TWAS hub - AGBL2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0340	0.0160	0.00076	0.023	0.026	0.032	0.026	0.029	0.00074	0.00037	7.9e-05	0.00037	0.00015
2	TCGA	Prostate Adenocarcinoma	0.0403	0.0267	0.00120	0.032	0.027	0.012	NA	0.023	0.00027	0.00078	1.9e-02	NA	0.00150

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Systolic Blood Pressure	27.0	135.2	153.8	-10.8	-12.4
High blood pressure	17.7	49.4	74.6	-8.6	-4.9
HDL Cholesterol	17.6	29.4	52.3	7.2	2.6
Hypertension (Self-reported)	16.9	46.9	71.7	-8.5	-4.7
Vascular/heart problems diagnosed by doctor	15.3	41.6	64.3	8.0	4.4
Medication: Blood pressure	14.6	25.7	35.9	-6.0	-3.9
Systolic blood pressure, automated reading	14.2	41.2	41.6	-6.4	-6.5
Eye problems/disorders: Glaucoma	11.4	13.5	17.5	4.2	3.1
Fasting Glucose	10.1	12.0	13.4	3.7	3.3
Medication: Bendroflumethiazide	9.7	14.8	20.1	-4.5	-3.1
Cardiovascular Disease	9.4	31.2	53.1	-7.3	-3.0
High blood pressure (siblings)	9.4	13.6	21.1	-4.6	-2.5
Diastolic blood pressure, automated reading	8.8	27.1	30.6	-5.5	-4.9
Trunk fat percentage	8.2	32.7	63.4	-1.4	8.0
Arm fat percentage (left)	7.9	31.5	55.7	-2.7	7.5
Guilty feelings	7.8	11.7	19.9	-1.9	-4.5
Body fat percentage	7.7	30.3	56.1	-2.1	7.5
Arm fat percentage (right)	7.6	30.1	54.5	-2.4	7.4
Body Mass Index (BMI) (2010)	7.4	10.2	20.0	-0.6	4.5
Medication: Amlodipine	7.3	10.2	14.1	-3.8	-2.5
Medication: Lisinopril	7.3	9.4	15.9	-4.0	-1.7
Illnesses of father: High blood pressure	7.3	9.0	12.2	-3.5	-2.4
Medication: Blood pressure	7.0	13.4	23.0	-4.8	-1.9
Medication: Metformin	6.5	9.2	17.2	1.0	4.2
Leg fat percentage (left)	6.1	22.1	38.2	-2.4	6.2
Trunk fat mass	6.0	25.6	50.6	-0.8	7.1
Waist circumference	5.7	20.8	41.6	0.2	6.5
Leg fat percentage (right)	5.5	20.0	34.9	-2.3	5.9
Alcohol intake frequency.	5.4	12.6	25.3	-0.1	5.0
Whole body fat mass	5.3	22.2	42.5	-1.3	6.5
Arm fat mass (left)	5.3	21.9	41.7	-1.5	6.5
Glaucoma (self-reported)	5.2	6.2	8.4	2.9	2.0
Hearing difficulty/problems with background noise	5.1	8.2	11.2	-2.3	-3.4
Arm fat mass (right)	5.1	20.8	38.8	-1.7	6.2
Hand grip strength (left)	4.9	13.0	25.9	0.5	-5.1
Ever had bowel cancer screening	4.8	5.6	7.2	2.0	2.7
Miserableness	4.8	8.4	13.5	-1.8	-3.7
High blood pressure (mother)	4.7	6.6	8.8	-3.0	-2.1
Type 2 Diabetes (T2D) (2018)	4.6	8.7	16.2	1.1	4.0
BMI	4.5	26.3	45.8	-2.6	6.8
Fed-up feelings	4.5	8.2	8.4	-2.9	-2.8
Medication for cholesterol, blood pressure or diabetes	4.5	7.4	11.9	3.4	1.7
Neuroticism (2016)	4.4	6.3	12.0	-0.8	-3.5
Body mass index (BMI)	4.3	18.4	31.1	-2.4	5.6
Medication: Allopurinol	4.2	5.5	7.1	-2.0	-2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.2	4.9	9.3	3.1	0.7
Basal cell carcinoma (self-reported)	4.2	5.0	7.3	-2.7	-1.7
Leg fat mass (left)	4.2	16.3	29.8	-1.7	5.5
Leg fat mass (right)	4.0	15.6	28.2	-1.7	5.3
Myopia	3.9	5.6	11.1	3.3	0.3
Blood Platelet Count	3.8	43.8	87.6	0.2	-9.4
Medication for cholesterol	3.8	5.8	9.9	3.1	1.3
Waist Hip Ratio (WHR)	3.6	16.1	18.7	4.3	3.7
