Hub : Genes

NCL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.199	0.0700	2.1e-03	0.028	NA	0.021	NA	0.038	2.0e-02	NA	4.0e-02	NA	8.8e-03
2	ROSMAP	Brain Pre-frontal Cortex	0.162	0.0451	5.1e-06	0.050	0.042	0.067	0.052	0.075	4.1e-07	3.7e-06	4.7e-09	2.5e-07	6.1e-10
3	YFS	Blood	0.256	0.0351	0.0e+00	0.131	0.144	0.148	0.148	0.141	1.3e-40	9.8e-45	4.1e-46	6.0e-46	7.8e-44
4	TCGA	Pheochromocytoma and Paraganglioma	0.118	0.0600	4.7e-03	-0.001	0.018	0.019	NA	-0.002	3.5e-01	6.4e-02	5.7e-02	NA	3.9e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.6	1.3	0.6	-0.9	1.1	-0.2
Bipolar Disorder or Schizophrenia	0.8	1.9	3.1	1.1	-1.8	1.7	0.3
Depressed Affect (Nagel 2018)	0.7	1.4	3.4	1.8	-1.1	0.9	-0.3
Depression (Nagel 2018)	0.7	1.1	3.9	0.1	-0.0	0.6	-2.0
Intelligence (Savage-Jansen 2018)	1.4	4.3	12.7	1.3	3.6	1.4	1.1
Neuroticism (Nagel 2018)	0.7	1.6	3.0	1.0	-1.7	0.7	-1.3
Schizophrenia (2018)	0.7	1.5	2.4	1.2	-1.5	1.3	0.6
Schizophrenia vs Biploar Disorder	0.5	0.6	1.0	-0.9	-1.0	-0.5	-0.6
Worry (Nagel 2018)	0.8	1.7	2.7	0.7	-1.4	1.6	-1.2
Alzheimer’s Disease (in mother)	1.4	1.6	3.2	0.7	-1.1	-1.2	1.8
Alzheimer’s Disease (in father)	0.5	0.6	1.9	-1.4	-0.1	0.5	-0.4
Alzheimer’s Disease (including proxy)	0.6	0.8	1.8	-0.7	-1.4	-0.5	0.8
Crohns Disease (2017)	0.8	1.8	6.6	-2.6	-0.4	-0.1	-0.6
Irritable Bowel Disease (IBD)	0.3	0.7	1.6	-1.3	-0.5	0.8	0.0
Ulcerative Colitis (UC)	0.3	0.6	1.8	-0.0	-0.1	1.4	0.6
Major Depression (MDD)	0.5	0.6	1.2	0.1	1.1	-0.8	0.7
Reaction Time	0.1	0.2	0.4	-0.2	-0.1	0.5	0.7
Verbal and Numeric Reasoning (VNR)	2.1	5.1	13.4	1.6	3.7	2.0	0.6
Breast Cancer	0.4	0.9	1.5	0.6	0.7	1.2	1.2
Ovarian Cancer	1.4	1.8	3.9	-0.6	2.0	0.5	-1.6
Prostate Cancer	0.6	0.8	2.3	0.5	1.5	0.8	0.3
Age at First Birth	0.8	1.2	1.7	1.3	0.9	1.1	1.1
Bipolar Disorder (2011)	0.4	0.4	1.4	-0.4	-0.1	1.2	0.0
Body Mass Index (BMI) (2010)	1.1	1.5	2.9	-1.7	-0.7	-0.7	-1.5
Coronary Artery Disease (CAD)	0.7	0.8	2.6	0.1	-0.5	-1.6	0.7
Crohns Disease (2012)	0.9	1.4	4.0	-2.0	-0.7	-1.0	-0.4
Mean Putamen Volume	1.5	1.7	3.5	1.9	1.2	1.3	0.2
Fasting Glucose	1.3	1.6	4.6	0.3	1.2	2.1	-0.4
HbA1C	0.6	0.6	1.6	0.3	0.5	0.8	1.2
HDL Cholesterol	1.2	2.0	3.2	1.1	1.8	1.8	0.7
LDL Cholesterol	1.0	1.6	3.3	-1.4	-0.2	-1.8	0.9
Lupus	0.6	0.9	1.4	1.1	0.3	0.8	-1.2
Neuroticism (2016)	0.2	0.3	0.8	0.1	-0.9	0.5	-0.3
Primary Biliary Cirrhosis	0.5	0.7	2.7	-0.0	-1.6	-0.0	-0.4
Rheumatoid Arthritis	0.7	0.9	3.1	0.3	-0.5	-0.3	1.8
Schizophrenia (2014)	0.9	2.0	4.9	1.3	-2.2	1.2	-0.1
Triglycerides	1.3	2.2	2.9	-1.4	-1.7	-1.5	-1.2
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.5	-1.2	-0.9	-0.6	-1.2
Ulcerative Colitis	0.5	0.7	1.2	0.7	0.6	0.9	1.1
