TWAS hub - CFL2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0600	0.0250	4.9e-03	0.012	0.011	-0.001	0.012	0.015	1.1e-02	1.4e-02	4.8e-01	1.0e-02	4.7e-03
2	GTEx	Cells Transformed fibroblasts	0.1440	0.0510	4.6e-04	0.081	NA	0.112	NA	0.085	1.2e-06	NA	9.8e-09	NA	6.0e-07
3	GTEx	Esophagus Mucosa	0.1300	0.0460	1.8e-03	0.065	NA	0.076	NA	0.073	4.0e-05	NA	8.2e-06	NA	1.4e-05
4	NTR	Blood	0.0523	0.0165	1.3e-05	0.042	0.020	0.041	0.042	0.042	1.5e-13	4.4e-07	3.9e-13	1.8e-13	1.3e-13
5	TCGA	Bladder Urothelial Carcinoma	0.0350	0.0180	4.7e-03	0.032	0.028	0.014	NA	0.017	9.2e-04	1.9e-03	2.0e-02	NA	1.3e-02
6	TCGA	Breast Invasive Carcinoma	0.0797	0.0267	3.8e-12	0.058	0.073	0.062	NA	0.056	5.0e-12	1.2e-14	1.2e-12	NA	1.3e-11
7	TCGA	Colon Adenocarcinoma	0.0780	0.0390	1.3e-03	0.067	0.032	0.015	NA	0.061	9.6e-05	5.7e-03	4.5e-02	NA	1.9e-04
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0645	0.0262	1.9e-07	0.074	0.061	0.066	NA	0.071	1.2e-08	2.0e-07	6.5e-08	NA	1.9e-08
9	TCGA	Lung Adenocarcinoma	0.0526	0.0241	8.1e-05	0.046	0.048	0.041	NA	0.041	4.4e-06	2.5e-06	1.3e-05	NA	1.4e-05
10	TCGA	Lung Squamous Cell Carcinoma	0.0354	0.0191	4.3e-03	0.017	0.022	0.023	NA	0.027	4.4e-03	1.4e-03	1.1e-03	NA	3.8e-04
11	TCGA	Ovarian Serous Cystadenocarcinoma	0.0650	0.0330	2.7e-03	0.029	0.046	0.039	NA	0.031	4.5e-03	4.7e-04	1.2e-03	NA	3.5e-03
12	TCGA	Testicular Germ Cell Tumors	0.1720	0.0660	3.5e-05	0.167	0.158	0.150	NA	0.155	1.7e-06	3.3e-06	5.7e-06	NA	3.9e-06
13	TCGA	Thyroid Carcinoma	0.0810	0.0350	8.2e-06	0.027	0.059	0.051	NA	0.050	1.1e-03	2.0e-06	9.8e-06	NA	1.2e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	9.5	11.2	17.7	0.7	3.4	3.6	3.5	3.7	2.9	3.4	3.5	3.9	4.2	2.6	3.0	3.7
Medication: Omeprazole (e.g. Zanprol)	6.4	7.8	12.8	0.0	1.9	3.2	3.6	2.8	3.2	3.3	3.1	2.9	3.4	1.6	2.2	3.0
Ever used hormone-replacement therapy (HRT)	5.9	7.5	12.5	2.0	2.6	2.9	2.7	3.5	2.3	2.6	2.7	3.0	3.5	2.1	2.5	2.7
Commuting to job workplace: Cycle	5.3	6.4	13.7	0.9	-2.2	-2.9	-3.7	-1.0	-2.6	-3.6	-3.4	-1.3	-3.1	-0.8	-2.4	-2.3
Medication: Cholesterol lowering	5.1	7.9	17.4	-1.1	-3.5	-2.7	-2.4	-2.8	-1.7	-2.4	-1.9	-3.0	-3.1	-4.2	-3.3	-3.1
Hearing difficulty/problems: Yes	5.0	7.7	14.5	0.2	2.7	2.8	3.6	1.8	3.1	3.6	3.8	2.3	3.2	2.0	2.9	2.1
Heel T-Score	4.9	39.3	66.3	-1.6	-8.1	-6.7	-5.8	-7.5	-4.5	-5.8	-5.3	-7.1	-7.7	-5.2	-5.2	-7.8
Supplements: Calcium	4.7	5.2	13.4	1.1	3.7	2.2	1.4	2.8	1.8	1.4	1.1	2.7	2.1	3.4	2.2	2.0
Age started oral contraceptive pill	4.4	5.5	8.4	-0.4	2.3	2.0	2.5	2.3	2.6	2.5	2.6	2.2	2.9	2.4	2.6	2.3
Average weekly fortified wine intake	3.8	4.4	6.6	0.0	-2.5	-2.5	-2.0	-2.3	-2.1	-2.1	-1.9	-2.2	-1.8	-2.2	-2.1	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	3.8	8.7	17.6	0.0	-3.7	-2.9	-2.2	-3.9	-1.8	-2.1	-1.8	-3.9	-3.8	-2.6	-2.3	-4.2
Gout (self-reported)	3.7	5.0	8.0	-0.7	-2.5	-2.4	-2.7	-1.7	-2.7	-2.4	-2.8	-1.9	-2.8	-0.8	-1.8	-2.5
Medication: Omeprazole	3.4	4.1	8.6	0.6	1.7	2.6	2.9	1.4	2.6	2.5	2.5	1.6	2.2	0.6	1.2	2.0
Ever had prostate specific antigen (PSA) test	2.9	3.4	7.7	1.3	1.9	2.8	2.2	1.0	2.0	2.2	2.2	1.4	1.3	1.7	2.0	0.8
Heel bone mineral density (BMD) T-score, automated (left)	2.8	6.4	12.9	0.2	-3.3	-2.1	-2.0	-3.2	-1.6	-2.0	-1.7	-3.4	-3.2	-2.1	-2.1	-3.6
Number of incorrect matches in round	2.8	4.6	7.6	1.8	2.7	2.8	2.0	1.7	1.9	2.0	2.1	2.6	2.3	2.4	1.8	1.4
Tinnitus: Yes, now most or all of the time	2.8	3.3	6.1	0.8	2.5	1.4	2.1	1.5	2.1	1.9	2.2	2.1	2.1	1.4	1.5	1.5
Medication for hormone replacement therapy	2.6	3.0	6.8	2.6	2.5	1.5	1.4	1.6	0.7	1.3	1.3	1.8	1.7	2.0	1.5	1.4
Trunk fat-free mass	2.6	14.8	51.1	-1.0	-7.2	-4.1	-3.3	-3.4	-2.4	-3.1	-2.9	-4.4	-3.9	-4.4	-3.2	-3.6
Trunk predicted mass	2.6	14.9	51.6	-1.0	-7.2	-4.1	-3.3	-3.4	-2.4	-3.2	-2.9	-4.4	-4.0	-4.4	-3.2	-3.6
Primary Biliary Cirrhosis	2.5	3.6	9.4	-3.1	1.1	1.2	1.8	1.9	2.2	1.5	1.7	1.8	1.8	1.2	1.7	2.7
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	4.8	-0.9	1.4	2.2	2.2	1.5	2.0	2.0	1.9	1.4	1.6	0.9	1.8	2.2
Osteoporosis (self-reported)	2.5	3.1	5.1	1.7	2.2	1.5	1.7	2.2	1.1	1.7	2.0	2.0	2.3	1.3	1.5	1.2
Illnesses of father: High blood pressure	2.5	3.1	5.0	-1.8	-2.0	-1.4	-1.4	-1.8	-0.9	-1.6	-1.6	-2.2	-2.2	-2.2	-2.0	-1.3
Hearing difficulty/problems with background noise	2.4	3.8	7.6	0.1	1.8	2.2	2.5	1.4	1.8	2.6	2.8	1.6	2.1	1.5	2.2	1.1
Impedance of arm (right)	2.4	11.4	24.8	1.4	5.0	3.1	2.7	2.7	3.2	2.6	2.4	3.2	3.3	4.8	3.9	3.8
Medication for cholesterol, blood pressure or diabetes	2.4	4.0	9.6	1.9	2.7	1.3	1.6	1.8	1.1	1.6	1.3	2.2	2.0	3.1	2.3	2.1
