TWAS hub - EVI2A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.1330	0.0640	5.6e-03	0.033	NA	-0.004	NA	0.009	3.0e-02	NA	4.4e-01	NA	1.5e-01
2	GTEx	Spleen	0.2150	0.1100	7.0e-03	0.121	NA	-0.012	NA	0.067	5.2e-04	NA	9.7e-01	NA	8.3e-03
3	GTEx	Whole Blood	0.0660	0.0270	1.3e-04	0.039	NA	0.012	NA	0.036	1.6e-04	NA	2.3e-02	NA	2.6e-04
4	YFS	Blood	0.0310	0.0105	1.9e-12	0.050	0.037	0.041	0.04	0.042	7.2e-16	4.2e-12	2.5e-13	3.4e-13	1.1e-13
5	TCGA	Bladder Urothelial Carcinoma	0.0320	0.0280	4.0e-03	0.029	0.027	0.023	NA	0.026	1.7e-03	2.3e-03	4.7e-03	NA	2.6e-03
6	TCGA	Breast Invasive Carcinoma	0.0288	0.0201	8.6e-07	0.032	0.030	0.027	NA	0.030	2.8e-07	6.9e-07	2.0e-06	NA	7.1e-07
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0361	0.0327	9.9e-03	0.003	0.013	0.008	NA	0.007	1.4e-01	1.1e-02	3.6e-02	NA	5.1e-02
8	TCGA	Brain Lower Grade Glioma	0.0319	0.0201	1.0e-05	0.035	0.039	0.036	NA	0.032	7.5e-05	3.0e-05	5.9e-05	NA	1.2e-04
9	TCGA	Lung Adenocarcinoma	0.0375	0.0216	1.8e-07	0.061	0.057	0.041	NA	0.050	1.2e-07	3.1e-07	1.2e-05	NA	1.6e-06
10	TCGA	Lung Squamous Cell Carcinoma	0.0289	0.0252	5.8e-03	0.025	0.017	0.018	NA	0.020	6.4e-04	4.3e-03	3.7e-03	NA	2.4e-03
11	TCGA	Prostate Adenocarcinoma	0.0754	0.0432	2.6e-12	0.123	0.120	0.116	NA	0.121	8.7e-13	1.8e-12	3.8e-12	NA	1.3e-12
12	TCGA	Stomach Adenocarcinoma	0.0470	0.0470	2.6e-03	0.033	0.032	0.042	NA	0.040	1.9e-03	2.1e-03	4.8e-04	NA	7.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Arm fat-free mass (right)	11.8	60.5	69.4	-8.2	-7.8	-8.0	-7.9	-7.8	-8.1	-6.2	-8.3	-8.2	-7.6	-8.3	-6.7
Arm predicted mass (right)	11.5	58.9	67.6	-8.1	-7.7	-7.8	-7.8	-7.7	-7.9	-6.2	-8.1	-8.1	-7.5	-8.2	-6.7
Trunk fat-free mass	10.5	60.3	70.7	-8.4	-7.8	-8.1	-7.8	-7.7	-8.0	-5.7	-8.4	-8.3	-7.5	-8.2	-7.1
Hip circumference	10.5	45.4	51.2	-7.1	-6.6	-7.1	-7.1	-6.8	-7.1	-5.6	-7.1	-7.0	-6.9	-7.2	-4.8
Trunk predicted mass	10.5	59.8	69.9	-8.3	-7.8	-8.0	-7.8	-7.6	-7.9	-5.7	-8.4	-8.2	-7.4	-8.2	-7.0
Arm fat-free mass (left)	10.5	53.4	60.8	-7.8	-7.3	-7.5	-7.5	-7.3	-7.6	-5.8	-7.8	-7.7	-7.2	-7.8	-6.0
Whole body fat-free mass	10.4	59.5	69.2	-8.3	-7.7	-8.0	-7.8	-7.7	-8.0	-5.8	-8.3	-8.2	-7.5	-8.2	-6.6
Whole body water mass	10.3	58.6	68.1	-8.2	-7.7	-8.0	-7.8	-7.6	-8.0	-5.8	-8.2	-8.1	-7.4	-8.1	-6.5
Arm predicted mass (left)	10.0	50.6	57.9	-7.5	-7.1	-7.3	-7.3	-7.1	-7.3	-5.7	-7.5	-7.5	-7.0	-7.6	-6.0
Basal metabolic rate	9.9	55.0	63.0	-7.9	-7.4	-7.7	-7.6	-7.4	-7.8	-5.7	-7.9	-7.8	-7.3	-7.9	-6.1
Blood Platelet Count	9.6	111.8	123.2	10.7	10.9	10.9	10.4	10.8	10.8	9.3	11.0	11.1	10.2	10.6	10.1
Alcohol intake frequency.	8.9	20.7	24.4	-4.0	-4.0	-4.4	-4.8	-4.8	-4.3	-4.9	-4.3	-4.5	-4.7	-4.9	-4.8
Leg predicted mass (right)	8.9	47.5	55.5	-7.5	-6.9	-7.2	-7.0	-6.9	-7.3	-5.2	-7.5	-7.3	-6.7	-7.3	-5.5
Leg fat-free mass (right)	8.8	47.2	54.9	-7.4	-6.9	-7.2	-6.9	-6.9	-7.3	-5.2	-7.4	-7.3	-6.7	-7.3	-5.5
Leg predicted mass (left)	8.6	45.7	53.4	-7.3	-6.8	-7.1	-6.9	-6.8	-7.2	-5.1	-7.3	-7.2	-6.7	-7.2	-5.2
Severe depression (siblings)	8.5	9.5	12.4	-2.7	-3.4	-2.9	-3.4	-3.2	-3.0	-3.5	-2.7	-2.9	-3.4	-3.2	-2.4
Comparative height size at age 10	8.4	46.2	57.3	-7.6	-7.5	-7.2	-6.4	-6.4	-6.6	-4.2	-7.5	-7.3	-6.3	-7.0	-6.9
Leg fat-free mass (left)	8.3	44.0	51.6	-7.2	-6.7	-7.0	-6.8	-6.6	-7.1	-5.0	-7.2	-7.0	-6.5	-7.0	-5.1
Weight	7.8	38.5	43.8	-6.5	-6.2	-6.4	-6.6	-6.3	-6.6	-5.2	-6.5	-6.5	-6.3	-6.6	-4.4
Medication: Amlodipine	7.6	10.6	14.0	-3.0	-2.9	-3.1	-3.3	-3.4	-3.1	-3.5	-3.1	-3.3	-3.2	-3.3	-3.7
Height	5.9	113.6	146.4	-12.1	-11.7	-11.0	-10.3	-9.7	-9.9	-5.8	-11.8	-11.4	-9.9	-11.0	-11.8
Lung FVC	5.8	29.4	35.8	5.3	5.2	5.2	5.7	5.6	5.2	5.1	5.4	5.5	5.5	6.0	5.2
Comparative body size at age 10	5.8	16.1	22.2	-4.3	-4.0	-4.3	-3.8	-4.1	-4.7	-3.2	-4.4	-4.3	-4.0	-4.5	-1.9
Medication: Co-codamol	5.6	6.4	8.3	-2.2	-2.3	-2.5	-2.4	-2.7	-2.9	-2.5	-2.6	-2.7	-2.3	-2.7	-2.5
Nervous feelings	5.6	10.4	20.6	-3.4	-3.3	-3.3	-2.7	-3.0	-2.9	-2.0	-3.5	-3.5	-2.8	-3.3	-4.5
Type 2 Diabetes (T2D) (2018)	5.4	10.1	12.4	-2.8	-2.5	-3.0	-3.3	-3.5	-3.3	-3.5	-3.1	-3.3	-3.1	-3.3	-3.2
Eye problems/disorders: Glaucoma	5.3	6.3	8.0	-2.6	-2.7	-2.6	-2.5	-2.4	-2.2	-1.9	-2.6	-2.6	-2.6	-2.6	-2.8
Impedance of arm (right)	5.2	24.4	29.1	4.9	4.4	4.9	5.2	5.2	5.3	4.7	5.1	5.1	5.0	5.4	3.9
Allergy or Eczema	5.1	13.5	15.5	-3.5	-3.9	-3.7	-3.9	-3.8	-3.9	-3.5	-3.6	-3.7	-3.6	-3.8	-2.7
Chest pain or discomfort	5.1	7.3	11.9	3.5	2.6	3.1	2.6	2.3	2.6	0.8	3.2	3.0	2.4	2.6	2.9