Blood Eosinophil Count	0.0	0.1	0.1	0.1	0.4	-0.3	-0.3
Blood Platelet Count	0.3	3.2	6.9	-2.6	-1.9	-1.3	-0.9
Blood Red Count	0.1	1.3	3.0	-0.5	-0.7	-1.7	-1.3
Blood White Count	0.6	4.1	5.7	-2.3	-2.4	-2.2	-0.9
Heel T-Score	0.2	1.8	3.1	-1.1	1.1	1.8	1.2
BMI	1.2	6.9	11.7	-2.1	-3.4	-2.8	-1.9
Height	5.0	96.9	198.8	9.7	14.1	8.3	5.2
Waist Hip Ratio (WHR)	1.8	8.2	14.7	1.9	3.8	3.8	0.5
Systolic Blood Pressure	0.4	2.1	4.9	-1.3	-0.5	-2.2	-1.3
Smoking Status	0.1	0.2	0.6	-0.8	0.0	0.4	0.2
Allergy or Eczema	0.3	0.7	2.4	-0.2	-1.5	-0.0	0.6
Cardiovascular Disease	0.3	0.9	1.9	-0.5	-0.9	-1.4	-0.8
Hypothyroidism (self reported)	0.1	0.3	1.0	-0.3	-1.0	0.2	-0.4
Respiratory disease	0.6	1.3	2.3	-0.9	-1.5	-1.5	-0.0
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.9	-0.2	-1.0	-0.3	-0.9
Lung FEV1/FVC ratio	1.0	5.0	12.7	3.6	-0.1	2.6	0.5
Lung FVC	0.6	2.9	10.0	-3.2	0.9	-0.7	0.6
Neuroticism	0.7	1.7	3.1	1.5	-1.1	1.8	0.1
Chronotype (morning person)	1.4	3.3	5.2	-1.4	-1.7	-1.8	-2.3
Hair Pigment	0.0	1.4	3.5	0.9	-1.9	-1.0	-0.0
Tanning	0.1	1.0	2.8	1.0	1.7	0.2	0.1
Hand grip strength (left)	3.1	8.1	14.5	3.2	3.8	2.3	1.5
Number of treatments/medications taken	0.2	0.3	0.8	0.7	-0.9	-0.3	0.1
Average weekly spirits intake	1.2	1.5	3.0	-1.6	-0.3	-0.7	-1.7
Sensitivity / hurt feelings	2.6	4.5	13.2	-1.2	-1.1	-1.4	-3.6
Frequency of depressed mood in last 2 weeks	1.6	2.3	8.7	-0.6	0.3	-0.1	-3.0
Hearing difficulty/problems: Yes	3.3	5.0	13.2	0.8	-3.6	-2.4	-0.7
Relative age of first facial hair	0.3	0.5	1.9	-1.4	-0.2	-0.2	0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.3	0.0	-0.2	-1.1	0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	0.7	0.5	-0.2	-0.4
Ever had hysterectomy (womb removed)	0.6	0.7	1.2	0.5	0.4	1.1	-1.0
Systolic blood pressure, automated reading	0.8	2.4	4.7	-1.4	-0.4	-2.2	-1.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.6	0.5	0.0	0.6	1.3
Angina	0.9	1.2	3.7	-0.3	-1.9	-0.5	-0.9
Medication for hormone replacement therapy	1.0	1.1	1.9	-1.3	0.4	0.7	-1.4
Vitamin and mineral supplements	0.5	0.7	2.2	0.2	1.5	-0.3	0.6
Supplements: Zinc	1.1	1.2	3.8	-0.4	-1.9	-0.4	-0.8
Medication: Co-codamol	1.4	1.6	3.7	0.4	-1.9	0.4	1.6
Medication: Metformin	0.5	0.7	1.8	-0.9	-1.4	0.3	-0.3
Diabetes (father)	0.8	1.0	2.5	0.1	-1.6	-0.2	1.1
Diabetes (mother)	1.5	1.9	5.1	-2.3	-0.8	-1.0	-0.8
Severe depression (siblings)	1.2	1.4	3.3	0.7	0.0	1.3	1.8
Pack years adult smoking proportion	0.7	1.0	2.5	0.2	-1.2	-1.6	-0.3
Impedance of leg (right)	0.7	3.2	7.8	-0.8	-2.8	-1.9	-0.6
Leg fat-free mass (left)	2.2	11.5	26.1	2.7	5.1	3.4	1.2
Trunk fat percentage	1.5	5.9	13.0	-2.1	-3.6	-2.1	-1.4
