TWAS hub - ANKS1A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1540	0.0380	1.0e-10	0.121	0.118	0.116	0.115	0.119	1.7e-14	3.1e-14	5.5e-14	7.4e-14	2.5e-14
2	GTEx	Artery Aorta	0.0990	0.0440	6.4e-03	0.097	NA	0.062	NA	0.083	5.2e-06	NA	2.5e-04	NA	2.4e-05
3	GTEx	Artery Coronary	0.2250	0.0930	8.7e-03	0.089	NA	0.016	NA	0.090	6.3e-04	NA	9.4e-02	NA	5.8e-04
4	ROSMAP	Brain Pre-frontal Cortex	0.1783	0.0389	2.2e-16	0.177	0.133	0.158	0.142	0.164	3.4e-22	8.7e-17	9.2e-20	7.1e-18	1.3e-20
5	YFS	Blood	0.0422	0.0133	1.9e-07	0.000	0.018	0.016	0.019	0.009	3.5e-01	8.1e-07	4.3e-06	6.8e-07	4.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Coronary Artery Disease (CAD)	8.8	10.5	22.5	-3.5	-4.7	-1.3	-3.5	-1.8
Medication for pain relief, constipation, heartburn	7.6	13.0	32.5	3.9	5.7	1.1	3.9	0.7
Medication: Atenolol	5.4	6.7	13.7	-2.9	-3.7	0.0	-2.9	-1.7
Leg fat percentage (left)	5.3	19.2	57.7	-4.3	-7.6	-0.1	-4.4	0.9
Medication: Levothyroxine sodium	5.1	8.6	18.3	-1.9	-4.1	-0.5	-1.9	-4.3
Leg fat percentage (right)	4.9	17.9	53.4	-4.2	-7.3	-0.0	-4.3	0.7
Number of treatments/medications taken	4.7	8.5	17.2	-3.5	-4.2	0.2	-3.4	-1.2
Body fat percentage	4.7	18.8	55.8	-4.2	-7.5	-0.4	-4.2	1.5
BMI	4.6	26.9	75.7	-5.2	-8.7	-0.5	-5.2	-2.2
Trunk fat percentage	4.6	18.3	52.6	-4.2	-7.2	-0.5	-4.2	2.0
Pain all over the body in last month	4.6	5.0	9.0	-3.0	-2.3	-0.3	-3.0	-1.4
Pain experienced in last month	4.4	7.3	15.6	2.7	4.0	1.5	2.7	2.2
Blood Eosinophil Count	4.3	32.9	55.9	-7.5	-6.8	1.9	-7.4	-2.1
Arm fat percentage (right)	4.3	17.0	54.5	-3.9	-7.4	0.2	-3.9	0.3
Leg fat mass (right)	4.1	15.8	47.2	-3.9	-6.9	-1.1	-3.9	0.9
Arm fat percentage (left)	4.1	16.5	54.9	-3.7	-7.4	-0.1	-3.7	0.4
Leg fat mass (left)	4.1	16.0	48.3	-3.8	-7.0	-1.4	-3.8	1.0
Body mass index (BMI)	3.9	16.5	52.1	-3.7	-7.2	-1.1	-3.8	-1.2
Current tobacco smoking	3.8	6.3	11.3	-3.0	-3.4	-1.4	-3.0	0.1
Taking other prescription medications	3.8	5.9	11.7	-2.6	-3.4	1.4	-2.5	-1.7
Medication: Aspirin	3.7	4.9	11.0	-2.5	-3.3	0.2	-2.6	0.3
Trunk fat mass	3.6	15.3	42.9	-3.8	-6.5	-1.2	-3.7	2.0
Number of full brothers	3.6	4.6	9.1	-2.3	-3.0	-0.6	-2.4	-1.6
Medication: Blood pressure	3.6	6.8	12.0	-3.0	-3.5	0.8	-3.0	-1.9
Birth weight of first child	3.5	6.3	11.3	2.7	3.4	1.4	2.9	-1.6
Whole body fat mass	3.5	14.8	43.4	-3.6	-6.6	-1.3	-3.6	1.6
Heart attack/myocardial infarction (self-reported)	3.5	4.6	7.4	-2.3	-2.7	-0.6	-2.4	2.0
Hand grip strength (left)	3.4	8.9	18.5	3.3	4.3	-1.3	3.4	1.2
Forced vital capacity (FVC)	3.4	13.2	27.4	4.0	5.2	-1.0	4.1	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.4	4.0	6.6	-2.5	-2.6	0.5	-2.5	-0.8
Smoking status: Current	3.4	5.4	9.7	-2.8	-3.1	-1.1	-2.8	0.2
Arm fat mass (right)	3.3	13.5	44.1	-3.3	-6.6	-1.1	-3.3	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	3.2	4.9	8.9	2.5	1.5	0.7	2.6	-3.0
Medication: Amlodipine	3.2	4.5	7.3	-2.7	-1.9	-1.4	-2.6	-1.7