Had major operations	5.1	6.0	7.7	-2.5	-2.4	-2.5	-2.7	-2.4	-2.4	-1.9	-2.6	-2.6	-2.2	-2.2	-2.8
Diverticular disease/diverticulitis (self-reported)	5.0	6.0	11.6	1.9	2.6	2.1	2.7	2.7	2.1	3.4	1.9	2.1	2.7	2.7	1.9
Impedance of arm (left)	4.9	22.5	26.7	4.8	4.2	4.8	5.1	5.0	5.1	4.5	4.9	4.9	4.8	5.2	3.6
Mean Putamen Volume	4.8	5.5	6.9	2.4	2.4	2.5	2.4	2.3	2.1	1.8	2.4	2.4	2.4	2.4	2.6
HbA1C	4.8	5.3	7.0	2.2	2.1	2.3	2.0	2.5	2.6	2.5	2.2	2.3	2.5	2.6	1.3
Diabetes diagnosed by doctor	4.8	7.9	11.4	-2.4	-2.1	-2.7	-3.1	-3.2	-3.1	-3.4	-2.7	-2.9	-2.9	-2.9	-2.2
Standing height	4.7	46.4	60.4	-7.6	-7.5	-7.0	-6.3	-6.3	-6.5	-4.0	-7.5	-7.3	-6.1	-7.0	-7.8
Diabetes (mother)	4.5	5.8	8.4	-2.2	-2.4	-2.3	-2.9	-2.5	-2.5	-2.5	-2.3	-2.4	-2.6	-2.4	-1.5
Impedance of whole body	4.5	22.8	27.6	4.9	4.3	4.9	5.1	5.0	5.2	4.2	5.0	5.0	4.8	5.1	3.2
Body Mass Index (BMI) (2010)	4.4	6.1	7.6	-2.8	-2.2	-2.7	-2.7	-2.4	-2.4	-1.8	-2.6	-2.6	-2.6	-2.5	-2.2
Supplements: Zinc	4.4	4.8	5.8	2.2	2.0	2.2	2.3	2.3	2.4	2.0	2.3	2.3	2.3	2.4	1.4
Supplements: Glucosamine	4.4	5.8	8.0	-2.8	-2.7	-2.8	-2.4	-2.2	-2.2	-1.5	-2.5	-2.5	-2.6	-2.5	-1.9
Bipolar Disorder (2011)	4.2	4.0	10.9	0.0	0.0	0.0	-2.3	-2.2	-1.9	-1.8	-2.4	-2.4	-2.1	-2.2	-3.3
Stomach or abdominal pain in last month	4.2	5.2	5.9	2.4	2.3	2.4	2.3	2.3	2.4	2.0	2.4	2.4	2.3	2.1	1.8
Ever had bowel cancer screening	4.1	4.8	6.1	2.3	1.9	2.2	2.2	2.2	2.2	1.9	2.3	2.3	2.2	2.5	2.0
Medication: Blood pressure	4.0	7.0	8.8	-2.5	-2.7	-2.6	-2.8	-2.7	-2.4	-2.7	-2.5	-2.6	-2.7	-2.6	-3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.8	8.1	11.9	2.4	2.8	2.6	3.2	3.1	2.8	3.5	2.5	2.7	3.1	3.3	2.0
Leg fat mass (left)	3.8	14.9	19.5	-3.8	-3.7	-3.9	-4.4	-4.1	-4.2	-4.0	-3.7	-3.8	-4.2	-4.2	-1.7
Medication: Allopurinol	3.7	4.9	6.4	-2.5	-2.4	-2.4	-2.3	-2.0	-2.0	-1.4	-2.3	-2.3	-2.3	-2.2	-2.1
Waist Hip Ratio (WHR)	3.6	16.3	20.2	4.5	3.8	4.5	4.3	3.9	4.1	2.7	4.4	4.3	3.9	4.0	3.7
Impedance of leg (right)	3.6	17.4	23.3	4.5	4.0	4.5	4.2	4.3	4.8	3.3	4.6	4.5	4.1	4.3	2.4
Hayfever, allergic rhinitis or eczema	3.6	7.7	10.0	-2.8	-2.8	-3.0	-2.8	-2.9	-3.2	-2.4	-2.9	-2.9	-2.7	-2.9	-1.8
Waist circumference	3.6	13.2	16.2	-3.5	-3.4	-3.7	-4.0	-3.9	-4.0	-3.8	-3.5	-3.6	-3.9	-4.0	-1.7
Age at First Birth	3.5	5.0	6.9	-2.4	-2.6	-2.5	-2.2	-2.2	-2.4	-1.5	-2.5	-2.4	-2.3	-2.3	-1.4
Average weekly red wine intake	3.5	5.1	6.6	2.0	1.5	2.4	2.1	2.4	2.2	2.5	2.2	2.3	2.4	2.6	2.5
Arm fat mass (left)	3.5	14.2	17.9	-3.8	-3.6	-3.9	-4.2	-4.0	-4.2	-3.7	-3.8	-3.8	-4.0	-4.0	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.4	4.0	4.6	2.1	2.1	2.1	1.9	2.1	2.1	1.8	2.1	2.1	2.1	1.9	1.5
Leg fat mass (right)	3.3	13.0	17.2	-3.5	-3.4	-3.6	-4.2	-3.8	-3.9	-3.7	-3.5	-3.5	-3.9	-4.0	-1.4
Number of full brothers	3.2	4.0	5.8	2.4	2.0	2.2	1.8	1.8	1.8	0.9	2.3	2.2	1.9	2.0	2.4
Whole body fat mass	3.2	13.4	16.6	-3.7	-3.6	-3.8	-4.1	-3.8	-4.0	-3.4	-3.7	-3.7	-3.9	-3.9	-1.8
Arm fat mass (right)	3.1	12.6	16.1	-3.6	-3.4	-3.7	-4.0	-3.7	-4.0	-3.4	-3.5	-3.6	-3.8	-3.8	-1.4
Heart disease (mother)	3.1	3.7	4.7	1.9	1.7	2.1	1.9	1.9	1.7	1.8	1.9	1.9	2.2	2.1	2.0
Knee pain experienced in last month	3.1	4.8	6.5	-2.1	-1.4	-2.1	-2.4	-2.4	-2.4	-2.5	-2.1	-2.2	-2.4	-2.5	-1.2
Medication: Lisinopril	3.1	4.0	5.5	-2.0	-2.3	-2.0	-2.1	-2.0	-1.8	-1.8	-1.9	-2.0	-2.1	-2.1	-1.9
Relative age of first facial hair	3.0	6.1	8.7	3.0	2.9	2.7	2.4	2.4	2.8	1.4	2.8	2.7	2.4	2.5	1.0
Impedance of leg (left)	3.0	14.7	20.0	4.2	3.6	4.2	3.9	3.9	4.5	2.8	4.2	4.1	3.8	4.0	2.1
Medication: Paracetamol	3.0	5.0	7.5	2.3	2.7	2.3	2.3	2.2	2.3	1.8	2.3	2.3	2.3	2.3	1.4
Glaucoma (self-reported)	3.0	3.5	5.2	-1.8	-1.9	-1.8	-1.8	-1.9	-1.5	-1.8	-1.8	-1.8	-2.0	-2.0	-2.3
Gout (self-reported)	2.9	4.0	6.5	-2.3	-2.5	-2.1	-2.1	-1.8	-1.7	-1.2	-2.0	-2.0	-2.1	-1.9	-1.8
LDL Cholesterol	2.8	4.4	8.0	2.2	2.2	2.2	1.8	1.9	1.9	1.3	2.3	2.2	1.9	2.2	2.8
Trunk fat mass	2.8	12.0	14.4	-3.7	-3.4	-3.7	-3.8	-3.5	-3.8	-3.0	-3.5	-3.5	-3.7	-3.7	-1.8
Osteoarthritis (self-reported)	2.8	3.7	5.0	-2.2	-2.2	-2.0	-1.9	-1.6	-1.9	-0.7	-2.2	-2.1	-1.7	-2.2	-1.8
Intelligence (Savage-Jansen 2018)	2.7	8.3	11.5	-3.2	-3.1	-3.2	-2.6	-2.9	-3.4	-2.0	-3.3	-3.2	-2.7	-2.9	-1.4
Diabetes (self-reported)	2.7	4.2	6.7	-1.7	-1.3	-2.0	-2.2	-2.4	-2.3	-2.6	-1.9	-2.1	-2.1	-2.1	-1.5
Body mass index (BMI)	2.6	11.3	15.1	-3.2	-3.0	-3.4	-3.9	-3.6	-3.8	-3.6	-3.2	-3.3	-3.7	-3.6	-0.9