Hand grip strength (right)	2.3	6.2	13.2	2.1	3.6	2.7	0.5
Townsend deprivation index at recruitment	0.6	0.8	1.4	-1.2	-1.1	-0.1	-0.8
Current tobacco smoking	0.3	0.5	1.5	-0.2	-1.2	0.3	0.4
Average weekly fortified wine intake	0.9	1.0	2.0	-1.1	0.9	1.4	-0.2
Maternal smoking around birth	0.2	0.3	1.0	0.3	-1.0	0.2	-0.5
Fed-up feelings	0.7	1.3	2.0	1.3	0.1	1.4	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	6.1	-1.0	-1.2	-1.1	-2.5
Relative age voice broke	0.4	0.7	1.0	-1.0	0.7	-0.6	-1.0
Taking other prescription medications	0.4	0.5	0.8	0.5	-0.9	-0.8	-0.8
Age when periods started (menarche)	0.5	1.1	3.9	-0.2	-2.0	-0.3	0.6
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	7.2	-0.7	0.6	-0.8	-2.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.8	-1.2	-0.5	0.1	1.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.7	0.3	-0.8	-0.0	-0.9
Qualifications: CSEs or equivalent	2.1	2.7	4.9	1.6	1.5	1.1	2.2
Serious illness, injury or assault to yourself	0.4	0.5	1.5	-1.2	-0.8	0.2	-0.0
High blood pressure	0.3	0.9	1.8	-0.3	-0.9	-0.9	-1.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.9	-0.9	-1.0	-0.6	0.5
Multivitamins +/- minerals	0.4	0.6	1.4	0.1	-1.2	0.4	-0.8
Stomach or abdominal pain in last month	2.7	3.4	6.6	-1.7	-2.6	0.4	-1.9
Supplements: Glucosamine	0.8	1.0	2.4	-0.8	-0.4	-1.5	-0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.7	0.4	-0.1	0.4
Medication: Atenolol	0.5	0.7	1.7	-0.2	-0.7	-1.3	-0.7
Medication: Levothyroxine sodium	0.4	0.7	1.3	1.1	-0.1	0.9	-0.9
Sitting height	3.2	23.0	63.8	3.0	8.0	3.1	3.1
Chronic bronchitis/emphysema (father)	0.9	1.1	2.2	1.5	1.3	-0.4	-0.3
High blood pressure (mother)	0.2	0.3	0.9	0.3	0.2	-1.0	-0.1
Body mass index (BMI)	1.0	4.4	7.6	-2.3	-2.8	-1.3	-1.8
Impedance of leg (left)	0.7	3.2	7.9	-1.1	-2.8	-1.9	-0.2
Leg predicted mass (left)	2.2	11.7	26.5	2.7	5.2	3.4	1.2
Trunk fat mass	0.3	1.2	1.8	-1.1	-1.3	-0.8	-1.0
Waist circumference	0.2	0.6	1.0	-1.0	-0.8	0.0	-0.8
Number of incorrect matches in round	1.5	2.5	5.2	2.3	0.4	1.0	1.9
Past tobacco smoking	0.7	1.3	4.1	-0.2	-2.0	-0.9	-0.4
Alcohol usually taken with meals	0.3	0.5	1.6	1.3	0.5	0.3	0.2
Nervous feelings	0.9	1.7	3.7	0.3	-1.9	0.3	-1.7
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	6.7	-1.2	-1.7	-1.9	-2.6
Hearing difficulty/problems with background noise	3.7	5.9	18.3	-0.2	-1.9	-4.3	-1.2
Hair/balding pattern: Pattern 2	0.9	1.1	1.5	-0.7	-1.1	-1.0	1.2
Had menopause	2.3	2.9	5.7	0.4	-2.4	-0.5	-2.4
Had other major operations	0.4	0.5	1.8	0.2	-0.4	-0.3	1.3
Forced vital capacity (FVC)	2.2	8.5	28.9	0.8	5.4	1.5	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.3	-0.8	-0.5	-0.2	1.5