Diverticular disease/diverticulitis (self-reported)	3.5	4.1	6.5	1.3	2.5
Depressed Affect (Nagel 2018)	3.4	7.1	10.6	-1.9	-3.3
Mean time to correctly identify matches	3.4	6.4	7.8	2.8	2.3
Qualifications: NVQ or HND or HNC or equivalent	3.4	4.1	4.3	2.1	2.0
Heel bone mineral density (BMD) T-score, automated (right)	3.3	7.6	9.5	3.1	2.4
Falls in the last year	3.3	4.5	4.7	-2.1	-2.2
Illnesses of siblings	3.2	4.5	8.6	2.9	0.6
Diabetes diagnosed by doctor	3.2	5.2	9.4	1.0	3.1
Comparative body size at age 10	3.1	8.7	14.8	-3.9	1.6
Leg pain on walking	3.1	3.9	3.9	-1.9	-2.0
Number of self-reported non-cancer illnesses	3.1	5.4	7.6	-2.8	-1.8
Hand grip strength (right)	3.0	8.2	16.4	-0.0	-4.1
Pulse rate, automated reading	3.0	9.8	12.2	2.7	3.5
Knee pain experienced in last month	2.9	4.5	6.1	2.5	1.7
Alcohol drinker status: Never	2.9	3.4	6.7	0.4	2.6
Blood White Count	2.8	20.7	41.3	-6.4	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	2.8	6.5	8.2	2.9	2.2
Prospective memory result	2.8	3.5	5.4	-2.3	-1.2
Reaction Time	2.7	5.2	5.3	2.3	2.3
Medication: Ramipril	2.7	3.4	5.0	-2.2	-1.4
Commuting to job workplace: Car/motor vehicle	2.6	3.0	4.1	1.4	2.0
Neuroticism (Nagel 2018)	2.5	5.8	9.7	-1.3	-3.1
Fluid intelligence score	2.5	5.2	10.3	3.2	0.3
Neuroticism score	2.5	5.2	9.9	-0.7	-3.1
Alcohol intake versus 10 years previously	2.5	3.8	6.8	0.9	2.6
Verbal and Numeric Reasoning (VNR)	2.4	5.8	11.5	3.4	-0.4
Chronotype (morning person)	2.4	5.4	10.6	-3.2	0.6
Hip circumference	2.4	10.4	17.4	-1.9	4.2
Illnesses of father: None of the above (group 1)	2.4	3.0	5.2	2.3	0.9
Commuting to job workplace: Public transport	2.4	2.9	4.7	-1.0	-2.2
Fractured/broken bones in last 5 years	2.4	3.1	5.8	-0.6	-2.4
Neuroticism	2.3	5.6	10.7	-0.8	-3.3
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	2.9	-1.4	-1.7
Forced vital capacity (FVC), Best measure	2.3	8.4	9.8	3.1	-2.6
Angina (self-reported)	2.3	3.0	4.9	-2.2	1.1
Suffer from ‘nerves’	2.3	3.6	4.1	1.8	-2.0
Mood swings	2.3	4.2	4.9	-1.9	-2.2
Heel T-Score	2.2	17.6	24.6	5.0	3.3
Angina	2.2	2.9	4.6	-2.1	1.1
Financial difficulties in last 2 years	2.2	3.0	5.4	-0.8	-2.3
Weight	2.2	11.0	21.8	0.5	4.7
Lung cancer (father)	2.2	2.5	5.0	2.2	0.3
Number of full sisters	2.2	2.7	2.8	-1.7	-1.6
Hearing aid user	2.2	2.5	2.8	-1.4	1.7
HbA1C	2.1	2.4	4.5	-0.5	-2.1
Age when periods started (menarche)	2.1	5.1	10.0	3.2	-0.5
Diabetes (self-reported)	2.1	3.3	6.3	0.5	2.5
Loud music exposure frequency	2.1	2.3	3.8	-1.9	0.9
Shortness of breath walking on level ground	2.1	2.4	4.9	-2.2	-0.0
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	3.7	-0.9	1.9
Number of live births	2.0	2.9	3.0	-1.7	-1.7
Mouth/teeth dental problems: Dentures	2.0	3.4	4.9	2.2	1.3
Illnesses of mother	2.0	2.4	3.2	1.8	1.3
Back pain experienced in last month	2.0	2.8	3.8	-1.4	-1.9
Had other major operations	1.9	2.3	2.7	1.4	1.6
Noisy workplace	1.9	2.3	3.9	-2.0	-0.9
Medication: Gliclazide	1.9	2.1	3.7	0.7	1.9
Number of treatments/medications taken	1.8	3.3	6.2	-2.5	0.6
