TWAS hub - NCL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.199	0.0700	2.1e-03	0.028	NA	0.021	NA	0.038	2.0e-02	NA	4.0e-02	NA	8.8e-03
2	ROSMAP	Brain Pre-frontal Cortex	0.162	0.0451	5.1e-06	0.050	0.042	0.067	0.052	0.075	4.1e-07	3.7e-06	4.7e-09	2.5e-07	6.1e-10
3	YFS	Blood	0.256	0.0351	0.0e+00	0.131	0.144	0.148	0.148	0.141	1.3e-40	9.8e-45	4.1e-46	6.0e-46	7.8e-44
4	TCGA	Pheochromocytoma and Paraganglioma	0.118	0.0600	4.7e-03	-0.001	0.018	0.019	NA	-0.002	3.5e-01	6.4e-02	5.7e-02	NA	3.9e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Height	5.0	96.9	198.8	9.7	14.1	8.3	5.2
Standing height	4.3	42.4	93.3	6.1	9.7	5.2	3.4
Trunk predicted mass	3.8	21.6	48.9	3.8	7.0	4.6	1.6
Hearing difficulty/problems with background noise	3.7	5.9	18.3	-0.2	-1.9	-4.3	-1.2
Trunk fat-free mass	3.7	21.1	48.2	3.7	6.9	4.5	1.7
Eye problems/disorders: Cataract	3.7	4.2	6.9	-2.6	-2.2	-1.9	-1.3
Eye problems/disorders: None of the above	3.6	4.2	8.9	2.4	3.0	0.4	1.3
Hearing difficulty/problems: Yes	3.3	5.0	13.2	0.8	-3.6	-2.4	-0.7
Sitting height	3.2	23.0	63.8	3.0	8.0	3.1	3.1
Pulse wave reflection index	3.2	3.9	10.4	-1.7	-1.2	-1.0	-3.2
Hand grip strength (left)	3.1	8.1	14.5	3.2	3.8	2.3	1.5
Whole body fat-free mass	3.1	17.9	40.7	3.3	6.4	4.2	1.5
Whole body water mass	3.1	17.8	40.7	3.3	6.4	4.1	1.6
Arm predicted mass (right)	3.0	15.5	37.7	3.1	6.1	3.6	1.2
Peak expiratory flow (PEF)	2.9	6.7	10.8	2.3	2.3	2.3	3.3
Leg fat percentage (right)	2.9	10.4	22.3	-2.7	-4.7	-2.2	-2.6
Leg fat percentage (left)	2.9	10.6	22.8	-3.0	-4.8	-2.2	-2.4
Arm fat-free mass (right)	2.8	14.1	35.0	2.8	5.9	3.5	1.2
Stomach or abdominal pain in last month	2.7	3.4	6.6	-1.7	-2.6	0.4	-1.9
Forced vital capacity (FVC), Best measure	2.7	10.0	31.0	1.2	5.6	1.9	2.0
Sensitivity / hurt feelings	2.6	4.5	13.2	-1.2	-1.1	-1.4	-3.6
Arm predicted mass (left)	2.6	13.1	29.2	2.7	5.4	3.8	1.1
Pulse wave peak to peak time	2.5	2.9	6.2	1.3	1.2	1.5	2.5
Leg fat-free mass (right)	2.5	13.2	30.5	2.8	5.5	3.5	1.5
Leg predicted mass (right)	2.5	13.3	30.7	2.7	5.5	3.6	1.5
Hair/balding pattern: Pattern 3	2.4	3.6	6.0	1.1	2.3	2.4	1.5
Alcohol intake frequency.	2.4	5.5	10.4	-2.2	-3.2	-2.0	-1.7
Friendships satisfaction	2.4	3.0	6.2	2.5	0.3	2.1	1.0
Arm fat-free mass (left)	2.4	12.3	28.1	2.6	5.3	3.6	1.1
Hand grip strength (right)	2.3	6.2	13.2	2.1	3.6	2.7	0.5
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	6.7	-1.2	-1.7	-1.9	-2.6
Had menopause	2.3	2.9	5.7	0.4	-2.4	-0.5	-2.4
Basal metabolic rate	2.3	12.8	29.6	2.7	5.4	3.6	1.3
Leg fat-free mass (left)	2.2	11.5	26.1	2.7	5.1	3.4	1.2
Leg predicted mass (left)	2.2	11.7	26.5	2.7	5.2	3.4	1.2