Loud music exposure frequency	2.6	2.9	3.8	-1.6	-1.2	-1.7	-1.6	-1.9	-1.7	-2.0	-1.6	-1.7	-1.7	-1.7	-1.6
Risk taking	2.5	3.6	7.5	2.0	1.8	1.8	2.1	1.7	1.4	1.2	2.0	1.9	1.8	2.0	2.7
Eye problems/disorders: None of the above	2.4	2.8	8.9	1.7	1.5	1.6	1.5	1.4	1.2	0.8	1.8	1.7	1.4	1.6	3.0
Commuting to job workplace: Public transport	2.4	2.9	5.8	-1.7	-2.0	-1.7	-1.6	-1.6	-1.2	-1.3	-1.7	-1.7	-1.7	-1.7	-2.4
Verbal and Numeric Reasoning (VNR)	2.3	5.6	7.6	-2.8	-2.3	-2.6	-2.2	-2.3	-2.6	-1.4	-2.7	-2.6	-2.1	-2.3	-1.9
Number of live births	2.3	3.2	3.9	1.9	1.4	1.9	1.7	1.9	1.9	1.5	2.0	2.0	1.7	1.9	1.8
Worry (Nagel 2018)	2.2	4.6	19.4	-2.2	-2.1	-1.9	-1.5	-1.6	-1.3	-0.7	-2.3	-2.2	-1.5	-1.9	-4.4
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	4.1	1.4	1.2	1.6	1.5	1.7	1.8	2.0	1.4	1.5	1.7	2.0	0.9
Ever smoked	2.2	3.8	4.8	2.2	2.1	2.2	1.9	1.8	1.7	1.3	2.1	2.0	2.0	2.0	2.0
Heart disease (siblings)	2.2	2.7	4.3	1.8	1.1	1.7	1.6	1.6	1.5	1.4	1.8	1.8	1.6	1.6	2.1
High blood pressure	2.1	5.8	8.8	-2.1	-1.8	-2.3	-2.6	-2.7	-2.4	-3.0	-2.2	-2.4	-2.5	-2.6	-2.3
HDL Cholesterol	2.0	3.3	7.1	1.4	2.0	1.6	2.1	2.1	1.9	2.7	1.4	1.5	2.1	1.9	0.6
Prospective memory result	2.0	2.4	3.0	-1.6	-1.4	-1.6	-1.5	-1.6	-1.6	-1.5	-1.6	-1.6	-1.6	-1.7	-1.3
High blood pressure (siblings)	2.0	2.9	4.0	-1.9	-1.5	-1.9	-1.9	-1.8	-2.0	-1.5	-1.8	-1.8	-1.9	-1.6	-0.5
Wheeze or whistling in the chest in last year	2.0	3.5	8.9	2.2	2.1	2.0	1.5	1.5	1.6	0.3	2.3	2.1	1.2	1.4	3.0
Hypertension (Self-reported)	2.0	5.5	8.6	-1.9	-1.7	-2.2	-2.4	-2.6	-2.3	-2.9	-2.1	-2.3	-2.3	-2.5	-2.3
Smoking Status	1.9	4.7	10.0	2.2	2.0	2.2	1.8	2.1	1.9	1.6	2.3	2.3	2.0	2.1	3.2
Suffer from ‘nerves’	1.9	3.0	8.8	-1.3	-1.7	-1.4	-1.5	-1.7	-1.4	-1.8	-1.6	-1.7	-1.5	-1.7	-3.0
Illnesses of siblings: Diabetes	1.9	2.3	3.0	-1.6	-1.5	-1.5	-1.7	-1.5	-1.3	-1.2	-1.5	-1.5	-1.7	-1.5	-1.4
Shortness of breath walking on level ground	1.8	2.1	3.3	1.7	1.8	1.6	1.4	1.4	1.6	0.8	1.6	1.6	1.2	1.5	0.9
Sitting height	1.7	12.0	18.7	-4.1	-3.3	-3.8	-3.1	-3.1	-3.3	-1.4	-4.1	-3.9	-2.9	-3.2	-4.3
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	5.1	1.2	2.2	1.2	1.7	1.4	1.4	1.6	1.2	1.2	1.6	1.7	0.2
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	4.4	1.3	1.8	1.5	1.9	1.8	1.5	2.1	1.4	1.6	1.8	1.5	1.7
Smoking status: Previous	1.7	2.6	3.1	1.5	1.8	1.6	1.5	1.6	1.6	1.5	1.6	1.6	1.7	1.7	1.5
Supplements: Fish oil (including cod liver oil)	1.7	2.2	4.5	-2.1	-1.6	-1.8	-1.4	-1.0	-1.2	0.0	-1.8	-1.6	-1.4	-1.5	-1.3
Breast Cancer	1.6	3.9	9.8	2.1	1.8	2.1	1.4	1.8	1.9	0.8	2.4	2.3	1.3	1.8	3.1
Lupus	1.6	2.4	3.0	-1.7	-1.5	-1.7	-1.4	-1.5	-1.5	-1.1	-1.7	-1.7	-1.4	-1.6	-1.6
Type 2 Diabetes (T2D) (2012)	1.6	1.9	3.9	-1.0	-1.1	-1.2	-1.5	-1.5	-1.1	-2.0	-1.0	-1.2	-1.7	-1.5	-1.2
Medication: Metformin	1.6	2.3	4.0	-1.2	-0.7	-1.4	-1.5	-1.8	-1.8	-2.0	-1.5	-1.6	-1.5	-1.6	-1.4
Wears glasses or contact lenses	1.6	1.9	3.4	-1.1	-1.3	-1.3	-1.4	-1.3	-1.1	-1.5	-1.2	-1.3	-1.5	-1.5	-1.8
Neuroticism (2016)	1.5	2.2	4.4	-1.5	-1.1	-1.5	-1.4	-1.5	-1.3	-1.3	-1.5	-1.6	-1.2	-1.4	-2.1
BMI	1.5	8.9	12.0	-3.2	-2.7	-3.2	-3.5	-3.1	-3.2	-2.7	-3.0	-3.0	-3.3	-3.1	-1.3
Vitamin and mineral supplements	1.5	2.1	3.1	-1.3	-1.8	-1.4	-1.5	-1.5	-1.4	-1.6	-1.3	-1.3	-1.6	-1.6	-1.1
Fed-up feelings	1.5	2.8	4.9	-1.4	-1.3	-1.5	-1.7	-1.8	-1.5	-1.9	-1.5	-1.6	-1.6	-1.6	-2.2
Pulse wave Arterial Stiffness index	1.5	1.7	2.2	-1.2	-1.1	-1.4	-1.5	-1.4	-1.3	-1.5	-1.2	-1.3	-1.4	-1.4	-0.8
Reaction Time	1.4	2.6	7.6	-1.5	-1.9	-1.5	-1.5	-1.4	-0.9	-1.2	-1.4	-1.5	-1.6	-1.7	-2.8
Fasting Glucose	1.4	1.6	2.8	-1.1	-0.9	-1.1	-1.3	-1.4	-1.3	-1.7	-1.1	-1.2	-1.4	-1.6	-1.0
Past tobacco smoking	1.4	2.6	3.8	-1.6	-1.8	-1.6	-1.5	-1.6	-1.4	-1.4	-1.6	-1.6	-1.7	-1.7	-2.0
Medication for pain relief, constipation, heartburn	1.4	2.3	7.1	-1.8	-2.7	-1.6	-1.5	-1.2	-1.5	-0.4	-1.6	-1.5	-1.4	-1.6	-0.5
Medication: Omeprazole	1.4	1.7	4.2	1.9	2.0	1.6	1.0	0.9	1.3	-0.4	1.6	1.4	1.1	0.9	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.2	1.8	1.1	1.6	1.0	1.0	1.2	0.1	1.6	1.5	1.0	1.0	1.7
Alcohol drinker status: Previous	1.4	1.6	5.0	-0.9	-0.6	-1.1	-1.2	-1.4	-1.1	-1.6	-1.1	-1.2	-1.1	-1.2	-2.2
Alzheimer’s Disease (including proxy)	1.3	1.8	2.9	-1.7	-1.5	-1.6	-1.0	-1.1	-1.2	-0.3	-1.6	-1.5	-1.3	-1.6	-1.4
Angina	1.3	1.7	2.5	1.3	1.0	1.3	1.2	1.3	1.3	1.1	1.4	1.4	1.3	1.6	1.5
Medication for hormone replacement therapy	1.3	1.5	2.5	1.0	1.4	1.2	1.2	1.4	1.5	1.6	1.0	1.1	1.2	1.3	0.0