Number of incorrect matches in round	1.8	2.9	3.0	1.7	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.8	7.2	2.7	-2.1
Standing height	1.8	18.1	34.3	5.9	-1.3
Birth weight of first child	1.8	3.3	5.0	2.2	1.2
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	3.6	-1.9	1.0
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	3.1	-1.6	-1.8
Intelligence (Savage-Jansen 2018)	1.7	5.2	10.4	3.2	-0.2
Crohns Disease (2017)	1.7	3.8	6.3	-2.5	-1.1
Height	1.7	32.5	64.0	8.0	-1.0
Diabetes (mother)	1.7	2.2	2.6	1.4	1.6
Forced vital capacity (FVC)	1.7	6.7	9.2	3.0	-2.1
Asthma	1.7	3.4	5.4	-2.3	-1.2
Number of full brothers	1.7	2.1	3.3	-1.0	-1.8
Worry too long after embarrassment	1.7	2.8	5.5	-0.1	-2.4
Loneliness, isolation	1.7	2.4	4.5	0.4	-2.1
Smoking Status	1.6	3.8	7.1	2.7	0.6
Taking other prescription medications	1.6	2.5	3.3	-1.3	1.8
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	4.3	-0.8	-2.1
Birth weight	1.6	3.4	4.5	2.1	-1.5
Overall health rating	1.6	3.4	5.3	-2.3	-1.2
Medication: Aspirin	1.6	2.1	3.9	-2.0	-0.5
Illnesses of siblings: Diabetes	1.6	2.0	3.9	-0.3	2.0
Asthma (self-reported)	1.6	3.1	4.9	-2.2	-1.1
Alcohol drinker status: Previous	1.6	1.8	3.4	0.5	1.9
Irritable Bowel Disease (IBD)	1.5	3.5	6.1	-2.5	-0.9
Severe depression (siblings)	1.5	1.6	3.3	1.8	-0.1
Medication: Levothyroxine sodium	1.5	2.5	4.9	-2.2	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.4	-1.8	-0.4
Number of operations (self-reported)	1.5	2.2	4.3	0.4	2.1
Bipolar Disorder (2011)	1.4	1.4	1.7	1.3	1.0
Mean Putamen Volume	1.4	1.6	2.1	-1.0	1.4
Supplements: Zinc	1.4	1.5	2.4	0.8	-1.5
Sitting height	1.4	10.0	19.2	0.9	-4.4
Number of children fathered	1.4	1.6	3.1	0.2	1.8
Heart disease (mother)	1.4	1.7	2.8	-1.7	-0.8
Maternal smoking around birth	1.3	1.9	3.8	-1.9	-0.2
Forced expiratory volume in 1-second (FEV1)	1.3	4.2	5.3	2.3	-1.8
Comparative height size at age 10	1.3	7.0	13.9	3.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	5.2	2.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.1	0.2	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	2.9	-0.5	-1.7
Tense / ‘highly strung’	1.2	2.0	2.2	-1.5	-1.3
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	2.3	1.2	1.5
Headache pain in last month	1.2	2.1	2.7	1.2	1.6
Eye problems/disorders: None of the above	1.2	1.4	2.8	0.2	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.8	0.2	1.7
Ever taken oral contraceptive pill	1.2	1.4	2.0	1.4	-0.8
Medication: Atorvastatin	1.2	1.5	3.0	-0.1	1.7
Heart disease (siblings)	1.2	1.5	1.9	1.0	1.4
Blood Eosinophil Count	1.1	8.2	16.2	-4.0	-0.4
Diabetes (father)	1.1	1.3	1.8	-1.0	1.3
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.0	-1.4	-0.7
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.2	-0.5	-1.8
Hair/balding pattern: Pattern 3	1.1	1.6	3.0	-1.7	0.5
Medication: Lansoprazole	1.1	1.3	2.5	-0.3	1.6
Peak expiratory flow (PEF)	1.1	2.5	3.4	1.8	-1.2
Supplements: Vitamin C	1.1	1.2	1.7	0.9	1.3
Ever depressed for a whole week	1.1	1.3	2.4	1.6	0.5
