[Hub]/) : Traits : Leg fat-free mass (right) :

chr5:129,797,129-132,839,137

Best TWAS P=2.47e-26 · Best GWAS P=1.67e-19 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PDLIM4 0.11 0.18 lasso 5 0.18 8.0e-21 -5.6 -5.9 3.9e-09 0.26 1.00 0.00 TRUE
2 GTEx Adipose Subcutaneous HINT1 0.10 0.07 enet 16 0.06 8.8e-06 -8.5 -10.6 2.5e-26 0.49 0.08 0.91 TRUE
3 GTEx Adipose Subcutaneous SLC22A5 0.05 0.04 lasso 4 0.04 4.2e-04 8.5 -7.1 1.3e-12 0.27 0.07 0.89 FALSE
4 GTEx Adipose Subcutaneous AC034220.3 0.11 0.11 lasso 10 0.09 4.8e-08 -6.9 7.0 3.8e-12 -0.13 0.99 0.01 FALSE
5 GTEx Adipose Visceral Omentum AC034220.3 0.10 0.09 lasso 7 0.08 7.3e-05 -6.9 6.9 5.1e-12 -0.12 0.49 0.20 FALSE
6 GTEx Adrenal Gland AC034220.3 0.12 0.11 lasso 16 0.08 7.7e-04 -7.0 7.0 3.3e-12 -0.13 0.69 0.09 FALSE
7 GTEx Artery Aorta P4HA2 0.12 0.14 lasso 2 0.11 1.2e-06 8.7 8.7 4.2e-18 -0.25 0.02 0.98 FALSE
8 GTEx Artery Aorta HINT1 0.07 0.07 enet 8 0.06 4.7e-04 -8.7 -9.8 1.5e-22 0.75 0.06 0.65 FALSE
9 GTEx Artery Aorta AC034220.3 0.08 0.06 lasso 3 0.05 1.1e-03 -6.9 8.0 1.7e-15 -0.17 0.51 0.22 FALSE
10 GTEx Artery Aorta P4HA2-AS1 0.08 0.03 lasso 3 0.01 6.6e-02 8.5 8.6 8.7e-18 -0.23 0.05 0.90 FALSE
11 GTEx Artery Tibial P4HA2 0.12 0.15 lasso 6 0.14 3.2e-11 8.7 9.1 7.6e-20 -0.24 0.02 0.98 FALSE
12 GTEx Artery Tibial HINT1 0.11 0.04 enet 18 0.06 1.0e-05 -8.4 -10.3 5.7e-25 0.55 0.08 0.87 FALSE
13 GTEx Artery Tibial LYRM7 0.10 0.03 lasso 3 0.04 3.1e-04 -6.2 5.6 2.6e-08 -0.75 0.47 0.16 FALSE
14 GTEx Artery Tibial SLC22A5 0.18 0.12 enet 8 0.12 2.5e-09 8.5 -7.5 4.2e-14 0.13 0.07 0.93 FALSE
15 GTEx Artery Tibial P4HA2-AS1 0.10 0.09 lasso 4 0.11 1.0e-08 8.7 8.4 2.8e-17 -0.23 0.02 0.98 FALSE
16 GTEx Brain Caudate basal ganglia AC034220.3 0.41 0.45 enet 19 0.46 8.8e-15 -6.9 7.2 4.3e-13 -0.13 0.98 0.02 FALSE
17 GTEx Brain Cortex AC034220.3 0.43 0.39 lasso 15 0.17 2.4e-05 -6.9 6.7 1.9e-11 -0.13 0.95 0.04 FALSE
18 GTEx Brain Frontal Cortex BA9 AC034220.3 0.31 0.20 lasso 14 0.21 3.3e-06 -7.1 5.5 3.2e-08 -0.11 0.64 0.22 FALSE
19 GTEx Brain Hippocampus AC034220.3 0.21 0.15 lasso 14 0.18 5.8e-05 -7.1 8.2 3.5e-16 -0.18 0.13 0.76 FALSE
20 GTEx Brain Nucleus accumbens basal ganglia SLC22A5 0.15 0.00 enet 24 0.05 1.4e-02 -7.0 5.2 1.5e-07 -0.13 0.06 0.49 FALSE