Forced vital capacity (FVC)	2.2	8.5	28.9	0.8	5.4	1.5	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.1	17.3	1.4	4.2	2.4	1.7
Osteoarthritis (self-reported)	2.2	2.9	5.7	1.2	-2.4	-2.1	0.2
Ever smoked	2.2	3.8	10.7	0.4	3.3	1.9	0.9
Verbal and Numeric Reasoning (VNR)	2.1	5.1	13.4	1.6	3.7	2.0	0.6
Qualifications: CSEs or equivalent	2.1	2.7	4.9	1.6	1.5	1.1	2.2
Qualifications: College or University degree	2.1	6.6	14.1	2.0	3.8	2.6	1.3
Glaucoma (self-reported)	2.0	2.4	4.1	2.0	-0.2	1.6	1.7
Body fat percentage	2.0	8.1	16.1	-2.8	-4.0	-2.2	-1.9
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	7.2	-0.7	0.6	-0.8	-2.7
Birth weight of first child	1.9	3.4	6.4	2.4	2.5	1.0	0.8
Pulse rate, automated reading	1.9	6.1	16.0	4.0	-0.9	2.1	1.8
Fractured/broken bones in last 5 years	1.9	2.5	7.5	0.0	2.7	1.2	-1.0
Heart disease (siblings)	1.9	2.4	4.2	-1.0	-0.8	-2.0	-1.9
Waist Hip Ratio (WHR)	1.8	8.2	14.7	1.9	3.8	3.8	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	6.1	-1.0	-1.2	-1.1	-2.5
Arm fat percentage (right)	1.8	7.0	14.3	-2.7	-3.8	-1.9	-1.7
Forced expiratory volume in 1-second (FEV1)	1.8	6.2	16.4	1.2	4.0	2.3	1.4
Birth weight	1.8	4.0	9.9	0.4	3.1	2.2	0.9
Arm fat percentage (left)	1.8	7.2	15.4	-2.5	-3.9	-2.2	-1.5
Wears glasses or contact lenses	1.8	2.1	5.4	2.3	-0.8	1.2	0.9
Age at first live birth	1.7	3.1	9.4	0.2	3.1	1.3	1.1
Migraine (self-reported)	1.7	2.1	4.2	1.2	1.2	2.0	-1.2
Pain experienced in last month	1.7	2.9	6.0	2.1	2.5	1.0	0.6
Alcohol drinker status: Previous	1.7	2.0	6.0	0.3	-2.4	-1.1	-0.8
Frequency of depressed mood in last 2 weeks	1.6	2.3	8.7	-0.6	0.3	-0.1	-3.0
Qualifications: A levels/AS levels or equivalent	1.6	3.6	8.0	0.7	2.8	2.1	1.1
Lung cancer (father)	1.6	1.8	5.7	2.4	0.2	1.1	0.7
Pulse wave Arterial Stiffness index	1.6	1.9	5.3	-0.7	-0.5	-1.2	-2.3
Hair/balding pattern: Pattern 4	1.6	3.9	13.5	1.2	3.7	0.5	0.6
Number of full brothers	1.6	2.0	7.3	0.8	2.7	0.1	-0.2
Neck or shoulder pain in last month	1.6	2.3	6.5	-1.1	-2.6	-0.9	-0.9
Comparative height size at age 10	1.6	8.9	12.7	3.5	3.6	2.9	1.5
Leg pain on walking	1.6	2.1	4.9	-0.0	-2.2	-1.1	1.5
Breast cancer (self-reported)	1.6	2.0	7.2	-0.8	-0.0	0.0	2.7
Average weekly champagne plus white wine intake	1.6	2.2	6.2	0.9	-2.5	-1.3	0.2
Mean Putamen Volume	1.5	1.7	3.5	1.9	1.2	1.3	0.2
Diabetes (mother)	1.5	1.9	5.1	-2.3	-0.8	-1.0	-0.8
Trunk fat percentage	1.5	5.9	13.0	-2.1	-3.6	-2.1	-1.4
Number of incorrect matches in round	1.5	2.5	5.2	2.3	0.4	1.0	1.9
Qualifications: None of the above	1.5	3.1	5.1	-1.3	-2.2	-1.2	-2.1
Noisy workplace	1.5	1.9	3.8	0.2	-1.3	-1.9	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.3	-0.4	-1.8	-1.3	-1.2
