[Hub]/) : Traits : Leg fat mass (right) :

chr11:46,565,407-48,485,877

Best TWAS P=1.15e-20 · Best GWAS P=1.11e-20 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FAM180B 0.07 0.08 lasso 3 0.08 9.1e-10 9.2 8.6 9.8e-18 0.95 0.02 0.98 FALSE
2 CommonMind Brain Pre-frontal Cortex MTCH2 0.03 0.00 bslmm 299 0.00 1.1e-01 1.8 5.5 3.1e-08 0.68 0.07 0.53 FALSE
3 GTEx Adipose Subcutaneous ACP2 0.08 0.03 enet 18 0.03 3.5e-03 -2.4 6.2 5.0e-10 0.73 0.08 0.78 FALSE
4 GTEx Adipose Subcutaneous C1QTNF4 0.16 0.22 lasso 4 0.22 2.5e-18 9.3 -8.9 7.7e-19 -0.98 0.00 1.00 FALSE
5 GTEx Artery Aorta C1QTNF4 0.09 0.10 lasso 1 0.08 3.2e-05 9.2 -9.2 3.7e-20 -1.00 0.00 0.99 FALSE
6 GTEx Brain Cerebellum MADD 0.21 0.00 enet 13 0.11 3.3e-04 -3.0 6.4 1.4e-10 0.63 0.07 0.68 FALSE
7 GTEx Brain Cortex MTCH2 0.21 0.19 lasso 6 0.16 4.0e-05 7.4 6.4 1.7e-10 0.79 0.35 0.18 FALSE
8 GTEx Brain Cortex C1QTNF4 0.26 0.04 lasso 8 0.02 1.2e-01 -7.8 -8.1 6.7e-16 -0.80 0.02 0.58 FALSE
9 GTEx Breast Mammary Tissue C1QTNF4 0.10 0.06 lasso 2 0.03 8.5e-03 7.1 -6.9 5.3e-12 -0.82 0.10 0.68 FALSE
10 GTEx Breast Mammary Tissue (Female) MADD 0.13 0.04 lasso 3 0.05 1.3e-02 7.1 7.4 1.3e-13 0.81 0.05 0.31 FALSE
11 GTEx Cells Transformed fibroblasts FNBP4 0.11 0.05 lasso 8 0.08 1.6e-06 -8.0 8.5 2.0e-17 0.88 0.04 0.96 FALSE
12 GTEx Cells Transformed fibroblasts PSMC3 0.07 0.00 enet 13 0.02 2.3e-02 -2.8 6.6 4.3e-11 0.83 0.03 0.77 FALSE
13 GTEx Cells Transformed fibroblasts C1QTNF4 0.13 0.11 enet 19 0.12 5.2e-09 7.5 -7.5 6.8e-14 -0.84 0.03 0.97 FALSE
14 GTEx Cells Transformed fibroblasts NDUFS3 0.08 0.01 lasso 2 0.01 3.3e-02 9.3 -9.0 2.5e-19 -0.98 0.00 0.98 FALSE
15 GTEx Colon Transverse C1QTNF4 0.07 0.02 lasso 6 0.03 2.0e-02 9.3 -8.7 3.4e-18 -0.96 0.01 0.96 FALSE
16 GTEx Esophagus Mucosa MADD 0.27 0.04 enet 18 0.12 4.1e-08 -3.1 5.9 4.0e-09 0.40 0.26 0.08 FALSE
17 GTEx Esophagus Mucosa C1QTNF4 0.10 0.11 lasso 1 0.10 5.0e-07 9.2 -9.2 3.7e-20 -1.00 0.00 1.00 FALSE
18 GTEx Esophagus Muscularis MTCH2 0.09 0.04 lasso 6 0.02 1.8e-02 7.5 7.3 2.0e-13 0.78 0.27 0.53 FALSE
19 GTEx Esophagus Muscularis C1QTNF4 0.10 0.05 enet 23 0.06 1.4e-04 9.3 -8.5 1.7e-17 -0.93 0.01 0.99 FALSE
20 GTEx Heart Atrial Appendage C1QTNF4 0.26 0.14 lasso 9 0.17 3.9e-08 9.2 -8.8 1.5e-18 -0.95 0.01 0.99 FALSE