Medication: Allopurinol	2.4	3.1	5.1	-0.1	-1.7	-1.9	-2.0	-1.8	-1.8	-1.9	-2.1	-1.8	-2.2	-0.6	-1.6	-2.2
Sensitivity / hurt feelings	2.3	3.9	10.2	-0.1	1.6	3.2	1.7	2.4	1.4	1.8	1.4	1.8	1.8	1.9	2.4	2.4
Arm predicted mass (right)	2.3	11.6	48.1	-2.1	-6.9	-3.5	-2.8	-2.6	-2.5	-2.5	-2.4	-3.7	-3.2	-3.9	-2.5	-2.8
Overall health rating	2.3	4.9	10.0	-0.3	1.6	2.7	3.1	1.3	1.8	3.2	3.1	1.6	2.6	0.8	2.2	2.2
Number of self-reported non-cancer illnesses	2.3	4.0	7.8	-0.3	1.7	2.1	2.5	1.6	1.7	2.5	2.8	2.3	2.5	0.9	2.0	1.8
Age at last live birth	2.2	3.2	5.3	-0.4	-2.3	-2.1	-2.0	-1.5	-1.2	-2.2	-2.1	-1.8	-2.1	-1.2	-1.9	-1.3
Loneliness, isolation	2.2	3.0	5.4	-0.7	0.6	1.7	1.9	1.9	1.2	1.9	1.7	2.1	2.3	1.6	1.6	2.1
Impedance of arm (left)	2.1	9.9	25.6	1.5	5.1	2.9	2.2	2.7	2.5	2.2	2.0	3.2	3.1	4.6	3.4	3.4
Birth weight	2.1	4.5	10.1	-0.7	-1.4	-1.3	-3.2	-1.2	-2.2	-3.1	-3.2	-1.9	-2.5	-1.4	-2.0	-1.7
Arm fat-free mass (right)	2.1	10.5	45.9	-1.9	-6.8	-3.3	-2.7	-2.4	-2.3	-2.4	-2.2	-3.4	-3.0	-3.7	-2.4	-2.7
Whole body fat-free mass	2.1	11.9	50.4	-1.6	-7.1	-3.7	-3.0	-2.6	-2.1	-2.7	-2.5	-3.7	-3.2	-3.9	-2.7	-2.8
Stomach or abdominal pain in last month	2.0	2.5	5.2	0.6	0.5	1.8	1.9	1.3	2.0	2.3	2.1	1.2	1.5	0.5	1.8	1.4
Whole body water mass	2.0	11.2	48.7	-1.5	-7.0	-3.6	-2.8	-2.6	-2.0	-2.6	-2.3	-3.6	-3.1	-3.8	-2.6	-2.7
Ovarian Cancer	1.9	2.5	3.8	-0.5	1.5	1.7	1.8	1.3	2.0	1.7	1.6	1.7	1.7	1.5	1.8	1.5
Age at first live birth	1.9	3.4	6.7	-0.7	-1.4	-2.6	-2.4	-1.0	-1.5	-2.5	-2.4	-1.5	-2.1	-1.2	-2.0	-1.2
Leg pain on walking	1.9	2.4	4.9	-0.4	0.9	2.2	1.6	1.7	1.2	1.6	1.5	2.1	1.5	1.4	1.4	1.7
Impedance of whole body	1.9	9.6	22.5	0.8	4.7	3.2	2.6	2.4	2.4	2.7	2.4	2.9	3.1	4.2	3.8	3.1
Age at First Birth	1.8	2.6	4.7	-1.1	1.6	0.8	2.1	1.0	2.0	2.2	2.1	1.3	1.4	1.5	2.0	1.2
Illnesses of siblings	1.8	2.6	6.7	1.4	1.1	1.2	1.0	1.9	1.2	1.1	0.9	1.6	1.5	2.6	2.2	2.0
Alcohol drinker status: Never	1.8	2.2	4.7	1.0	1.4	1.6	0.9	2.1	0.3	1.6	0.8	1.7	1.4	1.9	2.2	0.9
Arm fat-free mass (left)	1.8	9.0	48.4	-2.3	-7.0	-3.1	-2.0	-2.3	-1.6	-1.7	-1.6	-3.2	-2.5	-3.5	-1.8	-2.3
Heart attack/myocardial infarction (self-reported)	1.8	2.3	7.6	-0.9	-2.8	-1.3	-0.8	-1.9	-0.7	-1.0	-0.6	-2.0	-1.6	-1.7	-1.3	-1.5
Multivitamins +/- minerals	1.7	2.1	4.8	1.4	2.2	1.9	1.3	1.0	1.9	1.1	1.0	1.2	1.5	1.2	1.1	1.6
Heart attack	1.7	2.2	7.5	-0.8	-2.7	-1.1	-0.6	-2.0	-0.5	-0.8	-0.4	-2.2	-1.6	-1.8	-1.2	-1.5
Arm predicted mass (left)	1.7	8.8	45.7	-2.1	-6.8	-2.9	-2.1	-2.3	-1.6	-1.8	-1.7	-3.2	-2.6	-3.4	-1.9	-2.3
HbA1C	1.6	1.8	4.1	-0.4	-1.4	-1.2	-1.5	-1.3	-2.0	-1.3	-1.0	-1.5	-1.6	-0.8	-0.9	-1.9
Neuroticism	1.6	3.9	9.5	-0.7	2.1	3.1	2.2	1.7	1.7	2.2	2.2	1.9	2.2	1.3	1.5	1.9
Vitamin and mineral supplements	1.6	2.2	4.8	-0.6	-2.0	-2.2	-1.3	-1.0	-1.7	-1.3	-1.0	-1.2	-1.4	-1.7	-1.5	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	3.9	-1.3	-2.0	-1.3	-1.5	-1.4	-1.4	-1.7	-1.5	-1.5	-1.3	-1.4	-1.9	-0.0
Fluid intelligence score	1.6	3.3	9.7	-1.0	-2.0	-2.2	-0.3	-2.6	0.3	-0.9	-0.6	-2.5	-1.9	-3.1	-1.8	-1.3
Leg fat percentage (right)	1.6	5.7	11.1	-3.3	-0.7	1.9	2.9	1.7	2.4	3.0	3.0	1.7	2.6	1.0	2.4	2.9
Had major operations	1.6	1.9	4.9	1.7	0.6	-1.1	-1.0	-1.5	-0.6	-1.6	-1.2	-1.0	-1.6	-1.4	-2.2	-1.3
Mood swings	1.6	2.8	7.2	-2.3	1.5	2.1	1.2	1.9	0.8	0.8	1.1	1.8	2.0	1.2	1.1	2.7
Basal metabolic rate	1.6	8.8	44.4	-1.8	-6.7	-3.1	-2.3	-2.1	-1.5	-2.1	-1.9	-3.1	-2.6	-3.4	-2.2	-2.0
Fractured/broken bones in last 5 years	1.6	2.1	4.8	2.2	1.1	1.1	1.7	1.1	1.8	1.4	1.4	1.3	1.8	1.0	1.2	1.2
Chronotype (morning person)	1.5	3.4	14.7	-0.6	-2.4	-0.8	0.5	-2.3	0.1	0.3	0.4	-2.5	-1.6	-3.8	-1.8	-2.1
Worrier / anxious feelings	1.5	2.9	11.8	1.1	3.4	2.4	1.4	1.5	1.1	1.5	1.5	1.7	1.5	1.1	0.8	1.1
Medication: Lansoprazole	1.5	1.7	3.4	0.4	1.0	1.4	1.0	1.7	0.7	1.3	1.2	1.8	1.7	1.2	1.4	1.4
Medication: Gliclazide	1.5	1.7	4.8	-2.2	-1.5	-1.7	-1.5	-0.5	-1.7	-0.9	-1.3	-0.5	-1.2	-0.1	-0.8	-1.1
Leg predicted mass (right)	1.5	7.8	40.3	-1.6	-6.3	-3.0	-2.6	-1.5	-1.8	-2.3	-2.1	-2.6	-2.2	-3.0	-2.1	-1.6
Alzheimer’s Disease (in mother)	1.4	1.7	4.9	-0.3	-0.1	1.4	2.2	0.3	2.2	1.9	1.8	0.1	0.6	-0.1	1.4	1.0
Lupus	1.4	2.1	8.0	-2.8	-1.8	-1.0	-1.7	-0.3	-1.1	-1.8	-1.9	-0.7	-1.3	-0.1	-1.0	-0.1
Allergy or Eczema	1.4	3.7	18.5	4.3	3.5	0.9	0.6	1.4	0.2	0.8	0.6	1.8	0.8	2.7	1.4	-0.1
Impedance of leg (right)	1.4	6.8	16.2	0.3	4.0	2.5	3.0	1.5	2.4	3.0	2.7	2.0	2.3	3.0	3.2	2.1
Trunk fat percentage	1.4	5.7	10.9	-2.9	-0.8	2.2	2.2	2.2	2.3	2.4	2.5	1.9	2.7	1.9	2.9	3.3
Medication: Ramipril	1.4	1.8	8.1	0.2	-2.8	-1.3	-0.5	-1.4	-1.1	-0.4	0.0	-1.5	-1.0	-2.0	-1.0	-1.3
