TWAS hub - BLMH

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1169	0.0451	4.8e-09	0.044	NA	0.081	NA	0.076	2.2e-04	NA	6.7e-07	NA	1.5e-06
2	GTEx	Cells Transformed fibroblasts	0.0670	0.0320	2.6e-03	0.043	NA	0.041	NA	0.044	3.7e-04	NA	4.6e-04	NA	2.8e-04
3	GTEx	Esophagus Muscularis	0.1480	0.0610	3.4e-03	0.015	NA	0.003	NA	0.008	3.8e-02	NA	2.1e-01	NA	1.0e-01
4	GTEx	Lung	0.1207	0.0488	2.1e-03	0.000	NA	0.031	NA	-0.001	3.3e-01	NA	1.9e-03	NA	3.9e-01
5	GTEx	Muscle Skeletal	0.1105	0.0586	1.8e-03	-0.003	NA	0.028	NA	-0.003	8.1e-01	NA	7.7e-04	NA	8.9e-01
6	METSIM	Adipose	0.0260	0.0146	2.0e-04	0.033	0.027	0.014	0.022	0.017	7.5e-06	6.0e-05	2.8e-03	0.00025	1.1e-03
7	YFS	Blood	0.0661	0.0195	0.0e+00	0.072	0.072	0.082	NA	0.085	2.4e-22	1.3e-22	2.2e-25	NA	3.1e-26
8	TCGA	Breast Invasive Carcinoma	0.0256	0.0156	1.4e-03	0.009	0.012	0.017	NA	0.009	4.3e-03	1.4e-03	1.9e-04	NA	4.4e-03
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0230	0.0129	1.3e-03	0.025	0.024	0.019	NA	0.024	7.9e-04	8.2e-04	2.8e-03	NA	9.2e-04
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0840	0.0450	2.0e-04	0.078	0.050	0.055	NA	0.060	3.2e-05	7.7e-04	4.3e-04	NA	2.3e-04
11	TCGA	Prostate Adenocarcinoma	0.0450	0.0207	3.4e-06	0.034	0.047	0.035	NA	0.041	1.7e-04	1.1e-05	1.4e-04	NA	4.0e-05
12	TCGA	Thyroid Carcinoma	0.0240	0.0140	3.0e-03	0.029	0.021	0.011	NA	0.022	7.7e-04	3.6e-03	2.9e-02	NA	2.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Lung FEV1/FVC ratio	15.9	80.4	185.0	-12.0	-7.9	-1.8	-3.2	-5.1	-13.6	-10.5	-5.5	-10.2	-10.0	-10.1	-9.3
Peak expiratory flow (PEF)	6.1	14.1	26.2	-4.6	-4.0	-0.2	-2.3	-1.8	-5.1	-4.2	-3.2	-4.8	-3.6	-4.1	-4.1
Number of incorrect matches in round	5.9	9.8	17.3	3.6	3.1	2.3	0.8	0.8	4.2	3.6	1.2	3.8	3.9	3.5	3.8
Bipolar Disorder or Schizophrenia	4.4	10.7	22.2	3.4	3.2	0.5	3.0	-0.2	4.1	4.7	1.6	4.0	3.7	3.4	3.8
Cholesterol lowering medication	4.4	6.5	15.7	-3.7	-1.6	-3.2	-0.7	-1.3	-4.0	-2.7	-1.1	-2.4	-2.8	-2.9	-1.8
Intelligence (Savage-Jansen 2018)	4.1	12.7	22.0	-4.6	-3.8	-0.3	-2.2	-1.3	-4.7	-3.7	-3.1	-4.2	-3.9	-4.2	-3.9
Asthma	4.1	8.1	12.3	2.7	3.4	-1.1	2.0	1.9	3.1	3.2	2.0	3.5	3.0	3.4	3.5
Bipolar Disorder (2011)	3.8	3.6	8.2	2.8	1.7	0.4	1.2	0.8	2.9	2.2	1.1	2.2	1.9	2.1	1.8
Hair/balding pattern: Pattern 2	3.8	4.8	10.6	1.5	3.0	-0.7	1.6	-0.4	1.3	2.1	2.3	2.7	2.7	2.5	3.2
Heel T-Score	3.7	29.4	65.8	8.1	5.1	1.8	4.3	5.3	7.4	4.0	5.0	4.9	5.0	6.6	4.6
Average weekly champagne plus white wine intake	3.7	5.1	7.3	-2.3	-2.2	-2.3	-2.7	-1.2	-2.6	-2.6	-1.8	-2.2	-2.4	-2.7	-1.8
Leg fat percentage (right)	3.6	12.9	28.7	-5.4	-3.2	-1.5	-2.4	-2.2	-5.2	-3.1	-2.0	-3.7	-4.2	-4.0	-3.8
Smoking Status	3.5	8.3	11.6	3.3	3.2	0.1	2.4	2.4	3.3	3.1	2.6	3.4	2.9	3.4	2.9
Asthma (self-reported)	3.5	7.0	10.6	2.4	3.1	-1.4	1.8	2.1	2.9	3.0	2.1	3.3	2.6	3.0	3.2
Schizophrenia (2018)	3.4	7.0	13.6	2.8	2.9	-0.1	2.2	0.2	3.2	3.7	1.5	3.6	2.7	2.6	3.2
Primary Biliary Cirrhosis	3.4	4.9	7.7	2.3	2.8	0.8	1.6	0.3	2.3	2.5	2.4	2.8	2.3	2.6	2.4
Angina	3.4	4.4	12.0	-3.2	-1.5	-3.5	-1.2	0.4	-2.7	-1.8	-0.2	-1.9	-2.4	-2.4	-1.2
Alzheimer’s Disease (in mother)	3.3	3.9	7.3	2.5	1.9	-0.3	1.0	1.0	2.7	2.2	1.4	2.5	2.0	2.3	2.1
Leg fat percentage (left)	3.3	11.8	23.9	-4.9	-3.3	-0.9	-2.4	-2.0	-4.7	-3.1	-2.2	-3.7	-3.9	-3.9	-3.9
Back pain experienced in last month	3.2	4.7	10.3	-2.8	-1.8	-1.8	0.5	-0.4	-2.5	-1.8	-1.0	-2.5	-3.2	-2.9	-2.5
Had menopause	3.0	3.7	6.0	-2.1	-2.1	1.2	-1.6	-1.7	-1.7	-0.8	-2.4	-2.0	-2.2	-2.2	-2.5
Illnesses of siblings	2.9	4.1	9.4	3.0	0.9	2.7	-0.2	0.4	3.1	2.1	0.7	1.6	2.9	2.2	1.5
Worry too long after embarrassment	2.9	4.9	11.4	2.0	1.9	-0.4	0.1	1.8	3.0	3.4	1.8	2.8	2.3	1.9	2.8
Angina (self-reported)	2.9	3.8	12.6	-3.0	-1.2	-3.5	-1.0	0.6	-2.4	-1.6	-0.1	-1.6	-2.2	-2.2	-0.9
Alzheimer’s Disease (including proxy)	2.8	4.1	9.9	2.9	1.8	-0.1	0.4	1.1	3.2	2.2	1.9	2.6	1.8	2.3	1.6
Blood White Count	2.8	21.0	46.0	6.8	3.5	2.6	3.4	3.4	6.5	4.2	3.6	4.5	5.0	5.6	3.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.8	12.5	1.4	1.6	-1.6	2.2	1.1	1.9	2.2	3.5	1.9	1.4	1.6	1.8
Chronic bronchitis/emphysema (father)	2.8	3.2	7.5	1.6	1.3	2.1	1.3	-2.1	1.4	2.6	0.3	1.5	2.7	1.7	1.4
Triglycerides	2.7	4.4	6.6	2.0	2.5	-0.7	2.6	2.6	2.0	1.8	2.0	2.4	1.6	2.4	2.1
Arm fat percentage (left)	2.7	10.7	22.0	-4.6	-3.1	-0.6	-2.0	-2.0	-4.7	-2.9	-2.5	-3.6	-3.6	-3.4	-3.9