Medication: Allopurinol	3.2	4.3	7.3	-2.7	-2.4	0.8	-2.6	-0.8
Medication: Aspirin	3.2	4.2	9.1	-2.3	-3.0	0.2	-2.4	0.8
Arm fat mass (left)	3.2	13.2	43.6	-3.2	-6.6	-1.2	-3.2	0.8
Smoking Status	3.1	7.5	12.9	-3.3	-3.6	0.9	-3.4	-0.8
Heart attack	3.0	3.8	6.6	-2.1	-2.6	-0.7	-2.1	1.8
Chronic bronchitis/emphysema (mother)	3.0	3.5	7.3	-2.1	-2.7	0.9	-2.2	0.3
Knee pain experienced in last month	3.0	4.6	11.8	-1.6	-3.4	-1.9	-1.6	-1.7
Commuting to job workplace: Cycle	3.0	3.6	9.8	1.8	3.1	0.5	1.9	-1.1
Serious illness, injury or assault to yourself	2.9	3.5	6.4	-2.5	-1.9	0.7	-2.5	-0.7
Nervous feelings	2.9	5.3	10.0	3.1	1.8	-0.6	3.2	-1.9
Gout (self-reported)	2.9	3.9	6.0	-2.5	-2.4	0.6	-2.4	-1.3
Mood swings	2.9	5.2	11.1	-2.0	-2.6	-0.1	-2.0	-3.3
Heart disease (siblings)	2.9	3.5	5.6	-2.3	-2.3	-0.3	-2.4	1.1
Ever had hysterectomy (womb removed)	2.8	3.1	4.4	-1.9	-1.9	-0.6	-1.9	2.1
Worry too long after embarrassment	2.8	4.6	19.8	0.9	0.3	-1.2	1.0	-4.4
Number of full sisters	2.8	3.4	5.5	-2.3	-2.3	1.0	-2.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	2.8	3.4	8.9	-2.0	-3.0	-0.3	-2.0	-0.3
Height	2.7	51.7	94.1	6.1	7.4	-5.4	6.7	9.7
Maternal smoking around birth	2.7	3.9	6.8	-2.6	-2.3	-0.2	-2.6	-0.6
Medication: Omeprazole	2.7	3.2	8.1	-1.9	-2.8	0.1	-2.0	-0.7
Number of self-reported non-cancer illnesses	2.7	4.7	15.4	-2.0	-3.9	-0.4	-2.0	-0.1
Age at First Birth	2.5	3.7	5.6	2.4	2.0	0.7	2.4	-1.7
HDL Cholesterol	2.5	4.1	9.5	1.5	3.1	0.0	1.5	2.6
Waist circumference	2.5	9.3	27.4	-3.1	-5.2	-0.4	-3.0	-0.5
Forced expiratory volume in 1-second (FEV1)	2.5	8.5	18.2	3.3	4.3	-0.7	3.4	1.3
Back pain experienced in last month	2.5	3.6	10.4	-1.6	-3.2	-1.0	-1.6	-1.4
Worry (Nagel 2018)	2.4	5.1	9.5	2.5	1.7	-0.6	2.6	-3.1
Primary Biliary Cirrhosis	2.4	3.4	5.4	-2.2	-2.3	-0.2	-2.3	1.1
Hypothyroidism/myxoedema (self-reported)	2.4	4.8	11.4	-1.2	-3.0	-0.5	-1.2	-3.4
Forced vital capacity (FVC), Best measure	2.4	8.9	19.7	3.1	4.4	-1.0	3.2	2.0
Type 2 Diabetes (T2D) (2012)	2.3	2.6	4.8	-2.2	-0.9	1.3	-2.1	-1.2
Ulcerative Colitis	2.3	3.3	5.9	-2.4	-1.6	-1.2	-2.4	-1.0
Blood White Count	2.3	16.8	45.1	0.2	2.9	5.5	0.3	-6.7
Average weekly spirits intake	2.3	2.9	6.6	-1.6	-2.6	-0.5	-1.5	-1.6
Medication: Ramipril	2.3	3.0	5.7	-2.4	-1.1	0.5	-2.4	-1.5
Birth weight	2.3	5.1	6.6	2.4	2.6	0.5	2.5	-2.5
Exposure to tobacco smoke outside home	2.3	3.0	8.1	-1.6	-2.8	-1.2	-1.6	0.7
Angina (self-reported)	2.3	3.1	9.7	-1.6	-3.1	-0.6	-1.6	-0.2
Leg pain on walking	2.3	2.9	4.2	-1.6	-2.0	-1.7	-1.7	-1.4
Vascular/heart problems diagnosed by doctor	2.3	6.4	13.0	2.9	3.6	0.1	2.8	1.6
Frequency of depressed mood in last 2 weeks	2.2	3.1	6.0	2.0	2.4	-0.8	2.0	-1.0
Illnesses of siblings	2.2	3.1	6.4	2.5	1.6	-0.6	2.5	-0.1
Type 2 Diabetes (T2D) (2018)	2.1	3.8	8.1	-2.0	-1.3	1.2	-1.9	-2.8
Diabetes (father)	2.1	2.6	3.6	1.7	1.8	0.5	1.8	1.9
High blood pressure (mother)	2.1	2.9	5.8	2.4	0.5	0.3	2.4	-1.7
