TWAS hub - NF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0640	0.0300	6.2e-05	0.013	0.040	0.020	0.039	0.027	0.009	1.1e-05	0.0016	1.3e-05	0.00024
2	METSIM	Adipose	0.0352	0.0171	5.7e-04	0.000	0.012	0.003	0.011	0.002	0.300	5.5e-03	0.1100	8.2e-03	0.17000
3	TCGA	Liver Hepatocellular Carcinoma	0.0350	0.0260	9.1e-03	0.030	0.031	0.026	NA	0.014	0.014	1.3e-02	0.0210	NA	0.07200

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Trunk predicted mass	11.5	65.6	70.7	7.5	8.4	8.4
Arm fat-free mass (right)	11.5	58.8	65.6	6.8	8.0	8.1
Trunk fat-free mass	11.4	65.7	71.6	7.4	8.4	8.5
Whole body fat-free mass	11.1	63.4	69.2	7.2	8.3	8.3
Arm predicted mass (right)	10.9	56.0	62.9	6.5	7.9	7.9
Whole body water mass	10.9	62.4	67.9	7.2	8.2	8.2
Arm fat-free mass (left)	10.5	53.1	60.4	6.4	7.8	7.6
Basal metabolic rate	10.2	56.2	62.6	6.7	7.9	7.8
Leg predicted mass (right)	9.6	51.0	56.0	6.5	7.5	7.4
Arm predicted mass (left)	9.5	48.1	54.0	6.1	7.3	7.3
Hip circumference	9.4	40.4	46.8	5.5	6.6	6.8
Comparative height size at age 10	9.4	51.9	58.8	6.3	7.5	7.7
Leg fat-free mass (right)	9.4	50.3	55.1	6.5	7.4	7.3
Leg predicted mass (left)	9.1	48.1	52.6	6.3	7.2	7.2
Leg fat-free mass (left)	8.8	46.7	51.1	6.2	7.2	7.1
Blood Platelet Count	8.5	98.6	110.2	-9.2	-10.0	-10.5
Chest pain or discomfort	8.1	11.7	14.4	-3.5	-2.9	-3.8
Height	7.2	138.1	163.8	10.0	12.8	12.3
Weight	6.9	34.0	39.1	4.9	6.2	6.2
Comparative body size at age 10	6.2	17.1	19.0	4.4	4.0	4.1
Standing height	5.9	59.0	66.6	7.0	8.2	7.9
Nervous feelings	5.6	10.4	13.3	3.0	3.0	3.6
Osteoarthritis (self-reported)	4.8	6.3	9.0	2.0	3.0	2.4
Medication: Omeprazole	4.7	5.7	7.4	-2.7	-2.4	-2.0
Supplements: Zinc	4.6	5.0	9.3	-1.2	-3.0	-2.0
Medication: Co-codamol	4.6	5.4	5.9	2.4	2.2	2.4
Lung FVC	4.4	22.2	32.0	-3.1	-5.7	-5.0
Medication: Amlodipine	4.4	6.1	7.8	2.6	1.9	2.8
Age at First Birth	4.3	6.3	9.9	3.1	1.8	2.4
Supplements: Glucosamine	4.3	5.7	6.9	2.5	2.0	2.6
Intelligence (Savage-Jansen 2018)	4.1	12.4	15.6	3.2	3.9	3.3
Body Mass Index (BMI) (2010)	4.1	5.6	7.6	2.3	2.0	2.8
Number of full brothers	4.1	5.2	6.3	-2.1	-2.1	-2.5
Had major operations	4.1	4.8	7.4	1.9	1.8	2.7
Eye problems/disorders: Glaucoma	4.1	4.9	6.4	1.5	2.4	2.5
Waist Hip Ratio (WHR)	3.9	17.7	22.4	-4.4	-3.4	-4.7
Relative age of first facial hair	3.9	7.9	9.0	-2.6	-3.0	-2.8
Impedance of leg (right)	3.9	18.9	21.5	-4.6	-4.0	-4.4
Impedance of arm (right)	3.8	17.9	22.7	-3.7	-4.1	-4.8
Qualifications: A levels/AS levels or equivalent	3.8	8.3	11.8	3.1	3.4	1.9
Shortness of breath walking on level ground	3.8	4.5	6.4	-2.5	-1.9	-1.9
Alcohol intake frequency.	3.8	8.9	14.3	1.9	3.0	3.8
Impedance of whole body	3.8	19.3	23.0	-4.2	-4.2	-4.8
Medication: Omeprazole (e.g. Zanprol)	3.7	4.6	5.7	-2.4	-2.2	-1.8
Mean Putamen Volume	3.6	4.2	5.4	-2.0	-1.8	-2.3