Depression (Nagel 2018)	2.6	3.9	14.3	1.4	1.7	-1.6	1.8	0.9	1.8	2.4	3.8	2.1	1.3	1.8	1.8
Arm fat percentage (right)	2.6	10.3	21.5	-4.6	-3.0	-0.8	-2.1	-1.9	-4.6	-2.9	-2.4	-3.4	-3.5	-3.3	-3.8
Body fat percentage	2.6	10.2	21.0	-4.6	-3.1	-0.2	-2.2	-1.9	-4.4	-2.7	-2.6	-3.4	-3.5	-3.5	-3.8
Leg fat mass (right)	2.6	10.1	19.2	-4.4	-3.3	0.8	-1.7	-3.0	-4.2	-2.1	-2.5	-3.5	-3.2	-3.4	-4.0
Number of self-reported non-cancer illnesses	2.6	4.6	9.9	-3.1	-1.7	-1.9	-2.2	-1.8	-2.6	-1.7	-0.9	-2.0	-2.5	-2.4	-1.8
Forced vital capacity (FVC), Best measure	2.5	9.2	18.7	4.2	2.0	3.6	1.8	0.9	4.3	3.4	1.3	2.5	3.9	3.6	2.1
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.2	22.8	2.7	0.6	4.8	1.8	-1.1	2.4	2.8	0.4	1.3	2.8	1.9	0.5
Handedness (chirality/laterality): Left-handed	2.5	3.0	6.0	-1.1	-2.2	-1.6	-0.8	1.1	-1.0	-2.1	-0.8	-2.1	-2.5	-2.0	-2.3
Age started oral contraceptive pill	2.5	3.1	8.4	-1.8	-1.4	-0.2	-2.9	-0.3	-1.8	-1.9	-1.6	-1.8	-2.2	-1.7	-1.9
Leg fat mass (left)	2.5	9.7	16.6	-4.1	-3.4	1.3	-1.8	-2.8	-3.9	-2.1	-2.7	-3.5	-3.0	-3.3	-4.1
Bipolar Disorder (2018)	2.4	3.9	8.7	1.9	1.5	1.0	2.0	-0.3	2.6	2.9	0.7	2.0	2.5	2.1	2.1
Forced vital capacity (FVC)	2.3	8.9	19.4	4.3	1.8	3.4	1.7	1.6	4.4	3.2	1.1	2.5	3.8	3.5	2.0
Hayfever/allergic rhinitis (self-reported)	2.3	3.0	5.0	-1.6	-2.1	0.3	-1.5	0.1	-1.7	-2.1	-1.6	-2.2	-1.9	-1.8	-2.2
Heart disease (siblings)	2.3	2.9	6.8	-2.6	-0.7	-2.6	-1.4	-0.5	-2.3	-1.6	-0.7	-1.1	-2.1	-2.0	-0.5
Age at First Birth	2.2	3.2	6.6	-1.8	-1.6	0.6	-1.1	0.7	-2.4	-2.6	-1.4	-2.4	-1.8	-1.9	-1.8
HDL Cholesterol	2.2	3.7	7.1	1.8	1.1	2.7	0.5	-2.6	2.0	2.4	-0.8	1.7	2.5	1.6	2.0
BMI	2.2	12.6	25.0	-4.8	-3.5	-0.7	-0.9	-1.9	-5.0	-3.4	-2.5	-4.0	-4.1	-3.9	-4.5
Respiratory disease	2.2	5.0	9.2	2.0	2.1	-0.4	0.9	1.9	2.9	3.0	1.4	2.9	2.6	2.5	2.4
Eye problems/disorders: Diabetes related eye disease	2.2	2.5	6.9	1.5	1.6	1.1	1.9	0.5	1.4	1.8	2.6	1.3	1.3	1.8	0.9
Waist circumference	2.2	8.1	19.1	-3.3	-3.4	1.5	-1.1	-1.6	-3.1	-1.8	-2.6	-3.4	-3.0	-3.0	-4.4
Prospective memory result	2.2	2.7	5.8	2.4	1.8	0.5	0.8	0.3	2.4	1.8	0.6	2.1	1.6	1.6	1.9
Type 2 Diabetes (T2D) (2012)	2.1	2.5	6.4	-1.5	-0.4	-1.8	-0.1	1.9	-2.1	-2.5	1.2	-1.3	-2.1	-1.1	-0.8
Trunk fat percentage	2.1	8.2	15.9	-4.0	-2.9	0.4	-2.1	-1.6	-3.8	-2.3	-2.7	-3.0	-3.0	-3.0	-3.6
Migraine (self-reported)	2.1	2.6	4.3	1.8	1.8	0.4	0.4	0.3	1.8	1.6	1.9	1.7	2.0	1.8	2.1
Alcohol intake frequency.	2.1	4.9	11.2	2.2	1.9	1.0	1.3	1.3	3.1	3.4	1.7	2.9	2.4	1.9	2.1
Ever had bowel cancer screening	2.1	2.5	4.1	-2.0	-1.3	-0.9	-2.0	0.1	-2.0	-1.7	-1.4	-1.5	-1.8	-2.0	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	3.5	1.5	1.7	-0.1	1.9	1.2	1.7	1.4	1.9	1.4	1.3	1.7	1.4
Osteoarthritis (self-reported)	2.1	2.8	6.2	2.2	1.5	1.0	1.3	1.4	2.5	1.8	1.5	1.7	1.4	2.0	1.0
Headache pain in last month	2.0	3.4	5.6	1.6	1.8	-0.1	2.0	0.4	2.1	2.4	2.3	1.9	2.2	1.9	1.8
Age at first live birth	2.0	3.5	6.4	-2.1	-2.0	0.6	-1.6	-0.4	-2.5	-2.4	-2.3	-2.2	-1.4	-2.1	-1.5
Supplements: Vitamin C	2.0	2.3	4.5	-1.5	-1.9	1.5	-0.6	-0.7	-1.7	-1.6	-0.7	-1.8	-1.6	-1.8	-2.1
Lung FVC	1.9	9.5	18.4	3.2	3.7	-2.0	0.6	2.9	3.4	2.4	2.9	3.5	3.1	3.4	4.3
Financial difficulties in last 2 years	1.9	2.5	8.1	1.3	1.9	-1.4	1.3	0.5	1.4	1.4	2.9	1.7	1.3	1.6	1.5
Standing height	1.9	19.2	112.4	4.8	-0.1	10.6	1.6	-2.2	4.8	4.9	-1.7	1.8	4.9	3.2	0.2
Miserableness	1.9	3.3	11.0	1.1	2.0	-1.7	1.4	0.6	1.2	1.9	3.3	2.1	1.4	1.6	2.1
Illnesses of father: High blood pressure	1.9	2.3	4.9	-1.9	-1.1	-1.3	-0.0	-0.2	-2.2	-2.0	-1.3	-1.5	-1.8	-2.0	-1.1
Alcohol drinker status: Never	1.9	2.3	4.7	1.2	1.2	-0.5	1.1	0.9	2.0	2.2	1.9	1.9	1.8	1.3	1.4
Heart attack	1.8	2.3	4.3	-2.1	-1.0	-0.8	0.0	0.7	-2.0	-1.6	-1.6	-1.6	-2.1	-1.6	-1.7
Arm fat mass (right)	1.8	7.4	13.3	-3.5	-2.9	1.4	-1.3	-2.7	-3.5	-1.8	-2.6	-3.0	-2.5	-2.6	-3.6
High blood pressure (siblings)	1.8	2.6	6.4	-2.5	-0.5	-2.3	0.7	-0.9	-2.5	-1.4	-0.2	-1.2	-2.1	-1.6	-1.0
Whole body fat mass	1.8	7.5	13.4	-3.5	-3.0	1.7	-1.5	-2.5	-3.3	-1.5	-2.8	-2.9	-2.5	-2.8	-3.7
Breast Cancer	1.7	4.2	9.5	-2.8	-1.5	-3.1	-2.5	0.5	-1.9	-2.3	-1.2	-1.5	-2.2	-2.5	-0.5
Fluid intelligence score	1.7	3.6	9.2	-2.6	-1.6	-0.8	-0.5	-0.7	-3.0	-2.2	-0.3	-2.1	-2.2	-2.0	-2.1
Breastfed as a baby	1.7	2.0	5.0	-1.4	-2.2	1.2	-1.5	-0.7	-1.1	-0.3	-1.5	-1.5	-1.2	-1.7	-1.9
Chronic bronchitis/emphysema (mother)	1.7	2.0	3.4	-1.6	-1.3	-1.5	-1.2	1.3	-1.4	-1.3	-0.8	-1.2	-1.8	-1.6	-1.3