21 GTEx Brain Nucleus accumbens basal ganglia AC034220.3 0.24 0.24 enet 34 0.24 3.7e-07 -7.0 7.1 1.4e-12 -0.13 0.87 0.06 FALSE
22 GTEx Breast Mammary Tissue SLC22A5 0.10 0.02 enet 16 0.06 4.5e-04 8.6 -6.2 7.8e-10 -0.06 0.18 0.74 TRUE
23 GTEx Breast Mammary Tissue (Female) SLC22A5 0.04 -0.01 lasso 3 0.01 1.3e-01 -3.7 -6.0 2.6e-09 0.09 0.05 0.18 FALSE
24 GTEx Cells EBV-transformed lymphocytes SLC22A5 0.37 0.05 lasso 13 0.10 2.8e-04 8.6 -7.7 1.8e-14 0.08 0.09 0.83 FALSE
25 GTEx Cells Transformed fibroblasts PDLIM4 0.08 0.09 lasso 1 0.07 6.4e-06 -5.7 -5.7 9.7e-09 0.26 0.82 0.04 FALSE
26 GTEx Cells Transformed fibroblasts HINT1 0.10 0.06 lasso 2 0.05 2.1e-04 -8.4 -9.1 1.4e-19 0.57 0.10 0.88 FALSE
27 GTEx Cells Transformed fibroblasts SLC22A5 0.32 0.28 lasso 7 0.35 1.6e-27 -7.2 -8.0 1.3e-15 0.16 0.38 0.62 FALSE
28 GTEx Colon Sigmoid AC034220.3 0.18 0.11 lasso 12 0.06 3.7e-03 -7.1 6.7 1.6e-11 -0.11 0.21 0.28 FALSE
29 GTEx Colon Transverse SLC22A5 0.12 0.07 enet 8 0.07 2.5e-04 8.6 -7.4 1.2e-13 0.25 0.12 0.79 FALSE
30 GTEx Colon Transverse AC034220.3 0.30 0.15 lasso 3 0.11 8.4e-06 -6.9 7.4 1.4e-13 -0.13 0.93 0.03 FALSE
31 GTEx Esophagus Gastroesophageal Junction SEPT8 0.22 0.08 lasso 12 0.10 2.2e-04 -6.4 7.0 3.1e-12 -0.18 0.33 0.51 TRUE
32 GTEx Esophagus Mucosa P4HA2 0.23 0.10 lasso 6 0.14 6.1e-10 8.7 8.7 2.9e-18 -0.26 0.03 0.97 FALSE
33 GTEx Esophagus Mucosa SLC22A5 0.16 0.16 enet 8 0.16 6.3e-11 8.6 -8.9 7.1e-19 0.24 0.03 0.97 FALSE
34 GTEx Esophagus Mucosa AC034220.3 0.08 0.03 lasso 3 0.05 4.7e-04 -7.1 7.0 2.0e-12 -0.12 0.95 0.03 FALSE
35 GTEx Esophagus Mucosa P4HA2-AS1 0.09 0.06 lasso 6 0.08 5.4e-06 8.7 8.4 5.5e-17 -0.26 0.04 0.95 FALSE
36 GTEx Esophagus Muscularis AC034220.3 0.12 0.08 enet 20 0.07 3.8e-05 -6.9 6.4 1.5e-10 -0.14 0.77 0.14 FALSE
37 GTEx Heart Atrial Appendage AC034220.3 0.16 0.09 enet 17 0.18 1.7e-08 -7.0 7.3 2.4e-13 -0.13 0.68 0.32 FALSE
38 GTEx Heart Left Ventricle AC034220.3 0.25 0.22 lasso 6 0.25 8.6e-14 -6.9 7.7 1.5e-14 -0.15 0.98 0.02 FALSE
39 GTEx Liver AC034220.3 0.30 0.16 lasso 6 0.16 3.9e-05 -7.0 5.4 5.4e-08 -0.09 0.59 0.05 FALSE
40 GTEx Lung SLC22A5 0.10 0.15 enet 11 0.13 3.4e-10 8.6 -8.4 2.9e-17 0.19 0.05 0.95 FALSE