Serious illness, injury or assault to yourself	1.3	1.5	2.3	-1.1	-1.5	-1.3	-1.0	-1.4	-1.5	-1.4	-1.2	-1.3	-1.2	-1.2	-0.6
Multivitamins +/- minerals	1.3	1.7	2.5	1.1	1.6	1.2	1.3	1.3	1.3	1.4	1.2	1.2	1.3	1.4	1.2
Hearing difficulty/problems with background noise	1.3	2.0	2.9	1.6	1.2	1.6	1.5	1.5	1.7	1.1	1.6	1.6	1.5	1.5	0.5
Medication: Paracetamol	1.3	2.0	3.2	1.6	1.8	1.5	1.5	1.3	1.3	1.0	1.4	1.4	1.5	1.4	0.8
Number of treatments/medications taken	1.2	2.2	3.5	-1.3	-1.0	-1.5	-1.9	-1.6	-1.5	-1.7	-1.4	-1.4	-1.8	-1.6	-0.9
Sensitivity / hurt feelings	1.2	2.0	2.7	1.6	1.0	1.6	1.5	1.4	1.6	0.9	1.6	1.6	1.3	1.4	1.3
Hearing difficulty/problems: Yes	1.2	1.9	2.6	1.6	1.2	1.5	1.4	1.3	1.4	0.9	1.6	1.5	1.3	1.2	1.3
Maternal smoking around birth	1.2	1.8	2.9	1.7	1.5	1.5	1.3	1.2	1.4	0.5	1.5	1.4	1.3	1.3	0.8
Medication: Atenolol	1.2	1.4	2.5	-1.1	-1.3	-1.1	-1.4	-1.1	-1.0	-1.1	-1.1	-1.2	-1.2	-1.1	-1.6
Chronic bronchitis/emphysema (father)	1.2	1.4	2.2	1.4	1.5	1.3	1.4	1.0	1.1	0.5	1.4	1.3	1.1	1.1	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	3.0	1.3	1.4	1.3	1.7	1.3	1.6	1.3	1.1	1.1	1.6	1.5	-1.1
Fluid intelligence score	1.2	2.4	3.3	-1.8	-1.6	-1.7	-1.5	-1.5	-1.7	-0.9	-1.8	-1.7	-1.4	-1.6	-1.0
Length of working week for main job	1.2	1.3	2.5	-0.9	-0.6	-1.0	-1.4	-1.3	-1.3	-1.6	-1.0	-1.1	-1.3	-1.2	-0.6
Myopia	1.2	1.8	2.7	1.4	1.4	1.3	1.4	1.2	1.1	0.9	1.3	1.3	1.3	1.5	1.6
Schizophrenia vs Biploar Disorder	1.1	1.5	2.1	1.1	1.0	1.2	1.3	1.3	1.1	1.4	1.1	1.1	1.3	1.4	1.3
Exposure to tobacco smoke outside home	1.1	1.5	2.8	1.7	1.2	1.5	1.2	0.9	1.0	-0.1	1.5	1.3	1.0	1.0	1.4
Number of children fathered	1.1	1.3	2.1	1.4	1.4	1.1	0.9	0.9	1.1	0.0	1.4	1.3	0.8	1.2	1.1
Overall health rating	1.1	2.3	4.8	-1.0	-1.5	-1.4	-1.3	-1.7	-1.6	-2.2	-1.3	-1.4	-1.6	-1.7	-1.2
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.0	-1.2	-0.6	-1.3	-1.4	-1.4	-1.1	-1.5	-1.2	-1.3	-1.5	-1.3	-1.7
Medication: Blood pressure	1.1	2.0	2.9	-1.2	-0.9	-1.4	-1.6	-1.6	-1.5	-1.7	-1.3	-1.4	-1.4	-1.6	-1.2
Average weekly beer plus cider intake	1.1	1.6	2.5	1.6	1.3	1.4	1.4	1.1	1.1	0.6	1.4	1.3	1.2	1.0	1.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.2	1.8	1.8	1.4	0.8	0.6	1.1	-0.6	1.4	1.2	0.9	0.7	-0.0
Supplements: Calcium	1.1	1.2	2.2	1.1	0.8	1.2	0.7	1.2	1.2	1.0	1.2	1.2	0.9	1.0	1.5
High blood pressure (mother)	1.0	1.4	2.8	-1.4	-1.7	-1.2	-1.1	-1.1	-0.8	-0.9	-1.1	-1.1	-1.2	-1.2	-1.2
Worrier / anxious feelings	1.0	1.9	7.1	-1.4	-1.6	-1.3	-1.0	-0.9	-0.8	-0.2	-1.5	-1.4	-0.9	-1.1	-2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.3	1.5	0.8	1.4	0.9	1.1	1.2	0.5	1.4	1.3	1.0	0.9	1.1
Diastolic blood pressure, automated reading	1.0	3.2	4.5	-1.9	-2.1	-1.8	-1.7	-1.8	-1.9	-1.4	-1.9	-1.9	-1.6	-2.1	-1.2
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	2.8	1.0	0.4	1.0	0.9	0.9	0.8	0.6	1.0	1.0	0.8	0.8	1.7
Alcohol intake versus 10 years previously	0.9	1.4	5.1	-0.4	-0.5	-0.8	-1.3	-1.5	-1.4	-2.3	-0.6	-0.8	-1.3	-1.4	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.7	-0.8	-1.1	-0.8	-1.1	-1.1	-1.3	-1.2	-1.0	-1.0	-1.0	-1.3	-0.0
Tense / ‘highly strung’	0.9	1.5	2.6	1.0	0.6	1.2	1.4	1.4	1.6	1.5	1.0	1.0	1.3	1.0	-1.1
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.8	1.1	1.7	1.0	1.0	0.8	1.0	0.2	1.2	1.1	0.8	0.9	0.6
Angina (self-reported)	0.9	1.2	1.8	1.1	0.7	1.1	1.0	1.1	1.1	0.9	1.2	1.2	1.0	1.4	1.3
Vascular/heart problems diagnosed by doctor	0.9	2.3	4.8	1.1	0.9	1.4	1.7	1.8	1.4	2.2	1.2	1.4	1.6	1.6	1.5
Medication: Ramipril	0.8	1.1	3.4	-0.5	-0.5	-0.7	-1.2	-1.3	-1.1	-1.9	-0.7	-0.9	-1.1	-1.2	-0.3
Illnesses of siblings	0.8	1.1	1.8	1.2	1.0	1.2	1.3	1.1	1.2	0.8	1.0	1.0	1.3	0.9	-0.1
Neuroticism score	0.8	1.7	7.9	-1.1	-1.0	-1.1	-0.9	-1.1	-0.8	-1.1	-1.2	-1.3	-0.9	-1.1	-2.8
Medication: Ibuprofen	0.8	0.9	3.4	0.8	1.9	0.8	1.1	0.8	0.8	0.8	0.7	0.7	1.1	1.0	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.3	1.1	1.0	1.0	1.1	0.8	0.9	0.5	0.9	0.8	1.1	1.1	-0.0
Mineral and other dietary supplements	0.8	1.0	2.0	1.4	0.9	1.2	0.9	0.7	0.7	-0.0	1.2	1.1	0.9	0.9	1.4
Bipolar Disorder (2018)	0.7	1.0	3.1	-0.7	-0.7	-0.7	-1.3	-1.0	-0.4	-1.4	-0.6	-0.8	-1.1	-0.9	-1.8
Crohns Disease (2012)	0.7	1.1	1.5	-1.2	-0.6	-1.1	-1.1	-1.0	-1.1	-0.6	-1.2	-1.1	-0.9	-1.1	-1.1
Blood Eosinophil Count	0.7	5.6	6.6	2.0	2.5	2.1	2.4	2.5	2.3	2.6	2.2	2.3	2.4	2.6	2.3
Neuroticism	0.7	1.7	8.8	-1.0	-0.7	-1.1	-0.9	-1.1	-0.9	-1.1	-1.2	-1.3	-0.8	-1.0	-3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.4	-1.0	-1.1	-0.9	-0.9	-0.9	-1.0	-0.5	-1.1	-1.1	-0.7	-0.9	-1.2
