Best TWAS P=1.57e-12 · Best GWAS P=1.52e-10 conditioned to 0.00192
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Liver | PDE6D | 0.21 | 0.10 | lasso | 4 | 0.09 | 1.8e-03 | -5.4 | -5.9 | 3.9e-09 | -0.06 | 0.03 | 0.80 | TRUE |
| 2 | GTEx | Thyroid | GIGYF2 | 0.08 | 0.02 | lasso | 3 | 0.01 | 6.7e-02 | -6.1 | -5.2 | 2.4e-07 | 0.74 | 0.03 | 0.74 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | NCL | 0.16 | 0.05 | lasso | 6 | 0.08 | 6.1e-10 | 3.3 | 5.5 | 3.4e-08 | 0.00 | 0.02 | 0.98 | TRUE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C2orf52 | 0.15 | 0.14 | enet | 8 | 0.13 | 3.7e-11 | -5.4 | 5.3 | 1.3e-07 | 0.02 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | C2orf52 | 0.28 | 0.12 | lasso | 6 | 0.12 | 2.0e-06 | -5.5 | 5.6 | 2.1e-08 | 0.04 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | C2orf52 | 0.21 | 0.16 | blup | 42 | 0.24 | 7.1e-14 | -5.1 | 5.2 | 1.8e-07 | 0.04 | 0.01 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Glioblastoma Multiforme | C2orf52 | 0.28 | 0.12 | enet | 12 | 0.18 | 5.0e-06 | -5.3 | 5.3 | 1.2e-07 | 0.07 | 0.01 | 0.94 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EFHD1 | 0.11 | 0.01 | blup | 70 | 0.03 | 1.0e-02 | 5.7 | 7.1 | 1.6e-12 | -0.61 | 0.01 | 0.74 | TRUE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | KCNJ13 | 0.07 | 0.06 | enet | 13 | 0.05 | 4.7e-04 | -6.1 | 5.3 | 1.4e-07 | -0.83 | 0.02 | 0.92 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GIGYF2 | 0.02 | 0.01 | lasso | 3 | 0.01 | 5.3e-02 | -6.1 | -6.1 | 8.4e-10 | 0.91 | 0.03 | 0.87 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NGEF | 0.03 | 0.01 | blup | 130 | 0.01 | 2.0e-02 | -6.1 | 5.2 | 1.9e-07 | -0.77 | 0.03 | 0.84 | FALSE |
| 12 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C2orf52 | 0.13 | 0.06 | lasso | 4 | 0.05 | 2.1e-03 | -5.4 | 5.2 | 1.7e-07 | 0.01 | 0.01 | 0.84 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C2orf52 | 0.28 | 0.18 | lasso | 4 | 0.20 | 3.7e-22 | -5.5 | 5.3 | 1.1e-07 | 0.04 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C2orf52 | 0.32 | 0.21 | lasso | 7 | 0.21 | 3.6e-09 | -5.0 | 5.1 | 2.8e-07 | 0.03 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | KCNJ13 | 0.07 | 0.07 | blup | 36 | 0.06 | 2.4e-03 | -6.1 | 5.3 | 9.6e-08 | -0.86 | 0.01 | 0.86 | FALSE |
| 16 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C2orf52 | 0.27 | 0.27 | lasso | 5 | 0.28 | 1.7e-11 | -5.4 | 5.3 | 9.6e-08 | 0.02 | 0.01 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | C2orf52 | 0.21 | 0.20 | lasso | 1 | 0.18 | 1.4e-05 | -5.5 | 5.5 | 3.8e-08 | 0.03 | 0.00 | 0.93 | FALSE |
| 18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C2orf52 | 0.29 | 0.17 | enet | 10 | 0.19 | 3.2e-07 | -5.4 | 5.2 | 2.3e-07 | 0.03 | 0.01 | 0.98 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | KCNJ13 | 0.03 | 0.00 | blup | 35 | 0.01 | 4.3e-02 | 5.8 | -6.8 | 7.6e-12 | 0.86 | 0.01 | 0.52 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | NGEF | 0.04 | 0.03 | enet | 7 | 0.03 | 5.6e-04 | 5.9 | -6.8 | 1.1e-11 | 0.76 | 0.03 | 0.94 | FALSE |