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.0	-0.3	-1.2	-0.5	-1.7
Qualifications: None of the above	1.5	3.1	5.1	-1.3	-2.2	-1.2	-2.1
Financial difficulties in last 2 years	0.5	0.7	1.4	-1.2	0.3	1.1	0.4
Mouth/teeth dental problems	0.6	0.9	2.3	-0.8	1.5	0.7	0.3
Heart attack	0.8	1.1	3.0	-0.5	-1.7	-1.0	-0.2
Allergy	0.3	0.8	1.3	1.1	0.7	1.0	-0.4
Pain all over the body in last month	0.6	0.6	2.1	-0.4	1.4	0.5	-0.0
Diabetes (self-reported)	0.4	0.7	2.7	0.0	-1.6	0.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.6	1.2	-0.1	1.1	1.3
Medication: Ramipril	1.0	1.3	2.6	-1.5	-0.6	-1.6	-0.3
Medication: Simvastatin	1.1	1.6	3.2	-1.6	-0.7	-1.8	-0.1
Fluid intelligence score	1.3	2.7	5.1	1.7	2.2	1.6	0.5
Illnesses of siblings	0.2	0.3	0.8	0.5	-0.0	0.3	0.9
Neuroticism score	0.5	1.0	1.8	0.6	-1.3	0.5	-1.3
Weight	0.2	1.2	3.2	0.6	1.8	1.1	-0.1
Impedance of arm (right)	0.5	2.6	7.6	-0.4	-2.8	-1.6	0.2
Arm fat percentage (right)	1.8	7.0	14.3	-2.7	-3.8	-1.9	-1.7
Trunk fat-free mass	3.7	21.1	48.2	3.7	6.9	4.5	1.7
Hip circumference	0.3	1.4	2.7	-1.3	-1.6	-1.1	-0.5
Time employed in main current job	0.7	0.8	2.0	0.0	-1.4	-0.5	-0.9
Alcohol intake versus 10 years previously	0.7	1.1	2.7	-0.1	-1.1	1.6	0.5
Father’s age at death	0.1	0.1	0.2	-0.4	0.3	0.4	-0.1
Worrier / anxious feelings	0.5	0.9	2.2	-0.5	-1.5	0.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	6.4	-1.0	0.6	-0.8	-2.5
Falls in the last year	1.2	1.6	5.3	-0.7	-0.5	-0.6	-2.3
Hair/balding pattern: Pattern 3	2.4	3.6	6.0	1.1	2.3	2.4	1.5
Number of live births	0.9	1.3	4.5	0.5	0.2	0.5	-2.1
Forced expiratory volume in 1-second (FEV1)	1.8	6.2	16.4	1.2	4.0	2.3	1.4
Pulse rate	0.6	1.0	3.5	1.9	-0.1	0.5	0.6
Happiness	0.9	1.1	3.4	-0.8	0.7	-0.2	-1.8
Noisy workplace	1.5	1.9	3.8	0.2	-1.3	-1.9	-1.4
Qualifications: A levels/AS levels or equivalent	1.6	3.6	8.0	0.7	2.8	2.1	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.3	-0.4	-1.8	-1.3	-1.2
Mouth/teeth dental problems: Dentures	0.3	0.5	0.7	0.9	-0.8	0.1	-0.8
Asthma	0.3	0.5	1.0	-0.6	-1.0	-0.8	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	4.8	0.5	-0.6	-0.6	2.2
Medication: Cholesterol lowering	0.7	1.1	2.6	-0.8	-1.6	-0.8	0.6
Depression (self-reported)	0.3	0.4	0.7	0.8	-0.8	-0.5	-0.2
Medication: Lansoprazole	1.1	1.3	2.3	1.5	0.0	1.3	1.1
Prospective memory result	1.3	1.6	2.7	-1.6	-1.4	-1.4	-0.3
Lung cancer (father)	1.6	1.8	5.7	2.4	0.2	1.1	0.7
Illnesses of mother	1.5	1.9	7.4	-0.1	0.3	2.7	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.1	17.3	1.4	4.2	2.4	1.7
Pulse wave Arterial Stiffness index	1.6	1.9	5.3	-0.7	-0.5	-1.2	-2.3
Impedance of arm (left)	0.6	2.8	5.9	-0.3	-2.4	-2.1	0.8