Illnesses of mother	1.5	1.9	7.4	-0.1	0.3	2.7	-0.1
Chronic bronchitis/emphysema (mother)	1.5	1.8	4.8	0.0	-2.2	-1.2	0.9
Intelligence (Savage-Jansen 2018)	1.4	4.3	12.7	1.3	3.6	1.4	1.1
Alzheimer’s Disease (in mother)	1.4	1.6	3.2	0.7	-1.1	-1.2	1.8
Ovarian Cancer	1.4	1.8	3.9	-0.6	2.0	0.5	-1.6
Chronotype (morning person)	1.4	3.3	5.2	-1.4	-1.7	-1.8	-2.3
Medication: Co-codamol	1.4	1.6	3.7	0.4	-1.9	0.4	1.6
Heart disease (mother)	1.4	1.8	4.8	2.2	-1.1	-0.9	0.6
Age at last live birth	1.4	2.1	4.0	0.5	2.0	1.8	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	4.7	-1.1	0.4	-0.5	-2.2
Average weekly red wine intake	1.4	2.0	4.1	2.0	1.3	0.8	1.3
Commuting to job workplace: Walk	1.4	1.5	3.5	-0.9	1.9	1.2	-0.6
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.9	0.2	0.7	-1.7	-1.7
Fasting Glucose	1.3	1.6	4.6	0.3	1.2	2.1	-0.4
Triglycerides	1.3	2.2	2.9	-1.4	-1.7	-1.5	-1.2
Fluid intelligence score	1.3	2.7	5.1	1.7	2.2	1.6	0.5
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	6.4	-1.0	0.6	-0.8	-2.5
Prospective memory result	1.3	1.6	2.7	-1.6	-1.4	-1.4	-0.3
Exposure to tobacco smoke outside home	1.3	1.7	4.0	-1.3	-2.0	-0.0	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	4.6	1.1	-0.2	2.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.6	1.1	1.1	-0.0	1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.0	2.0	0.4	0.4	1.2
Qualifications: nursing, teaching	1.3	2.0	4.0	-1.9	0.2	-0.6	-2.0
Illnesses of father: None of the above (group 1)	1.3	1.6	2.9	1.7	1.7	0.4	0.9
Number of self-reported non-cancer illnesses	1.3	2.2	5.2	-0.4	-2.3	-1.9	0.1
HDL Cholesterol	1.2	2.0	3.2	1.1	1.8	1.8	0.7
BMI	1.2	6.9	11.7	-2.1	-3.4	-2.8	-1.9
Average weekly spirits intake	1.2	1.5	3.0	-1.6	-0.3	-0.7	-1.7
Severe depression (siblings)	1.2	1.4	3.3	0.7	0.0	1.3	1.8
Falls in the last year	1.2	1.6	5.3	-0.7	-0.5	-0.6	-2.3
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	4.8	0.5	-0.6	-0.6	2.2
Shortness of breath walking on level ground	1.2	1.4	2.6	1.6	1.6	0.7	-0.2
Overall health rating	1.2	2.5	8.6	-0.5	-2.9	-0.2	-1.0
Handedness (chirality/laterality): Left-handed	1.2	1.4	5.0	-0.5	-0.6	-0.4	-2.2
Ever taken oral contraceptive pill	1.2	1.4	2.7	1.4	1.6	-0.1	1.0
Financial situation satisfaction	1.2	1.5	2.1	-1.1	-0.6	-1.5	-1.5
Body Mass Index (BMI) (2010)	1.1	1.5	2.9	-1.7	-0.7	-0.7	-1.5
Supplements: Zinc	1.1	1.2	3.8	-0.4	-1.9	-0.4	-0.8
Medication: Simvastatin	1.1	1.6	3.2	-1.6	-0.7	-1.8	-0.1
Medication: Lansoprazole	1.1	1.3	2.3	1.5	0.0	1.3	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.7	1.7	0.2	1.1	-1.2
Medication: Seretide 50 evohaler	1.1	1.3	3.5	1.0	-0.7	1.9	0.3