Neuroticism score	1.4	3.0	8.8	-0.3	1.8	3.0	1.8	1.5	0.9	1.8	1.7	1.5	1.9	1.4	1.7	1.9
Leg fat-free mass (right)	1.4	7.7	40.2	-1.7	-6.3	-3.0	-2.6	-1.5	-1.8	-2.3	-2.0	-2.6	-2.1	-3.0	-2.1	-1.6
Hearing aid user	1.4	1.6	4.4	0.5	-0.4	1.4	1.8	0.8	0.8	2.1	1.5	0.7	1.5	0.1	1.9	0.8
Alzheimer’s Disease (in father)	1.3	1.4	7.1	-2.7	-0.4	0.9	0.8	0.9	0.2	0.9	0.7	1.0	1.3	0.4	0.8	1.8
Smoking Status	1.3	3.2	8.1	-1.6	0.3	2.8	1.6	1.8	2.1	1.7	1.4	0.9	1.8	0.9	1.8	2.7
Arm fat percentage (right)	1.3	5.1	9.9	-2.9	-0.8	2.1	2.1	2.2	2.5	2.3	2.2	2.0	2.4	1.6	2.3	3.1
Qualifications: A levels/AS levels or equivalent	1.3	2.9	5.5	-0.1	-0.9	-2.1	-1.1	-2.3	-0.8	-1.5	-1.2	-2.3	-2.1	-2.0	-1.9	-1.7
Leg fat percentage (left)	1.3	4.8	12.8	-3.6	-1.4	1.8	2.4	1.6	1.7	2.6	2.4	1.4	2.3	0.8	2.2	2.7
Relative age of first facial hair	1.2	2.5	5.6	1.0	1.7	2.4	2.0	0.4	1.6	2.1	2.0	0.6	1.4	1.4	1.7	0.8
Leg fat-free mass (left)	1.2	6.4	36.5	-1.7	-6.0	-2.8	-2.1	-1.4	-1.2	-1.9	-1.6	-2.4	-1.9	-2.7	-1.8	-1.3
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.3	0.8	0.9	0.9	1.8	0.5	0.6	1.8	1.8	1.0	1.5	0.4	1.3	1.0
Leg predicted mass (left)	1.2	6.2	36.1	-1.8	-6.0	-2.7	-2.0	-1.3	-1.2	-1.8	-1.6	-2.3	-1.9	-2.7	-1.7	-1.2
Allergy	1.2	2.7	8.4	-2.9	-2.8	-0.2	-1.1	-1.3	-0.3	-1.0	-1.2	-2.2	-1.5	-2.2	-1.4	-0.6
Time employed in main current job	1.2	1.3	6.0	-1.5	0.2	-2.4	-1.3	0.6	-1.7	-1.0	-0.8	0.6	-0.5	-0.6	-1.1	-0.8
Exposure to tobacco smoke at home	1.2	1.4	2.8	0.8	0.8	0.9	1.4	1.6	1.0	1.4	1.5	1.7	1.1	0.7	0.9	0.8
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	5.6	-1.7	1.5	2.1	2.4	0.4	0.6	2.4	1.9	0.9	1.5	0.3	1.3	0.8
Body fat percentage	1.2	4.7	10.3	-3.2	-1.2	1.8	2.1	1.8	2.1	2.3	2.3	1.5	2.3	1.2	2.4	3.0
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.5	-0.8	1.3	1.5	1.4	0.8	1.9	1.1	1.4	0.9	1.3	0.5	0.6	1.4
Friendships satisfaction	1.2	1.5	3.5	-1.9	0.5	0.7	1.4	1.2	0.9	1.4	1.3	1.2	1.4	0.4	1.2	1.6
Intelligence (Savage-Jansen 2018)	1.1	3.3	5.1	-1.2	-2.0	-2.0	-1.7	-2.0	-1.2	-2.1	-2.0	-2.1	-2.3	-1.6	-1.7	-1.2
LDL Cholesterol	1.1	1.8	2.9	-1.4	-1.6	-1.4	-1.6	-0.8	-1.5	-1.5	-1.7	-1.0	-1.5	-0.2	-1.3	-1.0
Lung FVC	1.1	5.8	12.8	-1.5	2.3	2.2	2.0	3.6	1.9	2.0	2.3	3.3	3.5	1.3	1.7	2.4
Hayfever, allergic rhinitis or eczema	1.1	2.4	13.8	3.7	2.8	0.3	0.3	1.0	0.1	0.4	0.3	1.6	0.4	2.0	1.0	-0.3
Alcohol intake versus 10 years previously	1.1	1.6	3.5	-0.9	1.6	1.0	0.8	1.6	0.5	1.0	0.7	1.9	1.3	1.5	1.1	1.7
Medication: Amlodipine	1.1	1.5	3.3	-0.7	-0.1	1.4	1.8	0.7	1.7	1.6	1.8	0.5	1.2	-1.2	0.6	0.7
Commuting to job workplace: Walk	1.1	1.2	2.1	1.1	-1.1	0.0	-0.9	-1.3	-0.8	-0.9	-0.8	-1.3	-1.3	-1.2	-1.1	-1.4
Ever depressed for a whole week	1.1	1.4	3.5	-1.7	0.8	0.9	0.2	1.7	1.1	0.3	-0.1	1.4	1.1	1.4	0.8	1.9
Alcohol drinker status: Previous	1.1	1.2	2.7	-0.6	-1.4	-1.1	-1.0	-1.5	-1.5	-0.7	-0.7	-1.6	-1.0	-0.1	-0.1	-1.5
Depressed Affect (Nagel 2018)	1.0	2.2	3.9	-0.9	1.6	1.4	1.4	1.7	0.7	1.3	1.5	2.0	2.0	1.2	1.0	1.8
Crohns Disease (2012)	1.0	1.6	5.5	-2.3	0.1	0.5	1.1	0.9	1.5	1.2	1.0	0.8	1.8	0.1	1.0	1.9
Current tobacco smoking	1.0	1.7	8.6	-0.6	0.1	2.9	1.2	1.1	1.9	1.2	1.0	0.3	0.8	0.2	0.8	1.5
Fed-up feelings	1.0	1.9	3.3	0.2	0.6	1.3	1.8	1.5	1.2	1.8	1.4	1.3	1.6	1.1	1.5	1.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.0	1.9	2.0	0.6	1.0	0.4	1.2	0.8	1.1	0.8	0.9	0.8	0.4	0.2
Medication: Simvastatin	1.0	1.5	3.8	-0.8	-1.4	-1.3	-0.9	-1.4	-0.3	-1.1	-0.7	-1.6	-1.5	-1.9	-1.4	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	3.5	0.8	-1.9	-1.4	-1.4	-0.2	-1.6	-0.9	-1.1	-0.7	-0.7	-0.0	0.0	-0.9
Lung cancer (father)	1.0	1.1	3.4	0.4	1.3	1.6	0.8	1.6	0.3	0.6	0.4	1.8	1.3	0.5	0.6	1.0
Medication: Ventolin 100micrograms inhaler	1.0	1.2	3.7	1.1	-1.2	-0.5	-0.9	-1.9	-0.8	-0.9	-0.9	-1.3	-1.2	-0.3	-0.8	-1.5
Alcohol intake frequency.	1.0	2.3	5.7	-0.2	1.3	1.2	1.5	1.2	0.2	1.9	1.4	1.5	1.7	2.2	2.4	1.0
Arm fat percentage (left)	1.0	3.9	8.3	-2.7	-0.9	1.9	1.7	2.0	1.9	1.8	1.8	1.7	2.1	1.4	1.9	2.9
Illnesses of father: None of the above (group 1)	1.0	1.3	3.5	1.9	1.3	1.3	1.0	1.2	0.3	1.3	0.9	1.1	1.1	0.7	1.2	0.7
Unable to work because of sickness or disability	1.0	1.3	4.6	1.0	-0.5	-0.4	-0.5	-2.1	-1.0	-1.0	-0.4	-1.9	-1.1	-1.5	-1.3	-0.4
Pack years of smoking	1.0	1.4	3.3	0.7	0.6	1.8	1.4	1.1	1.0	1.3	1.1	1.7	1.5	0.8	0.4	1.2
Alzheimer’s Disease (including proxy)	0.9	1.3	3.9	-2.0	-1.0	1.0	1.5	0.7	1.3	1.3	1.2	0.5	0.7	0.3	1.2	1.1
Irritable Bowel Disease (IBD)	0.9	2.2	12.0	-3.5	0.1	0.6	1.6	0.7	0.9	1.7	1.5	0.9	1.7	-0.5	0.5	1.5
Hypothyroidism (self reported)	0.9	2.1	4.4	-2.1	1.8	1.9	2.1	0.2	0.5	2.0	1.8	0.7	1.1	0.4	1.1	0.8