Comparative height size at age 10	1.7	9.2	58.2	2.8	-0.9	7.6	0.9	-2.1	3.3	3.6	-1.7	0.9	2.8	1.3	-0.6
Arm fat mass (left)	1.7	7.2	13.2	-3.4	-2.8	1.5	-1.3	-2.8	-3.4	-1.6	-2.5	-2.9	-2.4	-2.6	-3.6
Financial situation satisfaction	1.7	2.2	3.5	1.2	1.5	-0.7	1.4	1.3	1.6	1.8	1.9	1.4	1.4	1.5	1.6
Heart attack/myocardial infarction (self-reported)	1.7	2.1	4.2	-2.1	-0.9	-0.7	-0.1	0.7	-2.0	-1.5	-1.5	-1.6	-1.9	-1.6	-1.5
Verbal and Numeric Reasoning (VNR)	1.6	3.9	8.7	-2.8	-2.1	0.8	-0.7	-1.1	-3.0	-1.9	-1.0	-2.5	-1.8	-2.1	-2.4
Schizophrenia (2014)	1.6	3.5	9.7	1.9	1.6	-0.2	1.8	0.1	2.4	3.1	1.1	2.4	1.7	1.7	1.9
Blood Platelet Count	1.6	18.6	48.0	-4.0	-1.7	-3.7	2.8	4.6	-5.2	-6.9	0.5	-4.8	-6.0	-3.4	-3.9
Height	1.6	30.4	201.6	5.1	-1.3	14.2	0.8	-4.6	5.3	5.8	-3.2	1.1	5.4	3.3	-0.8
Trunk fat mass	1.6	6.8	12.6	-3.2	-2.9	2.1	-1.5	-2.2	-3.1	-1.4	-2.9	-2.8	-2.2	-2.5	-3.6
Number of full sisters	1.6	2.0	4.5	1.3	1.3	-0.3	0.4	0.1	1.5	2.1	2.1	1.9	1.5	1.3	1.3
Fractured/broken bones in last 5 years	1.6	2.1	7.5	-1.7	-1.2	0.5	-1.1	-1.6	-1.5	-0.9	-2.7	-1.3	-0.9	-1.6	-0.9
Coronary Artery Disease (CAD)	1.5	1.8	5.3	-1.8	-0.8	-2.3	-0.7	0.7	-1.8	-1.6	0.5	-1.0	-1.5	-1.5	-0.8
Blood Red Count	1.5	14.3	28.5	-5.3	-3.6	-0.0	-1.5	-3.5	-5.1	-3.1	-2.8	-4.6	-4.0	-4.1	-4.4
Ever used hormone-replacement therapy (HRT)	1.5	2.0	3.7	1.5	1.7	0.4	1.0	0.6	1.3	1.5	1.5	1.7	1.5	1.9	1.4
Hayfever, allergic rhinitis or eczema	1.5	3.3	5.6	-2.4	-2.2	-0.6	-0.7	0.9	-2.0	-1.8	-1.1	-2.0	-2.3	-2.3	-2.2
Body mass index (BMI)	1.5	6.6	13.0	-3.6	-2.5	-0.4	-1.0	-1.8	-3.6	-2.1	-1.6	-2.8	-2.9	-2.7	-3.4
Number of operations (self-reported)	1.5	2.2	7.9	-1.8	-1.0	-0.9	-2.8	-0.7	-1.8	-1.2	-1.5	-1.2	-1.3	-1.6	-0.8
Depressed Affect (Nagel 2018)	1.4	3.0	7.2	0.6	1.8	-1.1	1.9	-1.1	1.1	2.6	2.7	1.6	1.6	1.6	2.0
Neuroticism (Nagel 2018)	1.4	3.2	11.2	0.8	2.0	-1.7	1.4	-0.0	1.3	2.1	3.3	1.7	1.2	1.7	2.1
Cardiovascular Disease	1.4	4.6	11.8	-2.9	-0.4	-3.4	1.5	-0.9	-2.9	-1.8	1.5	-1.5	-3.1	-1.8	-1.8
Illnesses of father: None of the above (group 1)	1.4	1.7	3.8	1.7	0.7	1.5	0.7	0.7	2.0	1.9	0.9	1.1	1.3	1.6	0.6
Allergy or Eczema	1.3	3.4	6.6	-2.3	-2.1	-1.4	-0.7	1.8	-1.6	-1.4	-0.8	-1.8	-2.6	-2.4	-2.1
Relative age of first facial hair	1.3	2.7	6.2	-1.4	-2.3	-0.4	-0.2	1.8	-1.2	-1.5	-0.5	-2.0	-2.0	-1.8	-2.5
Supplements: Zinc	1.3	1.4	3.2	-1.8	-0.8	-1.2	-0.8	-0.7	-1.8	-1.3	-0.6	-1.1	-1.3	-1.6	-0.5
Lung cancer (father)	1.3	1.6	3.8	1.2	1.3	0.5	0.3	0.3	1.5	1.9	0.3	1.6	1.6	1.0	1.7
Hair/balding pattern: Pattern 4	1.3	3.2	5.4	-1.4	-2.2	0.4	-2.3	-1.1	-1.4	-1.9	-1.6	-2.0	-2.1	-1.8	-2.3
Birth weight	1.3	2.8	13.1	0.5	-1.3	3.3	-1.2	-3.6	0.2	0.2	-1.9	-1.0	0.6	-0.1	-1.2
Illnesses of father: Heart disease	1.3	1.8	5.6	-1.6	0.0	-1.9	-1.5	0.7	-1.8	-2.4	-0.4	-0.7	-1.4	-1.3	0.0
Vascular/heart problems diagnosed by doctor	1.3	3.5	7.9	2.8	0.8	2.8	-0.4	-0.2	2.6	1.4	-0.8	1.5	2.7	1.9	1.7
Body Mass Index (BMI) (2010)	1.2	1.7	3.9	-1.3	-1.3	-2.0	-1.3	0.3	-1.1	-1.2	-1.1	-1.0	-1.7	-1.5	-1.0
Townsend deprivation index at recruitment	1.2	1.7	3.5	1.6	1.1	0.8	1.0	0.7	1.9	1.9	0.4	1.4	1.4	1.5	1.1
Fed-up feelings	1.2	2.2	6.4	0.8	1.4	-0.4	2.5	-1.1	0.7	1.6	2.4	1.0	1.5	1.2	1.4
Qualifications: CSEs or equivalent	1.2	1.6	3.0	1.2	1.6	-1.1	-0.1	-0.6	1.5	1.2	1.1	1.7	1.2	1.1	1.7
Serious illness, injury or assault to yourself	1.2	1.5	3.6	-1.2	-1.5	-0.2	-1.9	0.4	-0.6	-0.1	-0.7	-1.1	-1.9	-1.4	-1.7
Sitting height	1.2	8.8	23.8	3.8	1.6	4.9	2.7	-0.3	3.6	3.7	1.0	2.5	3.4	3.1	1.5
Depression (self-reported)	1.2	1.4	2.5	-1.1	-0.9	-1.4	-0.9	1.6	-0.7	-1.2	0.9	-1.2	-1.6	-1.0	-1.2
Comparative body size at age 10	1.2	3.4	5.9	-1.7	-2.0	-1.1	-0.9	-0.8	-1.7	-2.1	-2.1	-2.1	-2.2	-2.4	-2.0
Smoking status: Previous	1.2	1.8	8.3	1.5	1.2	-0.4	1.1	2.9	1.2	1.2	1.5	1.1	0.2	1.4	0.5
Sensitivity / hurt feelings	1.1	2.0	3.7	1.5	1.5	-1.0	0.6	0.9	1.9	1.7	1.8	1.4	0.9	1.6	1.4
Ever had hysterectomy (womb removed)	1.1	1.2	3.2	0.9	1.1	-0.6	0.2	-0.4	1.6	1.8	1.2	1.4	1.0	1.1	1.0
Medication for hormone replacement therapy	1.1	1.2	1.9	1.1	1.0	-0.8	0.8	1.1	1.3	1.0	1.0	1.4	1.1	1.1	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	7.4	2.7	1.0	-0.1	1.3	2.7	2.2	0.6	1.9	0.8	0.4	1.9	0.2
Stomach or abdominal pain in last month	1.1	1.4	6.0	-1.1	1.6	-2.5	-0.3	0.1	-0.8	0.3	1.3	1.1	0.2	0.1	1.8
Qualifications: None of the above	1.1	2.5	3.8	1.4	1.8	-0.1	1.5	1.3	1.9	2.0	1.6	1.7	1.4	1.6	1.8