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.5	-1.1	1.9	-0.3	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	5.2	-0.2	2.3	0.1	0.4
LDL Cholesterol	1.0	1.6	3.3	-1.4	-0.2	-1.8	0.9
Lung FEV1/FVC ratio	1.0	5.0	12.7	3.6	-0.1	2.6	0.5
Medication for hormone replacement therapy	1.0	1.1	1.9	-1.3	0.4	0.7	-1.4
Body mass index (BMI)	1.0	4.4	7.6	-2.3	-2.8	-1.3	-1.8
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.0	-0.3	-1.2	-0.5	-1.7
Medication: Ramipril	1.0	1.3	2.6	-1.5	-0.6	-1.6	-0.3
Tense / ‘highly strung’	1.0	1.6	3.3	0.3	-1.8	-0.2	-1.8
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.1	1.3	1.0	1.4	1.3
Gout (self-reported)	1.0	1.4	2.0	-0.9	-1.4	-1.1	-1.3
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.0	0.9	-0.5	-1.7	0.9
Medication: Ibuprofen	1.0	1.2	2.6	0.4	-0.9	-1.2	1.6
Suffer from ‘nerves’	1.0	1.6	3.0	-0.0	-1.2	1.3	-1.7
Family relationship satisfaction	1.0	1.2	2.5	1.0	1.6	1.2	0.2
Illnesses of father: Heart disease	1.0	1.4	3.3	-0.4	-1.8	-1.5	0.3
Loneliness, isolation	1.0	1.4	4.1	0.4	-2.0	0.8	-0.8
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	5.6	0.2	-2.4	-0.8	0.6
Average weekly beer plus cider intake	1.0	1.5	3.3	-0.7	1.8	1.4	-0.4
Crohns Disease (2012)	0.9	1.4	4.0	-2.0	-0.7	-1.0	-0.4
Schizophrenia (2014)	0.9	2.0	4.9	1.3	-2.2	1.2	-0.1
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.5	-1.2	-0.9	-0.6	-1.2
Angina	0.9	1.2	3.7	-0.3	-1.9	-0.5	-0.9
Average weekly fortified wine intake	0.9	1.0	2.0	-1.1	0.9	1.4	-0.2
Chronic bronchitis/emphysema (father)	0.9	1.1	2.2	1.5	1.3	-0.4	-0.3
Nervous feelings	0.9	1.7	3.7	0.3	-1.9	0.3	-1.7
Hair/balding pattern: Pattern 2	0.9	1.1	1.5	-0.7	-1.1	-1.0	1.2
Number of live births	0.9	1.3	4.5	0.5	0.2	0.5	-2.1
Happiness	0.9	1.1	3.4	-0.8	0.7	-0.2	-1.8
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.1	-0.1	-2.0	0.3	-0.5
Emphysema/chronic bronchitis	0.9	1.0	1.8	-0.7	-1.1	-1.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.5	0.1	2.1	-0.4	1.7
Ever had bowel cancer screening	0.9	1.0	2.0	-0.5	-1.3	-1.4	-0.3
Osteoporosis (self-reported)	0.9	1.1	2.3	-1.3	-0.3	-0.1	-1.5
Eye problems/disorders: Glaucoma	0.9	1.0	2.0	1.0	-0.9	1.4	0.6
Irritability	0.9	1.5	3.5	0.3	-1.9	-1.5	-0.5
Age started oral contraceptive pill	0.9	1.1	3.4	-0.8	-0.2	0.7	-1.9
Bipolar Disorder or Schizophrenia	0.8	1.9	3.1	1.1	-1.8	1.7	0.3
Worry (Nagel 2018)	0.8	1.7	2.7	0.7	-1.4	1.6	-1.2
Crohns Disease (2017)	0.8	1.8	6.6	-2.6	-0.4	-0.1	-0.6
Age at First Birth	0.8	1.2	1.7	1.3	0.9	1.1	1.1
Systolic blood pressure, automated reading	0.8	2.4	4.7	-1.4	-0.4	-2.2	-1.6
Diabetes (father)	0.8	1.0	2.5	0.1	-1.6	-0.2	1.1
Supplements: Glucosamine	0.8	1.0	2.4	-0.8	-0.4	-1.5	-0.9