Relative age voice broke	0.7	1.0	2.0	1.4	1.0	1.2	0.8	0.9	1.1	0.2	1.2	1.1	1.0	1.1	0.4
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.9	-1.5	-1.6	-1.2	-0.6	-0.9	-1.2	0.2	-1.6	-1.4	-0.6	-1.0	-1.7
Medication: Lansoprazole	0.7	0.8	1.4	0.9	0.7	0.9	0.5	1.0	1.2	0.7	1.1	1.1	0.6	0.9	0.8
Peak expiratory flow (PEF)	0.7	1.7	2.8	1.3	1.7	1.3	1.4	1.3	1.4	1.2	1.3	1.2	1.4	1.6	0.5
Pulse wave reflection index	0.7	0.8	1.8	-1.0	-0.7	-1.0	-1.3	-0.9	-0.9	-0.8	-0.9	-0.9	-0.9	-0.8	-0.7
Neck or shoulder pain in last month	0.7	1.0	2.0	1.2	1.4	1.1	1.1	0.7	1.2	0.0	1.2	1.0	0.9	0.8	-0.3
Mean time to correctly identify matches	0.7	1.3	4.2	-1.0	-1.3	-0.9	-1.2	-0.9	-0.5	-0.9	-0.9	-1.0	-1.1	-1.2	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.7	-1.2	-0.8	-1.0	-0.9	-1.3	-1.1	-1.0	-1.3	-1.4	-0.8	-1.2	-2.2
Leg fat percentage (left)	0.7	2.7	5.4	-1.2	-1.2	-1.4	-2.1	-1.8	-1.9	-2.3	-1.2	-1.3	-2.0	-1.8	0.6
Neuroticism (Nagel 2018)	0.6	1.4	8.4	-0.9	-0.5	-0.8	-0.8	-1.0	-0.7	-0.7	-1.2	-1.2	-0.7	-1.0	-2.9
Alzheimer’s Disease (in mother)	0.6	0.7	1.1	-1.0	-1.0	-0.9	-0.7	-0.7	-0.8	-0.2	-0.9	-0.8	-0.8	-1.1	-0.6
Blood Red Count	0.6	5.9	9.5	3.1	2.4	2.9	2.3	2.0	2.2	0.8	2.9	2.7	2.4	2.1	2.6
Blood White Count	0.6	4.1	5.8	1.9	1.8	2.0	2.1	2.3	2.3	2.4	1.9	2.0	2.1	2.1	1.0
Cardiovascular Disease	0.6	2.0	4.4	-1.0	-0.8	-1.3	-1.4	-1.7	-1.5	-2.1	-1.2	-1.3	-1.4	-1.6	-1.2
Diabetes (father)	0.6	0.8	1.8	-0.9	-1.1	-0.9	-0.6	-0.7	-0.5	-0.5	-0.9	-0.8	-0.8	-1.0	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.6	-0.6	-1.0	-0.8	-1.3	-1.2	-0.8	-1.7	-0.8	-1.0	-1.3	-1.1	-1.9
Pulse wave peak to peak time	0.6	0.6	1.4	0.7	0.5	0.8	1.0	0.9	0.9	1.2	0.6	0.7	0.9	0.8	0.2
Arm fat percentage (left)	0.6	2.3	3.6	-1.2	-1.2	-1.4	-1.9	-1.6	-1.9	-1.9	-1.2	-1.3	-1.8	-1.5	0.8
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.2	-0.9	-0.8	-1.0	-1.1	-0.9	-0.7	-0.9	-0.7	-0.8	-1.1	-0.9	-0.4
Mood swings	0.6	1.0	2.2	-0.7	-0.5	-0.9	-1.0	-1.1	-0.9	-1.4	-0.9	-1.0	-0.9	-1.0	-1.5
Qualifications: nursing, teaching	0.6	0.9	1.5	-1.1	-1.1	-1.0	-0.9	-0.8	-0.8	-0.4	-1.1	-1.0	-0.8	-0.9	-1.2
Back pain experienced in last month	0.6	0.9	1.4	-0.9	-0.8	-0.9	-1.2	-0.9	-0.7	-0.9	-0.9	-0.9	-0.9	-0.9	-1.2
Guilty feelings	0.6	0.8	1.8	1.0	1.4	1.0	0.9	0.8	1.1	0.4	1.0	0.9	0.9	0.9	-0.0
Depressed Affect (Nagel 2018)	0.5	1.0	3.1	-0.6	-0.0	-0.8	-0.8	-1.1	-0.8	-1.4	-0.9	-1.0	-0.7	-0.9	-1.8
Schizophrenia (2018)	0.5	1.1	2.1	1.2	0.7	1.3	0.8	1.0	1.0	0.6	1.2	1.2	0.6	1.0	1.4
Systolic blood pressure, automated reading	0.5	1.6	2.2	-1.3	-1.2	-1.3	-1.4	-1.2	-1.0	-1.2	-1.1	-1.2	-1.3	-1.5	-1.2
Trunk fat percentage	0.5	2.0	3.0	-1.4	-1.4	-1.5	-1.7	-1.4	-1.6	-1.4	-1.3	-1.3	-1.7	-1.5	0.3
Hand grip strength (right)	0.5	1.3	6.4	-1.0	-1.1	-0.8	-1.1	-0.9	-0.4	-0.8	-0.9	-1.0	-1.0	-0.9	-2.5
Mouth/teeth dental problems	0.5	0.7	3.1	0.2	0.6	0.5	0.9	1.1	1.0	1.8	0.5	0.6	0.7	0.8	0.3
Allergy	0.5	1.1	1.8	1.1	0.9	1.3	0.9	1.1	1.4	0.8	1.1	1.1	1.1	1.3	0.1
Pain all over the body in last month	0.5	0.5	1.1	-0.6	-1.0	-0.8	-0.5	-0.7	-0.9	-0.8	-0.7	-0.7	-0.8	-0.6	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.4	-0.7	-1.2	-0.9	-1.0	-1.0	-1.0	-1.1	-0.8	-0.9	-1.0	-0.9	-0.5
Hair/balding pattern: Pattern 3	0.5	0.8	1.8	-0.6	-0.3	-0.7	-0.8	-1.1	-0.9	-1.4	-0.8	-0.9	-0.8	-1.1	-1.1
Body fat percentage	0.5	2.1	3.3	-1.3	-1.2	-1.4	-1.8	-1.5	-1.6	-1.7	-1.2	-1.2	-1.7	-1.5	0.6
Leg fat percentage (right)	0.5	1.7	3.8	-0.9	-0.8	-1.1	-1.8	-1.4	-1.5	-1.9	-0.8	-0.9	-1.6	-1.4	0.9
Qualifications: College or University degree	0.5	1.4	3.2	-1.6	-1.3	-1.2	-1.0	-0.9	-0.9	-0.2	-1.4	-1.3	-1.0	-1.1	-1.8
Family relationship satisfaction	0.5	0.6	0.8	0.8	0.7	0.8	0.9	0.8	0.9	0.5	0.8	0.9	0.6	0.7	0.5
Medication: Aspirin	0.5	0.7	1.9	-0.6	-0.4	-0.7	-0.9	-1.0	-0.8	-1.4	-0.6	-0.7	-1.0	-0.8	-0.3
Loneliness, isolation	0.5	0.7	1.2	-0.8	-1.1	-0.9	-0.5	-0.8	-0.8	-0.6	-0.9	-0.9	-0.6	-0.9	-1.1
Financial situation satisfaction	0.5	0.7	2.4	1.0	1.6	0.8	1.0	0.5	0.6	-0.1	0.8	0.7	0.8	0.7	-0.4
High cholesterol (Self-reported)	0.5	0.9	2.2	1.5	1.1	1.2	0.4	0.4	0.6	-0.7	1.2	1.0	0.7	0.7	1.1
Medication: Bendroflumethiazide	0.5	0.7	2.3	-0.5	-0.5	-0.7	-1.0	-1.0	-0.8	-1.5	-0.6	-0.7	-0.9	-0.9	-0.6
Alcohol drinker status: Never	0.5	0.6	2.1	-0.6	-1.0	-0.7	-0.7	-0.6	-0.3	-0.6	-0.7	-0.7	-0.8	-0.8	-1.5
Basal cell carcinoma (self-reported)	0.5	0.6	2.9	-1.0	-0.0	-0.9	-0.5	-0.3	-0.4	0.5	-1.0	-0.9	-0.3	-0.3	-1.7
