2 -3.0 -0.5 -1.2 -3.4
Medication: Amlodipine 3.2 4.5 7.3 -2.7 -1.9 -1.4 -2.6 -1.7
Medication: Ventolin 100micrograms inhaler 1.0 1.2 5.1 -0.5 0.2 0.7 -0.6 2.3
Birth weight 2.3 5.1 6.6 2.4 2.6 0.5 2.5 -2.5
Chronic bronchitis/emphysema (mother) 3.0 3.5 7.3 -2.1 -2.7 0.9 -2.2 0.3
High blood pressure (siblings) 0.6 0.8 2.0 -1.4 -0.6 -0.1 -1.3 -0.3
Forced vital capacity (FVC), Best measure 2.4 8.9 19.7 3.1 4.4 -1.0 3.2 2.0
Body fat percentage 4.7 18.8 55.8 -4.2 -7.5 -0.4 -4.2 1.5
Leg fat percentage (right) 4.9 17.9 53.4 -4.2 -7.3 -0.0 -4.3 0.7
Arm fat-free mass (right) 0.7 3.5 13.8 0.2 -1.2 -3.7 0.3 1.5
Exposure to tobacco smoke outside home 2.3 3.0 8.1 -1.6 -2.8 -1.2 -1.6 0.7
Comparative body size at age 10 0.8 2.2 7.0 -0.3 -2.6 -1.4 -0.4 -1.3
Number of full brothers 3.6 4.6 9.1 -2.3 -3.0 -0.6 -2.4 -1.6
Worry too long after embarrassment 2.8 4.6 19.8 0.9 0.3 -1.2 1.0 -4.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.6 0.7 0.1 -1.2 0.8 -0.5
Wheeze or whistling in the chest in last year 0.6 1.0 1.7 -1.1 -0.3 1.0 -1.1 1.3
Number of children fathered 1.8 2.0 4.7 -2.2 -0.8 -0.0 -2.1 0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.7 1.9 3.9 1.9 1.4 0.0 2.0 -0.1
Age at first live birth 1.2 2.1 3.4 1.5 1.8 1.4 1.5 -0.9
Pulse wave peak to peak time 1.0 1.2 3.5 0.9 0.9 -1.9 0.9 -0.5
Health satisfaction 0.6 0.7 1.6 0.7 -1.0 -1.3 0.7 0.1
Shortness of breath walking on level ground 1.4 1.6 6.0 -0.9 -2.4 -0.5 -1.0 0.4
Qualifications: College or University degree 0.3 0.9 3.5 -0.2 1.0 0.2 -0.2 1.9
Eye problems/disorders: None of the above 0.8 0.9 1.4 1.1 0.9 0.4 1.2 -0.8
Mouth/teeth dental problems: Loose teeth 1.0 1.1 1.7 -1.1 -1.3 0.6 -1.1 1.1
Emphysema/chronic bronchitis 0.9 1.1 3.6 -0.9 -1.9 0.1 -0.9 -0.0
Medication for pain relief, constipation, heartburn 7.6 13.0 32.5 3.9 5.7 1.1 3.9 0.7
Neck or shoulder pain in last month 1.1 1.6 3.8 -0.1 -0.9 -1.9 -0.1 -1.8
Medication: Blood pressure 1.9 3.4 4.5 -1.9 -2.1 -2.0 -1.9 -1.0
Angina (self-reported) 2.3 3.1 9.7 -1.6 -3.1 -0.6 -1.6 -0.2
Migraine (self-reported) 0.8 1.0 3.1 0.1 -1.8 -0.0 0.0 1.3
Medication: Ibuprofen 1.9 2.3 5.2 -1.1 -2.3 -1.8 -1.0 -0.9
Medication: Allopurinol 3.2 4.3 7.3 -2.7 -2.4 0.8 -2.6 -0.8
Medication: Omeprazole 2.7 3.2 8.1 -1.9 -2.8 0.1 -2.0 -0.7
Medication: Seretide 50 evohaler 2.0 2.4 3.3 -1.6 -1.8 0.8 -1.6 1.7
Mean time to correctly identify matches 0.2 0.4 1.0 -0.4 -1.0 0.7 -0.4 0.5