Cholesterol lowering medication	1.1	1.7	2.6	-0.9	1.6
Respiratory disease	1.0	2.2	3.1	-1.8	-1.2
Average weekly spirits intake	1.0	1.2	1.4	-1.2	-1.0
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.8	-0.2	-1.7
Time employed in main current job	1.0	1.1	1.8	0.7	1.3
Breastfed as a baby	1.0	1.3	1.9	1.4	-0.8
Wheeze or whistling in the chest in last year	1.0	1.8	3.5	-1.9	-0.3
Migraine (self-reported)	1.0	1.2	1.3	1.2	-1.1
Medication: Omeprazole	1.0	1.2	2.1	0.5	1.5
Commuting to job workplace: Cycle	1.0	1.2	1.2	-1.1	-1.1
Medication: Co-codamol	0.9	1.1	2.0	0.4	1.4
Serious illness, injury or assault to yourself	0.9	1.1	1.9	-1.4	0.5
Mouth/teeth dental problems	0.9	1.4	2.7	0.2	-1.6
Father’s age at death	0.9	1.2	1.8	1.3	0.7
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	3.4	-1.8	0.1
Medication: Ibuprofen	0.9	1.1	1.4	1.2	0.8
Average weekly red wine intake	0.9	1.3	2.7	0.1	-1.6
Ever smoked	0.9	1.6	2.2	1.0	-1.5
Alzheimer’s Disease (in father)	0.8	0.8	1.7	1.3	0.1
Multivitamins +/- minerals	0.8	1.0	1.9	-0.2	-1.4
Medication: Atenolol	0.8	1.0	1.3	-1.1	-0.9
Hair/balding pattern: Pattern 2	0.8	1.0	1.1	1.1	-0.9
Trunk fat-free mass	0.8	4.9	9.5	3.1	-0.4
Trunk predicted mass	0.8	4.5	8.9	3.0	-0.4
Length of working week for main job	0.8	0.9	1.5	-0.5	-1.2
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.8	-1.4	-0.2
Medication for pain relief, constipation, heartburn	0.8	1.4	2.2	0.8	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.3	1.1	0.6
Medication: Aspirin	0.8	1.1	2.2	-1.5	0.0
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.1	-1.1	-1.0
Average weekly beer plus cider intake	0.8	1.2	2.2	0.4	-1.5
Worry (Nagel 2018)	0.7	1.5	2.9	0.4	-1.7
Primary Biliary Cirrhosis	0.7	1.0	1.9	-0.2	-1.4
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.5	-0.4	1.2
Relative age of first facial hair	0.7	1.4	2.0	1.4	0.9
Average weekly fortified wine intake	0.7	0.8	1.0	1.0	-0.7
Exposure to tobacco smoke outside home	0.7	0.9	1.5	-1.2	0.5
Health satisfaction	0.7	1.0	1.6	-1.3	-0.6
Age at last live birth	0.7	1.1	1.4	1.2	-0.9
Osteoporosis (self-reported)	0.7	0.9	1.6	-0.5	-1.3
Average weekly champagne plus white wine intake	0.7	1.0	1.3	1.1	0.9
Pain experienced in last month	0.7	1.1	1.5	-0.8	-1.2
Bipolar Disorder (2018)	0.6	1.0	1.5	1.2	0.6
Ulcerative Colitis (UC)	0.6	1.2	2.3	-1.5	-0.4
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.4	-1.2	0.4
Ever had hysterectomy (womb removed)	0.6	0.7	0.9	-0.7	1.0
Medication for hormone replacement therapy	0.6	0.7	1.3	-0.1	-1.2
Leg fat-free mass (left)	0.6	3.2	5.3	1.1	2.3
Leg predicted mass (left)	0.6	3.3	5.4	1.1	2.3
Exposure to tobacco smoke at home	0.6	0.7	1.3	-1.2	-0.1
Pulse wave reflection index	0.6	0.8	0.8	-0.9	-0.8
Gout (self-reported)	0.6	0.8	0.9	-0.8	-1.0
Pulse wave peak to peak time	0.6	0.7	1.3	1.2	0.2
Smoking status: Previous	0.6	0.9	1.6	1.3	0.4
Eye problems/disorders: Cataract	0.6	0.7	1.1	-0.5	1.1
High cholesterol (Self-reported)	0.6	1.0	2.1	-1.4	0.1