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	4.0	1.9	1.6	0.8	2.0	-1.4
Neuroticism (Nagel 2018)	2.0	4.7	22.7	0.1	-0.6	-0.7	0.2	-4.8
Hypothyroidism (self reported)	2.0	4.5	10.4	-1.2	-3.0	-0.0	-1.2	-3.2
Hand grip strength (right)	2.0	5.4	10.3	2.3	3.2	-2.1	2.4	1.0
Medication: Cholesterol lowering	2.0	3.1	7.3	-2.0	-2.7	-0.3	-2.0	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.5	14.1	2.8	3.8	-0.8	2.8	1.4
Medication: Seretide 50 evohaler	2.0	2.4	3.3	-1.6	-1.8	0.8	-1.6	1.7
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	7.1	1.2	-0.3	-2.7	1.2	1.5
Hypertension (Self-reported)	2.0	5.6	11.2	-2.5	-3.3	-1.2	-2.4	-1.9
Osteoarthritis (self-reported)	2.0	2.6	6.5	-1.2	-2.6	-1.8	-1.3	0.2
Hearing aid user	2.0	2.3	9.1	-0.6	-0.6	3.0	-0.7	1.0
Irritability	2.0	3.4	4.5	-2.1	-2.0	-1.4	-2.1	-1.4
Blood Platelet Count	1.9	21.5	67.7	-2.5	1.6	8.2	-2.4	-5.0
Cardiovascular Disease	1.9	6.3	17.2	-2.4	-4.2	-0.0	-2.4	-1.8
Angina	1.9	2.5	8.4	-1.3	-2.9	-0.4	-1.4	-0.4
Medication: Blood pressure	1.9	3.4	4.5	-1.9	-2.1	-2.0	-1.9	-1.0
Medication: Ibuprofen	1.9	2.3	5.2	-1.1	-2.3	-1.8	-1.0	-0.9
Comparative height size at age 10	1.9	10.2	26.1	2.3	3.0	-1.9	2.6	5.1
Commuting to job workplace: Car/motor vehicle	1.9	2.2	3.8	-1.5	-1.9	0.4	-1.4	-1.6
HbA1C	1.8	2.0	2.7	-1.6	-1.6	1.1	-1.5	-1.2
Chronic bronchitis/emphysema (father)	1.8	2.1	4.8	-0.9	-2.2	0.5	-0.9	-1.9
Hearing difficulty/problems with background noise	1.8	2.8	6.5	2.5	0.8	-0.6	2.5	0.2
Standing height	1.8	17.6	37.7	3.0	4.7	-2.8	3.4	6.1
Peak expiratory flow (PEF)	1.8	4.1	7.1	2.5	2.7	-0.2	2.6	0.4
Number of children fathered	1.8	2.0	4.7	-2.2	-0.8	-0.0	-2.1	0.3
Eye problems/disorders: Glaucoma	1.8	2.1	3.6	-1.9	-1.4	0.1	-1.8	-1.3
Medication: Paracetamol	1.8	2.8	9.0	-1.4	-3.0	-0.8	-1.4	-0.7
Depressed Affect (Nagel 2018)	1.7	3.7	11.6	-1.2	-1.9	-0.1	-1.2	-3.4
Triglycerides	1.7	2.8	7.4	-1.6	-2.7	-1.1	-1.6	0.5
Time employed in main current job	1.7	1.9	4.6	2.1	0.7	-0.4	2.1	0.4
Mouth/teeth dental problems: Dentures	1.7	2.9	4.4	-1.7	-2.0	0.0	-1.7	-2.1
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	5.3	-0.6	-2.1	-2.3	-0.5	-0.3
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	5.7	1.8	2.4	0.7	1.8	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.7	1.9	3.9	1.9	1.4	0.0	2.0	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	7.4	-1.2	-2.7	-0.0	-1.2	-0.2
Ever depressed for a whole week	1.7	2.1	2.8	1.6	1.6	0.6	1.7	-1.4
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.1	1.3	1.8	0.4	1.3	1.4
High blood pressure	1.6	4.5	8.3	-2.2	-2.9	-0.8	-2.2	-1.9
Mouth/teeth dental problems	1.6	2.5	4.8	2.1	1.3	-0.6	2.2	0.8
Weight	1.6	8.1	23.5	-2.2	-4.8	-2.3	-2.1	1.6
Hip circumference	1.6	7.0	24.9	-1.8	-5.0	-1.2	-1.9	1.4
Handedness (chirality/laterality): Left-handed	1.6	1.9	3.8	-2.0	-1.1	0.8	-1.9	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	11.9	1.5	3.4	-0.2	1.5	0.7