Medication: Simvastatin	1.1	1.6	9.2	-1.5	-0.2	-3.0	0.1	0.8	-1.2	-0.9	1.1	-0.7	-1.5	-0.8	-0.6
Trunk fat-free mass	1.1	6.2	40.6	2.0	-0.7	6.4	1.5	-2.6	1.9	2.8	-1.1	0.2	2.2	1.3	-1.0
Trunk predicted mass	1.1	6.1	40.6	1.8	-0.9	6.4	1.4	-2.7	1.8	2.7	-1.2	0.0	2.1	1.2	-1.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.2	1.4	1.4	0.1	1.0	1.4	1.5	1.3	0.9	1.2	0.9	1.3	0.8
Number of full brothers	1.1	1.3	3.3	1.2	1.3	0.1	0.2	0.2	1.2	1.3	1.8	1.6	1.0	1.4	1.1
Neck or shoulder pain in last month	1.1	1.6	7.1	0.2	1.4	-1.8	1.6	0.7	0.1	1.1	2.7	1.0	0.3	0.4	1.0
Heart disease (mother)	1.1	1.4	4.0	-1.6	-0.2	-1.7	-0.7	0.0	-2.0	-1.4	0.3	-1.0	-1.4	-0.7	-0.7
Pulse rate, automated reading	1.1	3.4	9.1	1.8	1.6	3.0	1.0	0.0	1.6	2.3	1.0	1.6	2.4	2.5	1.3
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.1	-0.6	-1.8	0.9	-0.3	0.0	-0.5	-1.1	-1.6	-1.4	-1.1	-1.2	-1.6
Commuting to job workplace: Walk	1.1	1.2	2.2	-1.0	-1.3	-1.5	-1.4	1.2	-0.6	-0.9	-0.3	-0.7	-1.4	-1.4	-1.1
High cholesterol (Self-reported)	1.1	2.0	8.4	-1.6	-0.2	-2.9	0.6	-0.3	-1.9	-1.2	0.8	-1.2	-1.8	-1.0	-0.9
Irritability	1.1	1.8	3.5	-1.8	-1.3	0.4	0.4	-1.7	-1.9	-1.1	-0.7	-1.6	-1.2	-1.5	-1.3
Lupus	1.0	1.6	6.8	1.4	0.5	1.5	2.6	1.1	0.9	0.8	1.5	0.3	0.3	1.3	-0.7
Neuroticism	1.0	2.5	6.9	1.3	1.2	0.1	1.4	-0.1	1.7	2.4	2.6	1.4	1.7	1.8	1.2
Severe depression (siblings)	1.0	1.1	6.5	0.1	1.1	-2.5	0.6	0.5	0.5	0.5	0.6	1.1	0.4	0.4	1.6
Taking other prescription medications	1.0	1.5	4.2	-1.8	-1.4	0.3	-0.2	-2.1	-1.3	0.1	-1.2	-1.2	-0.8	-1.3	-1.4
Pain all over the body in last month	1.0	1.1	3.2	1.4	0.7	1.3	1.8	1.0	1.0	0.8	0.3	0.6	0.4	1.4	-0.5
Weight	1.0	4.8	19.4	-1.3	-2.5	4.4	-0.2	-2.7	-1.3	0.1	-2.4	-1.9	-0.7	-1.2	-3.2
Noisy workplace	1.0	1.2	2.6	1.2	1.0	-1.4	0.3	-0.0	1.3	0.7	1.6	1.0	0.9	1.2	1.3
Length of working week for main job	1.0	1.1	2.4	1.2	0.9	-0.3	1.1	0.4	1.6	1.4	-0.1	1.6	1.1	0.7	1.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.7	-1.4	-1.2	-0.9	-2.2	-1.0	-1.4	-1.3	-1.0	-1.1	-0.7	-1.3	-0.7
Shortness of breath walking on level ground	1.0	1.2	5.5	0.8	0.8	-0.6	2.4	0.9	0.6	0.5	2.2	0.4	0.2	0.9	0.3
Emphysema/chronic bronchitis	1.0	1.1	6.4	0.4	0.0	1.2	-0.4	-0.3	1.3	2.5	-0.1	1.0	1.3	0.5	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	5.5	0.7	0.6	-1.1	1.9	2.3	0.4	-0.5	1.7	0.5	-0.0	0.6	0.4
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.5	1.2	1.2	1.0	1.9	-0.3	0.6	0.6	0.9	0.8	1.3	1.4	0.9
Whole body fat-free mass	1.0	5.7	39.8	1.5	-1.0	6.3	1.4	-2.9	1.4	2.3	-1.3	-0.2	1.9	1.0	-1.4
Leg fat-free mass (right)	1.0	5.4	38.1	1.6	-0.8	6.2	1.6	-2.5	1.4	1.9	-1.2	-0.1	2.0	1.1	-1.4
Whole body water mass	1.0	5.6	38.7	1.5	-1.0	6.2	1.4	-2.7	1.4	2.3	-1.3	-0.2	1.8	1.0	-1.4
Leg predicted mass (right)	1.0	5.3	37.3	1.6	-0.8	6.1	1.6	-2.5	1.4	1.9	-1.2	-0.1	1.9	1.1	-1.4
Unable to work because of sickness or disability	1.0	1.3	3.9	1.3	0.1	0.8	0.7	1.1	2.0	1.9	1.4	0.9	0.6	0.9	0.2
Major Depression (MDD)	0.9	1.1	2.7	1.2	0.6	-0.7	1.0	0.2	1.6	1.5	-0.0	1.2	1.0	1.1	0.9
Ovarian Cancer	0.9	1.1	2.9	0.1	1.0	-1.3	-0.4	1.7	0.8	0.9	0.4	1.3	1.0	0.8	1.6
Age when periods started (menarche)	0.9	2.2	12.9	1.5	0.6	3.6	1.5	-0.4	1.0	0.8	-1.3	0.4	1.8	1.4	0.5
Past tobacco smoking	0.9	1.7	9.5	-1.4	-1.0	0.4	-1.0	-3.1	-1.0	-0.9	-1.5	-0.8	-0.1	-1.3	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.2	2.3	1.4	-0.6	1.5	2.0	1.9	0.4	1.4	0.9	0.5	1.8	0.8
Alcohol intake versus 10 years previously	0.9	1.3	3.2	-1.4	-1.7	0.0	-0.6	-0.5	-0.9	-0.0	-0.9	-1.3	-1.7	-1.1	-1.8
Pulse rate	0.9	1.5	3.3	0.9	1.1	1.5	0.5	-0.1	1.1	1.5	0.8	1.3	1.8	1.6	1.2
Tense / ‘highly strung’	0.9	1.5	2.5	1.4	1.4	0.5	1.6	0.3	1.5	1.3	1.6	1.1	1.1	1.5	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	2.5	-1.5	-1.1	-1.4	-1.6	-0.1	-1.2	-1.0	0.4	-1.0	-1.4	-1.4	-0.9
Loud music exposure frequency	0.9	1.0	4.6	0.9	0.9	1.2	2.1	1.1	0.7	0.5	1.0	0.2	0.7	1.0	0.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	5.3	1.7	-0.3	2.3	-0.8	-0.3	1.6	0.7	-1.2	0.4	1.7	0.7	0.6
Arm fat-free mass (right)	0.9	4.8	34.8	1.0	-1.1	5.9	1.3	-2.5	1.1	2.0	-1.4	-0.4	1.4	0.6	-1.6
Arm predicted mass (right)	0.9	4.8	32.8	1.2	-1.0	5.7	1.4	-2.6	1.3	2.2	-1.1	-0.3	1.6	0.8	-1.5
Hypertension (Self-reported)	0.9	2.6	6.2	-2.4	-0.7	-2.2	0.4	0.0	-2.2	-1.1	0.7	-1.2	-2.5	-1.8	-1.6
Eye problems/disorders: Cataract	0.9	1.1	3.2	-1.2	-0.7	-0.7	-1.3	-1.8	-1.4	-0.6	-0.6	-0.6	-0.7	-1.3	-0.2