Basal metabolic rate	0.6	3.2	3.2	1.8	1.8
Age started oral contraceptive pill	0.6	0.8	0.9	0.9	0.8
Supplements: Calcium	0.6	0.6	1.2	0.3	-1.1
Alzheimer’s Disease (including proxy)	0.5	0.8	1.2	1.1	-0.6
Coronary Artery Disease (CAD)	0.5	0.6	0.7	-0.9	0.7
Triglycerides	0.5	0.8	1.0	-1.0	0.8
Hypothyroidism (self reported)	0.5	1.1	2.0	-1.4	0.4
Current tobacco smoking	0.5	0.9	1.2	0.7	-1.1
Past tobacco smoking	0.5	1.0	1.5	-1.2	0.7
Worrier / anxious feelings	0.5	1.0	2.0	1.4	-0.0
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.2	1.5	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.3	-1.1	-0.1
Hair/balding pattern: Pattern 4	0.5	1.2	2.3	-1.5	0.3
Emphysema/chronic bronchitis	0.5	0.6	1.0	0.5	1.0
Neck or shoulder pain in last month	0.5	0.8	1.2	-0.6	-1.1
Arm predicted mass (right)	0.5	2.4	4.4	2.1	0.6
Illnesses of father: Heart disease	0.5	0.6	1.2	-1.1	0.2
Whole body fat-free mass	0.5	2.8	5.1	2.2	0.7
Leg fat-free mass (right)	0.5	2.7	4.2	1.1	2.0
Whole body water mass	0.5	2.9	5.3	2.3	0.7
Leg predicted mass (right)	0.5	2.8	4.5	1.1	2.1
Arm predicted mass (left)	0.5	2.7	4.1	2.0	1.1
Depression (Nagel 2018)	0.4	0.6	0.7	0.8	-0.7
Prostate Cancer	0.4	0.5	0.6	0.8	-0.7
Crohns Disease (2012)	0.4	0.7	1.3	-1.2	-0.2
Lung FVC	0.4	2.1	3.9	0.6	-2.0
Hair Pigment	0.4	10.9	18.1	4.3	1.9
Sensitivity / hurt feelings	0.4	0.8	0.8	-0.9	-0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.5	-0.7	-0.7
Qualifications: None of the above	0.4	0.9	1.1	-1.0	-0.8
Impedance of arm (right)	0.4	1.9	3.5	0.6	1.9
Pulse rate	0.4	0.7	1.4	0.2	1.2
Medication: Cholesterol lowering	0.4	0.7	0.8	-0.7	0.9
Impedance of arm (left)	0.4	1.9	3.6	0.5	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	0.6	-1.0
Arm fat-free mass (right)	0.4	1.9	3.6	1.9	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	1.0	0.2
Qualifications: College or University degree	0.4	1.3	1.3	-1.1	-1.2
Friendships satisfaction	0.4	0.5	0.7	0.5	-0.8
Mineral and other dietary supplements	0.4	0.5	0.9	1.0	0.2
Smoking status: Current	0.4	0.7	0.9	1.0	-0.7
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	0.9	0.3
Arm fat-free mass (left)	0.4	1.8	3.1	1.8	0.7
Schizophrenia (2018)	0.3	0.5	0.6	-0.7	0.8
Alzheimer’s Disease (in mother)	0.3	0.4	0.6	0.3	0.8
Major Depression (MDD)	0.3	0.4	0.7	0.2	-0.8
Breast Cancer	0.3	0.8	1.6	-1.3	-0.1
Age at First Birth	0.3	0.4	0.8	-0.9	-0.2
Rheumatoid Arthritis	0.3	0.4	0.6	0.5	0.7
Tanning	0.3	3.4	6.5	-0.7	-2.5
Impedance of leg (right)	0.3	1.5	2.2	0.9	-1.5
Had menopause	0.3	0.3	0.6	0.8	0.1
Heart attack	0.3	0.3	0.5	-0.4	0.7
Pain all over the body in last month	0.3	0.3	0.6	-0.7	0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	-0.9	0.1
Medication: Simvastatin	0.3	0.4	0.9	-0.9	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.5	0.7	0.5
Pulse wave Arterial Stiffness index	0.3	0.4	0.7	-0.8	-0.3
Medication: Paracetamol	0.3	0.6	0.7	-0.6	0.8
Chest pain or discomfort	0.3	0.4	0.6	-0.4	-0.8