Heart attack	0.8	1.1	3.0	-0.5	-1.7	-1.0	-0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.6	1.2	-0.1	1.1	1.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.7	1.1	1.7	0.8	0.7
Health satisfaction	0.8	1.0	2.0	-1.4	-0.3	0.1	-1.4
Angina (self-reported)	0.8	1.1	3.4	-0.1	-1.8	-0.6	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.3	-0.9	-1.5	-0.6	0.6
Medication: Atorvastatin	0.8	1.0	2.3	0.9	-0.8	1.5	0.5
Commuting to job workplace: Cycle	0.8	0.9	1.7	0.7	1.3	-0.2	1.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.1	-0.4	-1.8	-1.0	-0.1
Pack years of smoking	0.8	1.2	2.7	0.4	-1.3	-1.7	-0.5
Depressed Affect (Nagel 2018)	0.7	1.4	3.4	1.8	-1.1	0.9	-0.3
Depression (Nagel 2018)	0.7	1.1	3.9	0.1	-0.0	0.6	-2.0
Neuroticism (Nagel 2018)	0.7	1.6	3.0	1.0	-1.7	0.7	-1.3
Schizophrenia (2018)	0.7	1.5	2.4	1.2	-1.5	1.3	0.6
Coronary Artery Disease (CAD)	0.7	0.8	2.6	0.1	-0.5	-1.6	0.7
Rheumatoid Arthritis	0.7	0.9	3.1	0.3	-0.5	-0.3	1.8
Neuroticism	0.7	1.7	3.1	1.5	-1.1	1.8	0.1
Pack years adult smoking proportion	0.7	1.0	2.5	0.2	-1.2	-1.6	-0.3
Impedance of leg (right)	0.7	3.2	7.8	-0.8	-2.8	-1.9	-0.6
Fed-up feelings	0.7	1.3	2.0	1.3	0.1	1.4	-1.2
Impedance of leg (left)	0.7	3.2	7.9	-1.1	-2.8	-1.9	-0.2
Past tobacco smoking	0.7	1.3	4.1	-0.2	-2.0	-0.9	-0.4
Time employed in main current job	0.7	0.8	2.0	0.0	-1.4	-0.5	-0.9
Alcohol intake versus 10 years previously	0.7	1.1	2.7	-0.1	-1.1	1.6	0.5
Medication: Cholesterol lowering	0.7	1.1	2.6	-0.8	-1.6	-0.8	0.6
Exposure to tobacco smoke at home	0.7	0.8	1.3	-1.1	-0.8	-0.8	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.6	1.9	-0.7	0.6	-0.2
Blood clot in the leg (DVT)	0.7	0.9	3.5	-0.3	1.9	0.1	0.0
Headache pain in last month	0.7	1.3	1.9	-1.4	1.3	0.1	-1.2
Medication: Blood pressure	0.7	1.2	2.5	-1.3	-0.2	-0.5	-1.6
Leg fat mass (right)	0.7	2.6	4.2	-1.6	-2.0	-0.7	-1.8
Smoking status: Previous	0.7	1.0	3.7	0.5	1.9	0.3	-0.0
Unable to work because of sickness or disability	0.7	0.9	2.2	-0.4	-1.5	-0.5	-1.0
Supplements: Calcium	0.7	0.8	1.7	0.3	0.1	1.2	1.3
Leg fat mass (left)	0.7	2.8	4.0	-1.9	-2.0	-0.8	-1.8
Alzheimer’s Disease (including proxy)	0.6	0.8	1.8	-0.7	-1.4	-0.5	0.8
Prostate Cancer	0.6	0.8	2.3	0.5	1.5	0.8	0.3
HbA1C	0.6	0.6	1.6	0.3	0.5	0.8	1.2
Lupus	0.6	0.9	1.4	1.1	0.3	0.8	-1.2
Blood White Count	0.6	4.1	5.7	-2.3	-2.4	-2.2	-0.9
Respiratory disease	0.6	1.3	2.3	-0.9	-1.5	-1.5	-0.0
Lung FVC	0.6	2.9	10.0	-3.2	0.9	-0.7	0.6
Ever had hysterectomy (womb removed)	0.6	0.7	1.2	0.5	0.4	1.1	-1.0
Townsend deprivation index at recruitment	0.6	0.8	1.4	-1.2	-1.1	-0.1	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.8	-1.2	-0.5	0.1	1.9
