[Hub]/) : Traits : Leg fat-free mass (right) : ← →

chr5:136,723,696-140,767,031

Best TWAS P=3.21e-14 · Best GWAS P=8.24e-20 conditioned to 1.41e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FAM53C	0.05	0.02	bslmm	291	0.03	4.1e-04	7.3	5.4	6.8e-08	-0.06	0.02	0.94	FALSE
2	GTEx	Cells EBV-transformed lymphocytes	DNAJC18	0.26	0.09	lasso	2	0.12	9.7e-05	3.4	5.2	2.1e-07	0.49	0.18	0.30	FALSE
3	GTEx	Colon Transverse	TMCO6	0.15	0.06	enet	16	0.05	1.4e-03	4.6	-5.4	7.3e-08	-0.07	0.10	0.65	FALSE
4	GTEx	Colon Transverse	DNAJC18	0.37	-0.01	lasso	5	0.01	1.1e-01	3.4	5.1	3.1e-07	0.39	0.06	0.06	FALSE
5	GTEx	Esophagus Gastroesophageal Junction	DNAJC18	0.17	0.01	lasso	10	0.04	2.0e-02	3.3	6.9	4.5e-12	0.77	0.03	0.85	FALSE
6	GTEx	Esophagus Mucosa	TMEM173	0.10	0.03	enet	20	0.10	1.8e-07	9.1	-6.3	2.8e-10	-0.60	0.01	0.97	FALSE
7	GTEx	Esophagus Muscularis	DNAJC18	0.22	0.10	lasso	6	0.13	3.2e-08	3.4	5.2	1.9e-07	0.40	0.56	0.10	FALSE
8	GTEx	Nerve Tibial	HARS	0.07	0.01	enet	16	0.04	1.1e-03	-4.5	5.6	2.8e-08	-0.03	0.06	0.89	TRUE
9	GTEx	Skin Sun Exposed Lower leg	WDR55	0.04	0.01	enet	10	0.01	2.8e-02	-4.8	-5.5	2.9e-08	-0.02	0.03	0.92	FALSE
10	GTEx	Vagina	PURA	0.52	0.05	enet	51	0.09	3.6e-03	5.8	-6.6	5.3e-11	-0.44	0.06	0.10	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	WNT8A	0.05	0.01	blup	300	0.03	1.0e-04	-1.7	-6.6	4.8e-11	0.05	0.08	0.88	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	FAM53C	0.13	0.06	lasso	4	0.05	4.6e-07	6.1	6.0	1.9e-09	0.05	0.99	0.00	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	KDM3B	0.07	0.01	blup	307	0.03	1.0e-04	6.1	-6.2	5.3e-10	-0.03	0.08	0.87	FALSE
14	YFS	Blood	CXXC5	0.01	0.00	bslmm	244	0.01	2.6e-03	9.1	-6.5	8.1e-11	-0.67	0.00	0.95	FALSE
15	YFS	Blood	TMCO6	0.01	0.00	blup	329	0.01	4.1e-03	-4.4	-5.2	1.9e-07	-0.03	0.06	0.91	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIF20A	0.01	0.00	blup	27	0.01	1.4e-02	-2.6	5.3	9.2e-08	-0.01	0.01	0.39	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM173	0.02	0.03	blup	7	0.03	4.6e-07	4.6	-5.3	1.4e-07	-0.40	0.07	0.93	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	WDR55	0.10	0.03	enet	8	0.04	3.3e-09	-4.8	-5.3	1.2e-07	0.01	0.02	0.97	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBE2D2	0.05	0.02	enet	6	0.03	4.4e-04	4.9	7.6	3.2e-14	0.76	0.01	0.97	TRUE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	BRD8	0.12	0.07	lasso	4	0.05	1.2e-03	6.7	-6.6	4.5e-11	0.03	0.00	0.98	TRUE