Hand grip strength (left)	0.4	1.0	4.2	-1.0	-0.9	-0.8	-0.9	-0.9	-0.5	-0.8	-0.9	-0.9	-0.9	-0.8	-2.1
Average weekly fortified wine intake	0.4	0.5	1.5	0.4	0.1	0.6	0.7	0.9	0.8	1.2	0.5	0.7	0.8	0.6	0.3
Hair/balding pattern: Pattern 2	0.4	0.5	1.8	-0.9	-1.2	-0.7	-0.4	-0.3	-0.0	0.1	-0.6	-0.5	-0.6	-0.4	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	1.7	0.9	1.2	1.0	1.3	1.1	0.9	1.3	0.8	0.9	1.2	1.2	0.7
Hair/balding pattern: Pattern 4	0.4	0.9	1.7	-0.9	-1.3	-0.9	-1.0	-0.9	-1.3	-0.6	-0.9	-0.9	-0.8	-0.7	1.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.0	-0.8	-1.0	-0.7	-0.8	-0.7	-1.0	-0.5	-0.9	-0.8	-0.6	-0.9	-0.2
Headache pain in last month	0.4	0.8	1.9	-0.9	-0.0	-0.9	-0.6	-0.9	-0.7	-0.6	-0.9	-1.0	-0.9	-0.9	-1.4
Forced vital capacity (FVC), Best measure	0.4	1.5	3.6	0.8	1.3	1.0	1.6	1.4	1.1	1.9	0.8	0.9	1.5	1.4	0.4
Osteoporosis (self-reported)	0.4	0.5	1.1	0.6	0.2	0.7	0.4	0.8	0.8	0.8	0.7	0.7	0.4	0.8	1.1
Medication: Aspirin	0.4	0.6	1.6	-0.5	-0.4	-0.7	-0.9	-0.9	-0.8	-1.3	-0.5	-0.6	-0.9	-0.7	-0.4
Ever taken oral contraceptive pill	0.4	0.5	2.0	0.9	1.4	0.8	0.5	0.3	0.3	-0.2	0.6	0.5	0.8	0.7	0.1
Fractured/broken bones in last 5 years	0.4	0.5	1.4	0.9	0.2	0.9	0.6	0.6	0.4	0.2	0.8	0.7	0.7	0.8	1.2
Cholesterol lowering medication	0.4	0.5	3.6	0.8	0.5	0.6	0.2	0.4	0.2	-0.1	0.8	0.7	0.4	0.4	1.9
Pain experienced in last month	0.4	0.6	1.4	0.5	-0.0	0.7	0.6	0.9	0.7	1.2	0.6	0.7	0.9	1.0	0.8
Alzheimer’s Disease (in father)	0.3	0.3	1.3	0.2	0.4	0.3	0.9	0.7	0.5	1.1	0.2	0.3	0.7	0.5	-0.1
Crohns Disease (2017)	0.3	0.6	1.5	-0.8	-0.3	-0.7	-0.8	-0.8	-0.7	-0.6	-0.8	-0.8	-0.3	-0.7	-1.2
Coronary Artery Disease (CAD)	0.3	0.3	2.8	0.4	0.3	0.3	0.5	0.3	-0.1	0.2	0.3	0.3	0.2	0.5	1.7
Primary Biliary Cirrhosis	0.3	0.4	1.3	-0.8	-0.0	-0.7	-0.4	-0.6	-0.7	-0.3	-0.9	-0.8	-0.4	-0.5	-1.2
Rheumatoid Arthritis	0.3	0.4	1.1	-0.4	-0.3	-0.5	-0.6	-0.8	-1.0	-1.1	-0.5	-0.6	-0.6	-0.6	0.2
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.6	-0.7	-0.7	-0.7	-0.7	-0.7	-0.7	-0.6	-0.7	-0.7	-0.6	-0.7	-0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.5	-0.4	-0.5	-0.5	-0.5	-0.5	-0.5	-0.5	-0.5	-0.5	-0.5	-0.6	-0.7
Alcohol usually taken with meals	0.3	0.6	1.2	-0.5	-0.5	-0.5	-1.0	-0.8	-0.5	-1.1	-0.5	-0.6	-0.8	-0.9	-0.9
Had other major operations	0.3	0.4	0.8	0.9	0.5	0.7	0.8	0.6	0.5	0.3	0.7	0.7	0.7	0.6	0.7
Forced vital capacity (FVC)	0.3	1.2	3.8	0.5	0.7	0.7	1.5	1.2	1.0	1.9	0.6	0.7	1.3	1.3	-0.3
Heart attack	0.3	0.4	0.6	-0.5	-0.7	-0.7	-0.7	-0.6	-0.8	-0.6	-0.6	-0.6	-0.5	-0.5	0.2
Arm fat percentage (right)	0.3	1.3	2.2	-0.8	-0.8	-1.0	-1.4	-1.2	-1.4	-1.5	-0.7	-0.8	-1.3	-1.1	1.3
Time employed in main current job	0.3	0.4	1.6	0.1	0.7	0.3	0.7	0.7	0.5	1.3	0.2	0.3	0.6	0.6	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.2	0.7	1.0	0.8	1.3	1.1	1.0	1.5	0.7	0.8	1.2	1.3	0.1
Happiness	0.3	0.4	1.1	0.6	1.0	0.6	0.6	0.4	0.7	0.2	0.5	0.4	0.6	0.4	-0.8
Blood clot in the leg (DVT)	0.3	0.4	2.3	0.6	0.4	0.5	0.8	0.4	0.2	0.2	0.6	0.6	0.4	0.3	1.5
Age at first live birth	0.3	0.5	1.2	-0.8	-1.1	-0.8	-0.5	-0.6	-0.7	-0.5	-0.7	-0.7	-0.6	-0.6	-0.3
Medication: Seretide 50 evohaler	0.3	0.4	1.3	0.8	1.1	0.6	0.5	0.5	0.7	0.1	0.7	0.6	0.5	0.6	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.1	-0.2	-1.1	-0.3	-0.3	-0.6	-0.4	-0.9	-0.3	-0.4	-0.4	-0.3	-0.9
Medication: Gliclazide	0.3	0.4	1.0	-0.3	-0.4	-0.5	-0.5	-0.7	-0.9	-1.0	-0.4	-0.5	-0.7	-0.5	0.5
Number of self-reported non-cancer illnesses	0.3	0.4	1.3	0.9	0.6	0.7	0.4	0.5	0.5	0.1	0.8	0.7	0.5	0.5	1.1
Illnesses of father: High blood pressure	0.3	0.4	0.8	-0.6	0.1	-0.6	-0.6	-0.7	-0.9	-0.8	-0.6	-0.7	-0.6	-0.8	0.0
Commuting to job workplace: Cycle	0.3	0.3	0.6	0.7	0.6	0.5	0.8	0.3	0.2	-0.0	0.6	0.5	0.7	0.6	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.4	0.6	0.5	0.5	0.9	0.4	0.3	0.2	0.6	0.6	0.4	0.4	1.2
Tanning	0.2	2.5	3.5	1.5	0.7	1.8	1.2	1.8	1.9	1.6	1.7	1.7	1.4	1.7	1.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	-0.2	-0.1	-0.3	-0.4	-0.7	-0.6	-0.9	-0.4	-0.5	-0.5	-0.6	-0.4
Number of incorrect matches in round	0.2	0.4	1.1	0.3	0.6	0.4	0.7	0.7	0.5	1.0	0.4	0.5	0.7	0.7	0.6
Mouth/teeth dental problems: Dentures	0.2	0.4	1.1	-0.2	-0.6	-0.4	-0.6	-0.7	-0.8	-1.0	-0.4	-0.5	-0.4	-0.6	-0.3
Asthma	0.2	0.4	1.0	0.6	0.9	0.6	0.6	0.7	0.6	0.6	0.6	0.7	0.4	0.4	1.0
Medication: Cholesterol lowering	0.2	0.3	1.3	-0.1	-0.5	-0.3	-0.6	-0.7	-0.5	-1.1	-0.3	-0.4	-0.5	-0.4	-0.8