Mouth/teeth dental problems	0.6	0.9	2.3	-0.8	1.5	0.7	0.3
Pain all over the body in last month	0.6	0.6	2.1	-0.4	1.4	0.5	-0.0
Pulse rate	0.6	1.0	3.5	1.9	-0.1	0.5	0.6
Impedance of arm (left)	0.6	2.8	5.9	-0.3	-2.4	-2.1	0.8
Wheeze or whistling in the chest in last year	0.6	1.1	2.9	-0.0	-1.1	-1.7	0.1
Number of children fathered	0.6	0.7	1.4	0.5	1.2	-0.1	1.0
Had major operations	0.6	0.8	1.4	-0.9	-0.1	-1.2	-0.8
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.0	-0.9	-0.1	-0.9	-1.0
Knee pain experienced in last month	0.6	0.9	1.7	-0.6	-1.3	-1.3	-0.2
Illnesses of siblings: Diabetes	0.6	0.7	2.1	0.7	1.4	0.5	0.4
Long-standing illness, disability or infirmity	0.6	0.9	2.5	-0.5	-1.6	-0.5	0.8
Back pain experienced in last month	0.6	0.8	1.7	0.9	-0.8	-0.5	1.3
Impedance of whole body	0.6	3.0	6.9	-0.4	-2.6	-2.2	0.5
Schizophrenia vs Biploar Disorder	0.5	0.6	1.0	-0.9	-1.0	-0.5	-0.6
Alzheimer’s Disease (in father)	0.5	0.6	1.9	-1.4	-0.1	0.5	-0.4
Major Depression (MDD)	0.5	0.6	1.2	0.1	1.1	-0.8	0.7
Primary Biliary Cirrhosis	0.5	0.7	2.7	-0.0	-1.6	-0.0	-0.4
Ulcerative Colitis	0.5	0.7	1.2	0.7	0.6	0.9	1.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.6	0.5	0.0	0.6	1.3
Vitamin and mineral supplements	0.5	0.7	2.2	0.2	1.5	-0.3	0.6
Medication: Metformin	0.5	0.7	1.8	-0.9	-1.4	0.3	-0.3
Age when periods started (menarche)	0.5	1.1	3.9	-0.2	-2.0	-0.3	0.6
Medication: Atenolol	0.5	0.7	1.7	-0.2	-0.7	-1.3	-0.7
Financial difficulties in last 2 years	0.5	0.7	1.4	-1.2	0.3	1.1	0.4
Neuroticism score	0.5	1.0	1.8	0.6	-1.3	0.5	-1.3
Impedance of arm (right)	0.5	2.6	7.6	-0.4	-2.8	-1.6	0.2
Worrier / anxious feelings	0.5	0.9	2.2	-0.5	-1.5	0.2	-1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.0	1.4	0.7	-0.3	0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.0	-1.4	-0.3	0.6	-0.5
Medication: Aspirin	0.5	0.7	2.3	0.6	-0.1	-0.2	1.5
Hearing aid user	0.5	0.6	1.3	-1.1	-0.1	-0.8	-0.6
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.3	0.3	-1.1	0.9	0.6
Illnesses of father: High blood pressure	0.5	0.7	1.4	-1.2	-0.8	-0.7	-0.3
Alcohol drinker status: Never	0.5	0.6	1.2	-1.1	-0.3	-1.1	-0.1
Number of operations (self-reported)	0.5	0.8	1.4	-1.0	-0.7	-1.2	-0.1
Ever depressed for a whole week	0.5	0.6	1.1	0.6	0.9	1.1	0.4
Bipolar Disorder (2018)	0.4	0.6	1.3	0.6	-0.9	1.1	-0.2
Breast Cancer	0.4	0.9	1.5	0.6	0.7	1.2	1.2
Bipolar Disorder (2011)	0.4	0.4	1.4	-0.4	-0.1	1.2	0.0
Systolic Blood Pressure	0.4	2.1	4.9	-1.3	-0.5	-2.2	-1.3
Relative age voice broke	0.4	0.7	1.0	-1.0	0.7	-0.6	-1.0
Taking other prescription medications	0.4	0.5	0.8	0.5	-0.9	-0.8	-0.8
Serious illness, injury or assault to yourself	0.4	0.5	1.5	-1.2	-0.8	0.2	-0.0