Heart disease (mother) 0.6 0.8 1.1 -1.0 -0.6 -0.8 -1.1 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.4 -0.3 -0.4 -0.6 -0.3 -0.4
Whole body fat mass 3.5 14.8 43.4 -3.6 -6.6 -1.3 -3.6 1.6
Leg fat mass (right) 4.1 15.8 47.2 -3.9 -6.9 -1.1 -3.9 0.9
Arm predicted mass (right) 0.7 3.6 14.7 0.1 -1.2 -3.8 0.2 1.4
Pulse rate, automated reading 0.7 2.4 4.6 1.6 2.1 0.7 1.8 -1.1
Alcohol intake frequency. 0.4 0.9 1.9 -0.6 -1.4 -1.2 -0.6 -0.6
Comparative height size at age 10 1.9 10.2 26.1 2.3 3.0 -1.9 2.6 5.1
Number of full sisters 2.8 3.4 5.5 -2.3 -2.3 1.0 -2.3 -0.4
Suffer from ‘nerves’ 1.1 1.8 3.6 1.8 1.0 -0.5 1.9 -1.0
Overall health rating 1.0 2.2 7.1 -1.2 -2.7 -0.8 -1.1 -0.6
Chest pain or discomfort 0.4 0.6 1.0 -0.8 -0.7 0.1 -0.9 1.0
Had major operations 0.6 0.7 1.9 0.8 1.4 -0.1 0.8 -0.5
Age at last live birth 0.4 0.5 2.0 0.4 0.4 0.5 0.4 -1.4
Family relationship satisfaction 1.1 1.3 1.8 1.3 1.1 0.9 1.4 -1.0
Leg pain on walking 2.3 2.9 4.2 -1.6 -2.0 -1.7 -1.7 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.8 0.0 0.2 0.9 -0.1 0.4
Commuting to job workplace: Car/motor vehicle 1.9 2.2 3.8 -1.5 -1.9 0.4 -1.4 -1.6
Illness, injury, bereavement, stress in last 2 years 2.0 2.5 7.1 1.2 -0.3 -2.7 1.2 1.5
Medication: Aspirin 3.7 4.9 11.0 -2.5 -3.3 0.2 -2.6 0.3
Supplements: Vitamin C 0.2 0.3 0.7 0.3 0.8 0.7 0.3 0.2
Knee pain experienced in last month 3.0 4.6 11.8 -1.6 -3.4 -1.9 -1.6 -1.7
Hypertension (Self-reported) 2.0 5.6 11.2 -2.5 -3.3 -1.2 -2.4 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.4 4.0 6.6 -2.5 -2.6 0.5 -2.5 -0.8
Illnesses of father: Heart disease 0.3 0.4 1.0 -0.1 -1.0 -0.3 -0.1 1.0
Illnesses of siblings: Diabetes 0.8 1.0 2.0 -1.1 0.1 0.6 -1.1 -1.4
Smoking status: Previous 0.3 0.4 1.0 0.3 -1.0 0.5 0.2 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 4.8 1.4 2.2 -0.4 1.6 0.1
Whole body fat-free mass 0.6 3.2 12.2 0.4 -0.9 -3.5 0.5 1.5
Leg fat-free mass (right) 0.6 3.3 8.1 -0.3 -2.5 -2.8 -0.1 1.4
Arm fat percentage (left) 4.1 16.5 54.9 -3.7 -7.4 -0.1 -3.7 0.4
Average weekly red wine intake 1.3 1.9 4.8 1.5 0.5 0.5 1.4 2.2
Handedness (chirality/laterality): Left-handed 1.6 1.9 3.8 -2.0 -1.1 0.8 -1.9 -0.1
Mood swings 2.9 5.2 11.1 -2.0 -2.6 -0.1 -2.0 -3.3
Loneliness, isolation 1.5 2.0 6.1 -0.8 -1.4 -0.7 -0.9 -2.5
Long-standing illness, disability or infirmity 0.9 1.4 5.3 -0.6 -2.3 -0.9 -0.6 -0.6
Ever had bowel cancer screening 0.1 0.1 0.1 0.3 -0.2 -0.2 0.3 0.3
Diabetes diagnosed by doctor 1.0 1.6 6.2 -0.8 -0.2 1.0 -0.6 -2.5