Financial situation satisfaction	1.6	2.0	4.2	2.0	1.0	-0.0	2.1	-1.0
Sensitivity / hurt feelings	1.5	2.6	11.4	-0.7	0.0	-0.9	-0.6	-3.4
Hearing difficulty/problems: Yes	1.5	2.3	4.0	-1.4	-1.4	1.3	-1.4	-2.0
Neuroticism score	1.5	3.2	12.5	0.9	-0.2	-1.4	0.9	-3.5
Headache pain in last month	1.5	2.5	6.5	-0.2	-2.5	-1.0	-0.2	-2.2
Loneliness, isolation	1.5	2.0	6.1	-0.8	-1.4	-0.7	-0.9	-2.5
Commuting to job workplace: Walk	1.5	1.6	2.7	1.3	1.6	-0.1	1.4	1.2
Mineral and other dietary supplements	1.5	2.0	6.1	1.3	-0.9	0.1	1.3	-2.5
Guilty feelings	1.5	2.3	4.2	1.5	1.5	-0.6	1.6	-2.0
Waist Hip Ratio (WHR)	1.4	6.3	13.5	-1.6	1.9	3.7	-1.4	-3.1
Lung FVC	1.4	6.9	13.8	3.1	3.7	0.7	3.1	-1.2
Medication for hormone replacement therapy	1.4	1.6	5.6	1.0	2.4	0.4	1.0	0.5
Severe depression (siblings)	1.4	1.5	2.3	1.2	0.2	1.5	1.3	-1.4
Average weekly fortified wine intake	1.4	1.6	4.1	-0.9	-0.4	-1.4	-0.9	2.0
Fed-up feelings	1.4	2.6	9.5	-0.4	-1.6	-0.8	-0.4	-3.1
Hair/balding pattern: Pattern 4	1.4	3.3	5.6	-1.9	-0.7	2.4	-1.9	-1.9
Medication: Paracetamol	1.4	2.4	8.7	-0.9	-3.0	-1.1	-0.9	-0.7
Shortness of breath walking on level ground	1.4	1.6	6.0	-0.9	-2.4	-0.5	-1.0	0.4
Neuroticism	1.3	3.2	14.6	0.7	-0.1	-0.8	0.7	-3.8
Medication: Metformin	1.3	1.8	2.5	-1.6	-1.3	-0.4	-1.5	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	9.1	-1.4	-0.5	0.9	-1.5	-3.0
Financial difficulties in last 2 years	1.3	1.8	3.0	-1.4	-1.7	0.7	-1.4	-1.3
Medication: Simvastatin	1.3	2.0	3.0	-1.6	-1.7	0.9	-1.6	-1.0
Average weekly red wine intake	1.3	1.9	4.8	1.5	0.5	0.5	1.4	2.2
Pain type(s) experienced in last month: Hip pain	1.3	1.7	5.4	-1.0	-2.3	-0.4	-1.1	-0.9
Supplements: Calcium	1.3	1.4	4.3	-0.5	1.5	2.1	-0.5	0.3
Worrier / anxious feelings	1.2	2.3	7.0	1.3	0.1	-0.8	1.4	-2.6
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	4.4	-0.4	1.4	2.1	-0.4	-0.1
Lung cancer (father)	1.2	1.4	3.2	-1.2	-1.8	-0.3	-1.2	-0.8
Exposure to tobacco smoke at home	1.2	1.4	3.3	0.7	-1.6	-1.8	0.5	0.5
Age at first live birth	1.2	2.1	3.4	1.5	1.8	1.4	1.5	-0.9
Qualifications: nursing, teaching	1.2	1.8	5.5	0.5	2.3	1.8	0.4	0.2
Ever had prostate specific antigen (PSA) test	1.2	1.3	3.1	0.5	0.6	-1.7	0.4	1.8
Basal cell carcinoma (self-reported)	1.2	1.4	2.2	1.0	1.2	1.5	1.0	-1.2
Pack years of smoking	1.2	1.8	2.7	-1.6	-1.3	-0.1	-1.6	-1.3
Depression (Nagel 2018)	1.1	1.7	4.1	0.9	2.0	-0.1	1.1	-1.5
Neuroticism (2016)	1.1	1.6	3.1	1.3	0.6	-0.9	1.3	-1.8
Supplements: Zinc	1.1	1.2	5.8	-0.3	0.1	-0.4	-0.3	2.4
Medication: Co-codamol	1.1	1.3	2.2	1.4	0.6	1.5	1.3	0.2
Supplements: Glucosamine	1.1	1.4	5.8	-0.4	0.8	-0.5	-0.3	2.4
Alcohol intake versus 10 years previously	1.1	1.6	7.6	-0.2	0.1	0.6	-0.0	-2.8
Depression (self-reported)	1.1	1.3	2.5	1.5	0.1	-0.7	1.6	-1.0
Neck or shoulder pain in last month	1.1	1.6	3.8	-0.1	-0.9	-1.9	-0.1	-1.8
Suffer from ‘nerves’	1.1	1.8	3.6	1.8	1.0	-0.5	1.9	-1.0