Diabetes (mother)	0.9	1.1	5.6	-2.4	-0.6	0.1	1.1	-0.4	1.4	1.4	1.4	-0.2	0.4	0.3	1.0	-0.0
Hand grip strength (right)	0.9	2.4	7.2	-0.4	-2.7	-0.9	-0.1	-2.4	-0.0	-0.0	0.0	-2.1	-1.8	-2.4	-0.8	-1.6
Townsend deprivation index at recruitment	0.9	1.3	2.8	-0.7	-0.2	1.6	0.8	1.6	-0.2	1.5	0.7	1.2	1.2	1.1	1.7	1.0
Happiness	0.9	1.0	1.8	-0.4	0.5	0.5	1.0	1.3	1.2	1.0	0.9	1.4	1.3	0.9	0.9	1.3
Glaucoma (self-reported)	0.9	1.1	5.4	0.6	2.3	0.7	1.0	0.0	1.6	0.7	0.8	0.3	0.8	0.8	0.3	1.2
Exposure to tobacco smoke outside home	0.9	1.2	2.9	1.7	1.4	1.6	1.4	0.6	0.7	1.5	1.0	0.8	0.5	1.0	0.8	0.2
Shortness of breath walking on level ground	0.9	1.1	3.5	-1.9	-1.0	-0.9	-0.4	-1.0	-1.6	-0.1	-0.5	-1.0	-0.7	-1.3	-0.8	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.3	0.2	1.5	1.5	1.1	0.7	1.1	1.0	1.2	0.6	0.7	0.9	1.2	1.2
Diabetes diagnosed by doctor	0.9	1.4	3.3	-1.5	-1.6	-1.8	-1.0	-1.6	-0.8	-0.9	-0.8	-1.1	-1.2	-0.8	-1.0	-0.8
Risk taking	0.9	1.3	7.1	-2.7	-0.4	-0.2	-0.6	1.8	-0.5	-0.6	-1.1	1.2	0.0	0.1	-0.4	1.5
Pain experienced in last month	0.9	1.5	4.0	0.9	0.0	-0.9	-1.8	-0.5	-2.0	-1.7	-1.9	-0.9	-1.3	-0.2	-1.0	-1.0
Ulcerative Colitis (UC)	0.8	1.5	9.3	-3.1	0.8	0.5	1.3	0.8	0.7	1.3	1.3	0.9	1.0	-0.3	0.2	1.1
Number of treatments/medications taken	0.8	1.4	3.6	-0.5	0.9	1.1	1.7	0.1	1.4	1.4	1.9	0.8	1.3	0.1	1.1	1.2
Average weekly spirits intake	0.8	1.0	2.9	0.8	-0.1	-0.9	-1.4	0.6	-1.7	-1.4	-1.5	0.5	-0.2	0.3	-1.3	0.5
Frequency of depressed mood in last 2 weeks	0.8	1.1	4.6	-0.9	0.4	1.0	1.0	0.9	0.7	0.6	1.1	0.8	1.5	0.7	0.8	2.1
Supplements: Zinc	0.8	0.9	2.7	-1.1	0.3	0.5	-0.4	-1.5	0.1	-0.8	-0.6	-1.6	-1.0	-1.3	-1.2	-0.5
Relative age voice broke	0.8	1.2	3.9	0.9	0.5	-1.5	-0.1	-2.0	-0.1	-0.3	-0.3	-1.7	-1.3	-0.6	-0.7	-1.5
Taking other prescription medications	0.8	1.2	4.2	-0.7	2.0	0.8	1.4	0.5	0.5	1.3	1.4	1.0	1.2	0.7	0.7	1.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.8	1.7	0.6	0.7	0.9	0.4	0.7	0.9	0.9	1.0	1.2	0.9	0.7	0.7
High blood pressure (mother)	0.8	1.2	2.9	-0.5	0.7	1.1	1.7	0.2	1.2	1.7	1.7	0.7	0.8	0.6	1.2	0.2
Impedance of leg (left)	0.8	4.0	10.0	-0.1	3.2	2.2	2.1	1.1	1.2	2.3	1.8	1.4	1.9	2.4	2.8	1.6
Hair/balding pattern: Pattern 2	0.8	1.0	1.7	1.2	-1.3	-1.0	-1.2	-0.5	-0.8	-1.2	-1.1	-1.0	-0.9	-0.8	-0.7	-0.9
Had other major operations	0.8	1.0	2.6	0.5	0.5	0.5	1.2	0.9	0.8	1.4	1.3	0.6	1.6	0.2	1.0	1.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.3	-1.1	-0.4	-1.8	-1.4	-0.8	-1.3	-1.2	-1.1	-0.7	-1.3	-0.6	-1.1	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.9	-1.4	1.0	1.1	0.7	0.7	0.9	0.7	1.0	1.1	1.3	0.1	0.8	1.3
Medication: Aspirin	0.8	1.1	2.2	-1.0	-1.1	0.4	1.1	0.8	0.7	1.3	1.5	0.5	1.1	0.5	1.4	1.3
Long-standing illness, disability or infirmity	0.8	1.2	4.1	-0.1	1.0	1.1	1.8	-0.1	0.7	1.5	2.0	0.6	1.3	-0.0	0.5	1.0
Ever had bowel cancer screening	0.8	1.0	3.6	-1.7	1.9	0.7	0.4	1.1	-0.3	0.7	0.3	1.2	0.7	0.9	0.4	0.6
Medication for cholesterol	0.8	1.1	2.5	0.0	-1.6	-0.9	-1.4	-1.1	-0.9	-1.2	-1.2	-1.2	-1.2	0.0	-0.4	-1.3
Miserableness	0.8	1.4	2.9	-0.6	1.2	1.0	1.2	1.3	0.9	1.2	1.2	1.3	1.5	1.1	0.9	1.7
Medication: Atorvastatin	0.8	1.0	5.1	-0.8	-1.4	-0.8	0.1	-1.0	-0.3	-0.0	0.0	-1.1	-0.7	-2.3	-1.2	-0.5
Average weekly beer plus cider intake	0.8	1.2	2.2	-0.5	-0.1	-1.2	-1.3	-0.7	-1.4	-1.2	-1.5	-0.7	-0.9	-1.4	-1.5	-0.4
Heart disease (siblings)	0.8	1.0	2.3	0.1	-1.0	-0.9	-0.7	-1.4	-0.9	-0.7	-0.6	-1.2	-0.5	-1.5	-1.2	-1.1
Schizophrenia (2018)	0.7	1.5	4.1	-1.0	0.3	1.5	1.7	0.1	1.5	1.4	2.0	0.8	1.2	-0.2	0.7	1.7
Verbal and Numeric Reasoning (VNR)	0.7	1.6	3.4	-1.8	-1.8	-1.6	0.4	-1.9	0.7	-0.1	0.0	-1.7	-0.9	-1.7	-0.8	-0.5
Ulcerative Colitis	0.7	1.0	4.2	-2.1	0.6	-0.3	0.9	1.3	0.2	1.0	0.6	1.5	0.8	0.5	0.3	0.9
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.4	1.2	-0.1	-0.7	-1.2	0.4	-1.9	-0.7	-0.8	0.6	-0.2	1.6	0.5	-0.9
Hip circumference	0.7	2.9	6.0	-2.4	-2.4	1.0	1.1	1.9	2.4	1.1	1.3	1.1	1.5	1.1	1.6	2.2
Father’s age at death	0.7	0.9	4.5	0.8	2.1	0.3	0.7	0.0	1.7	0.2	0.6	0.4	0.1	1.0	0.3	1.2
Mouth/teeth dental problems: Dentures	0.7	1.2	7.5	-2.7	-1.1	-0.0	0.5	1.0	1.3	0.5	0.3	0.6	1.2	-0.1	0.6	1.3
Standing height	0.7	7.4	23.4	0.4	-4.8	-3.3	-2.7	-3.0	-1.6	-2.5	-2.4	-3.6	-2.9	-1.9	-1.3	-2.4
Comparative body size at age 10	0.7	1.9	7.5	-2.7	-1.7	1.0	1.3	1.2	1.1	1.3	1.3	0.4	1.4	-0.0	1.4	1.5
Chest pain or discomfort	0.7	1.1	2.3	-0.9	0.8	1.0	1.4	0.5	0.6	1.5	1.4	0.2	1.3	-0.6	0.7	1.4
Illnesses of siblings: Diabetes	0.7	0.9	2.5	-1.2	-0.7	-1.4	-0.3	-1.0	-0.0	-0.4	-0.4	-0.9	-0.7	-1.6	-0.9	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.7	-1.7	-0.9	-1.9	-0.8	-1.6	-0.1	-0.8	-0.6	-1.9	-1.7	-1.0	-0.5	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.9	1.7	1.6	1.0	-0.2	0.6	-0.3	-0.4	-0.2	0.8	0.5	1.4	0.3	0.4