Impedance of arm (left)	3.6	16.6	21.3	-3.6	-3.9	-4.6
Verbal and Numeric Reasoning (VNR)	3.5	8.4	12.4	2.0	3.5	3.0
Impedance of leg (left)	3.5	17.0	19.4	-4.4	-3.8	-4.2
Ever had bowel cancer screening	3.5	4.1	5.2	-1.5	-2.3	-2.3
LDL Cholesterol	3.4	5.4	5.6	-2.3	-2.4	-2.4
Stomach or abdominal pain in last month	3.4	4.2	5.0	-1.7	-2.2	-2.2
Bipolar Disorder (2011)	3.2	3.1	6.6	0.0	1.6	2.6
Wheeze or whistling in the chest in last year	3.2	5.7	7.2	-2.5	-2.0	-2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.2	3.7	5.1	-2.3	-1.6	-1.9
Medication for pain relief, constipation, heartburn	3.0	5.0	9.0	3.0	1.8	1.7
Medication: Allopurinol	3.0	4.0	5.6	1.1	2.2	2.4
Supplements: Fish oil (including cod liver oil)	3.0	3.9	4.8	1.9	1.8	2.2
Hayfever, allergic rhinitis or eczema	2.9	6.3	8.9	1.6	2.7	3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.5	4.4	-1.5	-1.9	-2.1
High cholesterol (Self-reported)	2.9	5.1	7.3	-2.3	-2.7	-1.6
Breast Cancer	2.8	6.7	9.6	-1.8	-3.1	-2.7
Allergy or Eczema	2.8	7.5	12.3	1.5	2.8	3.5
Type 2 Diabetes (T2D) (2018)	2.7	5.1	7.9	1.8	2.1	2.8
Severe depression (siblings)	2.6	2.9	4.8	1.1	1.7	2.2
Medication: Paracetamol	2.6	4.2	6.4	-2.5	-1.4	-2.1
HbA1C	2.5	2.7	3.3	-1.8	-1.3	-1.8
Number of children fathered	2.4	2.7	3.9	-1.4	-2.0	-1.6
Arm fat mass (left)	2.4	10.0	12.4	2.5	3.5	3.4
Gout (self-reported)	2.3	3.1	4.0	1.2	2.0	2.0
Whole body fat mass	2.3	9.6	12.7	2.2	3.6	3.4
Risk taking	2.3	3.4	4.1	-1.8	-1.7	-2.0
Lupus	2.2	3.4	6.1	0.9	2.5	1.8
Diabetes (mother)	2.2	2.8	4.0	1.1	1.8	2.0
Sitting height	2.2	16.0	21.4	3.8	3.5	4.6
Trunk fat mass	2.2	9.5	12.1	2.3	3.5	3.3
Arm fat mass (right)	2.2	9.3	11.2	2.5	3.4	3.2
Leg fat mass (left)	2.2	8.5	11.3	1.9	3.4	3.3
Alzheimer’s Disease (including proxy)	2.1	3.1	4.4	1.5	2.1	1.6
Sensitivity / hurt feelings	2.1	3.5	5.4	-1.5	-2.3	-1.7
Prospective memory result	2.1	2.6	4.0	2.0	1.2	1.5
Exposure to tobacco smoke outside home	2.1	2.9	3.8	-1.7	-1.4	-1.9
Ever smoked	2.1	3.8	4.6	-1.9	-1.8	-2.2
Waist circumference	2.0	7.3	9.3	1.8	3.0	3.0
Eye problems/disorders: None of the above	2.0	2.3	3.6	-1.0	-1.5	-1.9
Neck or shoulder pain in last month	2.0	2.9	3.9	-2.0	-1.8	-1.2
Medication: Blood pressure	2.0	3.5	5.7	1.8	1.2	2.4
Commuting to job workplace: Public transport	2.0	2.4	3.4	1.1	1.9	1.5
Medication: Lisinopril	2.0	2.6	3.0	1.7	1.3	1.7
Maternal smoking around birth	1.9	2.8	3.2	-1.7	-1.5	-1.8
Number of live births	1.9	2.7	4.0	-1.3	-1.6	-2.0
Chronic bronchitis/emphysema (mother)	1.9	2.3	2.8	-1.7	-1.6	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	3.2	-1.8	-1.2	-1.6
Leg fat mass (right)	1.9	7.3	10.1	1.6	3.2	3.0
Worry (Nagel 2018)	1.8	3.8	6.5	1.1	1.9	2.5
Knee pain experienced in last month	1.8	2.9	4.1	1.0	2.0	1.9
Smoking Status	1.7	4.2	5.5	-2.0	-1.7	-2.3