Family relationship satisfaction	1.1	1.3	1.8	1.3	1.1	0.9	1.4	-1.0
Medication: Lisinopril	1.1	1.5	2.1	-1.4	-1.4	0.1	-1.4	-1.1
Bipolar Disorder (2011)	1.0	0.9	3.2	0.7	-0.5	-0.5	0.8	1.8
Mean Putamen Volume	1.0	1.1	2.6	1.6	0.5	0.1	1.6	-0.6
Alcohol usually taken with meals	1.0	1.5	3.6	1.8	0.7	-0.1	1.9	-0.5
Medication: Ventolin 100micrograms inhaler	1.0	1.2	5.1	-0.5	0.2	0.7	-0.6	2.3
Pulse wave peak to peak time	1.0	1.2	3.5	0.9	0.9	-1.9	0.9	-0.5
Mouth/teeth dental problems: Loose teeth	1.0	1.1	1.7	-1.1	-1.3	0.6	-1.1	1.1
Overall health rating	1.0	2.2	7.1	-1.2	-2.7	-0.8	-1.1	-0.6
Diabetes diagnosed by doctor	1.0	1.6	6.2	-0.8	-0.2	1.0	-0.6	-2.5
Mother’s age at death	1.0	1.3	3.1	1.1	1.8	-0.0	1.1	1.0
Age started oral contraceptive pill	1.0	1.2	3.0	1.7	0.4	-0.2	1.7	0.1
Intelligence (Savage-Jansen 2018)	0.9	2.7	5.8	-2.3	-1.2	-0.8	-2.4	-0.0
Fasting Glucose	0.9	1.1	4.0	-0.5	-0.5	-2.0	-0.5	0.7
Schizophrenia (2014)	0.9	1.9	3.9	-1.2	-0.5	1.6	-1.2	2.0
Heel T-Score	0.9	7.4	15.1	-2.9	1.1	2.0	-2.9	-3.9
Respiratory disease	0.9	2.1	9.1	-0.6	-0.8	0.1	-0.5	3.0
Pack years adult smoking proportion	0.9	1.4	2.8	-1.2	-1.1	0.1	-1.2	-1.7
Relative age voice broke	0.9	1.4	3.4	0.5	0.3	-1.7	0.5	1.9
Number of incorrect matches in round	0.9	1.5	2.9	1.7	1.0	0.0	1.7	0.9
Impedance of arm (right)	0.9	4.1	10.6	0.4	1.7	2.6	0.5	3.3
Noisy workplace	0.9	1.1	3.4	-0.7	-0.1	1.1	-0.7	-1.8
Medication: Lansoprazole	0.9	1.1	1.9	-1.2	-1.4	0.1	-1.2	-0.7
Impedance of arm (left)	0.9	4.0	11.6	1.0	1.6	1.9	1.1	3.4
Pulse wave reflection index	0.9	1.1	2.8	-1.1	-1.7	-0.4	-1.2	0.4
Emphysema/chronic bronchitis	0.9	1.1	3.6	-0.9	-1.9	0.1	-0.9	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.8	1.4	2.2	-0.4	1.6	0.1
Long-standing illness, disability or infirmity	0.9	1.4	5.3	-0.6	-2.3	-0.9	-0.6	-0.6
Asthma (self-reported)	0.9	1.8	4.2	-1.2	-1.2	0.4	-1.2	2.0
Supplements: Fish oil (including cod liver oil)	0.9	1.2	5.7	-0.1	0.4	-0.4	-0.1	2.4
Cholesterol lowering medication	0.9	1.3	1.8	-1.0	-1.3	1.1	-1.1	1.1
Schizophrenia (2018)	0.8	1.7	4.1	-0.3	0.8	2.0	-0.3	2.0
Irritable Bowel Disease (IBD)	0.8	1.9	4.4	-1.6	-0.5	-0.3	-1.5	-2.1
Crohns Disease (2012)	0.8	1.2	5.1	-0.7	-0.1	-0.3	-0.6	-2.3
Sitting height	0.8	5.5	16.8	1.7	0.2	-4.1	2.0	2.0
Hair/balding pattern: Pattern 2	0.8	1.0	4.3	-0.1	-0.8	-2.1	-0.1	0.0
Diabetes (self-reported)	0.8	1.2	3.5	-1.0	-0.7	0.5	-0.9	-1.9
Tense / ‘highly strung’	0.8	1.4	3.7	0.6	-0.2	-1.9	0.6	-1.6
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.0	-1.4	-0.7	0.7	-1.4	-0.1
Comparative body size at age 10	0.8	2.2	7.0	-0.3	-2.6	-1.4	-0.4	-1.3
Eye problems/disorders: None of the above	0.8	0.9	1.4	1.1	0.9	0.4	1.2	-0.8
Migraine (self-reported)	0.8	1.0	3.1	0.1	-1.8	-0.0	0.0	1.3
Illnesses of siblings: Diabetes	0.8	1.0	2.0	-1.1	0.1	0.6	-1.1	-1.4
Medication: Atorvastatin	0.8	1.0	2.0	-0.5	-1.4	0.9	-0.5	1.3