Arm fat mass (right)	0.3	1.4	2.3	-1.3	-1.5	-0.6	-1.1
Trunk predicted mass	3.8	21.6	48.9	3.8	7.0	4.6	1.6
Standing height	4.3	42.4	93.3	6.1	9.7	5.2	3.4
Length of working week for main job	0.2	0.2	0.7	-0.5	-0.8	-0.1	0.2
Exposure to tobacco smoke at home	0.7	0.8	1.3	-1.1	-0.8	-0.8	-0.6
Breastfed as a baby	0.3	0.4	1.4	-1.2	0.5	-0.1	-0.0
Tense / ‘highly strung’	1.0	1.6	3.3	0.3	-1.8	-0.2	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.6	1.9	-0.7	0.6	-0.2
Hair/balding pattern: Pattern 4	1.6	3.9	13.5	1.2	3.7	0.5	0.6
Birth weight of first child	1.9	3.4	6.4	2.4	2.5	1.0	0.8
Peak expiratory flow (PEF)	2.9	6.7	10.8	2.3	2.3	2.3	3.3
Pulse wave reflection index	3.2	3.9	10.4	-1.7	-1.2	-1.0	-3.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.1	-0.1	-2.0	0.3	-0.5
Loud music exposure frequency	0.1	0.1	0.2	-0.1	-0.4	0.1	0.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.1	1.3	1.0	1.4	1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.0	1.4	0.7	-0.3	0.5
Blood clot in the leg (DVT)	0.7	0.9	3.5	-0.3	1.9	0.1	0.0
Medication: Paracetamol	0.0	0.1	0.2	0.1	0.5	-0.1	-0.1
Headache pain in last month	0.7	1.3	1.9	-1.4	1.3	0.1	-1.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.7	1.1	1.7	0.8	0.7
Glaucoma (self-reported)	2.0	2.4	4.1	2.0	-0.2	1.6	1.7
Gout (self-reported)	1.0	1.4	2.0	-0.9	-1.4	-1.1	-1.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.4	0.7	-0.7	1.2	0.1
Medication: Amlodipine	0.2	0.3	0.6	0.8	0.2	-0.6	0.4
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.0	-1.4	-0.3	0.6	-0.5
Birth weight	1.8	4.0	9.9	0.4	3.1	2.2	0.9
Chronic bronchitis/emphysema (mother)	1.5	1.8	4.8	0.0	-2.2	-1.2	0.9
High blood pressure (siblings)	0.1	0.2	0.5	-0.7	-0.1	0.0	-0.5
Forced vital capacity (FVC), Best measure	2.7	10.0	31.0	1.2	5.6	1.9	2.0
Body fat percentage	2.0	8.1	16.1	-2.8	-4.0	-2.2	-1.9
Leg fat percentage (right)	2.9	10.4	22.3	-2.7	-4.7	-2.2	-2.6
Arm fat-free mass (right)	2.8	14.1	35.0	2.8	5.9	3.5	1.2
Exposure to tobacco smoke outside home	1.3	1.7	4.0	-1.3	-2.0	-0.0	-1.1
Comparative body size at age 10	0.2	0.6	1.8	-0.5	-1.4	0.7	-0.1
Number of full brothers	1.6	2.0	7.3	0.8	2.7	0.1	-0.2
Worry too long after embarrassment	0.1	0.1	0.2	-0.2	-0.3	-0.3	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.7	1.7	0.2	1.1	-1.2
Wheeze or whistling in the chest in last year	0.6	1.1	2.9	-0.0	-1.1	-1.7	0.1
Number of children fathered	0.6	0.7	1.4	0.5	1.2	-0.1	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	4.6	1.1	-0.2	2.1	0.1
Age at first live birth	1.7	3.1	9.4	0.2	3.1	1.3	1.1
Pulse wave peak to peak time	2.5	2.9	6.2	1.3	1.2	1.5	2.5
Health satisfaction	0.8	1.0	2.0	-1.4	-0.3	0.1	-1.4