Back pain experienced in last month	0.7	1.0	2.2	0.6	0.0	1.5	1.1	1.0	0.5	1.3	1.4	1.2	1.3	0.8	1.1	0.3
Smoking status: Current	0.7	1.2	6.1	-0.5	-0.3	2.5	0.8	1.2	1.6	0.9	0.7	0.4	0.7	-0.1	0.6	1.4
Guilty feelings	0.7	1.1	2.6	0.3	1.2	1.5	1.4	0.5	1.2	1.1	1.6	0.4	1.0	-0.5	0.4	1.2
Wears glasses or contact lenses	0.7	0.8	3.0	1.1	1.7	1.0	-0.2	0.9	0.3	-0.4	-0.6	0.9	0.6	1.4	0.1	0.4
Commuting to job workplace: Public transport	0.7	0.8	2.2	-0.0	-0.5	-0.7	-0.7	-1.5	-1.3	-0.6	-0.6	-1.2	-0.8	-1.0	-0.7	-1.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.1	-0.8	0.6	1.1	1.3	-0.4	1.4	1.4	1.1	0.2	0.3	0.8	1.1	0.3
High cholesterol (Self-reported)	0.7	1.3	5.5	-1.9	-1.2	-1.1	-0.1	-0.8	-0.0	0.2	0.1	-0.9	-1.0	-2.3	-0.9	-1.2
Bipolar Disorder or Schizophrenia	0.6	1.5	4.2	0.3	0.8	1.3	1.5	0.5	1.8	1.1	2.0	0.9	1.2	0.5	0.7	1.9
Crohns Disease (2017)	0.6	1.3	7.2	-2.7	-0.7	0.0	1.1	0.0	0.6	1.0	1.1	0.1	1.6	-0.9	0.2	1.2
Fasting Glucose	0.6	0.7	1.8	-0.1	1.0	1.3	1.3	-1.0	-0.0	0.8	-1.2	-0.3	-1.1	-0.0	0.0	-0.4
Neuroticism (2016)	0.6	0.8	4.2	-2.0	-2.0	-0.3	-0.2	-0.0	-0.4	0.1	-0.5	-0.8	-0.1	-0.9	-0.0	0.3
Schizophrenia (2014)	0.6	1.4	3.5	-0.7	0.8	1.9	1.4	0.3	1.4	1.0	1.6	1.0	1.1	-0.0	0.4	1.8
Blood Eosinophil Count	0.6	4.6	15.3	-0.2	-2.3	-1.1	-1.7	-1.9	-1.5	-1.3	-1.1	-1.8	-3.2	-2.7	-2.1	-3.9
Blood White Count	0.6	4.7	8.1	-1.8	1.5	2.8	2.8	1.8	2.5	2.7	2.2	1.7	1.6	1.0	2.5	2.1
BMI	0.6	3.4	23.8	-3.6	-4.9	-0.9	-0.7	-0.0	-0.7	-0.4	-0.4	-1.2	-0.4	-1.8	-0.5	0.4
Respiratory disease	0.6	1.3	2.3	1.1	1.1	0.7	1.0	0.9	-0.1	1.1	1.1	1.2	1.4	1.5	1.5	1.1
Pack years adult smoking proportion	0.6	0.9	2.3	0.4	0.0	1.5	1.2	0.9	0.8	1.1	0.9	1.3	1.1	0.5	0.3	1.1
Maternal smoking around birth	0.6	0.8	2.4	-1.0	1.0	1.6	0.5	0.8	0.5	0.5	0.4	1.0	0.5	1.2	1.0	1.0
Trunk fat mass	0.6	2.5	8.4	-2.9	-2.6	0.8	1.1	1.1	1.4	1.3	1.4	0.6	1.3	0.6	1.7	2.0
Diabetes (self-reported)	0.6	1.0	4.4	-2.1	-1.3	-1.3	-0.3	-1.3	-0.1	-0.3	-0.4	-1.0	-0.8	-0.8	-0.6	-0.2
Loud music exposure frequency	0.6	0.6	2.5	-0.8	-1.6	0.8	0.2	1.4	0.4	0.4	0.0	1.1	0.5	0.3	0.5	0.5
Medication for pain relief, constipation, heartburn	0.6	1.1	5.1	2.2	0.4	0.1	-1.1	-0.5	-0.5	-1.1	-1.2	-0.9	-1.3	-0.7	-1.0	-0.9
Heart disease (mother)	0.6	0.7	4.9	-2.2	0.1	-0.8	0.3	-0.6	0.4	0.2	0.5	-0.5	-0.1	-1.4	-0.5	-0.7
Leg fat mass (right)	0.6	2.2	11.1	-3.3	-3.3	0.1	0.8	0.5	0.8	1.1	1.1	-0.0	0.8	-0.5	0.7	1.3
Suffer from ‘nerves’	0.6	0.9	2.8	-1.7	1.3	1.4	0.6	1.1	0.3	0.9	0.8	0.9	0.9	0.3	0.5	0.7
Supplements: Vitamin C	0.6	0.7	2.3	0.3	0.9	1.2	0.7	0.2	1.2	0.6	0.1	0.1	0.3	1.5	1.0	0.7
Cholesterol lowering medication	0.6	0.9	2.2	-1.3	0.3	0.2	1.5	-0.5	1.1	1.3	1.3	-0.4	0.4	-0.5	0.1	1.3
Leg fat mass (left)	0.6	2.4	12.9	-3.5	-3.6	0.1	0.7	0.4	0.5	1.0	0.9	-0.2	0.7	-0.6	0.7	1.3
Neuroticism (Nagel 2018)	0.5	1.3	3.5	-0.2	1.9	1.9	1.1	0.9	0.4	0.9	1.3	1.0	1.3	0.5	0.6	1.1
Reaction Time	0.5	0.9	4.0	0.2	-0.9	-1.1	-0.7	-0.5	-0.1	-1.0	-0.8	-0.6	-0.6	-2.0	-1.6	-0.7
Prostate Cancer	0.5	0.7	4.7	0.5	2.2	-0.4	0.7	-0.6	0.9	0.7	0.7	0.4	0.4	0.1	-0.4	-0.6
HDL Cholesterol	0.5	0.8	2.9	-0.7	0.2	-0.2	-0.9	1.7	-0.4	-0.7	-0.7	1.4	0.9	1.0	0.3	1.0
Nervous feelings	0.5	0.9	2.5	0.7	1.6	1.6	0.4	1.4	0.2	0.5	0.4	1.1	1.1	0.2	0.4	0.5
Mouth/teeth dental problems	0.5	0.7	3.0	1.7	-0.2	-0.1	-0.7	-0.8	-1.0	-0.7	-0.9	-0.7	-1.2	0.0	-0.5	-0.7
Weight	0.5	2.6	22.8	-2.3	-4.8	-1.1	-0.4	-0.6	0.1	-0.2	-0.1	-1.3	-0.5	-1.6	-0.3	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.2	-0.5	1.1	0.9	0.9	1.1	-0.2	1.0	0.3	1.3	1.2	0.3	0.5	1.5
Number of live births	0.5	0.7	1.7	-0.3	-0.3	1.0	1.3	0.3	1.2	1.2	1.1	0.5	1.2	0.0	0.6	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	6.0	-2.5	-0.1	-0.4	0.5	-0.3	0.4	0.3	0.2	-0.1	-0.0	-0.8	-0.3	-0.3
Arm fat mass (right)	0.5	2.1	9.7	-3.0	-3.1	0.5	0.7	0.8	1.1	1.0	1.0	0.3	0.8	0.0	1.0	1.5
Blood clot in the leg (DVT)	0.5	0.7	2.0	-0.6	0.1	0.1	1.3	0.2	0.9	0.9	1.4	0.1	1.1	-0.3	0.4	1.4
Headache pain in last month	0.5	0.8	1.7	-1.0	0.5	-0.0	1.2	0.2	1.1	1.1	1.3	0.2	1.0	-0.6	0.6	1.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	3.8	-1.3	-1.9	0.1	-0.5	0.5	-0.8	0.2	-0.5	-0.2	0.4	-0.5	0.5	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.0	-0.9	1.4	-0.0	0.3	1.2	0.2	0.3	0.5	1.2	1.0	0.1	-0.1	1.4
Emphysema/chronic bronchitis	0.5	0.6	2.4	-1.6	-1.4	-0.8	-0.1	0.4	-0.6	-0.1	-0.8	0.5	0.4	0.7	-0.1	0.4