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.5 -0.0 -0.7 -0.4 -0.1 -0.7
Friendships satisfaction 0.7 0.8 1.7 1.3 0.6 0.1 1.3 -0.6
Qualifications: nursing, teaching 1.2 1.8 5.5 0.5 2.3 1.8 0.4 0.2
Commuting to job workplace: Walk 1.5 1.6 2.7 1.3 1.6 -0.1 1.4 1.2
Eye problems/disorders: Cataract 0.5 0.6 1.1 -0.7 -1.0 -0.0 -0.8 0.8
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 -0.3 0.3 0.2 -0.4 0.4
Medication for cholesterol 0.5 0.7 1.3 1.1 1.0 -0.6 1.1 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 7.4 -1.2 -2.7 -0.0 -1.2 -0.2
Back pain experienced in last month 2.5 3.6 10.4 -1.6 -3.2 -1.0 -1.6 -1.4
Mineral and other dietary supplements 1.5 2.0 6.1 1.3 -0.9 0.1 1.3 -2.5
Breast cancer (self-reported) 0.3 0.3 0.5 -0.6 0.2 0.7 -0.6 0.6
Asthma (self-reported) 0.9 1.8 4.2 -1.2 -1.2 0.4 -1.2 2.0
Osteoporosis (self-reported) 0.3 0.3 1.1 -0.4 -1.0 0.1 -0.4 0.5
Osteoarthritis (self-reported) 2.0 2.6 6.5 -1.2 -2.6 -1.8 -1.3 0.2
Medication: Aspirin 3.2 4.2 9.1 -2.3 -3.0 0.2 -2.4 0.8
Medication: Gliclazide 0.2 0.2 0.9 0.3 1.0 -0.0 0.3 -0.2
Illnesses of father: None of the above (group 1) 0.5 0.6 1.4 -0.7 -0.5 0.5 -0.8 -1.2
Smoking status: Current 3.4 5.4 9.7 -2.8 -3.1 -1.1 -2.8 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.4 11.9 1.5 3.4 -0.2 1.5 0.7
Whole body water mass 0.5 3.0 11.6 0.4 -0.9 -3.4 0.5 1.4
Leg predicted mass (right) 0.6 3.3 8.1 -0.2 -2.5 -2.9 -0.1 1.4
Arm fat mass (left) 3.2 13.2 43.6 -3.2 -6.6 -1.2 -3.2 0.8
Number of self-reported non-cancer illnesses 2.7 4.7 15.4 -2.0 -3.9 -0.4 -2.0 -0.1
Average weekly champagne plus white wine intake 0.2 0.3 0.7 0.5 0.8 -0.2 0.6 0.2
Miserableness 0.1 0.2 0.7 -0.3 -0.5 -0.2 -0.3 -0.8
Guilty feelings 1.5 2.3 4.2 1.5 1.5 -0.6 1.6 -2.0
Wears glasses or contact lenses 0.1 0.1 0.3 0.2 0.2 0.2 0.2 0.6
Ever taken oral contraceptive pill 0.7 0.8 3.5 -0.3 0.2 0.3 -0.3 -1.9
Hearing aid user 2.0 2.3 9.1 -0.6 -0.6 3.0 -0.7 1.0
Mother’s age at death 1.0 1.3 3.1 1.1 1.8 -0.0 1.1 1.0
Financial situation satisfaction 1.6 2.0 4.2 2.0 1.0 -0.0 2.1 -1.0
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.4 -0.7 -0.2 0.2 -0.6 0.0
Commuting to job workplace: Public transport 0.6 0.7 1.9 0.5 1.4 -0.0 0.5 -1.1
Eye problems/disorders: Glaucoma 1.8 2.1 3.6 -1.9 -1.4 0.1 -1.8 -1.3
Medication: Blood pressure 3.6 6.8 12.0 -3.0 -3.5 0.8 -3.0 -1.9
Pain type(s) experienced in last month: Hip pain 1.3 1.7 5.4 -1.0 -2.3 -0.4 -1.1 -0.9
Supplements: Fish oil (including cod liver oil) 0.9 1.2 5.7 -0.1 0.4 -0.4 -0.1 2.4