21 GTEx Heart Left Ventricle MADD 0.14 0.01 enet 17 0.05 7.0e-04 -3.0 7.1 1.5e-12 0.70 0.02 0.96 FALSE
22 GTEx Heart Left Ventricle C1QTNF4 0.10 0.11 lasso 1 0.09 1.1e-05 9.2 -9.2 3.7e-20 -1.00 0.00 0.99 FALSE
23 GTEx Liver C1QTNF4 0.25 0.14 enet 16 0.20 2.3e-06 9.2 -8.5 2.1e-17 -0.84 0.02 0.97 FALSE
24 GTEx Lung C1QTNF4 0.18 0.15 lasso 6 0.13 3.2e-10 7.0 -7.9 3.2e-15 -0.91 0.08 0.92 FALSE
25 GTEx Muscle Skeletal MTCH2 0.05 0.03 enet 15 0.04 1.5e-04 6.8 7.5 4.7e-14 0.84 0.05 0.94 FALSE
26 GTEx Muscle Skeletal C1QTNF4 0.09 0.14 lasso 3 0.13 9.9e-13 9.2 -8.9 3.9e-19 -0.98 0.00 1.00 FALSE
27 GTEx Nerve Tibial NR1H3 0.10 0.00 enet 24 0.08 4.7e-06 -1.3 -6.0 1.6e-09 -0.52 0.01 0.82 FALSE
28 GTEx Nerve Tibial C1QTNF4 0.20 0.23 enet 12 0.23 1.7e-16 9.2 -8.5 2.5e-17 -0.96 0.00 1.00 FALSE
29 GTEx Pituitary MADD 0.42 0.32 lasso 6 0.39 8.9e-11 -3.8 6.6 4.7e-11 0.60 0.25 0.63 FALSE
30 GTEx Skin Not Sun Exposed Suprapubic C1QTNF4 0.32 0.18 enet 33 0.20 5.2e-11 9.2 -8.3 8.7e-17 -0.90 0.00 1.00 FALSE
31 GTEx Skin Sun Exposed Lower leg C1QTNF4 0.25 0.22 lasso 12 0.23 4.2e-19 9.2 -8.8 9.4e-19 -0.95 0.00 1.00 FALSE
32 GTEx Spleen C1QTNF4 0.31 0.28 enet 29 0.34 1.8e-09 7.4 -8.4 3.5e-17 -0.89 0.07 0.92 FALSE
33 GTEx Testis MTCH2 0.17 0.16 lasso 3 0.16 1.0e-07 7.1 7.1 1.2e-12 0.83 0.52 0.47 FALSE
34 GTEx Testis C1QTNF4 0.14 0.12 lasso 4 0.11 1.6e-05 -8.1 -8.0 1.3e-15 -0.73 0.28 0.67 FALSE
35 GTEx Whole Blood C1QTNF4 0.09 0.05 lasso 3 0.03 1.4e-03 7.4 -7.4 1.0e-13 -0.86 0.18 0.73 FALSE
36 METSIM Adipose C1QTNF4 0.24 0.31 lasso 7 0.31 1.2e-46 7.4 -7.2 5.0e-13 -0.86 1.00 0.00 FALSE
37 METSIM Adipose MYBPC3 0.11 0.10 enet 26 0.11 1.0e-15 7.1 -6.1 1.0e-09 -0.81 0.31 0.69 FALSE
38 METSIM Adipose PSMC3 0.06 0.03 enet 28 0.04 2.3e-06 3.2 5.7 1.6e-08 0.79 0.03 0.96 FALSE
39 NTR Blood MTCH2 0.02 0.04 lasso 1 0.04 1.3e-11 7.5 -7.5 4.6e-14 -0.88 0.90 0.10 FALSE
40 ROSMAP Brain Pre-frontal Cortex MTCH2 0.35 0.40 enet 9 0.40 4.7e-56 7.4 7.8 5.1e-15 0.91 1.00 0.00 FALSE
41 ROSMAP Brain Pre-frontal Cortex FNBP4 0.04 0.04 lasso 3 0.04 8.2e-06 -8.1 8.4 4.3e-17 0.69 0.94 0.05 FALSE
42 ROSMAP Brain Pre-frontal Cortex ACP2 0.03 0.00 blup 295 0.02 1.5e-03 7.0 5.8 7.5e-09 0.72 0.06 0.86 FALSE