Medication: Gliclazide	0.9	1.0	1.6	-1.2	-1.1	0.3	-0.6	-0.9	-1.1	-0.7	-1.3	-1.2	-1.0	-1.1	-1.1
Basal metabolic rate	0.9	4.8	34.2	0.9	-1.4	5.8	1.1	-2.8	0.8	1.8	-1.4	-0.6	1.3	0.5	-1.8
Supplements: Calcium	0.9	1.0	3.3	-1.2	-0.7	-1.8	-0.8	-1.1	-0.9	-0.6	-0.8	-0.6	-1.0	-0.9	-0.7
Blood Eosinophil Count	0.8	6.2	20.9	1.9	3.2	-1.3	4.6	1.0	1.6	2.0	3.1	2.6	1.4	2.8	2.2
Medication: Co-codamol	0.8	1.0	6.7	0.9	0.7	0.6	0.4	2.6	0.9	0.6	0.6	0.7	0.2	1.0	0.1
Leg fat-free mass (left)	0.8	4.3	31.0	0.6	-1.3	5.6	1.2	-2.8	0.5	1.4	-1.4	-0.7	1.2	0.4	-1.8
High blood pressure	0.8	2.1	4.7	-2.0	-0.3	-2.2	0.9	0.2	-2.0	-0.9	1.3	-0.9	-2.1	-1.4	-1.3
Leg predicted mass (left)	0.8	4.4	31.7	0.8	-1.2	5.6	1.2	-2.8	0.6	1.5	-1.4	-0.6	1.2	0.5	-1.8
Had other major operations	0.8	0.9	1.7	-1.1	-0.6	-0.9	-1.2	0.3	-1.0	-0.9	-1.3	-0.8	-1.2	-1.1	-0.7
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.9	0.7	0.7	1.4	1.3	-1.0	0.6	1.1	-0.2	0.5	1.3	1.1	0.8
Number of children fathered	0.8	0.9	1.7	-0.8	-1.1	0.9	-0.7	-0.9	-1.0	-1.0	-1.0	-1.1	-0.8	-0.9	-1.3
Breast cancer (self-reported)	0.8	1.0	6.3	0.5	-0.7	2.5	-0.5	0.7	0.6	0.7	-1.7	-0.1	0.4	0.2	-0.7
Arm fat-free mass (left)	0.8	4.1	28.6	0.7	-1.4	5.3	1.0	-2.4	0.8	1.9	-1.3	-0.6	1.1	0.4	-1.8
Ever had prostate specific antigen (PSA) test	0.8	1.0	2.7	-0.9	0.2	-1.6	-0.4	-1.2	-1.4	-1.5	-0.2	-0.7	-1.1	-0.7	-0.1
Ever depressed for a whole week	0.8	1.0	2.7	1.1	0.9	-0.8	1.6	0.1	0.8	0.5	1.6	0.6	0.6	1.3	0.5
Alcohol drinker status: Previous	0.8	0.9	3.1	0.2	0.7	-0.8	-1.8	-0.1	1.2	1.2	0.5	1.1	0.5	0.1	1.4
Arm predicted mass (left)	0.8	4.0	27.1	0.6	-1.4	5.2	1.0	-2.7	0.7	1.7	-1.2	-0.7	1.0	0.3	-1.9
Hearing difficulty/problems with background noise	0.7	1.1	7.1	-0.9	-0.4	-2.7	-0.6	0.8	-0.4	-0.4	1.1	-0.6	-1.2	-0.8	-0.4
Hip circumference	0.7	3.2	11.3	-1.4	-2.1	3.4	-0.2	-1.6	-1.3	-0.1	-2.1	-1.5	-0.8	-1.2	-2.7
Father’s age at death	0.7	1.0	3.8	0.1	-0.9	1.6	-1.3	-1.1	0.1	-0.1	-1.9	-0.8	0.1	-0.4	-0.7
Illnesses of mother	0.7	0.9	3.3	1.3	-0.3	1.8	-0.2	-0.5	1.6	0.9	0.0	0.4	1.2	0.7	0.4
Exposure to tobacco smoke at home	0.7	0.8	1.6	1.0	0.8	1.1	0.9	0.4	1.0	1.3	-0.4	0.8	0.8	1.3	0.4
Pulse wave reflection index	0.7	0.8	1.4	-0.6	-1.0	0.9	-1.0	-0.1	-1.2	-1.1	-1.0	-0.9	-0.8	-0.8	-1.2
Health satisfaction	0.7	0.9	3.8	0.6	1.0	-0.3	1.9	-0.4	0.7	1.3	1.1	0.8	0.4	0.7	0.5
Medication: Blood pressure	0.7	1.3	4.0	-2.0	-0.3	-1.4	0.5	-0.9	-1.9	-0.5	0.3	-0.6	-1.4	-1.4	-0.9
Age at last live birth	0.7	1.0	2.3	-1.0	-1.4	-0.6	-1.5	0.9	-0.5	-0.8	-1.2	-1.0	-0.8	-1.2	-0.6
Medication: Aspirin	0.7	0.9	3.1	-1.8	0.3	-1.7	0.3	0.5	-1.7	-0.0	0.0	-0.5	-0.9	-0.4	-0.4
Mineral and other dietary supplements	0.7	0.9	1.5	1.1	1.1	0.8	1.1	1.0	1.0	0.7	1.2	0.9	0.8	0.9	0.9
Osteoporosis (self-reported)	0.7	0.9	3.4	0.1	1.3	-1.5	-0.6	0.1	0.3	0.4	0.2	1.3	1.0	0.4	1.8
Guilty feelings	0.7	1.1	3.6	1.0	1.0	-0.2	1.1	0.7	1.1	0.9	1.9	0.9	1.0	1.1	1.0
Hearing aid user	0.7	0.8	1.5	1.1	1.1	0.4	-0.1	0.7	1.2	0.5	1.2	1.0	0.6	1.1	0.8
Eye problems/disorders: Glaucoma	0.7	0.8	1.8	1.1	0.0	0.6	1.3	1.2	1.3	1.3	0.3	0.8	0.8	0.7	0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.4	-1.5	-0.0	-1.3	0.1	0.2	-1.5	-0.3	0.2	-0.6	-1.5	-1.4	-0.4
Medication: Paracetamol	0.7	1.1	3.3	0.5	0.4	-1.2	0.4	-0.1	1.6	1.8	1.7	0.8	1.0	0.6	0.8
Worry (Nagel 2018)	0.6	1.3	5.6	1.0	1.1	-0.4	0.6	0.9	1.3	1.3	2.4	0.9	0.6	1.3	0.6
HbA1C	0.6	0.7	1.6	0.6	0.6	-1.0	0.7	0.7	0.9	1.3	0.7	0.9	0.6	0.6	0.9
Neuroticism (2016)	0.6	0.8	1.4	0.7	0.6	-1.1	1.2	0.8	1.0	0.8	0.9	0.8	0.7	0.9	1.2
Ulcerative Colitis	0.6	0.8	3.4	-1.0	-0.1	-1.8	-1.3	-1.2	-0.8	-0.6	0.3	-0.2	-0.7	-0.9	0.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.3	0.5	1.1	-0.1	1.8	0.2	0.6	1.7	1.0	1.1	0.9	1.2	0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	2.1	0.8	0.8	0.7	1.4	-0.6	0.7	0.9	0.4	0.6	0.8	0.8	0.6
Multivitamins +/- minerals	0.6	0.8	2.1	-0.0	1.0	-0.7	-0.1	-1.3	-0.5	0.4	-1.1	0.9	1.2	0.5	1.4
Medication: Atenolol	0.6	0.8	4.3	-1.3	-0.0	-2.1	-0.8	0.3	-0.9	-0.2	0.9	-0.3	-0.8	-0.7	-0.0
High blood pressure (mother)	0.6	0.8	1.9	-0.9	-0.5	1.0	1.4	-1.2	-1.3	-0.2	-0.7	-0.8	-0.3	-0.7	-0.8
Time employed in main current job	0.6	0.7	2.1	-0.5	-0.4	-1.3	-1.4	-0.9	0.0	0.3	-1.4	0.2	0.2	-0.6	0.7
Worrier / anxious feelings	0.6	1.1	3.8	-0.8	-0.5	-1.9	-0.9	1.1	-0.8	-1.2	1.1	-0.7	-1.2	-0.9	-0.5
Number of live births	0.6	0.9	1.9	0.3	0.8	-0.8	-0.8	0.7	1.1	1.4	1.1	1.0	0.9	0.7	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.2	-1.2	-0.5	-0.4	-0.8	-1.2	-1.5	-0.9	0.1	-1.1	-0.1	-0.7	-0.1