Whole body fat mass	0.5	2.1	11.4	-3.2	-3.4	0.0	0.6	0.5	0.8	0.8	0.8	-0.1	0.7	-0.2	0.9	1.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.3	-0.5	0.3	-0.3	1.1	-0.3	1.5	0.8	0.9	-0.2	0.7	-0.5	0.4	1.2
Smoking status: Previous	0.5	0.8	1.8	-0.6	0.4	0.6	1.1	1.0	0.8	1.0	0.8	0.4	0.9	0.4	1.2	1.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	0.8	0.3	-0.4	-0.2	-1.2	0.0	-0.9	-0.1	-1.1	-0.9	-1.1	-1.3	-0.5
Qualifications: nursing, teaching	0.5	0.7	2.0	0.1	-1.1	0.1	1.3	-0.3	1.4	1.0	1.3	-0.5	0.0	-0.8	0.5	0.5
Medication: Aspirin	0.5	0.7	1.5	-0.8	-1.2	0.2	0.8	0.6	0.3	1.0	1.2	0.4	0.9	0.4	1.0	1.0
Arm fat mass (left)	0.5	1.9	11.4	-3.0	-3.4	0.3	0.4	0.6	0.8	0.7	0.7	0.1	0.5	-0.2	0.7	1.2
Mother’s age at death	0.5	0.6	2.5	1.6	0.7	0.4	0.6	-0.7	1.3	0.2	0.7	-0.2	0.0	1.1	0.6	-0.2
Eye problems/disorders: Glaucoma	0.5	0.6	2.3	0.0	1.5	0.3	0.7	-0.2	1.5	0.1	0.3	-0.0	0.6	0.5	-0.1	1.4
Medication: Blood pressure	0.5	1.0	2.2	-1.4	0.2	0.8	1.5	0.0	1.2	1.2	1.4	0.6	0.8	-1.2	0.0	0.5
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.2	-0.3	0.2	1.5	1.2	-0.7	0.9	0.9	1.3	-0.1	0.2	-0.7	-0.1	-0.3
Medication: Lisinopril	0.5	0.6	1.4	-0.3	0.9	0.6	0.7	1.2	0.7	0.9	0.6	1.1	0.8	0.5	0.8	0.4
Bipolar Disorder (2018)	0.4	0.6	2.6	1.6	1.0	0.2	0.3	0.7	0.9	-0.1	0.7	0.5	0.5	1.0	0.4	0.9
Breast Cancer	0.4	1.0	2.6	1.2	0.4	1.4	0.7	0.6	1.2	0.8	0.7	0.2	0.4	1.6	1.6	1.2
Body Mass Index (BMI) (2010)	0.4	0.5	1.4	1.1	-1.1	0.9	-0.3	0.1	0.3	-0.3	-0.2	0.1	0.2	1.2	0.9	0.9
Triglycerides	0.4	0.6	2.5	-0.2	-0.1	1.6	0.8	-0.2	0.9	1.1	0.9	-0.5	0.5	-0.4	0.9	0.1
Blood Platelet Count	0.4	5.2	8.5	1.0	0.9	2.8	2.4	2.5	0.7	2.7	2.0	2.6	2.9	2.2	2.9	2.3
Hand grip strength (left)	0.4	1.0	4.3	-1.0	-2.1	-0.2	0.7	-1.1	0.8	0.8	0.9	-1.0	-0.7	-1.2	0.1	-0.6
Systolic blood pressure, automated reading	0.4	1.2	3.3	-1.6	0.6	0.8	1.8	-0.4	1.0	1.7	1.8	0.5	0.3	-0.7	0.1	-0.7
Medication: Levothyroxine sodium	0.4	0.7	3.0	-1.7	0.0	1.0	1.0	-0.6	-0.7	1.0	0.8	-0.4	0.2	-1.3	-0.2	-0.6
Sitting height	0.4	2.8	17.9	-1.4	-4.2	-2.1	-1.1	-1.4	0.3	-1.0	-0.9	-2.0	-1.1	-0.9	0.1	-0.8
Body mass index (BMI)	0.4	1.8	8.7	-2.8	-2.9	0.4	0.8	0.7	0.8	0.9	1.0	0.3	0.8	-0.8	0.3	1.3
Waist circumference	0.4	1.4	5.1	-1.1	-2.3	0.8	1.3	0.7	1.4	1.3	1.5	0.4	0.9	-0.1	0.7	1.3
Had menopause	0.4	0.5	2.0	-0.1	0.3	0.2	0.5	0.8	0.0	0.3	0.4	0.8	1.4	0.7	0.6	1.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.6	0.2	0.2	0.3	-0.2	1.2	0.2	0.0	-0.4	0.9	0.3	1.2	0.7	1.3
Qualifications: None of the above	0.4	0.8	2.1	1.1	-0.4	-0.1	-0.8	-1.3	-1.5	-0.7	-1.0	-0.7	-0.8	-0.2	-0.6	-1.3
Falls in the last year	0.4	0.6	2.3	1.1	0.3	-0.4	-0.6	-0.6	-0.2	-1.0	-0.5	-0.6	-0.5	-1.0	-1.5	-0.5
Noisy workplace	0.4	0.5	3.5	-1.9	-0.7	0.6	-0.4	1.1	-0.3	0.3	-0.2	0.6	0.5	0.1	0.3	0.3
Illnesses of mother	0.4	0.4	2.5	1.6	0.3	-0.1	-0.7	-0.0	-0.9	-0.7	-0.8	-0.0	-0.1	0.4	-0.2	0.6
Pulse wave Arterial Stiffness index	0.4	0.4	1.7	-0.7	-1.2	-0.1	-0.0	-0.7	0.5	0.0	-0.3	-1.3	-0.5	-0.8	-0.3	-0.3
Tense / ‘highly strung’	0.4	0.7	6.0	-2.5	0.1	1.2	0.3	-0.1	-0.1	0.3	0.1	-0.6	0.2	0.4	0.3	0.8
Hair/balding pattern: Pattern 4	0.4	1.0	3.2	-1.8	-1.4	-1.7	-0.9	-0.8	-0.4	-1.0	-0.8	-0.4	-0.5	-0.6	-1.2	-0.0
Medication: Paracetamol	0.4	0.7	4.0	-2.0	-1.1	-1.6	-0.4	-0.6	-0.6	-0.2	-0.2	-0.3	-0.2	-0.3	-0.3	-0.7
Worry too long after embarrassment	0.4	0.7	3.9	1.2	2.0	0.7	-0.0	0.8	-0.5	-0.2	-0.1	0.9	0.5	0.8	0.2	0.7
Wheeze or whistling in the chest in last year	0.4	0.7	1.7	1.1	1.0	1.1	1.1	-0.1	0.3	1.1	1.3	0.3	1.1	0.4	0.7	0.4
Neck or shoulder pain in last month	0.4	0.5	3.2	-1.8	-0.2	-0.4	0.5	0.9	1.1	0.2	0.1	0.6	0.4	-0.3	-0.4	0.8
Angina (self-reported)	0.4	0.5	1.4	1.2	-1.1	0.9	0.8	-0.2	0.5	1.0	0.7	-0.4	-0.1	-0.7	0.6	-0.1
Migraine (self-reported)	0.4	0.5	1.4	-0.7	0.8	0.3	0.8	-0.2	1.2	0.8	1.1	-0.1	-0.2	-0.9	-0.2	-0.1
Number of full sisters	0.4	0.5	0.9	-0.9	-0.0	0.4	0.1	0.8	-0.8	0.5	-0.1	0.7	0.9	0.8	0.8	0.9
Knee pain experienced in last month	0.4	0.7	1.2	-1.0	0.5	0.7	0.9	0.5	0.7	0.9	1.0	0.9	1.1	0.5	0.7	1.0
Mineral and other dietary supplements	0.4	0.5	1.7	0.5	-1.2	-1.3	-0.2	-0.5	-0.7	-0.3	0.0	-0.5	-0.3	-1.0	-0.5	-0.6
Breast cancer (self-reported)	0.4	0.5	1.6	-0.6	0.9	-0.5	-0.7	0.2	-0.9	-0.8	-0.7	0.2	-0.7	-0.3	-1.3	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.9	-0.5	-0.1	-0.0	1.0	0.3	0.9	0.6	1.1	0.2	1.0	-0.3	0.1	1.4
Worry (Nagel 2018)	0.3	0.7	3.3	-0.3	1.8	1.8	0.9	0.2	0.3	0.9	0.8	0.3	0.5	-0.1	0.1	0.1
Major Depression (MDD)	0.3	0.4	1.3	-0.3	-0.2	-0.7	-0.6	-0.3	-0.5	-0.7	-0.3	-0.5	-0.8	-0.9	-1.2	-0.4
Coronary Artery Disease (CAD)	0.3	0.3	1.1	0.1	0.8	1.0	0.6	0.5	0.7	0.7	0.7	0.5	0.0	-0.1	0.0	-0.4