Shortness of breath walking on level ground	1.2	1.4	2.6	1.6	1.6	0.7	-0.2
Qualifications: College or University degree	2.1	6.6	14.1	2.0	3.8	2.6	1.3
Eye problems/disorders: None of the above	3.6	4.2	8.9	2.4	3.0	0.4	1.3
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.0	0.9	-0.5	-1.7	0.9
Emphysema/chronic bronchitis	0.9	1.0	1.8	-0.7	-1.1	-1.4	-0.7
Medication for pain relief, constipation, heartburn	0.4	0.7	2.1	0.2	0.2	0.7	-1.5
Neck or shoulder pain in last month	1.6	2.3	6.5	-1.1	-2.6	-0.9	-0.9
Medication: Blood pressure	0.7	1.2	2.5	-1.3	-0.2	-0.5	-1.6
Angina (self-reported)	0.8	1.1	3.4	-0.1	-1.8	-0.6	-0.7
Migraine (self-reported)	1.7	2.1	4.2	1.2	1.2	2.0	-1.2
Medication: Ibuprofen	1.0	1.2	2.6	0.4	-0.9	-1.2	1.6
Medication: Allopurinol	0.4	0.5	1.2	-0.2	-1.1	-0.7	-0.5
Medication: Omeprazole	0.3	0.3	0.8	-0.5	0.3	0.3	-0.9
Medication: Seretide 50 evohaler	1.1	1.3	3.5	1.0	-0.7	1.9	0.3
Mean time to correctly identify matches	0.1	0.2	0.5	-0.3	-0.3	-0.3	0.7
Heart disease (mother)	1.4	1.8	4.8	2.2	-1.1	-0.9	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.6	1.1	1.1	-0.0	1.9
Whole body fat mass	0.4	1.8	2.6	-1.6	-1.6	-0.8	-1.2
Leg fat mass (right)	0.7	2.6	4.2	-1.6	-2.0	-0.7	-1.8
Arm predicted mass (right)	3.0	15.5	37.7	3.1	6.1	3.6	1.2
Pulse rate, automated reading	1.9	6.1	16.0	4.0	-0.9	2.1	1.8
Alcohol intake frequency.	2.4	5.5	10.4	-2.2	-3.2	-2.0	-1.7
Comparative height size at age 10	1.6	8.9	12.7	3.5	3.6	2.9	1.5
Number of full sisters	0.2	0.2	0.6	0.4	0.2	0.3	0.8
Suffer from ‘nerves’	1.0	1.6	3.0	-0.0	-1.2	1.3	-1.7
Overall health rating	1.2	2.5	8.6	-0.5	-2.9	-0.2	-1.0
Chest pain or discomfort	0.0	0.0	0.1	0.4	0.2	-0.1	-0.1
Had major operations	0.6	0.8	1.4	-0.9	-0.1	-1.2	-0.8
Age at last live birth	1.4	2.1	4.0	0.5	2.0	1.8	1.0
Family relationship satisfaction	1.0	1.2	2.5	1.0	1.6	1.2	0.2
Leg pain on walking	1.6	2.1	4.9	-0.0	-2.2	-1.1	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.9	0.2	-0.1	-0.1	1.4
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.0	-0.9	-0.1	-0.9	-1.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.2	0.0	-0.5	-0.4
Medication: Aspirin	0.4	0.5	1.8	0.4	-0.2	-0.2	1.3
Supplements: Vitamin C	0.2	0.3	0.6	-0.7	-0.2	-0.2	-0.7
Knee pain experienced in last month	0.6	0.9	1.7	-0.6	-1.3	-1.3	-0.2
Hypertension (Self-reported)	0.4	1.1	2.4	-0.7	-0.4	-1.2	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	4.7	-1.1	0.4	-0.5	-2.2
Illnesses of father: Heart disease	1.0	1.4	3.3	-0.4	-1.8	-1.5	0.3
Illnesses of siblings: Diabetes	0.6	0.7	2.1	0.7	1.4	0.5	0.4
Smoking status: Previous	0.7	1.0	3.7	0.5	1.9	0.3	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.5	0.1	2.1	-0.4	1.7