Fluid intelligence score	1.7	3.6	5.2	1.4	2.3	1.9
Heart disease (mother)	1.7	2.1	3.0	-0.7	-1.6	-1.7
Average weekly red wine intake	1.7	2.5	3.9	-1.2	-1.4	-2.0
Diabetes diagnosed by doctor	1.7	2.9	5.0	1.5	1.1	2.2
Qualifications: nursing, teaching	1.7	2.7	4.3	1.6	2.1	1.2
Heart disease (siblings)	1.7	2.1	3.6	-0.8	-1.4	-1.9
Chronic bronchitis/emphysema (father)	1.6	1.9	2.2	-1.2	-1.4	-1.5
High blood pressure (mother)	1.6	2.2	4.0	1.1	2.0	1.1
Glaucoma (self-reported)	1.6	1.9	2.9	0.6	1.7	1.5
High blood pressure (siblings)	1.6	2.3	3.8	0.6	1.9	1.7
Hearing difficulty/problems with background noise	1.5	2.5	3.2	-1.3	-1.8	-1.6
Loud music exposure frequency	1.5	1.6	2.3	0.6	1.5	1.5
Qualifications: College or University degree	1.5	4.9	7.2	2.2	2.7	1.7
Hearing difficulty/problems: Yes	1.4	2.2	3.0	-0.8	-1.7	-1.7
Body mass index (BMI)	1.4	5.9	7.7	1.8	2.6	2.8
Smoking status: Previous	1.4	2.0	2.3	-1.4	-1.5	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	3.9	-1.1	-2.0	-2.0
Average weekly beer plus cider intake	1.4	2.0	3.2	-1.8	0.0	-1.6
Diastolic blood pressure, automated reading	1.4	4.3	6.9	1.6	2.6	1.9
Schizophrenia (2018)	1.3	2.6	3.8	-1.9	-1.3	-1.5
Illnesses of siblings: Diabetes	1.3	1.6	2.1	1.1	1.2	1.4
Mineral and other dietary supplements	1.3	1.8	2.6	-1.2	-1.1	-1.6
Blood Red Count	1.2	11.5	18.1	-4.3	-2.5	-3.2
Relative age voice broke	1.2	1.9	3.0	-0.9	-1.7	-1.4
Serious illness, injury or assault to yourself	1.2	1.5	3.2	0.4	1.8	1.0
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.3	-0.7	-1.5	-1.3
Past tobacco smoking	1.2	2.1	2.2	1.5	1.4	1.5
Medication: Seretide 50 evohaler	1.2	1.4	3.4	-1.8	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	2.5	1.6	1.6	1.5
Guilty feelings	1.2	1.8	3.5	-1.9	-1.0	-1.0
Cholesterol lowering medication	1.2	1.8	3.1	-1.2	-1.8	-1.0
BMI	1.1	6.4	8.3	1.7	2.9	2.9
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.6	4.0	-2.0	-0.5	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.6	-1.6	-0.5	-0.9
Financial situation satisfaction	1.1	1.3	1.7	-1.2	-1.3	-0.9
Medication: Paracetamol	1.1	1.8	2.6	-1.6	-0.9	-1.4
Supplements: Calcium	1.1	1.2	1.6	-0.8	-1.1	-1.2
Basal cell carcinoma (self-reported)	1.1	1.3	2.0	0.4	1.3	1.4
Medication: Lansoprazole	1.0	1.1	1.6	-1.2	-0.8	-1.0
Neuroticism (2016)	0.9	1.3	2.4	0.2	1.1	1.6
Medication for hormone replacement therapy	0.9	1.1	1.6	-1.0	-1.3	-0.8
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.6	-0.9	-0.8	-1.3
Worrier / anxious feelings	0.9	1.7	2.6	1.2	1.0	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.0	1.4	0.9	0.5
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.8	0.8	1.7	0.8
Reaction Time	0.8	1.4	2.5	0.1	1.6	1.3
High blood pressure	0.8	2.3	3.9	1.0	1.4	2.0
Medication: Atenolol	0.8	1.0	1.5	0.5	1.2	1.1