High cholesterol (Self-reported) 0.7 1.3 4.5 -0.6 -2.1 -0.1 -0.7 0.9
Medication: Bendroflumethiazide 0.5 0.8 2.8 -0.4 -1.7 -0.3 -0.4 -0.8
Medication: Paracetamol 1.8 2.8 9.0 -1.4 -3.0 -0.8 -1.4 -0.7
Medication: Lisinopril 1.1 1.5 2.1 -1.4 -1.4 0.1 -1.4 -1.1
Medication: Atorvastatin 0.8 1.0 2.0 -0.5 -1.4 0.9 -0.5 1.3
Illnesses of father: High blood pressure 0.7 0.9 2.8 0.8 0.2 -0.1 0.9 -1.7
Alcohol drinker status: Never 0.5 0.5 0.8 0.9 0.5 0.9 0.9 0.2
Ever smoked 0.3 0.5 1.1 0.5 -0.1 1.0 0.5 1.0
Basal metabolic rate 0.6 3.4 10.3 -0.2 -2.1 -3.2 -0.1 1.5
Leg fat percentage (left) 5.3 19.2 57.7 -4.3 -7.6 -0.1 -4.4 0.9
Arm fat-free mass (left) 0.7 3.6 13.5 -0.1 -1.5 -3.7 0.0 1.6
Number of operations (self-reported) 0.7 1.0 4.1 0.6 0.5 -2.0 0.6 -0.1
Average weekly beer plus cider intake 0.5 0.7 2.3 -0.7 0.3 1.5 -0.7 -0.4
Irritability 2.0 3.4 4.5 -2.1 -2.0 -1.4 -2.1 -1.4
Risk taking 0.2 0.3 0.6 -0.2 -0.3 0.8 -0.2 -0.8
Ever had prostate specific antigen (PSA) test 1.2 1.3 3.1 0.5 0.6 -1.7 0.4 1.8
Fractured/broken bones in last 5 years 0.2 0.2 0.7 0.0 -0.6 0.8 0.1 -0.4
Age started oral contraceptive pill 1.0 1.2 3.0 1.7 0.4 -0.2 1.7 0.1
Diastolic blood pressure, automated reading 0.8 2.6 6.4 -1.5 -2.5 -1.3 -1.5 -0.2
Ever depressed for a whole week 1.7 2.1 2.8 1.6 1.6 0.6 1.7 -1.4
Unable to work because of sickness or disability 0.8 1.0 4.2 -0.6 -2.0 -0.2 -0.6 0.5
Commuting to job workplace: Cycle 3.0 3.6 9.8 1.8 3.1 0.5 1.9 -1.1
Myopia 0.3 0.4 0.8 0.4 0.2 0.8 0.5 -0.9
Vascular/heart problems diagnosed by doctor 2.3 6.4 13.0 2.9 3.6 0.1 2.8 1.6
Cholesterol lowering medication 0.9 1.3 1.8 -1.0 -1.3 1.1 -1.1 1.1
Medication: Omeprazole (e.g. Zanprol) 2.8 3.4 8.9 -2.0 -3.0 -0.3 -2.0 -0.3
Pain experienced in last month 4.4 7.3 15.6 2.7 4.0 1.5 2.7 2.2
Supplements: Calcium 1.3 1.4 4.3 -0.5 1.5 2.1 -0.5 0.3
Basal cell carcinoma (self-reported) 1.2 1.4 2.2 1.0 1.2 1.5 1.0 -1.2
Heart attack/myocardial infarction (self-reported) 3.5 4.6 7.4 -2.3 -2.7 -0.6 -2.4 2.0
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.0 -1.0 -0.8 0.1 -1.0 -0.2
Heart disease (siblings) 2.9 3.5 5.6 -2.3 -2.3 -0.3 -2.4 1.1
Alcohol drinker status: Previous 0.8 0.9 1.7 -1.3 -1.0 -0.5 -1.3 0.1
Pack years of smoking 1.2 1.8 2.7 -1.6 -1.3 -0.1 -1.6 -1.3
Impedance of whole body 0.7 3.6 11.6 0.7 1.8 1.5 0.8 3.4
Leg fat mass (left) 4.1 16.0 48.3 -3.8 -7.0 -1.4 -3.8 1.0
Arm predicted mass (left) 0.7 3.6 13.2 -0.2 -1.7 -3.6 -0.1 1.4