Multivitamins +/- minerals	0.4	0.6	1.4	0.1	-1.2	0.4	-0.8
Medication: Levothyroxine sodium	0.4	0.7	1.3	1.1	-0.1	0.9	-0.9
Had other major operations	0.4	0.5	1.8	0.2	-0.4	-0.3	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.3	-0.8	-0.5	-0.2	1.5
Diabetes (self-reported)	0.4	0.7	2.7	0.0	-1.6	0.1	-0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	2.1	0.2	0.2	0.7	-1.5
Medication: Allopurinol	0.4	0.5	1.2	-0.2	-1.1	-0.7	-0.5
Whole body fat mass	0.4	1.8	2.6	-1.6	-1.6	-0.8	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.9	0.2	-0.1	-0.1	1.4
Medication: Aspirin	0.4	0.5	1.8	0.4	-0.2	-0.2	1.3
Hypertension (Self-reported)	0.4	1.1	2.4	-0.7	-0.4	-1.2	-1.5
Diabetes diagnosed by doctor	0.4	0.6	1.8	-0.1	-1.3	0.5	-0.5
Medication: Gliclazide	0.4	0.4	0.9	-0.2	-0.9	0.3	0.9
Smoking status: Current	0.4	0.6	1.6	-0.7	-1.3	0.6	0.4
Arm fat mass (left)	0.4	1.5	3.1	-1.2	-1.8	-0.8	-1.0
Mother’s age at death	0.4	0.5	1.7	0.5	1.3	0.2	-0.1
Medication: Lisinopril	0.4	0.5	1.4	-0.7	-1.2	-0.1	-0.6
Myopia	0.4	0.6	1.3	1.0	-0.3	-0.1	1.2
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.1	0.4	1.5	1.0	1.1
Cholesterol lowering medication	0.4	0.7	1.5	-1.2	-0.7	-0.8	0.1
Irritable Bowel Disease (IBD)	0.3	0.7	1.6	-1.3	-0.5	0.8	0.0
Ulcerative Colitis (UC)	0.3	0.6	1.8	-0.0	-0.1	1.4	0.6
Blood Platelet Count	0.3	3.2	6.9	-2.6	-1.9	-1.3	-0.9
Allergy or Eczema	0.3	0.7	2.4	-0.2	-1.5	-0.0	0.6
Cardiovascular Disease	0.3	0.9	1.9	-0.5	-0.9	-1.4	-0.8
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.9	-0.2	-1.0	-0.3	-0.9
Relative age of first facial hair	0.3	0.5	1.9	-1.4	-0.2	-0.2	0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.3	0.0	-0.2	-1.1	0.5
Current tobacco smoking	0.3	0.5	1.5	-0.2	-1.2	0.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.7	0.3	-0.8	-0.0	-0.9
High blood pressure	0.3	0.9	1.8	-0.3	-0.9	-0.9	-1.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.9	-0.9	-1.0	-0.6	0.5
Trunk fat mass	0.3	1.2	1.8	-1.1	-1.3	-0.8	-1.0
Alcohol usually taken with meals	0.3	0.5	1.6	1.3	0.5	0.3	0.2
Allergy	0.3	0.8	1.3	1.1	0.7	1.0	-0.4
Hip circumference	0.3	1.4	2.7	-1.3	-1.6	-1.1	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	0.7	0.9	-0.8	0.1	-0.8
Asthma	0.3	0.5	1.0	-0.6	-1.0	-0.8	-0.2
Depression (self-reported)	0.3	0.4	0.7	0.8	-0.8	-0.5	-0.2
Arm fat mass (right)	0.3	1.4	2.3	-1.3	-1.5	-0.6	-1.1
Breastfed as a baby	0.3	0.4	1.4	-1.2	0.5	-0.1	-0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.4	0.7	-0.7	1.2	0.1
Medication: Omeprazole	0.3	0.3	0.8	-0.5	0.3	0.3	-0.9
Asthma (self-reported)	0.3	0.7	1.3	-0.7	-1.1	-1.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.7	-0.7	1.3	-0.4	-0.3