43 ROSMAP Brain Pre-frontal Cortex C1QTNF4 0.05 0.06 blup 281 0.06 1.7e-08 7.0 -6.8 1.0e-11 -0.86 0.09 0.91 FALSE
44 YFS Blood FNBP4 0.02 0.01 bslmm 301 0.01 8.9e-05 -6.7 7.8 5.0e-15 0.78 0.03 0.95 FALSE
45 YFS Blood PSMC3 0.02 0.01 blup 289 0.01 2.8e-05 9.3 6.7 1.9e-11 0.84 0.00 0.99 FALSE
46 YFS Blood PTPMT1 0.03 0.01 lasso 5 0.01 3.2e-04 -7.9 -6.6 5.3e-11 -0.67 0.28 0.61 FALSE
47 YFS Blood SPI1 0.65 0.18 enet 75 0.27 1.6e-87 7.0 -5.2 2.5e-07 -0.62 1.00 0.00 FALSE
48 The Cancer Genome Atlas Bladder Urothelial Carcinoma C1QTNF4 0.06 0.07 lasso 2 0.06 4.9e-06 7.5 -8.2 3.3e-16 -0.93 0.01 0.99 FALSE
49 The Cancer Genome Atlas Breast Invasive Carcinoma C1QTNF4 0.02 0.01 lasso 5 0.02 2.1e-04 -2.0 -5.9 3.9e-09 -0.74 0.01 0.83 FALSE
50 The Cancer Genome Atlas Breast Invasive Carcinoma MADD 0.11 0.03 enet 14 0.06 1.4e-11 -4.3 7.1 1.0e-12 0.56 0.04 0.96 FALSE
51 The Cancer Genome Atlas Breast Invasive Carcinoma MYBPC3 0.02 0.01 blup 43 0.01 3.4e-03 7.0 -6.3 3.2e-10 -0.74 0.01 0.97 FALSE
52 The Cancer Genome Atlas Colon Adenocarcinoma C1QTNF4 0.12 0.12 lasso 1 0.12 1.6e-07 9.2 -9.2 3.7e-20 -1.00 0.00 1.00 FALSE
53 The Cancer Genome Atlas Colon Adenocarcinoma KBTBD4 0.14 0.01 blup 13 0.02 1.6e-02 -7.9 7.2 4.6e-13 0.90 0.00 0.53 FALSE
54 The Cancer Genome Atlas Colon Adenocarcinoma NUP160 0.05 0.05 blup 44 0.05 7.7e-04 -8.1 8.8 1.6e-18 0.82 0.02 0.84 FALSE
55 The Cancer Genome Atlas Colon Adenocarcinoma PSMC3 0.09 0.05 blup 39 0.05 1.0e-03 -4.2 5.6 1.7e-08 0.55 0.02 0.74 FALSE
56 The Cancer Genome Atlas Esophageal Carcinoma C1QTNF4 0.39 0.33 blup 15 0.35 6.1e-12 9.2 -8.9 6.7e-19 -0.98 0.00 1.00 FALSE
57 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C1QTNF4 0.06 0.08 lasso 3 0.08 7.5e-09 7.4 -7.5 9.4e-14 -0.88 0.04 0.96 FALSE
58 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MYBPC3 0.05 0.03 blup 43 0.04 6.0e-05 5.1 -5.6 2.2e-08 -0.71 0.01 0.98 FALSE
59 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma NUP160 0.08 0.03 blup 42 0.04 6.7e-05 7.3 5.8 8.2e-09 0.71 0.24 0.13 FALSE
60 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C1QTNF4 0.12 0.14 enet 4 0.16 6.5e-18 7.4 -8.3 7.0e-17 -0.95 0.03 0.97 FALSE
