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chr17:27,200,734-30,380,381

Best TWAS P=6.43e-29 · Best GWAS P=1.32e-31 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Artery Tibial	RP11-848P1.7	0.54	0.00	lasso	10	0.02	7.3e-03	-7.435	-11.2	6.4e-29	0.47	0.02	0.06	TRUE
30	METSIM	Adipose	TEFM	0.08	0.06	blup	246	0.06	8.8e-10	-11.697	-8.5	2.3e-17	0.57	0.00	1.00	TRUE
5	GTEx	Artery Aorta	CRLF3	0.12	0.03	enet	33	0.06	3.8e-04	2.235	-8.0	1.6e-15	0.53	0.25	0.70	TRUE
3	GTEx	Artery Aorta	ABHD15	0.20	0.03	enet	36	0.06	2.9e-04	-5.254	-6.6	4.5e-11	0.08	0.00	0.86	TRUE
57	The Cancer Genome Atlas	Stomach Adenocarcinoma	SUZ12P	0.05	0.05	blup	29	0.04	5.1e-04	3.843	-6.2	5.7e-10	0.32	0.16	0.16	TRUE
15	GTEx	Esophagus Muscularis	BLMH	0.15	0.02	lasso	8	0.01	1.0e-01	-3.982	6.2	7.0e-10	-0.13	0.04	0.46	TRUE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	ABHD15	0.04	0.03	lasso	2	0.02	1.4e-05	-5.254	-5.4	7.4e-08	-0.01	0.00	1.00	TRUE
8	GTEx	Brain Cerebellum	CRLF3	0.52	0.12	lasso	27	0.20	1.3e-06	-10.261	-9.7	3.6e-22	0.56	0.09	0.74	FALSE
16	GTEx	Esophagus Muscularis	CRLF3	0.17	0.12	lasso	6	0.18	5.1e-11	3.229	-7.8	9.5e-15	0.46	0.94	0.05	FALSE
28	METSIM	Adipose	CTD-2349P21.5	0.02	0.00	bslmm	252	0.01	3.0e-03	-9.003	-7.7	1.6e-14	0.33	0.04	0.31	FALSE
40	The Cancer Genome Atlas	Esophageal Carcinoma	OMG	0.09	0.09	blup	31	0.11	2.0e-04	7.262	-7.5	5.9e-14	0.18	0.02	0.92	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	GOSR1	0.02	0.01	enet	4	0.01	1.7e-02	-7.457	7.5	6.2e-14	-0.27	0.01	0.83	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	OMG	0.02	0.02	blup	31	0.03	6.9e-04	7.236	-7.5	8.9e-14	0.17	0.02	0.89	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	OMG	0.02	0.01	blup	32	0.02	4.8e-03	7.012	-7.4	1.1e-13	0.18	0.02	0.86	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	EVI2A	0.13	0.03	lasso	4	0.01	1.5e-01	7.086	-7.4	1.2e-13	0.17	0.16	0.04	FALSE
29	METSIM	Adipose	NF1	0.04	0.00	blup	396	0.01	5.5e-03	7.297	7.4	1.2e-13	-0.30	0.80	0.02	FALSE
34	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	OMG	0.02	0.02	blup	31	0.02	3.2e-03	6.950	-7.4	1.2e-13	0.15	0.03	0.78	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	EVI2A	0.03	0.03	blup	38	0.04	3.0e-05	6.891	-7.4	1.3e-13	0.16	0.04	0.96	FALSE
45	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	NF1	0.04	0.03	blup	111	0.03	1.3e-02	7.315	7.3	2.4e-13	-0.19	0.05	0.67	FALSE
47	The Cancer Genome Atlas	Lung Adenocarcinoma	EVI2A	0.04	0.06	blup	38	0.06	3.0e-07	6.798	-7.3	2.9e-13	0.15	0.08	0.92	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	EVI2A	0.03	0.03	blup	38	0.03	6.9e-07	6.887	-7.3	3.2e-13	0.12	0.08	0.92	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	EVI2A	0.08	0.12	lasso	3	0.12	1.3e-12	7.297	-7.3	3.8e-13	0.12	0.07	0.93	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	OMG	0.03	0.04	lasso	1	0.04	1.1e-08	7.211	-7.2	5.5e-13	0.23	0.01	0.99	FALSE
27	GTEx	Whole Blood	EVI2A	0.07	0.04	lasso	4	0.04	2.6e-04	6.969	-7.2	5.6e-13	0.14	0.89	0.00	FALSE
50	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GOSR1	0.15	0.00	blup	56	0.04	1.1e-03	-3.638	7.2	6.8e-13	-0.35	0.04	0.19	FALSE
11	GTEx	Cells Transformed fibroblasts	OMG	0.06	0.02	lasso	2	0.01	2.5e-02	7.012	7.1	9.1e-13	-0.22	0.14	0.07	FALSE
4	GTEx	Artery Aorta	TEFM	0.13	0.02	enet	34	0.03	5.8e-03	2.249	-7.1	1.3e-12	0.57	0.15	0.78	FALSE