Whole body fat-free mass	3.1	17.9	40.7	3.3	6.4	4.2	1.5
Leg fat-free mass (right)	2.5	13.2	30.5	2.8	5.5	3.5	1.5
Arm fat percentage (left)	1.8	7.2	15.4	-2.5	-3.9	-2.2	-1.5
Average weekly red wine intake	1.4	2.0	4.1	2.0	1.3	0.8	1.3
Handedness (chirality/laterality): Left-handed	1.2	1.4	5.0	-0.5	-0.6	-0.4	-2.2
Mood swings	0.1	0.2	0.4	0.7	-0.2	-0.0	-0.4
Loneliness, isolation	1.0	1.4	4.1	0.4	-2.0	0.8	-0.8
Long-standing illness, disability or infirmity	0.6	0.9	2.5	-0.5	-1.6	-0.5	0.8
Ever had bowel cancer screening	0.9	1.0	2.0	-0.5	-1.3	-1.4	-0.3
Diabetes diagnosed by doctor	0.4	0.6	1.8	-0.1	-1.3	0.5	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.0	2.0	0.4	0.4	1.2
Friendships satisfaction	2.4	3.0	6.2	2.5	0.3	2.1	1.0
Qualifications: nursing, teaching	1.3	2.0	4.0	-1.9	0.2	-0.6	-2.0
Commuting to job workplace: Walk	1.4	1.5	3.5	-0.9	1.9	1.2	-0.6
Eye problems/disorders: Cataract	3.7	4.2	6.9	-2.6	-2.2	-1.9	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	5.6	0.2	-2.4	-0.8	0.6
Medication for cholesterol	0.1	0.1	0.3	0.2	-0.1	-0.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.3	-0.9	-1.5	-0.6	0.6
Back pain experienced in last month	0.6	0.8	1.7	0.9	-0.8	-0.5	1.3
Mineral and other dietary supplements	0.2	0.3	0.8	-0.6	0.4	-0.9	-0.2
Breast cancer (self-reported)	1.6	2.0	7.2	-0.8	-0.0	0.0	2.7
Asthma (self-reported)	0.3	0.7	1.3	-0.7	-1.1	-1.0	-0.3
Osteoporosis (self-reported)	0.9	1.1	2.3	-1.3	-0.3	-0.1	-1.5
Osteoarthritis (self-reported)	2.2	2.9	5.7	1.2	-2.4	-2.1	0.2
Medication: Aspirin	0.5	0.7	2.3	0.6	-0.1	-0.2	1.5
Medication: Gliclazide	0.4	0.4	0.9	-0.2	-0.9	0.3	0.9
Illnesses of father: None of the above (group 1)	1.3	1.6	2.9	1.7	1.7	0.4	0.9
Smoking status: Current	0.4	0.6	1.6	-0.7	-1.3	0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.7	-0.7	1.3	-0.4	-0.3
Whole body water mass	3.1	17.8	40.7	3.3	6.4	4.1	1.6
Leg predicted mass (right)	2.5	13.3	30.7	2.7	5.5	3.6	1.5
Arm fat mass (left)	0.4	1.5	3.1	-1.2	-1.8	-0.8	-1.0
Number of self-reported non-cancer illnesses	1.3	2.2	5.2	-0.4	-2.3	-1.9	0.1
Average weekly champagne plus white wine intake	1.6	2.2	6.2	0.9	-2.5	-1.3	0.2
Miserableness	0.2	0.4	0.8	0.1	-0.6	-0.7	-0.9
Guilty feelings	0.3	0.5	1.3	1.1	0.2	0.7	-0.4
Wears glasses or contact lenses	1.8	2.1	5.4	2.3	-0.8	1.2	0.9
Ever taken oral contraceptive pill	1.2	1.4	2.7	1.4	1.6	-0.1	1.0
Hearing aid user	0.5	0.6	1.3	-1.1	-0.1	-0.8	-0.6
Mother’s age at death	0.4	0.5	1.7	0.5	1.3	0.2	-0.1
Financial situation satisfaction	1.2	1.5	2.1	-1.1	-0.6	-1.5	-1.5
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.5	-1.1	1.9	-0.3	-0.5