Medication: Cholesterol lowering	0.6	1.0	4.2	-0.6	0.6	-2.0	1.3	1.4	-0.5	0.1	1.2	-0.1	-1.1	0.1	-0.3
Blood clot in the leg (DVT)	0.6	0.8	2.4	-1.5	-0.4	0.1	-0.0	-0.5	-1.4	-0.9	-0.1	-1.0	-1.1	-0.9	-0.8
Eye problems/disorders: None of the above	0.6	0.7	2.0	-1.1	-0.3	-0.5	-1.3	-0.5	-1.0	-1.4	-0.4	-0.6	-0.7	-0.7	-0.3
Medication: Ibuprofen	0.6	0.7	2.6	0.7	0.3	1.6	1.2	-0.8	0.9	0.7	0.2	0.2	1.2	0.6	0.3
Mean time to correctly identify matches	0.6	1.2	2.9	-1.5	-1.2	0.1	-1.1	-0.3	-0.7	-0.0	-1.7	-0.8	-1.1	-1.7	-1.0
Overall health rating	0.6	1.3	3.7	0.2	0.9	-1.5	1.6	1.3	1.0	1.9	1.1	1.2	0.0	0.5	0.4
Knee pain experienced in last month	0.6	0.9	1.4	-1.1	-0.9	1.1	-0.4	-1.1	-0.9	0.4	-1.2	-0.6	-0.8	-1.1	-1.2
Qualifications: nursing, teaching	0.6	0.9	1.9	-1.0	-0.5	0.4	-0.9	-0.5	-1.4	-1.2	-1.3	-0.6	-0.8	-1.0	-0.9
Medication: Aspirin	0.6	0.8	3.3	-1.3	1.0	-1.8	0.8	0.7	-1.3	0.2	0.6	0.1	-0.5	0.2	0.4
Mother’s age at death	0.6	0.8	2.6	-1.0	-0.6	-0.5	-1.2	-1.4	-0.7	-0.1	-1.6	-0.6	-0.3	-0.8	-0.2
Medication: Lisinopril	0.6	0.7	4.9	-0.7	-0.3	0.9	0.4	-2.2	-0.7	0.9	-0.0	-0.1	-0.3	-0.8	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	3.3	0.3	-0.6	1.8	0.7	0.4	0.6	0.8	-1.7	-0.1	-0.0	-0.2	-0.7
Crohns Disease (2017)	0.5	1.1	2.8	1.0	0.8	-0.6	-1.0	0.1	1.3	1.3	1.2	1.7	0.7	0.6	1.1
Ulcerative Colitis (UC)	0.5	1.0	4.8	-1.1	0.3	-2.2	-0.9	-0.8	-1.1	-1.2	-0.3	-0.1	-0.9	-1.0	0.3
LDL Cholesterol	0.5	0.9	2.0	0.5	1.4	-0.5	1.0	-0.4	0.4	0.9	0.6	1.2	0.8	1.1	1.4
Hearing difficulty/problems: Yes	0.5	0.8	5.8	-1.1	-0.1	-2.4	-0.3	-0.0	-0.6	0.3	0.8	0.1	-0.7	-0.8	0.0
Medication: Metformin	0.5	0.7	3.8	-0.8	0.2	-2.0	-0.1	0.3	-0.8	-0.4	0.9	-0.3	-1.1	-0.3	-0.3
Hand grip strength (right)	0.5	1.5	3.7	1.3	1.0	0.7	0.3	-0.9	1.3	1.3	1.0	1.4	1.9	1.2	1.5
Average weekly fortified wine intake	0.5	0.6	2.9	-0.0	-0.5	-1.1	-1.7	-0.6	-0.1	-0.8	-0.6	-0.3	-0.5	-0.7	-0.1
Relative age voice broke	0.5	0.8	3.6	-0.4	-1.0	-0.4	-0.9	1.9	-0.5	-1.2	-0.0	-0.8	-0.9	-0.5	-0.9
Nervous feelings	0.5	1.0	2.9	1.0	1.0	-0.3	0.5	1.4	0.9	0.4	1.7	0.8	1.0	1.1	0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.1	4.0	-1.1	-0.5	-0.7	-0.9	-0.5	-2.0	-1.8	-0.3	-1.1	-0.7	-0.8	-0.4
Birth weight of first child	0.5	0.9	3.5	0.9	-1.1	1.9	-0.9	-0.8	0.9	0.4	-0.9	-0.8	0.5	0.4	-1.1
Medication for pain relief, constipation, heartburn	0.5	0.8	2.7	-0.1	-0.8	-0.5	-1.5	0.7	-0.6	-1.6	-0.7	-0.6	-1.0	-0.7	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	3.5	-1.0	-0.4	0.2	-0.0	-1.9	-0.9	-0.2	-0.7	-0.5	-0.4	-1.0	-0.5
Ever taken oral contraceptive pill	0.5	0.5	2.0	0.0	0.1	-0.6	0.8	1.4	-0.7	-1.0	0.7	-0.6	-0.7	0.0	-0.6
Average weekly beer plus cider intake	0.5	0.8	2.6	0.3	0.9	-0.5	0.5	0.0	0.5	1.3	1.6	1.0	0.8	1.1	0.9
Pain experienced in last month	0.5	0.9	3.1	0.9	-0.8	1.8	-1.2	-0.4	0.2	-1.4	-1.4	-0.8	0.3	0.5	-0.2
Crohns Disease (2012)	0.4	0.6	1.8	1.0	0.6	0.0	-0.6	-1.3	0.7	0.7	0.8	0.9	0.7	0.9	0.3
Fasting Glucose	0.4	0.5	2.0	1.0	0.0	0.6	-0.4	1.4	1.3	0.1	0.4	-0.0	-0.1	0.6	-0.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	3.2	0.1	-0.3	-1.2	0.8	0.5	0.5	0.7	1.8	0.1	-0.4	-0.1	-0.4
Pack years adult smoking proportion	0.4	0.6	2.5	0.4	0.8	0.8	1.6	0.4	0.2	0.4	0.4	0.6	1.0	0.9	0.9
Maternal smoking around birth	0.4	0.5	2.3	0.4	-0.1	1.0	0.1	1.5	1.1	1.2	0.1	0.3	0.3	0.4	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.8	0.3	0.1	0.1	1.7	0.7	1.0	1.5	0.5	0.5	0.4	0.3	0.1
Neuroticism score	0.4	0.9	3.3	0.8	0.6	-0.7	0.9	0.3	1.1	1.5	1.8	0.6	0.8	0.9	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	4.0	0.2	0.8	-0.9	0.6	-0.3	0.4	0.8	2.0	0.6	0.4	0.5	0.5
Falls in the last year	0.4	0.5	2.6	-0.5	-1.2	0.5	-1.6	-0.5	-0.2	0.1	-0.7	-0.7	-0.1	-0.6	-0.5
Happiness	0.4	0.5	1.6	0.6	0.1	0.5	1.1	1.1	0.9	1.3	0.1	0.2	0.4	0.6	-0.1
Medication: Lansoprazole	0.4	0.5	2.4	-0.0	-0.4	-0.2	-0.6	-1.0	0.8	1.5	-1.0	0.3	0.4	0.0	0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.2	-1.2	-0.7	0.5	1.8	-1.0	-1.0	0.3	-0.5	-0.7	-0.5	-0.7	-0.9
Medication: Amlodipine	0.4	0.5	3.2	-1.0	0.4	-1.8	0.6	0.1	-0.9	0.2	0.3	0.4	-0.1	-0.3	0.5
Qualifications: College or University degree	0.4	1.4	4.3	-0.7	-1.1	-0.1	-0.3	0.9	-1.7	-2.1	-1.1	-1.5	-0.9	-0.8	-1.3
Medication: Seretide 50 evohaler	0.4	0.5	3.3	0.2	0.3	-1.2	0.4	1.8	0.5	0.3	0.4	0.7	0.1	0.2	0.4
