Best TWAS P=1.52e-10 · Best GWAS P=5.45e-11 conditioned to 0.000482
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PPP2R3C | 0.21 | 0.12 | lasso | 10 | 0.14 | 2.6e-11 | -6.2 | 5.9 | 4.3e-09 | 0.15 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | PPP2R3C | 0.31 | 0.10 | lasso | 10 | 0.18 | 4.0e-13 | -6.2 | 6.2 | 6.7e-10 | 0.26 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | CFL2 | 0.14 | 0.08 | enet | 39 | 0.11 | 9.9e-09 | -2.5 | -6.3 | 2.3e-10 | -0.06 | 0.59 | 0.04 | TRUE |
| 4 | GTEx | Thyroid | FAM177A1 | 0.13 | 0.04 | enet | 18 | 0.07 | 5.5e-06 | -4.8 | 5.3 | 1.4e-07 | 0.19 | 0.50 | 0.49 | FALSE |
| 5 | NTR | Blood | KIAA0391 | 0.05 | 0.05 | lasso | 10 | 0.05 | 2.4e-15 | -6.2 | -5.3 | 1.5e-07 | -0.14 | 0.02 | 0.98 | FALSE |
| 6 | NTR | Blood | NFKBIA | 0.26 | 0.09 | lasso | 10 | 0.12 | 3.4e-36 | -4.1 | -6.1 | 1.3e-09 | -0.50 | 1.00 | 0.00 | TRUE |
| 7 | YFS | Blood | KIAA0391 | 0.29 | 0.36 | lasso | 7 | 0.38 | 5.8e-132 | -6.2 | -6.1 | 8.2e-10 | -0.18 | 0.02 | 0.98 | FALSE |
| 8 | YFS | Blood | NFKBIA | 0.24 | 0.11 | enet | 33 | 0.17 | 3.5e-53 | -4.0 | -6.3 | 3.5e-10 | -0.43 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PPP2R3C | 0.08 | 0.04 | blup | 51 | 0.07 | 7.8e-09 | -5.0 | 6.4 | 1.5e-10 | 0.27 | 0.01 | 0.99 | TRUE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA0391 | 0.12 | 0.11 | enet | 14 | 0.14 | 2.0e-13 | -4.1 | 5.1 | 2.8e-07 | -0.03 | 0.75 | 0.25 | FALSE |