61 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MADD 0.20 0.07 enet 9 0.08 2.4e-09 -4.3 5.7 1.4e-08 0.32 0.92 0.01 FALSE
62 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PSMC3 0.05 0.04 lasso 3 0.05 3.8e-06 3.2 5.2 2.2e-07 0.73 0.03 0.97 FALSE
63 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C1QTNF4 0.13 0.16 lasso 1 0.16 3.1e-09 7.5 -7.5 5.4e-14 -0.88 0.15 0.85 FALSE
64 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PSMC3 0.07 0.07 enet 7 0.06 1.4e-04 7.1 7.1 1.1e-12 0.82 0.02 0.96 FALSE
65 The Cancer Genome Atlas Brain Lower Grade Glioma MADD 0.08 0.01 lasso 5 0.05 3.1e-06 7.0 7.5 7.7e-14 0.62 0.00 0.95 FALSE
66 The Cancer Genome Atlas Brain Lower Grade Glioma MTCH2 0.11 0.11 lasso 2 0.10 6.4e-12 7.4 7.4 1.2e-13 0.87 0.09 0.91 FALSE
67 The Cancer Genome Atlas Brain Lower Grade Glioma PSMC3 0.10 0.05 blup 39 0.08 3.7e-09 7.1 6.7 2.0e-11 0.79 0.03 0.97 FALSE
68 The Cancer Genome Atlas Liver Hepatocellular Carcinoma C1QTNF4 0.19 0.19 lasso 3 0.19 3.2e-09 7.4 -7.4 1.2e-13 -0.87 0.09 0.91 FALSE
69 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PSMC3 0.09 0.07 blup 39 0.06 8.7e-04 7.1 7.4 1.6e-13 0.85 0.02 0.97 FALSE
70 The Cancer Genome Atlas Lung Adenocarcinoma C1QTNF4 0.03 0.02 blup 15 0.02 1.3e-03 9.2 -9.3 1.1e-20 -0.97 0.00 0.97 TRUE
71 The Cancer Genome Atlas Lung Adenocarcinoma MYBPC3 0.04 0.02 enet 10 0.04 2.9e-05 7.0 -5.3 9.6e-08 -0.68 0.01 0.98 FALSE
72 The Cancer Genome Atlas Prostate Adenocarcinoma AGBL2 0.04 0.03 blup 49 0.03 7.8e-04 -6.9 5.3 1.1e-07 0.41 0.18 0.07 FALSE
73 The Cancer Genome Atlas Prostate Adenocarcinoma MADD 0.15 0.04 enet 10 0.06 4.5e-07 -4.3 5.6 2.0e-08 0.30 0.20 0.03 FALSE
74 The Cancer Genome Atlas Prostate Adenocarcinoma NUP160 0.03 0.02 enet 7 0.02 6.3e-03 6.8 7.7 1.1e-14 0.83 0.06 0.38 FALSE
75 The Cancer Genome Atlas Prostate Adenocarcinoma PSMC3 0.02 0.02 blup 39 0.02 5.7e-03 7.1 5.8 6.6e-09 0.78 0.01 0.58 FALSE
76 The Cancer Genome Atlas Stomach Adenocarcinoma C1QTNF4 0.06 0.04 lasso 4 0.03 4.3e-03 7.4 -8.0 1.1e-15 -0.92 0.00 0.92 FALSE
77 The Cancer Genome Atlas Thyroid Carcinoma C1QTNF4 0.04 0.01 blup 15 0.03 7.9e-04 9.2 -8.6 7.0e-18 -0.89 0.00 0.95 FALSE
78 The Cancer Genome Atlas Thyroid Carcinoma MADD 0.07 0.00 enet 11 0.03 6.7e-04 -3.0 5.5 3.9e-08 0.36 0.05 0.13 FALSE