Mean Putamen Volume	0.3	0.3	0.9	-0.3	-0.3	0.6	-0.0	-0.9	0.9	-0.5	0.3	-0.7	0.2	-0.6	-0.7	0.2
Rheumatoid Arthritis	0.3	0.5	2.1	0.9	-1.4	-0.5	-0.6	0.2	-0.3	-0.4	-0.2	0.2	-0.6	-0.8	-0.9	-0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.4	-0.1	-0.5	-0.2	-1.0	-0.0	-0.6	-0.9	-0.8	-0.1	-0.1	1.2	0.1	-0.2
Cardiovascular Disease	0.3	1.0	5.3	-2.3	-0.2	0.0	0.5	-0.3	0.4	0.2	0.9	-0.3	0.0	-2.3	-0.9	-0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.1	-1.4	-1.4	-1.1	0.4	-0.9	-0.1	0.5	0.5	-0.4	0.2	-0.0	0.5	0.1
Lung FEV1/FVC ratio	0.3	1.5	4.7	2.0	0.1	1.0	1.3	0.9	2.2	1.4	1.1	0.6	0.9	-0.1	1.4	0.9
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.4	-0.6	1.5	0.2	0.8	-0.5	-0.2	0.4	0.5	-0.1	0.3	-0.9	-0.2	0.6
Ever had hysterectomy (womb removed)	0.3	0.4	1.3	0.6	0.5	1.1	0.6	0.5	0.1	0.8	0.8	0.5	0.4	0.3	0.7	-0.1
Angina	0.3	0.4	1.6	1.2	-1.2	0.6	0.5	-0.4	0.1	0.7	0.4	-0.5	-0.3	-0.7	0.4	-0.4
Medication: Co-codamol	0.3	0.3	1.2	0.3	0.9	0.4	0.4	0.5	0.2	0.3	0.5	0.8	0.4	-1.1	-0.5	0.6
Diabetes (father)	0.3	0.4	1.0	-0.8	0.1	-1.0	-0.6	0.1	-0.8	-0.6	-0.5	-0.1	-0.4	-0.8	-0.7	-0.1
High blood pressure	0.3	0.9	4.1	-1.2	-0.3	1.0	1.2	-0.2	1.3	0.7	1.1	-0.4	0.3	-2.0	-0.3	0.1
Alcohol usually taken with meals	0.3	0.6	5.3	2.3	-0.2	-0.4	0.1	-0.7	0.3	-0.2	0.0	-0.9	-0.3	0.2	0.3	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.2	-0.9	-0.2	-0.1	-0.2	0.6	-0.3	-0.6	-0.2	0.4	0.9	-0.7	-0.8	1.5
Financial difficulties in last 2 years	0.3	0.4	1.4	-1.2	-0.3	-0.0	0.3	-1.0	-0.3	0.1	-0.1	-0.6	-0.6	-1.1	-0.8	0.0
Pain all over the body in last month	0.3	0.4	2.6	-0.4	1.6	0.2	0.4	0.1	-0.2	0.4	0.4	0.7	0.5	0.8	0.1	-0.1
Hair/balding pattern: Pattern 3	0.3	0.5	1.8	-0.1	0.7	0.6	-0.0	1.3	-0.3	0.3	0.3	1.0	0.9	1.0	0.8	0.3
Pulse rate	0.3	0.4	1.8	-0.1	-0.6	-1.4	-0.3	0.7	-1.3	-0.0	-0.1	0.7	0.7	0.1	0.1	0.2
Depression (self-reported)	0.3	0.4	1.7	-0.8	0.0	-0.2	-0.4	1.2	0.2	-0.7	-0.2	0.7	0.2	0.3	-0.0	1.3
Prospective memory result	0.3	0.4	1.6	1.3	0.3	0.9	0.5	-0.5	0.6	0.5	0.8	-0.1	0.2	-0.9	0.4	-0.5
Birth weight of first child	0.3	0.6	1.6	-0.7	0.9	-0.4	0.9	0.7	0.6	1.3	1.1	0.7	0.7	-0.5	0.7	0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	3.8	-2.0	-0.1	-0.4	0.5	-0.7	-0.0	0.5	0.7	-0.2	0.2	-0.0	0.3	-0.2
High blood pressure (siblings)	0.3	0.4	2.2	-0.5	0.1	0.0	0.2	-1.0	-0.0	-0.0	0.5	-0.7	-0.4	-1.5	-0.9	-0.9
Number of full brothers	0.3	0.3	1.8	1.3	0.7	0.5	0.4	0.5	0.3	0.3	0.6	0.5	0.7	-0.3	-0.0	0.2
Number of children fathered	0.3	0.4	2.9	0.1	-1.7	-0.2	-0.1	0.1	0.7	-0.0	0.1	-0.2	-0.4	-0.9	-0.2	-0.1
Medication: Blood pressure	0.3	0.5	2.4	-1.5	-1.1	0.4	-0.1	0.1	0.3	-0.0	0.3	-0.4	0.1	-1.5	-0.5	-0.1
Medication: Ibuprofen	0.3	0.4	4.1	-2.0	0.5	-0.1	0.5	0.1	0.5	0.4	0.4	0.3	0.2	-0.1	0.0	0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	0.5	0.6	-0.1	0.8	0.7	0.6	0.5	0.7	0.9	0.8	0.4	0.4	0.4
Hypertension (Self-reported)	0.3	0.9	5.5	-1.4	-0.5	0.8	0.9	-0.3	1.0	0.5	1.1	-0.5	0.1	-2.3	-0.5	-0.0
Average weekly red wine intake	0.3	0.4	3.3	-1.8	-0.8	-0.9	0.0	0.1	0.4	-0.1	-0.1	-0.3	0.4	-0.7	-0.1	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.5	-1.2	-0.8	-0.7	0.1	-0.5	0.3	0.1	0.1	-0.5	-0.4	-0.9	-0.1	0.2
Osteoarthritis (self-reported)	0.3	0.3	0.9	0.1	-0.1	0.8	0.8	0.2	0.4	0.6	0.9	0.8	0.9	0.2	0.5	0.3
Ever taken oral contraceptive pill	0.3	0.3	1.0	-0.4	0.2	1.0	0.4	0.7	0.0	0.5	0.4	0.1	0.6	0.2	1.0	0.6
Diastolic blood pressure, automated reading	0.3	0.8	2.8	-1.3	1.2	0.9	0.9	1.0	0.5	0.8	0.7	1.7	0.6	0.6	-0.2	0.3
Myopia	0.3	0.4	1.3	1.1	0.7	0.7	-0.7	-0.5	-0.2	-0.9	-0.7	-0.8	-0.5	0.4	-0.3	-0.4
Vascular/heart problems diagnosed by doctor	0.3	0.8	5.3	1.0	0.5	-0.8	-0.9	0.5	-0.9	-0.4	-0.9	0.6	-0.2	2.3	0.6	-0.1
Basal cell carcinoma (self-reported)	0.3	0.4	1.6	-1.2	-0.8	-0.4	-0.5	-0.2	-0.9	-0.3	-0.7	-0.6	0.1	0.2	-0.2	0.6
Depression (Nagel 2018)	0.2	0.3	2.0	-1.4	-0.4	-0.1	-0.2	0.2	-0.2	-0.4	0.2	-0.1	0.3	0.1	-0.1	0.8
Height	0.2	3.2	9.4	1.5	-3.1	-1.9	-1.7	-2.3	-0.6	-1.7	-1.6	-2.8	-1.8	-0.1	0.0	-1.4
Waist Hip Ratio (WHR)	0.2	1.1	6.6	2.6	0.3	0.5	1.0	-1.2	-0.4	0.9	1.0	-0.9	-0.6	-1.0	-0.1	-0.6
Systolic Blood Pressure	0.2	1.2	4.8	-2.2	0.4	0.6	1.1	-1.1	0.5	1.0	0.9	-0.5	-0.8	-1.4	-0.9	-1.4
Tanning	0.2	2.0	9.2	-3.0	-2.3	-0.9	0.6	-1.9	0.3	0.3	-0.1	-1.6	-1.0	-1.5	-0.4	-0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.9	-1.0	-1.0	-0.2	-0.2	-0.2	0.2	-0.2	-0.2	-0.3	-0.2	0.8	0.2	-0.2
Medication: Metformin	0.2	0.2	1.2	-1.1	-0.2	-0.4	-0.4	0.1	-0.5	-0.3	-0.4	0.4	-0.5	0.3	-0.5	0.3
Severe depression (siblings)	0.2	0.2	1.1	0.1	0.5	0.8	0.1	-0.3	0.1	-0.3	0.1	-0.1	-0.0	-1.1	-0.9	0.2