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.6	-0.5	-0.3	0.3
Eye problems/disorders: Glaucoma	0.9	1.0	2.0	1.0	-0.9	1.4	0.6
Medication: Blood pressure	0.1	0.2	0.3	0.0	-0.6	-0.4	-0.6
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	0.3	-1.1	0.9	0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	0.2	0.8	1.0	0.3
High cholesterol (Self-reported)	0.3	0.4	1.3	0.0	-0.5	-0.4	1.2
Medication: Bendroflumethiazide	0.3	0.4	1.1	-0.2	1.1	0.6	-0.4
Medication: Paracetamol	0.3	0.5	1.3	0.0	0.2	-0.7	-1.1
Medication: Lisinopril	0.4	0.5	1.4	-0.7	-1.2	-0.1	-0.6
Medication: Atorvastatin	0.8	1.0	2.3	0.9	-0.8	1.5	0.5
Illnesses of father: High blood pressure	0.5	0.7	1.4	-1.2	-0.8	-0.7	-0.3
Alcohol drinker status: Never	0.5	0.6	1.2	-1.1	-0.3	-1.1	-0.1
Ever smoked	2.2	3.8	10.7	0.4	3.3	1.9	0.9
Basal metabolic rate	2.3	12.8	29.6	2.7	5.4	3.6	1.3
Leg fat percentage (left)	2.9	10.6	22.8	-3.0	-4.8	-2.2	-2.4
Arm fat-free mass (left)	2.4	12.3	28.1	2.6	5.3	3.6	1.1
Number of operations (self-reported)	0.5	0.8	1.4	-1.0	-0.7	-1.2	-0.1
Average weekly beer plus cider intake	1.0	1.5	3.3	-0.7	1.8	1.4	-0.4
Irritability	0.9	1.5	3.5	0.3	-1.9	-1.5	-0.5
Risk taking	0.2	0.3	0.6	-0.7	0.2	0.8	-0.3
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.9	0.2	0.7	-1.7	-1.7
Fractured/broken bones in last 5 years	1.9	2.5	7.5	0.0	2.7	1.2	-1.0
Age started oral contraceptive pill	0.9	1.1	3.4	-0.8	-0.2	0.7	-1.9
Diastolic blood pressure, automated reading	0.3	0.8	1.2	-0.5	1.1	-1.0	-0.7
Ever depressed for a whole week	0.5	0.6	1.1	0.6	0.9	1.1	0.4
Unable to work because of sickness or disability	0.7	0.9	2.2	-0.4	-1.5	-0.5	-1.0
Commuting to job workplace: Cycle	0.8	0.9	1.7	0.7	1.3	-0.2	1.2
Myopia	0.4	0.6	1.3	1.0	-0.3	-0.1	1.2
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.1	0.4	1.5	1.0	1.1
Cholesterol lowering medication	0.4	0.7	1.5	-1.2	-0.7	-0.8	0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.3	-0.2	0.1	-0.8
Pain experienced in last month	1.7	2.9	6.0	2.1	2.5	1.0	0.6
Supplements: Calcium	0.7	0.8	1.7	0.3	0.1	1.2	1.3
Basal cell carcinoma (self-reported)	0.1	0.2	0.2	-0.4	-0.5	-0.4	0.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.1	-0.4	-1.8	-1.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	5.2	-0.2	2.3	0.1	0.4
Heart disease (siblings)	1.9	2.4	4.2	-1.0	-0.8	-2.0	-1.9
Alcohol drinker status: Previous	1.7	2.0	6.0	0.3	-2.4	-1.1	-0.8
Pack years of smoking	0.8	1.2	2.7	0.4	-1.3	-1.7	-0.5
Impedance of whole body	0.6	3.0	6.9	-0.4	-2.6	-2.2	0.5
Leg fat mass (left)	0.7	2.8	4.0	-1.9	-2.0	-0.8	-1.8
Arm predicted mass (left)	2.6	13.1	29.2	2.7	5.4	3.8	1.1