51	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	OMG	0.05	0.03	blup	32	0.03	5.6e-03	7.012	-7.0	2.9e-12	0.25	0.01	0.77	FALSE
31	YFS	Blood	EVI2A	0.03	0.05	lasso	4	0.04	1.0e-13	6.915	-6.9	4.1e-12	0.10	1.00	0.00	FALSE
23	GTEx	Spleen	EVI2A	0.22	0.12	lasso	4	0.07	8.3e-03	6.915	-6.9	4.8e-12	0.17	0.11	0.05	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EVI2A	0.03	0.03	blup	37	0.03	2.3e-03	6.951	-6.9	6.9e-12	0.10	0.04	0.56	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC37B2	0.09	0.00	enet	11	0.03	7.3e-03	4.368	-6.8	1.1e-11	0.47	0.01	0.26	FALSE
32	YFS	Blood	EVI2B	0.01	0.00	blup	339	0.00	6.4e-02	-0.018	6.8	1.4e-11	-0.26	0.07	0.02	FALSE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EVI2A	0.03	0.03	lasso	1	0.02	2.4e-03	6.722	-6.7	1.8e-11	0.10	0.04	0.40	FALSE
21	GTEx	Ovary	CRLF3	0.21	0.14	lasso	4	0.11	1.0e-03	3.229	-6.7	2.0e-11	0.40	0.06	0.58	FALSE
19	GTEx	Nerve Tibial	CRLF3	0.38	0.16	lasso	14	0.19	3.0e-13	3.333	-6.7	3.0e-11	0.38	1.00	0.00	FALSE
26	GTEx	Thyroid	CRLF3	0.10	0.04	enet	35	0.08	1.1e-06	3.333	-6.6	5.2e-11	0.38	0.91	0.05	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	OMG	0.05	0.03	lasso	5	0.04	3.6e-05	6.925	-6.5	5.8e-11	0.10	0.06	0.86	FALSE
7	GTEx	Brain Cerebellar Hemisphere	CRLF3	0.38	0.35	enet	26	0.35	6.0e-10	3.120	-6.5	7.8e-11	0.32	0.97	0.01	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NF1	0.06	0.01	blup	410	0.04	1.1e-05	7.086	6.5	8.7e-11	-0.20	0.95	0.00	FALSE
22	GTEx	Pituitary	SUZ12P	0.29	0.23	lasso	9	0.32	6.0e-09	3.118	-6.5	9.6e-11	0.40	0.86	0.07	FALSE
2	GTEx	Adipose Visceral Omentum	TEFM	0.12	0.02	lasso	14	0.05	1.0e-03	2.227	-6.4	1.4e-10	0.21	0.08	0.09	FALSE
24	GTEx	Spleen	OMG	0.41	0.10	enet	26	0.08	4.5e-03	7.012	6.4	1.5e-10	-0.23	0.64	0.03	FALSE
25	GTEx	Testis	CRLF3	0.26	0.19	enet	23	0.17	3.8e-08	3.359	-6.1	1.1e-09	0.38	0.99	0.00	FALSE
9	GTEx	Breast Mammary Tissue	CRLF3	0.10	0.10	lasso	3	0.05	9.6e-04	3.843	-6.0	2.1e-09	0.31	0.09	0.62	FALSE
13	GTEx	Colon Transverse	CRLF3	0.16	0.07	lasso	6	0.05	1.5e-03	2.235	-5.9	2.8e-09	0.42	0.15	0.64	FALSE
17	GTEx	Muscle Skeletal	TP53I13	0.08	0.02	lasso	4	0.02	2.2e-03	-5.254	5.8	4.9e-09	-0.08	0.00	0.94	FALSE
18	GTEx	Nerve Tibial	TEFM	0.16	0.01	lasso	4	0.06	2.7e-05	2.235	-5.6	2.2e-08	0.43	0.26	0.59	FALSE
53	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CRLF3	0.28	0.13	blup	40	0.11	3.1e-05	2.999	-5.6	2.5e-08	0.28	0.33	0.06	FALSE
46	The Cancer Genome Atlas	Lung Adenocarcinoma	C17orf42	0.04	0.02	enet	5	0.04	5.4e-05	-1.015	-5.5	4.2e-08	0.46	0.17	0.46	FALSE
56	The Cancer Genome Atlas	Stomach Adenocarcinoma	EVI2A	0.05	0.03	enet	7	0.04	4.8e-04	2.947	-5.5	4.6e-08	0.13	0.04	0.65	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	ATAD5	0.14	0.08	enet	11	0.09	4.1e-10	2.217	5.4	5.4e-08	-0.41	0.99	0.01	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	CRLF3	0.07	0.06	blup	37	0.08	2.8e-09	3.346	-5.3	9.4e-08	0.37	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CRLF3	0.07	0.06	blup	40	0.06	2.0e-03	3.346	-5.3	1.1e-07	0.32	0.09	0.20	FALSE
20	GTEx	Nerve Tibial	SUZ12P	0.25	0.34	enet	44	0.35	1.1e-25	3.324	-5.3	1.4e-07	0.29	1.00	0.00	FALSE
14	GTEx	Esophagus Mucosa	ABHD15	0.21	0.13	lasso	1	0.10	1.7e-07	-5.254	-5.2	1.5e-07	0.00	0.00	1.00	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EVI2A	0.04	0.00	blup	37	0.01	1.1e-02	6.873	-5.2	1.8e-07	0.00	0.02	0.23	FALSE
12	GTEx	Cells Transformed fibroblasts	TEFM	0.15	0.09	lasso	16	0.09	6.1e-07	2.227	-5.2	2.0e-07	0.45	0.96	0.04	FALSE