Age when periods started (menarche)	0.2	0.4	0.9	0.8	0.7	0.8	0.4	-0.9	0.7	0.3	-0.1	-0.5	-0.8	0.6	0.4	-0.9
Qualifications: CSEs or equivalent	0.2	0.3	1.0	-1.0	-0.2	0.2	-0.3	1.0	-0.4	-0.2	-0.5	0.5	0.5	0.1	-0.2	0.7
Serious illness, injury or assault to yourself	0.2	0.2	1.2	-1.1	-1.0	0.6	-0.2	0.5	-0.2	0.1	-0.1	0.3	0.2	-0.2	0.1	0.3
Supplements: Glucosamine	0.2	0.3	0.7	-0.0	-0.7	0.3	-0.8	-0.4	-0.5	-0.7	-0.8	-0.6	-0.6	0.2	-0.0	-0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.9	-0.5	0.2	0.1	0.5	-0.0	0.5	0.5	0.5	0.3	0.1	0.9	0.8	0.2
Past tobacco smoking	0.2	0.4	1.7	1.1	0.9	-0.3	-0.5	-0.7	-0.3	-0.4	-0.2	0.2	-0.5	0.5	-0.5	-1.3
Asthma	0.2	0.4	0.8	0.5	0.8	0.1	0.6	-0.4	-0.3	0.9	0.9	0.2	0.5	0.5	0.9	-0.2
Length of working week for main job	0.2	0.2	0.7	0.4	0.3	-0.1	0.3	0.8	-0.4	0.9	0.3	0.8	0.2	0.2	0.2	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.6	-0.5	0.5	0.2	-0.2	0.9	0.7	-0.7	-0.3	0.6	0.3	0.4	-0.3	1.3
Pulse wave reflection index	0.2	0.3	1.2	-0.2	-0.2	0.9	0.5	0.4	1.1	0.5	0.0	0.1	0.3	0.6	0.5	0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	-0.7	-0.2	0.5	-0.1	0.2	-0.4	0.1	-0.2	-0.1	0.3	0.9	0.6	0.8
Pulse wave peak to peak time	0.2	0.2	0.9	0.7	0.7	-0.1	-0.1	0.3	-0.5	-0.1	0.2	0.9	0.2	0.7	0.3	0.0
Health satisfaction	0.2	0.3	0.7	0.7	0.2	0.7	0.8	-0.1	0.3	0.8	0.6	-0.0	0.5	-0.1	0.5	0.8
Eye problems/disorders: None of the above	0.2	0.2	0.7	0.1	-0.6	0.2	-0.6	0.1	-0.6	-0.1	-0.8	-0.7	-0.7	-0.2	0.2	-0.4
Medication: Seretide 50 evohaler	0.2	0.3	1.0	-0.9	0.3	-0.3	-0.1	-0.2	-1.0	0.0	0.0	0.3	-0.1	-0.5	-0.4	-0.9
Comparative height size at age 10	0.2	1.2	9.7	0.5	-3.1	-0.8	-0.9	-0.8	-0.2	-1.0	-0.5	-1.2	-0.5	-0.4	-0.1	-0.0
Eye problems/disorders: Cataract	0.2	0.2	1.1	-0.2	0.2	0.4	0.7	-0.2	-0.3	0.6	1.1	0.4	0.6	-0.2	-0.0	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	0.3	0.5	-0.4	-0.9	0.7	-0.5	-0.8	-0.5	0.6	0.2	0.9	-0.0	-0.3
Medication: Paracetamol	0.2	0.4	1.8	-1.3	0.0	-1.0	-0.3	-0.7	-0.3	-0.3	-0.0	-0.2	-0.3	0.2	-0.3	-0.9
Schizophrenia vs Biploar Disorder	0.1	0.2	0.7	-0.4	-0.2	0.3	0.3	-0.5	-0.9	0.4	0.3	0.0	0.4	-0.8	-0.2	-0.3
Bipolar Disorder (2011)	0.1	0.1	1.0	-0.1	1.0	0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.1	1.4	9.7	-1.4	0.4	0.5	1.2	-0.0	3.1	0.2	0.9	0.2	0.5	1.1	1.0	1.3
Hair Pigment	0.1	2.9	6.7	1.2	-0.1	-1.3	-2.0	-1.3	-2.6	-2.0	-1.5	-0.8	-2.0	-1.0	-2.0	-2.5
Medication: Atenolol	0.1	0.1	0.6	-0.1	0.7	0.4	-0.3	-0.2	-0.1	-0.5	-0.0	0.1	-0.3	0.5	-0.6	0.1
Forced vital capacity (FVC)	0.1	0.2	1.1	-0.6	-1.1	-0.7	-0.6	0.7	0.1	-0.5	-0.2	0.2	0.3	-0.2	0.1	0.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.7	0.0	-0.7	-0.5	-0.4	0.8	0.3	-0.3	-0.1	0.3	0.5	-0.1	-0.0	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.1	-0.7	-1.1	-0.4	-0.1	0.9	0.3	0.1	0.2	0.2	0.8	-0.1	0.6	0.6
Breastfed as a baby	0.1	0.1	0.5	0.2	-0.1	-0.7	0.3	-0.1	0.3	0.4	0.0	-0.3	-0.1	-0.4	-0.0	0.0
Peak expiratory flow (PEF)	0.1	0.3	1.0	1.0	-0.4	-0.5	-0.9	-0.1	-0.5	-0.8	-0.8	-0.2	-0.2	0.5	-0.1	-0.4
Forced vital capacity (FVC), Best measure	0.1	0.5	2.9	-1.2	-1.7	-0.9	-0.8	0.3	-0.4	-0.4	-0.3	-0.3	0.2	-0.2	0.3	-0.2
Qualifications: College or University degree	0.1	0.4	2.6	0.9	0.1	0.5	0.6	-0.2	1.6	0.1	0.8	0.1	0.1	0.2	0.5	0.1
Pulse rate, automated reading	0.1	0.2	0.6	-0.3	-0.2	-0.4	0.3	-0.2	-0.8	0.6	0.2	0.2	0.7	-0.0	0.4	0.1
Family relationship satisfaction	0.1	0.1	0.3	-0.5	0.3	0.4	0.3	-0.4	0.5	0.1	0.0	-0.3	-0.1	-0.4	-0.4	0.3
Illnesses of father: Heart disease	0.1	0.1	0.7	-0.8	-0.5	0.2	0.3	-0.6	0.5	0.2	0.3	-0.1	-0.0	0.2	0.1	-0.2
Asthma (self-reported)	0.1	0.2	0.7	0.2	0.5	0.2	0.4	-0.5	-0.6	0.7	0.7	-0.1	0.3	0.3	0.8	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	-0.4	0.4	0.2	0.4	0.5	0.4	0.5	0.6	0.4	0.7	0.2	0.6	0.3
Average weekly champagne plus white wine intake	0.1	0.1	0.3	0.3	0.0	-0.3	-0.2	0.4	-0.2	-0.0	-0.4	-0.0	-0.0	0.4	0.4	-0.5
Financial situation satisfaction	0.1	0.2	0.6	-0.0	0.3	0.4	0.5	0.7	0.5	0.6	0.2	0.4	0.4	-0.1	-0.1	0.4
Medication: Bendroflumethiazide	0.1	0.2	1.0	-0.3	-0.6	0.3	-0.1	-0.1	0.2	-0.0	0.1	-0.3	-0.3	-1.0	-0.7	-0.5
Ever smoked	0.1	0.2	1.1	-0.4	-0.5	0.6	0.3	0.6	0.2	0.1	0.1	-0.5	0.2	-0.6	0.3	1.1
Number of operations (self-reported)	0.1	0.2	2.1	1.4	0.4	0.3	0.3	0.1	0.1	0.3	0.1	-0.1	-0.0	-0.1	-0.1	0.1
Irritability	0.1	0.2	0.7	-0.5	0.3	0.8	0.3	-0.6	-0.2	0.0	0.0	-0.3	0.1	-0.4	-0.1	0.5
Mean time to correctly identify matches	0.0	0.1	0.3	0.5	-0.1	-0.3	-0.2	0.1	-0.0	-0.4	-0.3	0.1	0.1	-0.5	-0.3	0.1

Hub : Genes

CFL2

Models

Trait associations