Diastolic blood pressure, automated reading	0.8	2.6	6.4	-1.5	-2.5	-1.3	-1.5	-0.2
Unable to work because of sickness or disability	0.8	1.0	4.2	-0.6	-2.0	-0.2	-0.6	0.5
Alcohol drinker status: Previous	0.8	0.9	1.7	-1.3	-1.0	-0.5	-1.3	0.1
Ulcerative Colitis (UC)	0.7	1.3	2.2	-1.5	-0.2	-0.5	-1.4	-1.4
Reaction Time	0.7	1.4	4.4	-1.0	-2.1	0.7	-1.0	-0.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.6	-1.2	-0.2	-0.1	-1.2	1.1
Leg predicted mass (left)	0.7	3.5	8.1	-0.4	-2.7	-2.8	-0.3	1.2
Had menopause	0.7	0.8	3.0	-0.6	-0.4	-0.5	-0.6	1.7
Happiness	0.7	0.9	2.1	1.0	1.5	0.2	1.0	-0.4
Qualifications: A levels/AS levels or equivalent	0.7	1.6	6.9	0.7	2.6	-0.2	0.7	0.2
Pulse wave Arterial Stiffness index	0.7	0.8	2.0	-0.6	-0.5	1.4	-0.6	1.0
Length of working week for main job	0.7	0.7	1.8	-0.2	-0.8	-1.3	-0.2	-1.0
Glaucoma (self-reported)	0.7	0.8	1.6	-0.6	-1.3	0.7	-0.5	-1.1
Arm fat-free mass (right)	0.7	3.5	13.8	0.2	-1.2	-3.7	0.3	1.5
Arm predicted mass (right)	0.7	3.6	14.7	0.1	-1.2	-3.8	0.2	1.4
Pulse rate, automated reading	0.7	2.4	4.6	1.6	2.1	0.7	1.8	-1.1
Friendships satisfaction	0.7	0.8	1.7	1.3	0.6	0.1	1.3	-0.6
Ever taken oral contraceptive pill	0.7	0.8	3.5	-0.3	0.2	0.3	-0.3	-1.9
High cholesterol (Self-reported)	0.7	1.3	4.5	-0.6	-2.1	-0.1	-0.7	0.9
Illnesses of father: High blood pressure	0.7	0.9	2.8	0.8	0.2	-0.1	0.9	-1.7
Arm fat-free mass (left)	0.7	3.6	13.5	-0.1	-1.5	-3.7	0.0	1.6
Number of operations (self-reported)	0.7	1.0	4.1	0.6	0.5	-2.0	0.6	-0.1
Impedance of whole body	0.7	3.6	11.6	0.7	1.8	1.5	0.8	3.4
Arm predicted mass (left)	0.7	3.6	13.2	-0.2	-1.7	-3.6	-0.1	1.4
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	-1.1	-0.0	-0.5	-1.1	-1.0
Major Depression (MDD)	0.6	0.7	1.3	0.9	0.8	1.2	0.8	-0.4
Blood Red Count	0.6	5.4	8.8	1.7	2.7	2.2	1.7	-3.0
Chronotype (morning person)	0.6	1.3	2.1	1.5	1.3	0.6	1.4	-0.5
Relative age of first facial hair	0.6	1.2	4.0	-0.5	0.7	-1.0	-0.4	2.0
Leg fat-free mass (left)	0.6	3.4	8.2	-0.4	-2.7	-2.9	-0.3	1.3
Hayfever, allergic rhinitis or eczema	0.6	1.3	1.7	-1.3	-0.9	1.2	-1.3	-0.9
Qualifications: None of the above	0.6	1.3	2.9	-0.9	-1.7	-1.3	-0.9	-0.1
Trunk fat-free mass	0.6	3.4	12.5	1.1	0.5	-3.5	1.2	1.3
Number of live births	0.6	0.9	2.6	-0.6	-0.9	-1.6	-0.6	-0.5
Pulse rate	0.6	1.0	3.5	0.5	0.6	1.9	0.6	-0.6
Asthma	0.6	1.2	3.9	-0.8	-0.9	-0.1	-0.8	2.0
Trunk predicted mass	0.6	3.5	12.7	1.1	0.5	-3.6	1.2	1.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.4	0.4	1.8	0.0	0.4	-1.2
High blood pressure (siblings)	0.6	0.8	2.0	-1.4	-0.6	-0.1	-1.3	-0.3
Wheeze or whistling in the chest in last year	0.6	1.0	1.7	-1.1	-0.3	1.0	-1.1	1.3
Health satisfaction	0.6	0.7	1.6	0.7	-1.0	-1.3	0.7	0.1
Heart disease (mother)	0.6	0.8	1.1	-1.0	-0.6	-0.8	-1.1	0.8
Had major operations	0.6	0.7	1.9	0.8	1.4	-0.1	0.8	-0.5
Whole body fat-free mass	0.6	3.2	12.2	0.4	-0.9	-3.5	0.5	1.5