Had major operations	0.3	0.4	0.6	-0.8	-0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.7	0.3	0.8
Long-standing illness, disability or infirmity	0.3	0.4	0.8	-0.9	0.3
Commuting to job workplace: Walk	0.3	0.3	0.6	-0.2	-0.8
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.4	0.6	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.6	1.1	0.2	1.1
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	-0.3	-0.7
Ovarian Cancer	0.2	0.3	0.5	0.7	0.2
Lupus	0.2	0.3	0.4	0.6	-0.4
Ulcerative Colitis	0.2	0.3	0.5	-0.4	0.7
Blood Red Count	0.2	1.9	2.3	1.5	1.2
Hearing difficulty/problems: Yes	0.2	0.4	0.6	-0.4	-0.7
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.8	-0.2
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	0.2	0.7
Impedance of leg (left)	0.2	1.0	1.6	0.7	-1.3
Nervous feelings	0.2	0.4	0.6	-0.3	-0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.3	0.6	-0.2
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	0.6	0.4
Qualifications: nursing, teaching	0.2	0.4	0.5	-0.7	-0.4
Osteoarthritis (self-reported)	0.2	0.3	0.3	0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.8	0.4	-0.9
Mother’s age at death	0.2	0.3	0.4	0.7	-0.3
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	-0.3	0.7
Medication: Paracetamol	0.2	0.2	0.5	-0.0	0.7
Irritability	0.2	0.4	0.4	0.6	0.6
Risk taking	0.2	0.4	0.6	0.8	-0.4
Unable to work because of sickness or disability	0.2	0.2	0.4	-0.2	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.3	-0.3	0.6
Pack years of smoking	0.2	0.3	0.5	0.7	0.1
LDL Cholesterol	0.1	0.1	0.1	0.4	0.3
Schizophrenia (2014)	0.1	0.2	0.4	-0.1	0.6
Lung FEV1/FVC ratio	0.1	0.3	0.4	0.4	0.6
Vitamin and mineral supplements	0.1	0.1	0.1	-0.2	-0.3
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.5	-0.2
Supplements: Glucosamine	0.1	0.2	0.2	0.4	-0.4
Alcohol usually taken with meals	0.1	0.2	0.3	0.1	0.6
Allergy	0.1	0.3	0.6	0.8	0.0
Happiness	0.1	0.1	0.1	0.1	-0.3
Depression (self-reported)	0.1	0.1	0.2	0.2	-0.4
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.2	0.4	-0.4
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.4	-0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.5	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	-0.3	-0.2
Age at first live birth	0.1	0.2	0.3	0.5	-0.2
Medication: Seretide 50 evohaler	0.1	0.2	0.2	-0.4	0.4
Family relationship satisfaction	0.1	0.1	0.1	0.3	-0.3
Wears glasses or contact lenses	0.1	0.1	0.2	0.5	0.1
Financial situation satisfaction	0.1	0.1	0.2	0.5	0.1
Impedance of whole body	0.1	0.4	0.4	0.6	0.6
Allergy or Eczema	0.0	0.1	0.1	-0.3	0.1
Pack years adult smoking proportion	0.0	0.1	0.1	0.3	-0.2
Relative age voice broke	0.0	0.0	0.0	0.2	0.1
Qualifications: CSEs or equivalent	0.0	0.0	0.1	0.0	0.3
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	-0.3	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.1	0.1	0.2	0.2
Breast cancer (self-reported)	0.0	0.0	0.0	0.0	0.2
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.1	-0.1	-0.3

Hub : Genes

AGBL2

Models

Trait associations