Depression (self-reported)	0.2	0.2	0.5	0.7	0.4	0.6	0.2	0.2	0.3	-0.1	0.4	0.4	0.5	0.5	-0.3
Lung cancer (father)	0.2	0.3	1.3	-0.7	-0.6	-0.6	-0.2	-0.2	-0.1	0.3	-0.5	-0.5	-0.2	-0.3	-1.1
Exposure to tobacco smoke at home	0.2	0.3	1.0	-0.2	-0.5	-0.2	-0.4	-0.6	-0.4	-1.0	-0.3	-0.4	-0.4	-0.6	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	2.2	0.6	0.2	0.6	0.3	0.6	0.7	0.4	0.8	0.8	0.3	0.6	1.5
Worry too long after embarrassment	0.2	0.3	2.0	-0.1	-0.1	0.1	0.3	0.4	0.6	0.7	0.0	0.1	0.3	0.3	-1.4
Mouth/teeth dental problems: Loose teeth	0.2	0.2	1.3	-0.3	-0.8	-0.2	-0.3	-0.2	-0.1	-0.3	0.0	0.0	-0.5	-0.2	1.2
Emphysema/chronic bronchitis	0.2	0.3	1.3	-0.0	-0.3	-0.1	-0.5	-0.5	-0.1	-1.2	0.1	-0.1	-0.8	-0.6	0.1
Pulse rate, automated reading	0.2	0.6	1.3	0.9	1.0	0.8	1.2	0.6	0.9	0.2	0.8	0.8	0.7	0.6	0.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	-0.7	-0.2	-0.6	-0.5	-0.5	-0.4	-0.2	-0.6	-0.6	-0.5	-0.5	-0.9
Illnesses of father: Heart disease	0.2	0.3	1.4	-0.2	-0.2	-0.3	-0.7	-0.5	-0.7	-0.7	-0.2	-0.3	-0.6	-0.4	1.2
Long-standing illness, disability or infirmity	0.2	0.4	2.1	0.1	-0.2	-0.2	-0.5	-0.8	-0.6	-1.4	-0.2	-0.4	-0.6	-0.7	-0.4
Eye problems/disorders: Cataract	0.2	0.2	1.4	-0.4	-0.3	-0.4	-0.2	-0.3	-0.2	-0.0	-0.5	-0.5	-0.2	-0.3	-1.2
Medication for cholesterol	0.2	0.3	0.5	0.3	0.3	0.5	0.5	0.5	0.5	0.6	0.5	0.5	0.5	0.5	0.7
Breast cancer (self-reported)	0.2	0.2	0.6	0.3	-0.0	0.4	0.2	0.6	0.5	0.7	0.4	0.5	0.3	0.2	0.8
Average weekly champagne plus white wine intake	0.2	0.3	1.1	0.1	0.5	0.4	0.5	0.6	0.5	1.0	0.2	0.3	0.6	0.5	0.3
Miserableness	0.2	0.4	2.1	0.1	0.8	-0.2	-0.4	-0.7	-0.3	-1.4	-0.0	-0.2	-0.5	-0.6	-0.7
Mother’s age at death	0.2	0.2	1.1	-0.3	-1.1	-0.4	-0.6	-0.3	-0.2	-0.4	-0.2	-0.2	-0.6	-0.4	0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.8	-0.3	-0.2	-0.4	-0.4	-0.6	-0.6	-0.9	-0.4	-0.5	-0.5	-0.5	-0.3
Medication: Atorvastatin	0.2	0.3	1.0	-0.1	-0.0	-0.2	-0.6	-0.6	-0.4	-1.0	-0.3	-0.4	-0.3	-0.4	-0.8
Ever depressed for a whole week	0.2	0.2	0.9	-0.0	0.4	-0.0	0.5	0.4	0.1	0.6	0.1	0.2	0.3	0.5	1.0
Unable to work because of sickness or disability	0.2	0.2	0.4	-0.3	-0.1	-0.4	-0.4	-0.6	-0.6	-0.6	-0.5	-0.6	-0.4	-0.5	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	-0.4	-0.6	-0.5	-0.6	-0.5	-0.6	-0.5	-0.4	-0.4	-0.5	-0.5	0.2
Bipolar Disorder or Schizophrenia	0.1	0.1	0.3	0.5	0.1	0.5	-0.2	0.1	0.5	-0.4	0.5	0.4	-0.2	0.2	0.0
Irritable Bowel Disease (IBD)	0.1	0.2	1.1	-0.3	0.0	-0.3	-0.4	-0.4	-0.1	-0.4	-0.3	-0.3	-0.2	-0.3	-1.1
Major Depression (MDD)	0.1	0.1	0.3	0.0	0.2	0.2	0.0	0.1	0.3	-0.0	0.1	0.1	0.3	0.3	-0.6
Ovarian Cancer	0.1	0.2	0.4	0.6	0.4	0.3	0.5	0.1	0.2	-0.3	0.5	0.4	0.5	0.5	0.1
Prostate Cancer	0.1	0.2	0.6	0.2	0.1	0.2	0.6	0.5	0.4	0.8	0.2	0.2	0.6	0.4	-0.1
Schizophrenia (2014)	0.1	0.2	0.4	0.5	0.1	0.6	0.4	0.5	0.6	0.4	0.5	0.5	0.1	0.4	0.6
Triglycerides	0.1	0.2	1.2	-0.1	-0.3	-0.1	-0.5	-0.5	-0.2	-1.1	0.1	-0.1	-0.6	-0.3	0.3
Ulcerative Colitis	0.1	0.1	0.4	0.1	0.6	0.2	0.2	0.3	0.5	0.4	0.2	0.2	0.0	0.2	-0.4
Systolic Blood Pressure	0.1	0.5	2.3	-0.6	-0.0	-0.7	-0.4	-0.6	-0.3	-0.6	-0.6	-0.6	-0.4	-0.6	-1.5
Chronotype (morning person)	0.1	0.2	0.4	-0.6	-0.4	-0.6	-0.3	-0.4	-0.4	-0.3	-0.4	-0.4	-0.6	-0.6	0.1
Average weekly spirits intake	0.1	0.1	0.5	0.6	0.6	0.4	0.1	-0.0	0.2	-0.7	0.4	0.3	0.0	-0.0	0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.6	-0.0	-0.1	0.0	-0.1	-0.0	0.2	0.1	-0.1	-0.1	0.1	-0.2	-0.8
Pack years adult smoking proportion	0.1	0.2	0.3	0.4	-0.1	0.4	0.6	0.5	0.5	0.5	0.4	0.4	0.3	0.5	0.4
Townsend deprivation index at recruitment	0.1	0.2	0.5	0.6	0.5	0.5	0.7	0.2	0.2	0.1	0.3	0.3	0.6	0.4	0.1
Current tobacco smoking	0.1	0.1	1.2	0.2	-0.4	0.0	-0.1	-0.1	-0.3	-0.3	0.1	0.1	-0.2	-0.1	1.1
Age when periods started (menarche)	0.1	0.1	0.3	0.4	0.5	0.4	0.3	0.3	0.2	0.2	0.4	0.4	0.3	0.4	0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.6	-0.2	-0.1	-0.2	-0.7	-0.3	-0.1	-0.3	-0.2	-0.2	-0.4	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.0	-0.1	-0.2	-0.1	-0.6	-0.5	-0.2	-0.9	-0.2	-0.3	-0.6	-0.5	-1.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	0.1	-0.0	-0.1	-0.2	-0.2	-0.2	-0.7	0.1	0.0	-0.2	-0.1	0.3
Qualifications: None of the above	0.1	0.2	1.1	0.4	0.1	0.1	-0.4	-0.4	-0.2	-1.0	0.1	0.0	-0.5	-0.4	0.1
Financial difficulties in last 2 years	0.1	0.1	0.7	0.3	0.8	0.3	0.2	-0.0	-0.0	-0.3	0.2	0.2	0.2	0.2	0.1
Medication: Simvastatin	0.1	0.1	0.4	0.4	-0.1	0.2	-0.1	-0.1	-0.2	-0.5	0.2	0.1	0.0	0.1	0.6