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.7	-1.6	0.1	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.9	-1.4	-0.9	-0.7
Pulse wave reflection index	0.8	1.0	1.6	1.3	0.2	1.1
Loneliness, isolation	0.8	1.1	2.5	-0.4	1.6	0.9
Bipolar Disorder or Schizophrenia	0.7	1.7	3.5	-1.9	-1.0	-0.8
Alzheimer’s Disease (in mother)	0.7	0.9	1.6	0.6	1.3	0.8
Crohns Disease (2012)	0.7	1.2	2.0	0.7	1.0	1.4
Diabetes (self-reported)	0.7	1.1	2.4	0.7	0.6	1.5
Medication: Simvastatin	0.7	1.0	1.6	-1.3	-1.1	-0.5
Pulse wave Arterial Stiffness index	0.7	0.8	1.6	0.8	0.5	1.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.3	-1.5	0.3	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.4	-0.8	-0.8	-1.2
Medication: Ibuprofen	0.7	0.8	1.7	-1.3	-0.7	-0.4
Hypertension (Self-reported)	0.7	2.0	3.5	1.1	1.2	1.9
Miserableness	0.7	1.2	3.3	-1.8	-0.6	-0.2
Myopia	0.7	1.1	1.9	-1.1	-0.4	-1.4
Schizophrenia vs Biploar Disorder	0.6	0.8	1.4	-1.2	-0.3	-1.0
Average weekly spirits intake	0.6	0.7	1.1	-1.1	-0.6	-0.8
Angina	0.6	0.9	1.6	-0.7	-0.7	-1.3
Fed-up feelings	0.6	1.1	1.8	-0.4	1.2	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.5	0.6	0.7	1.2
Multivitamins +/- minerals	0.6	0.7	1.2	-0.5	-1.1	-0.9
Allergy	0.6	1.3	2.2	-0.3	-1.5	-1.3
Suffer from ‘nerves’	0.6	1.0	1.6	0.6	0.9	1.3
Medication: Blood pressure	0.6	1.2	2.2	0.1	1.5	1.2
Ovarian Cancer	0.5	0.6	1.1	-1.1	-0.7	-0.5
HDL Cholesterol	0.5	0.8	1.6	-0.0	-1.3	-0.8
Blood Eosinophil Count	0.5	3.8	5.2	-2.3	-1.8	-1.8
Vitamin and mineral supplements	0.5	0.7	1.1	0.3	1.1	0.9
Diabetes (father)	0.5	0.6	0.8	0.9	0.7	0.8
Had other major operations	0.5	0.6	1.0	-1.0	-0.3	-0.9
Qualifications: None of the above	0.5	1.0	1.5	-1.2	-1.1	-0.6
Heart attack	0.5	0.6	1.1	0.6	1.1	0.5
Peak expiratory flow (PEF)	0.5	1.2	1.5	-1.2	-1.1	-1.0
Age at first live birth	0.5	0.9	1.4	1.2	0.9	0.8
Health satisfaction	0.5	0.7	1.8	-1.3	-0.5	-0.2
Age at last live birth	0.5	0.8	1.9	1.4	0.5	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	-0.6	-1.2	-0.2
Friendships satisfaction	0.5	0.6	1.3	-1.1	-0.6	-0.4
Number of self-reported non-cancer illnesses	0.5	0.8	1.4	-1.2	-0.3	-0.9
Ever taken oral contraceptive pill	0.5	0.5	1.1	-1.0	-0.4	-0.6
Depressed Affect (Nagel 2018)	0.4	0.9	2.0	-1.4	0.2	0.8
Neuroticism (Nagel 2018)	0.4	0.8	1.9	-0.4	0.6	1.4
Primary Biliary Cirrhosis	0.4	0.6	1.4	0.3	0.6	1.2
Rheumatoid Arthritis	0.4	0.6	1.3	1.1	0.6	0.4
Schizophrenia (2014)	0.4	0.9	1.9	-1.4	-0.5	-0.7
Neuroticism	0.4	1.0	1.6	-0.5	1.0	1.3
Hand grip strength (left)	0.4	1.1	2.2	0.2	1.5	1.0
Medication: Metformin	0.4	0.5	1.3	0.2	0.4	1.2
Hair/balding pattern: Pattern 2	0.4	0.5	0.8	0.9	0.0	0.8
Had menopause	0.4	0.6	1.0	-0.6	-1.0	-0.4
Pain all over the body in last month	0.4	0.5	1.1	1.1	0.3	0.4
Illnesses of siblings	0.4	0.6	0.9	-0.1	-1.0	-1.0
Neuroticism score	0.4	0.9	1.4	-0.1	1.1	1.2