Guilty feelings	0.3	0.5	1.3	1.1	0.2	0.7	-0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	0.2	0.8	1.0	0.3
High cholesterol (Self-reported)	0.3	0.4	1.3	0.0	-0.5	-0.4	1.2
Medication: Bendroflumethiazide	0.3	0.4	1.1	-0.2	1.1	0.6	-0.4
Medication: Paracetamol	0.3	0.5	1.3	0.0	0.2	-0.7	-1.1
Diastolic blood pressure, automated reading	0.3	0.8	1.2	-0.5	1.1	-1.0	-0.7
Neuroticism (2016)	0.2	0.3	0.8	0.1	-0.9	0.5	-0.3
Heel T-Score	0.2	1.8	3.1	-1.1	1.1	1.8	1.2
Number of treatments/medications taken	0.2	0.3	0.8	0.7	-0.9	-0.3	0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	0.7	0.5	-0.2	-0.4
Maternal smoking around birth	0.2	0.3	1.0	0.3	-1.0	0.2	-0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.7	0.4	-0.1	0.4
High blood pressure (mother)	0.2	0.3	0.9	0.3	0.2	-1.0	-0.1
Waist circumference	0.2	0.6	1.0	-1.0	-0.8	0.0	-0.8
Illnesses of siblings	0.2	0.3	0.8	0.5	-0.0	0.3	0.9
Weight	0.2	1.2	3.2	0.6	1.8	1.1	-0.1
Length of working week for main job	0.2	0.2	0.7	-0.5	-0.8	-0.1	0.2
Medication: Amlodipine	0.2	0.3	0.6	0.8	0.2	-0.6	0.4
Comparative body size at age 10	0.2	0.6	1.8	-0.5	-1.4	0.7	-0.1
Number of full sisters	0.2	0.2	0.6	0.4	0.2	0.3	0.8
Supplements: Vitamin C	0.2	0.3	0.6	-0.7	-0.2	-0.2	-0.7
Mineral and other dietary supplements	0.2	0.3	0.8	-0.6	0.4	-0.9	-0.2
Miserableness	0.2	0.4	0.8	0.1	-0.6	-0.7	-0.9
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.6	-0.5	-0.3	0.3
Risk taking	0.2	0.3	0.6	-0.7	0.2	0.8	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.3	-0.2	0.1	-0.8
Reaction Time	0.1	0.2	0.4	-0.2	-0.1	0.5	0.7
Blood Red Count	0.1	1.3	3.0	-0.5	-0.7	-1.7	-1.3
Smoking Status	0.1	0.2	0.6	-0.8	0.0	0.4	0.2
Hypothyroidism (self reported)	0.1	0.3	1.0	-0.3	-1.0	0.2	-0.4
Tanning	0.1	1.0	2.8	1.0	1.7	0.2	0.1
Father’s age at death	0.1	0.1	0.2	-0.4	0.3	0.4	-0.1
Loud music exposure frequency	0.1	0.1	0.2	-0.1	-0.4	0.1	0.3
High blood pressure (siblings)	0.1	0.2	0.5	-0.7	-0.1	0.0	-0.5
Worry too long after embarrassment	0.1	0.1	0.2	-0.2	-0.3	-0.3	-0.4
Mean time to correctly identify matches	0.1	0.2	0.5	-0.3	-0.3	-0.3	0.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.2	0.0	-0.5	-0.4
Mood swings	0.1	0.2	0.4	0.7	-0.2	-0.0	-0.4
Medication for cholesterol	0.1	0.1	0.3	0.2	-0.1	-0.5	0.3
Medication: Blood pressure	0.1	0.2	0.3	0.0	-0.6	-0.4	-0.6
Basal cell carcinoma (self-reported)	0.1	0.2	0.2	-0.4	-0.5	-0.4	0.4
Blood Eosinophil Count	0.0	0.1	0.1	0.1	0.4	-0.3	-0.3
Hair Pigment	0.0	1.4	3.5	0.9	-1.9	-1.0	-0.0
Medication: Paracetamol	0.0	0.1	0.2	0.1	0.5	-0.1	-0.1
Chest pain or discomfort	0.0	0.0	0.1	0.4	0.2	-0.1	-0.1

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