Leg fat-free mass (right)	0.6	3.3	8.1	-0.3	-2.5	-2.8	-0.1	1.4
Leg predicted mass (right)	0.6	3.3	8.1	-0.2	-2.5	-2.9	-0.1	1.4
Commuting to job workplace: Public transport	0.6	0.7	1.9	0.5	1.4	-0.0	0.5	-1.1
Basal metabolic rate	0.6	3.4	10.3	-0.2	-2.1	-3.2	-0.1	1.5
Bipolar Disorder (2018)	0.5	0.7	2.2	0.2	-0.9	-1.5	0.1	0.8
Alzheimer’s Disease (including proxy)	0.5	0.8	0.9	-1.0	0.9	-0.9	-0.9	-0.7
Body Mass Index (BMI) (2010)	0.5	0.6	2.0	-0.2	-1.4	-1.0	-0.2	-0.3
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.8	0.9	0.7	-0.8	0.9	0.1
Diabetes (mother)	0.5	0.6	1.2	1.0	1.1	0.1	1.0	0.1
Impedance of leg (right)	0.5	2.7	5.7	0.5	2.4	1.2	0.5	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.5	-0.3	1.2	0.3	-0.2	-1.2
Qualifications: CSEs or equivalent	0.5	0.7	1.3	1.1	-0.9	-0.3	1.1	0.2
Impedance of leg (left)	0.5	2.6	8.0	0.2	1.9	1.1	0.2	2.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.6	0.9	1.3	0.5	0.9	-0.5
Had other major operations	0.5	0.7	1.3	1.1	0.3	-0.7	1.2	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.4	-0.8	0.5	1.1	-0.8	-1.9
Allergy	0.5	1.1	2.0	1.4	1.1	-0.5	1.4	-0.4
Father’s age at death	0.5	0.7	1.1	0.8	0.7	-1.1	0.9	0.7
Falls in the last year	0.5	0.7	1.7	0.6	-0.6	0.8	0.7	1.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.0	-1.0	-0.6	-0.9	-1.0	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.6	0.7	0.1	-1.2	0.8	-0.5
Eye problems/disorders: Cataract	0.5	0.6	1.1	-0.7	-1.0	-0.0	-0.8	0.8
Medication for cholesterol	0.5	0.7	1.3	1.1	1.0	-0.6	1.1	0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.4	-0.7	-0.5	0.5	-0.8	-1.2
Whole body water mass	0.5	3.0	11.6	0.4	-0.9	-3.4	0.5	1.4
Medication: Bendroflumethiazide	0.5	0.8	2.8	-0.4	-1.7	-0.3	-0.4	-0.8
Alcohol drinker status: Never	0.5	0.5	0.8	0.9	0.5	0.9	0.9	0.2
Average weekly beer plus cider intake	0.5	0.7	2.3	-0.7	0.3	1.5	-0.7	-0.4
Alzheimer’s Disease (in father)	0.4	0.5	1.4	-0.6	1.2	-0.1	-0.7	0.1
Crohns Disease (2017)	0.4	0.8	2.4	-0.9	-0.4	-0.0	-0.7	-1.6
Systolic Blood Pressure	0.4	2.2	3.5	1.7	1.7	1.2	1.9	-0.6
Lung FEV1/FVC ratio	0.4	2.1	3.6	-1.7	-0.9	0.4	-1.8	-1.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.7	0.1	-1.3	-0.7	0.1	0.3
Vitamin and mineral supplements	0.4	0.5	0.9	0.9	0.5	-0.2	0.9	0.8
Townsend deprivation index at recruitment	0.4	0.5	1.2	0.6	-1.1	-0.9	0.6	-0.4
Age when periods started (menarche)	0.4	1.0	1.9	-1.3	-0.0	1.0	-1.4	-0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.1	-0.7	-0.5	-1.0	-0.7	0.3
Prospective memory result	0.4	0.5	1.1	0.4	-1.0	-0.9	0.4	0.2
Illnesses of mother	0.4	0.5	1.5	0.3	1.2	0.8	0.4	0.5
Breastfed as a baby	0.4	0.5	0.8	0.8	-0.2	-0.5	0.9	0.9
Alcohol intake frequency.	0.4	0.9	1.9	-0.6	-1.4	-1.2	-0.6	-0.6
Chest pain or discomfort	0.4	0.6	1.0	-0.8	-0.7	0.1	-0.9	1.0
Age at last live birth	0.4	0.5	2.0	0.4	0.4	0.5	0.4	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	-1.0	-0.8	0.1	-1.0	-0.2