Family relationship satisfaction	0.4	0.5	1.2	-1.1	-1.1	0.3	-0.1	-0.3	-0.4	0.4	-1.0	-0.8	-0.5	-0.9	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.2	-0.8	-0.4	-1.5	-0.7	-1.2	-0.3	-0.1	-0.1	-0.3	-0.5	-0.7	0.0
Average weekly red wine intake	0.4	0.6	1.7	0.8	0.5	1.1	0.7	-0.2	0.6	0.7	-0.1	0.5	1.3	0.8	0.9
Mood swings	0.4	0.7	1.7	-1.3	-1.1	-0.2	-0.2	-1.3	-0.9	0.5	-0.2	-0.8	-0.6	-1.0	-0.8
Medication for cholesterol	0.4	0.6	2.4	0.6	-0.2	1.6	-1.5	-0.2	0.6	-0.4	-1.2	-0.2	0.2	0.2	-0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	2.9	-0.5	-0.2	-1.7	0.9	1.0	-0.4	-0.2	0.2	0.0	0.0	-0.1	0.2
Medication: Blood pressure	0.4	0.7	3.3	-0.4	0.5	-1.3	1.4	0.3	-0.7	0.4	1.8	0.3	-0.5	-0.1	0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.8	-1.4	-0.3	0.4	-0.1	-0.3	-1.1	-0.6	0.2	-0.8	-0.9	-0.7	-0.8
Schizophrenia vs Biploar Disorder	0.3	0.5	0.9	0.2	1.0	-0.9	0.9	1.0	0.1	0.5	0.7	0.7	0.1	0.6	0.5
Alzheimer’s Disease (in father)	0.3	0.3	2.2	0.5	0.0	-0.2	-1.5	-0.3	0.6	0.5	-0.1	0.3	-0.2	-0.0	-0.0
Irritable Bowel Disease (IBD)	0.3	0.7	4.1	-0.5	0.4	-2.0	-1.3	-0.7	-0.2	-0.1	0.4	0.7	-0.4	-0.6	0.7
Prostate Cancer	0.3	0.4	2.3	-0.3	-0.2	-0.1	-1.5	-0.9	-0.2	-0.6	-0.2	-0.4	-0.4	-0.4	-0.3
Hypothyroidism (self reported)	0.3	0.7	3.1	-1.3	-0.0	-0.4	1.8	-1.3	-1.0	0.8	0.0	-0.1	-0.3	-0.6	-0.1
Hair Pigment	0.3	7.9	14.2	3.8	2.1	0.1	2.9	3.7	3.6	2.6	2.8	2.6	2.2	3.5	1.6
Number of treatments/medications taken	0.3	0.5	1.7	-1.3	-0.5	-0.6	0.5	-0.8	-0.6	0.7	-0.5	-0.4	-0.6	-0.6	-0.7
Average weekly spirits intake	0.3	0.4	1.0	0.6	-0.2	0.9	-0.4	0.3	1.0	1.0	0.0	0.2	0.7	0.6	-0.1
Vitamin and mineral supplements	0.3	0.3	1.5	0.4	0.1	0.3	0.6	1.2	0.6	0.3	1.0	-0.1	-0.5	0.3	-0.5
Diabetes (father)	0.3	0.3	1.5	-0.7	-0.4	-0.5	-1.2	-0.5	-0.2	-0.3	-0.7	0.1	-0.1	-0.7	0.2
Diabetes (mother)	0.3	0.3	0.9	-0.4	0.1	0.6	0.6	0.2	-0.9	-0.9	0.3	-0.5	-0.6	-0.1	-0.8
Supplements: Glucosamine	0.3	0.4	1.3	-0.2	-0.8	1.1	0.2	0.3	-0.5	-0.4	-1.2	-0.6	-0.1	-0.2	-0.9
Medication: Ramipril	0.3	0.4	1.3	0.1	0.9	-1.0	0.6	0.3	-0.2	0.2	1.1	0.6	0.1	0.3	0.5
Hair/balding pattern: Pattern 3	0.3	0.4	2.5	-0.2	-0.4	-0.3	0.2	1.6	-0.3	-0.6	-0.0	-0.7	-0.6	-0.4	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	2.8	0.3	-0.1	1.7	0.7	-1.1	0.3	0.1	0.1	-0.3	0.6	0.1	-0.2
Pulse wave Arterial Stiffness index	0.3	0.3	1.5	0.7	0.2	1.2	-0.0	0.7	0.3	0.1	-0.1	0.4	0.6	0.7	0.0
Gout (self-reported)	0.3	0.4	2.9	-0.0	0.5	0.2	0.9	-0.2	-0.1	0.9	1.7	0.5	0.2	0.3	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.0	-0.3	0.4	-1.0	-0.4	-0.6	-0.8	-0.7	-0.1	-0.2	-0.7	-0.2	0.2
Medication: Allopurinol	0.3	0.4	1.1	-0.9	-0.3	-0.5	0.7	0.5	-1.0	-0.0	0.6	-0.4	-0.7	-0.6	-0.4
Medication: Omeprazole	0.3	0.3	2.0	0.1	0.1	1.4	0.8	0.4	0.1	0.2	-1.0	-0.1	-0.1	-0.0	-0.3
Chest pain or discomfort	0.3	0.5	1.8	-1.4	-0.0	-0.8	0.4	-0.1	-1.3	0.6	0.2	-0.1	-0.6	-0.5	-0.3
Loneliness, isolation	0.3	0.4	1.6	-0.2	0.1	-1.3	0.6	0.6	0.6	0.7	0.7	0.4	0.2	0.1	0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.3	-0.6	-0.2	-1.2	-0.4	-1.1	-0.6	-0.3	-0.7	-0.3	-0.2	-0.2	-0.2
Medication: Bendroflumethiazide	0.3	0.5	2.1	-0.0	0.7	-0.6	0.0	1.5	0.1	0.8	0.8	0.9	-0.2	0.2	0.6
Ever smoked	0.3	0.5	3.2	0.0	-0.3	-0.5	-0.3	1.8	-0.3	-0.6	-0.0	-0.5	-0.8	-0.3	-0.7
Basal cell carcinoma (self-reported)	0.3	0.3	1.9	0.1	-0.1	-1.4	-0.4	0.5	0.5	-0.3	-0.9	-0.3	-0.4	-0.3	0.1
Pack years of smoking	0.3	0.4	2.0	0.1	0.6	0.8	1.4	0.5	0.1	0.4	-0.1	0.5	0.8	0.6	0.6
Reaction Time	0.2	0.4	1.6	-0.9	-0.8	-0.5	-0.4	-0.3	0.1	0.4	-0.8	-0.4	-0.6	-1.3	-0.5
Mean Putamen Volume	0.2	0.2	0.5	-0.7	0.2	-0.7	-0.6	-0.3	-0.5	0.2	-0.4	-0.4	-0.5	-0.2	-0.2
Hand grip strength (left)	0.2	0.6	1.6	0.9	0.6	0.6	0.7	-0.4	0.7	0.7	1.3	0.7	1.2	0.7	0.8
Impedance of leg (right)	0.2	0.8	2.9	-1.1	-0.3	-1.7	-1.5	0.6	-0.8	-0.6	-0.0	-0.3	-1.0	-0.9	0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.2	-0.1	0.2	0.9	0.1	-1.1	-0.1	0.1	-0.9	0.1	0.1	0.1	-0.1
Medication: Levothyroxine sodium	0.2	0.3	2.4	-0.4	-0.3	0.4	1.5	-0.0	-0.0	0.7	0.5	-0.2	0.1	-0.2	-0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.7	-0.1	-0.0	-0.8	1.3	-0.7	0.0	0.1	0.6	-0.1	0.1	0.1	-0.2
Mouth/teeth dental problems	0.2	0.3	1.0	0.3	0.6	0.1	-0.4	-1.0	-0.5	-1.0	-0.4	0.0	0.6	0.4	0.9