Happiness	0.4	0.5	1.2	-1.1	0.0	-0.5
Depression (self-reported)	0.4	0.4	0.7	-0.9	-0.5	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.5	1.0	-1.0	-0.5	-0.6
Hair/balding pattern: Pattern 4	0.4	0.9	1.2	1.1	0.9	0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.2	-1.1	-0.3	-0.2
Angina (self-reported)	0.4	0.6	1.2	-0.5	-0.5	-1.1
Family relationship satisfaction	0.4	0.5	1.0	-0.8	-0.2	-1.0
Eye problems/disorders: Cataract	0.4	0.5	1.0	0.3	1.0	0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.1	0.1	1.0	1.1
Back pain experienced in last month	0.4	0.6	0.9	-0.6	0.9	0.8
Wears glasses or contact lenses	0.4	0.5	1.0	-0.2	0.7	1.0
Illnesses of father: High blood pressure	0.4	0.5	1.1	0.2	1.1	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.8	-0.9	0.2	0.8
Fasting Glucose	0.3	0.4	0.6	0.6	0.3	0.8
Blood White Count	0.3	2.6	3.0	-1.7	-1.4	-1.6
Cardiovascular Disease	0.3	0.9	1.4	-0.6	1.2	1.0
Number of treatments/medications taken	0.3	0.6	1.5	-0.2	0.6	1.2
Systolic blood pressure, automated reading	0.3	0.8	1.2	0.2	1.1	1.1
Trunk fat percentage	0.3	1.0	1.9	0.2	1.4	1.1
Average weekly fortified wine intake	0.3	0.4	0.6	0.7	0.8	-0.4
Taking other prescription medications	0.3	0.4	0.7	-0.8	0.7	0.2
Qualifications: CSEs or equivalent	0.3	0.4	0.6	0.6	-0.8	-0.5
Pulse rate	0.3	0.4	1.1	-0.4	1.1	-0.2
Asthma	0.3	0.6	1.3	-1.1	0.3	-0.6
Medication: Cholesterol lowering	0.3	0.4	1.2	-1.1	0.1	-0.0
Lung cancer (father)	0.3	0.4	0.6	0.6	0.5	0.8
Length of working week for main job	0.3	0.3	0.8	0.0	0.3	0.9
Tense / ‘highly strung’	0.3	0.6	0.8	-0.8	-0.6	-0.9
Birth weight of first child	0.3	0.6	1.4	1.2	0.5	0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	-0.9	0.1	-0.7
Headache pain in last month	0.3	0.5	1.2	0.2	0.5	1.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.3	-0.1	-0.4	-1.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	0.9	-0.5	-0.8	-0.9
Migraine (self-reported)	0.3	0.4	1.1	0.1	-1.0	-0.1
Number of full sisters	0.3	0.4	0.6	-0.8	-0.3	-0.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.6	0.5	0.3	0.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.6	0.8	0.3	0.8
Breast cancer (self-reported)	0.3	0.4	0.6	0.8	0.5	-0.4
Osteoporosis (self-reported)	0.3	0.4	0.6	0.1	-0.7	-0.8
Average weekly champagne plus white wine intake	0.3	0.5	1.1	1.0	0.6	0.0
Fractured/broken bones in last 5 years	0.3	0.4	0.9	0.1	-0.6	-0.9
Pain experienced in last month	0.3	0.4	1.1	1.0	-0.2	-0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	0.5	0.8	0.4
Alcohol drinker status: Previous	0.3	0.4	0.9	0.1	0.4	1.0
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.7	0.2	0.1
Crohns Disease (2017)	0.2	0.5	1.1	-0.3	0.5	1.0
Major Depression (MDD)	0.2	0.3	0.5	-0.7	-0.6	0.0
Prostate Cancer	0.2	0.3	0.7	0.8	-0.3	-0.1