Father’s age at death	0.1	0.1	0.2	-0.3	-0.4	-0.2	-0.4	-0.3	-0.2	-0.3	-0.2	-0.3	-0.4	-0.3	-0.4
Pulse rate	0.1	0.1	0.6	0.3	0.2	0.2	0.8	0.2	0.1	0.3	0.2	0.2	0.5	0.2	0.1
Noisy workplace	0.1	0.1	0.3	0.1	-0.1	0.1	0.5	0.3	0.2	0.5	0.1	0.2	0.3	0.3	0.1
Illnesses of mother	0.1	0.1	0.6	0.5	0.7	0.3	0.4	0.2	0.2	0.2	0.3	0.2	0.5	0.3	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.4	0.5	0.4	0.2	0.2	0.3	-0.1	0.5	0.4	0.1	0.4	0.6
Birth weight of first child	0.1	0.2	1.1	-0.4	-0.3	-0.3	-0.1	-0.1	0.0	0.2	-0.4	-0.3	-0.1	-0.2	-1.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.9	0.3	0.9	0.2	0.2	0.0	0.1	-0.3	0.2	0.2	0.3	0.2	0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.6	0.5	0.1	0.4	-0.2	-0.1	-0.1	-0.7	0.3	0.2	0.1	0.1	0.8
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.9	0.3	-0.2	0.2	-0.3	-0.3	-0.3	-0.9	0.2	0.1	-0.3	-0.2	0.8
Health satisfaction	0.1	0.1	0.7	0.2	0.6	0.1	0.1	0.1	0.3	-0.2	0.1	0.1	0.0	0.1	-0.8
Number of full sisters	0.1	0.1	0.4	0.6	0.2	0.4	0.4	0.1	0.1	-0.4	0.4	0.3	0.2	0.0	0.6
Age at last live birth	0.1	0.2	0.9	-0.5	-1.0	-0.4	-0.3	-0.2	-0.3	-0.0	-0.4	-0.3	-0.3	-0.2	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	1.0	0.2	0.3	-0.0	-0.3	-0.4	-0.2	-1.0	0.0	-0.1	-0.3	-0.2	-0.3
Friendships satisfaction	0.1	0.1	0.6	0.2	0.1	0.1	-0.2	-0.2	0.2	-0.8	0.2	0.1	-0.2	-0.2	-0.5
Commuting to job workplace: Walk	0.1	0.1	0.7	0.4	0.0	0.3	0.1	-0.2	-0.1	-0.8	0.3	0.2	-0.0	-0.3	0.4
Asthma (self-reported)	0.1	0.1	0.4	0.2	0.6	0.3	0.2	0.4	0.3	0.4	0.3	0.4	0.1	0.2	0.6
Illnesses of father: None of the above (group 1)	0.1	0.1	1.1	-0.3	-0.5	-0.2	-0.2	-0.1	0.0	0.2	-0.3	-0.3	0.0	-0.0	-1.1
Smoking status: Current	0.1	0.1	1.5	0.3	-0.1	0.2	0.2	0.1	-0.2	-0.1	0.2	0.2	0.1	0.1	1.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.4	-0.4	0.2	0.1	-0.2	-0.2	-0.5	0.1	0.1	0.1	-0.0	0.3
Irritability	0.1	0.2	1.0	-0.2	0.4	-0.2	-0.2	-0.5	-0.5	-0.6	-0.4	-0.5	0.0	-0.3	-1.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	-0.6	0.1	-0.5	-0.4	-0.1	-0.2	0.3	-0.4	-0.3	-0.3	-0.0	0.0
Age started oral contraceptive pill	0.1	0.1	0.6	-0.2	-0.3	-0.1	-0.3	-0.0	-0.2	0.0	-0.1	-0.0	-0.3	-0.5	0.8
Pack years of smoking	0.1	0.2	0.3	0.3	-0.1	0.3	0.5	0.5	0.5	0.6	0.4	0.4	0.2	0.5	0.3
Depression (Nagel 2018)	0.0	0.1	0.3	0.1	0.4	0.2	0.2	0.3	0.2	0.5	0.1	0.2	0.4	0.3	0.2
Ulcerative Colitis (UC)	0.0	0.1	0.2	0.3	0.5	0.3	0.3	0.2	0.4	-0.0	0.3	0.3	0.1	0.1	-0.3
Heel T-Score	0.0	0.2	0.9	0.4	0.3	0.2	-0.3	-0.1	0.0	-0.7	0.4	0.3	-0.1	0.2	0.9
Hypothyroidism (self reported)	0.0	0.0	0.2	0.0	-0.4	0.0	-0.2	0.0	0.2	-0.1	0.2	0.1	-0.3	-0.1	0.3
Respiratory disease	0.0	0.1	0.4	0.1	-0.0	0.0	-0.3	-0.1	-0.0	-0.5	0.2	0.1	-0.5	-0.4	0.6
Lung FEV1/FVC ratio	0.0	0.1	1.0	-0.1	-0.2	-0.0	-0.3	0.1	-0.1	0.3	0.0	0.0	0.2	0.4	1.0
Hair Pigment	0.0	0.4	2.3	0.2	0.3	-0.1	-0.5	-0.8	-0.7	-1.5	-0.2	-0.3	-0.3	-0.4	-0.3
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.2	-0.0	-0.3	0.1	-0.4	0.1	0.3	0.2	0.1	0.1	-0.3	-0.0	0.2
Taking other prescription medications	0.0	0.1	0.4	-0.2	-0.6	-0.2	-0.2	0.1	-0.0	0.3	-0.2	-0.1	-0.2	0.0	-0.0
Qualifications: CSEs or equivalent	0.0	0.1	0.3	0.2	-0.0	0.3	0.0	-0.0	0.3	-0.5	0.3	0.2	-0.1	0.1	0.0
Medication: Levothyroxine sodium	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.4	-0.1	-0.0	-0.2	-0.0	-0.1	-0.3	-0.2	0.2
Had menopause	0.0	0.1	0.3	0.2	-0.1	0.0	-0.3	0.1	0.2	-0.2	0.3	0.3	-0.1	-0.1	0.6
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	-0.1	-0.0	-0.1	0.1	0.1	-0.1	0.1	-0.0	0.0	0.1	0.1	0.2
Falls in the last year	0.0	0.0	0.0	0.0	-0.0	-0.0	0.1	-0.0	-0.2	0.1	-0.1	-0.1	0.1	-0.0	0.2
Breastfed as a baby	0.0	0.0	0.1	0.2	-0.1	0.1	0.3	-0.0	-0.1	-0.1	0.1	0.0	0.1	-0.1	0.4
Birth weight	0.0	0.0	0.2	-0.1	-0.5	-0.0	-0.3	-0.1	-0.2	-0.1	-0.1	-0.2	-0.0	-0.2	-0.2
Migraine (self-reported)	0.0	0.1	0.4	0.2	0.2	0.1	0.2	-0.1	0.1	-0.3	0.0	-0.0	0.2	0.2	-0.7
Leg pain on walking	0.0	0.0	0.1	-0.1	0.1	-0.0	0.1	0.1	0.2	0.1	0.0	0.0	-0.2	-0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	-0.2	-0.0	-0.2	-0.3	0.0	0.1	0.1	-0.0	-0.0	-0.2	-0.0	0.0
Supplements: Vitamin C	0.0	0.0	0.2	0.1	-0.0	0.2	-0.2	0.2	0.4	0.2	0.2	0.2	0.1	0.3	-0.1
Hearing aid user	0.0	0.1	0.1	0.3	0.2	0.1	0.3	0.1	0.0	-0.1	0.2	0.2	0.3	0.3	0.3
Number of operations (self-reported)	0.0	0.1	0.1	-0.1	-0.3	-0.2	-0.3	-0.3	-0.3	-0.3	-0.2	-0.2	-0.1	-0.2	-0.1

Hub : Genes

EVI2A

Models

Trait associations