Mouth/teeth dental problems: Dentures	0.2	0.3	1.7	0.1	-0.2	0.5	0.6	1.3	0.7	0.9	-0.4	0.2	-0.1	0.0	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	5.4	0.4	-0.4	2.3	0.5	-0.6	-0.0	0.0	-0.3	-0.6	0.7	0.4	-0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.8	0.1	-0.9	0.2	-0.1	0.5	0.6	0.5	0.3	-0.2	-0.5	-0.6	-0.7
Medication: Paracetamol	0.2	0.4	1.7	-0.3	-0.4	-1.0	-0.2	-0.6	0.6	0.6	1.3	-0.2	-0.0	-0.2	-0.2
Glaucoma (self-reported)	0.2	0.3	1.7	0.2	-0.2	-0.3	0.8	1.3	-0.1	0.0	0.2	-0.1	-0.5	-0.2	-0.5
Exposure to tobacco smoke outside home	0.2	0.3	1.4	-0.6	0.4	-0.0	-0.2	0.6	0.3	0.7	-0.7	0.5	0.3	-0.2	1.2
Wheeze or whistling in the chest in last year	0.2	0.3	2.3	-0.6	0.3	-1.5	-0.1	-0.1	0.0	0.6	-0.8	0.4	-0.0	-0.2	0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.6	0.2	0.1	0.5	-0.5	-0.7	0.6	0.7	-0.4	0.3	0.6	0.3	0.5
Had major operations	0.2	0.3	1.6	-0.2	-0.1	0.4	-1.2	-0.5	-0.2	-0.2	-0.8	-0.0	-0.3	-0.2	-0.2
Leg pain on walking	0.2	0.2	0.9	0.2	0.0	0.7	0.6	-0.6	0.8	0.9	-0.3	0.3	0.1	0.1	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	0.3	0.6	-0.7	0.3	-0.4	0.7	0.7	0.6	0.5	0.3	0.4	0.6
Long-standing illness, disability or infirmity	0.2	0.2	1.1	-0.3	-0.2	-0.8	-0.4	0.3	0.5	1.0	0.5	0.1	-0.4	-0.2	-0.1
Diabetes diagnosed by doctor	0.2	0.3	0.8	-0.7	-0.0	-0.4	0.7	0.3	-0.9	-0.1	0.9	-0.6	-0.6	-0.0	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.4	0.2	-0.1	0.1	0.9	0.7	-0.1	0.3	1.2	-0.3	-0.3	0.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.0	-0.9	-0.5	-1.0	-0.3	-0.6	-0.8	-0.5	0.0	-0.7	-0.6	-0.6	-0.5
Wears glasses or contact lenses	0.2	0.2	1.6	-0.4	0.0	0.2	-0.8	-1.3	0.1	0.6	-0.3	0.2	-0.1	-0.2	0.1
Commuting to job workplace: Public transport	0.2	0.2	0.8	-0.4	-0.9	0.4	-0.4	-0.4	0.0	0.2	-0.7	-0.5	-0.0	-0.6	-0.4
Medication: Atorvastatin	0.2	0.2	0.8	-0.6	0.2	-0.6	0.9	-0.2	-0.7	0.2	-0.3	-0.0	-0.1	-0.0	-0.1
Risk taking	0.2	0.3	1.2	0.1	0.4	-0.5	0.6	-1.1	0.3	1.0	-0.1	0.6	0.5	0.5	0.6
Diastolic blood pressure, automated reading	0.2	0.5	2.2	-0.8	-0.1	0.7	1.5	-0.7	-0.9	0.1	-0.6	-0.4	-0.4	-0.1	-1.0
Commuting to job workplace: Cycle	0.2	0.3	1.5	-0.2	0.4	-1.2	-0.2	-0.1	-0.4	-0.2	0.4	0.4	0.2	-0.2	0.9
Rheumatoid Arthritis	0.1	0.2	0.6	-0.2	-0.1	0.7	0.4	-0.6	-0.7	-0.1	0.1	-0.4	0.3	-0.0	-0.3
Waist Hip Ratio (WHR)	0.1	0.5	1.4	-0.2	-0.4	-0.3	0.9	0.9	-0.2	-0.6	-0.4	-1.1	-1.1	-0.4	-1.2
Systolic Blood Pressure	0.1	0.7	3.5	-0.6	0.7	-0.4	0.9	-1.7	-0.3	0.1	1.9	0.2	-0.2	0.3	0.5
Tanning	0.1	1.5	5.3	-0.8	-2.3	1.4	-0.6	-0.5	0.1	-0.2	-1.8	-1.2	-0.6	-1.4	-1.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.9	-0.5	-0.3	-0.9	-0.1	-0.3	-0.0	0.1	-0.3	-0.3	-0.6	-0.5	-0.5
Systolic blood pressure, automated reading	0.1	0.3	0.9	-0.8	-0.3	0.0	0.6	-1.0	-0.3	0.2	-0.2	-0.4	-0.7	-0.4	-0.8
Current tobacco smoking	0.1	0.1	0.6	0.3	-0.3	0.8	0.1	0.2	0.3	0.0	0.2	-0.0	0.2	0.0	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	0.1	0.5	-0.6	0.3	-0.3	-0.2	0.1	-0.1	0.4	-0.5	-0.2	0.0
Impedance of leg (left)	0.1	0.5	2.1	-0.4	-0.2	-1.1	-1.5	1.0	-0.1	-0.4	-0.1	-0.1	-0.5	-0.6	0.4
Alcohol usually taken with meals	0.1	0.2	0.8	0.9	0.2	0.2	-0.0	0.2	0.4	-0.3	-0.7	0.1	0.3	-0.0	0.3
Allergy	0.1	0.3	0.8	0.7	0.4	0.4	-0.7	-0.9	0.2	-0.1	-0.1	0.3	0.5	0.3	0.7
Diabetes (self-reported)	0.1	0.2	0.7	-0.4	0.5	-0.3	0.8	-0.3	-0.5	0.3	0.5	-0.0	-0.2	0.2	0.1
Impedance of arm (right)	0.1	0.4	2.8	-0.3	-0.1	-0.5	-1.7	0.4	-0.1	-0.4	-0.9	0.1	0.1	-0.3	0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	3.6	0.7	-0.4	1.9	0.6	0.2	0.2	0.0	-0.3	-0.5	0.7	0.4	-0.6
Impedance of arm (left)	0.1	0.4	1.8	0.2	0.0	0.4	-1.4	0.2	0.3	0.1	-1.2	0.2	0.5	-0.0	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	0.2	-0.1	0.3	0.5	0.5	0.6	0.4	0.8	-0.1	0.0	0.2	-0.2
Pulse wave peak to peak time	0.1	0.1	1.0	-0.4	-0.1	-0.5	0.1	-1.0	0.1	0.3	-0.0	-0.2	-0.1	-0.5	0.1
Suffer from ‘nerves’	0.1	0.2	0.8	0.1	-0.0	-0.1	-0.9	0.1	0.6	0.8	-0.0	0.1	0.0	0.0	0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.3	0.1	-0.1	0.3	0.1	-0.5	-0.1	-0.5	-0.5	-0.0	-0.3	-0.3	-0.3
Friendships satisfaction	0.1	0.1	0.4	-0.1	-0.3	0.6	0.6	0.4	0.3	0.6	-0.2	-0.3	0.1	0.1	-0.4
Smoking status: Current	0.1	0.2	0.7	0.5	-0.0	0.9	0.4	0.5	0.5	0.1	0.2	0.1	0.4	0.3	0.0
Myopia	0.1	0.2	1.0	-0.4	-0.2	0.2	-0.7	-0.0	-0.5	-0.3	-1.0	0.0	0.3	-0.3	0.4
Impedance of whole body	0.1	0.5	2.7	-0.3	-0.2	-0.7	-1.6	0.9	-0.1	-0.4	-0.9	-0.0	-0.3	-0.5	0.4
Chronotype (morning person)	0.0	0.1	0.3	0.1	0.1	-0.2	0.5	-0.2	0.3	-0.2	-0.1	-0.1	-0.6	0.2	-0.5

Hub : Genes

BLMH

Models

Trait associations