Triglycerides	0.2	0.4	1.0	-1.0	-0.2	-0.4
Heel T-Score	0.2	1.8	4.5	-0.4	-2.1	-0.8
Respiratory disease	0.2	0.5	0.9	-0.9	0.6	-0.4
Chronotype (morning person)	0.2	0.5	1.1	1.0	0.3	0.5
Tanning	0.2	2.4	3.2	-1.2	-1.6	-1.8
Hand grip strength (right)	0.2	0.5	0.9	0.0	0.8	1.0
Number of incorrect matches in round	0.2	0.4	0.7	0.8	-0.7	-0.1
Mouth/teeth dental problems	0.2	0.3	0.7	0.8	-0.2	-0.1
Time employed in main current job	0.2	0.3	0.4	0.6	-0.6	0.1
Alcohol intake versus 10 years previously	0.2	0.2	0.4	-0.6	-0.6	0.1
Exposure to tobacco smoke at home	0.2	0.2	0.7	-0.1	0.8	-0.0
Blood clot in the leg (DVT)	0.2	0.2	0.7	-0.0	-0.2	-0.8
Body fat percentage	0.2	0.6	1.1	-0.1	1.1	0.9
Pulse rate, automated reading	0.2	0.6	0.9	-0.8	-0.5	-1.0
Overall health rating	0.2	0.5	1.0	-0.2	1.0	0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	-0.8	-0.0	0.2
Supplements: Vitamin C	0.2	0.3	0.7	-0.9	0.1	-0.1
Long-standing illness, disability or infirmity	0.2	0.3	0.8	-0.9	-0.4	-0.3
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.3	-0.4	-0.7
Medication for cholesterol	0.2	0.3	0.6	0.8	-0.1	-0.4
Asthma (self-reported)	0.2	0.4	0.8	-0.9	0.5	-0.3
Hearing aid user	0.2	0.2	0.5	-0.7	-0.2	-0.2
Alcohol drinker status: Never	0.2	0.2	0.4	-0.5	0.2	0.6
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.0	-0.2	-0.9	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.7	-0.0	-0.2	-0.8
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.3	-0.0	0.5
Depression (Nagel 2018)	0.1	0.2	0.3	-0.6	-0.4	0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.7	0.1	0.3
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.6	-0.2	-0.5
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.3	0.1	-0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.1	0.1	0.5
Systolic Blood Pressure	0.1	0.5	0.6	-0.5	0.8	0.8
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	-0.1	0.2	0.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.4	-0.2	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.0	-0.5	-0.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.4	-0.2	0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	0.2	0.2	0.4
Pack years adult smoking proportion	0.1	0.1	0.3	-0.0	0.0	-0.6
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.3	0.1	-0.4
Current tobacco smoking	0.1	0.1	0.1	0.0	0.4	-0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	-0.3	-0.3	0.1
Forced vital capacity (FVC)	0.1	0.3	0.8	0.9	-0.0	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	-0.3	-0.6	-0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.1	0.5	0.1
Medication: Ramipril	0.1	0.1	0.1	0.2	-0.3	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.3	0.5	0.6
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.2	0.4	0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.4	0.4	-0.7	-0.3