Bipolar Disorder or Schizophrenia	0.3	0.7	3.2	-0.2	0.0	0.6	-0.2	1.8
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.5	-1.2	0.8	0.0	-1.2	-0.4
Lupus	0.3	0.4	1.2	0.2	-1.1	-0.8	0.3	-0.2
Rheumatoid Arthritis	0.3	0.4	1.6	-0.5	-0.3	-0.1	-0.5	1.3
Stomach or abdominal pain in last month	0.3	0.4	0.8	0.9	-0.6	-0.1	0.9	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.1	0.1	1.1	-0.0	0.1	0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.1	-0.4	-0.3	-0.4	-0.4	-1.0
Fluid intelligence score	0.3	0.7	1.2	-1.1	-0.1	0.5	-1.1	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	2.7	-0.1	-0.1	-0.1	-0.1	-1.7
Hair/balding pattern: Pattern 3	0.3	0.4	1.5	0.5	1.2	-0.1	0.5	0.0
Loud music exposure frequency	0.3	0.4	1.4	0.3	0.1	1.2	0.4	0.4
Qualifications: College or University degree	0.3	0.9	3.5	-0.2	1.0	0.2	-0.2	1.9
Illnesses of father: Heart disease	0.3	0.4	1.0	-0.1	-1.0	-0.3	-0.1	1.0
Smoking status: Previous	0.3	0.4	1.0	0.3	-1.0	0.5	0.2	-0.7
Breast cancer (self-reported)	0.3	0.3	0.5	-0.6	0.2	0.7	-0.6	0.6
Osteoporosis (self-reported)	0.3	0.3	1.1	-0.4	-1.0	0.1	-0.4	0.5
Ever smoked	0.3	0.5	1.1	0.5	-0.1	1.0	0.5	1.0
Myopia	0.3	0.4	0.8	0.4	0.2	0.8	0.5	-0.9
LDL Cholesterol	0.2	0.4	0.8	0.7	-0.2	-0.9	0.6	0.2
Allergy or Eczema	0.2	0.6	1.1	-1.0	-0.8	-0.1	-1.0	-0.2
Multivitamins +/- minerals	0.2	0.2	0.8	-0.2	-0.5	0.0	-0.2	-0.9
Past tobacco smoking	0.2	0.3	1.4	0.1	1.2	-0.4	0.2	-0.0
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.8	-0.6	0.1	-0.7	-0.1
Mean time to correctly identify matches	0.2	0.4	1.0	-0.4	-1.0	0.7	-0.4	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.8	0.0	0.2	0.9	-0.1	0.4
Supplements: Vitamin C	0.2	0.3	0.7	0.3	0.8	0.7	0.3	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.0	-0.7	-0.4	-0.1	-0.7
Medication: Gliclazide	0.2	0.2	0.9	0.3	1.0	-0.0	0.3	-0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.7	0.5	0.8	-0.2	0.6	0.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.7	-0.2	0.2	-0.6	0.0
Risk taking	0.2	0.3	0.6	-0.2	-0.3	0.8	-0.2	-0.8
Fractured/broken bones in last 5 years	0.2	0.2	0.7	0.0	-0.6	0.8	0.1	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.0	0.5	0.5	0.0	0.4
Breast Cancer	0.1	0.2	0.4	-0.4	-0.3	-0.6	-0.4	0.0
Ovarian Cancer	0.1	0.1	0.3	-0.6	0.3	0.1	-0.5	-0.1
Hair Pigment	0.1	2.6	8.7	-0.7	-0.3	-1.9	-0.6	-3.0
Tanning	0.1	0.7	2.3	-0.3	0.8	1.5	-0.3	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	-0.3	-0.4	-0.6	-0.3	-0.4
Ever had bowel cancer screening	0.1	0.1	0.1	0.3	-0.2	-0.2	0.3	0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	-0.3	0.3	0.2	-0.4	0.4
Miserableness	0.1	0.2	0.7	-0.3	-0.5	-0.2	-0.3	-0.8
Wears glasses or contact lenses	0.1	0.1	0.3	0.2	0.2	0.2	0.2	0.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Systolic blood pressure, automated reading	0.0	0.0	0.1	0.1	0.0	-0.2	0.2	-0.3

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