Noisy workplace	0.1	0.1	0.3	0.5	-0.2	-0.1
Illnesses of mother	0.1	0.1	0.2	-0.3	-0.4	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	0.6	-0.8	-0.5
Birth weight	0.1	0.3	0.7	0.8	0.4	0.1
Forced vital capacity (FVC), Best measure	0.1	0.2	0.5	0.7	-0.4	-0.3
Leg fat percentage (right)	0.1	0.3	0.7	-0.8	0.4	0.4
Pulse wave peak to peak time	0.1	0.2	0.4	-0.3	0.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.0	0.4	-0.2
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.1	-0.1	-0.5
Mean time to correctly identify matches	0.1	0.3	0.6	0.0	0.4	0.8
Leg pain on walking	0.1	0.2	0.4	-0.7	-0.2	-0.1
Medication: Aspirin	0.1	0.1	0.1	0.4	0.2	0.3
Illnesses of father: Heart disease	0.1	0.1	0.2	0.4	0.4	-0.1
Arm fat percentage (left)	0.1	0.6	1.0	0.3	1.0	0.8
Mood swings	0.1	0.3	0.5	-0.5	0.2	0.7
Medication: Aspirin	0.1	0.1	0.2	0.4	-0.0	0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	0.0	-0.1	0.5
Smoking status: Current	0.1	0.1	0.2	-0.1	0.3	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.2	-0.3	-0.5
Medication: Bendroflumethiazide	0.1	0.1	0.1	0.2	0.3	0.4
Leg fat percentage (left)	0.1	0.4	0.5	-0.5	0.7	0.7
Number of operations (self-reported)	0.1	0.2	0.4	0.4	-0.6	0.2
Irritability	0.1	0.1	0.2	-0.2	-0.2	0.5
Age started oral contraceptive pill	0.1	0.1	0.3	0.6	-0.1	-0.2
Ever depressed for a whole week	0.1	0.2	0.3	-0.6	0.4	0.0
Unable to work because of sickness or disability	0.1	0.2	0.4	0.0	0.6	0.4
Commuting to job workplace: Cycle	0.1	0.2	0.4	-0.3	0.2	-0.6
Pack years of smoking	0.1	0.1	0.2	-0.1	-0.0	-0.5
Ulcerative Colitis	0.0	0.0	0.1	-0.3	0.1	-0.2
Hypothyroidism (self reported)	0.0	0.0	0.1	-0.1	-0.2	-0.3
Lung FEV1/FVC ratio	0.0	0.2	0.3	0.5	-0.5	-0.1
Hair Pigment	0.0	0.4	0.8	-0.9	-0.5	-0.2
Age when periods started (menarche)	0.0	0.1	0.2	-0.0	0.2	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	-0.3	-0.1	0.4
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.2	-0.1	-0.0
Alcohol usually taken with meals	0.0	0.1	0.1	0.0	-0.2	0.4
Financial difficulties in last 2 years	0.0	0.0	0.1	0.0	-0.3	-0.2
Arm fat percentage (right)	0.0	0.2	0.4	-0.0	0.6	0.4
Father’s age at death	0.0	0.1	0.2	0.4	0.1	0.1
Falls in the last year	0.0	0.0	0.0	0.1	0.2	0.0
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	-0.1	0.1	0.2
Breastfed as a baby	0.0	0.1	0.1	0.2	0.3	-0.2
Worry too long after embarrassment	0.0	0.0	0.1	-0.1	0.2	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	-0.3	0.2	0.1
Medication: Gliclazide	0.0	0.0	0.1	0.2	-0.2	0.1
Mother’s age at death	0.0	0.0	0.0	-0.1	-0.1	-0.0
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	-0.1	-0.3	0.2
Medication: Atorvastatin	0.0	0.0	0.1	-0.3	0.2	0.1

Hub : Genes

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Trait associations