41 GTEx Muscle Skeletal AC034220.3 0.27 0.23 lasso 9 0.24 9.1e-24 -6.9 7.2 7.3e-13 -0.18 1.00 0.00 FALSE
42 GTEx Muscle Skeletal MIR3936 0.04 0.01 lasso 4 0.00 9.9e-02 -5.7 7.4 1.7e-13 -0.25 0.14 0.44 FALSE
43 GTEx Nerve Tibial P4HA2 0.19 0.12 enet 26 0.14 6.2e-10 -7.0 7.5 6.7e-14 -0.15 0.03 0.97 FALSE
44 GTEx Nerve Tibial LYRM7 0.05 0.02 enet 11 0.04 7.0e-04 -5.9 5.5 4.9e-08 -0.60 0.38 0.31 FALSE
45 GTEx Nerve Tibial AC034220.3 0.15 0.11 lasso 5 0.10 1.9e-07 -7.0 7.1 1.2e-12 -0.13 0.99 0.01 FALSE
46 GTEx Nerve Tibial P4HA2-AS1 0.14 0.05 lasso 8 0.08 3.8e-06 7.6 8.5 2.3e-17 -0.16 0.06 0.94 FALSE
47 GTEx Ovary PDLIM4 0.25 0.22 enet 10 0.05 2.1e-02 -4.5 5.6 2.4e-08 -0.28 0.35 0.22 FALSE
48 GTEx Ovary AC004041.2 0.21 -0.01 lasso 2 -0.01 7.7e-01 -5.3 7.0 3.5e-12 -0.26 0.06 0.27 FALSE
49 GTEx Pancreas P4HA2 0.22 0.21 lasso 13 0.20 5.3e-09 -4.8 6.6 4.8e-11 -0.05 0.51 0.47 FALSE
50 GTEx Pancreas P4HA2-AS1 0.16 0.16 lasso 5 0.16 3.2e-07 -4.8 5.7 1.4e-08 0.01 0.47 0.45 TRUE
51 GTEx Pituitary AC034220.3 0.25 0.22 lasso 12 0.18 3.1e-05 -6.2 6.8 1.0e-11 -0.14 0.69 0.06 FALSE
52 GTEx Prostate AC034220.3 0.38 0.37 lasso 5 0.37 3.0e-10 -6.9 6.4 2.1e-10 -0.13 0.93 0.06 FALSE
53 GTEx Skin Not Sun Exposed Suprapubic PDLIM4 0.13 0.08 lasso 2 0.06 2.6e-04 8.6 -8.1 5.9e-16 0.27 0.09 0.85 FALSE
54 GTEx Skin Not Sun Exposed Suprapubic SLC22A4 0.13 0.00 lasso 4 0.01 7.1e-02 -2.6 -5.3 1.0e-07 0.11 0.14 0.16 FALSE
55 GTEx Skin Not Sun Exposed Suprapubic SLC22A5 0.13 0.05 lasso 8 0.05 8.3e-04 -7.0 -7.8 4.2e-15 0.12 0.24 0.75 FALSE
56 GTEx Skin Sun Exposed Lower leg PDLIM4 0.09 0.08 lasso 8 0.09 1.0e-07 8.7 -8.8 1.1e-18 0.22 0.04 0.96 TRUE
57 GTEx Skin Sun Exposed Lower leg SLC22A5 0.25 0.21 lasso 3 0.20 1.4e-16 8.5 -8.5 2.4e-17 0.14 0.07 0.93 FALSE
58 GTEx Spleen SLC22A5 0.26 0.28 lasso 4 0.28 6.6e-08 8.6 8.8 2.1e-18 -0.14 0.05 0.87 FALSE
59 GTEx Stomach SLC22A5 0.09 0.04 lasso 4 0.01 9.0e-02 -6.7 -7.4 1.8e-13 0.17 0.10 0.40 FALSE
60 GTEx Stomach AC034220.3 0.17 0.15 enet 21 0.16 4.2e-08 -6.2 7.3 2.4e-13 -0.20 0.99 0.00 FALSE
61 GTEx Testis P4HA2 0.14 0.13 lasso 5 0.11 1.4e-05 8.7 8.9 4.5e-19 -0.25 0.04 0.96 FALSE
62 GTEx Testis PDLIM4 0.15 0.07 enet 8 0.05 2.5e-03 -7.1 7.4 1.5e-13 -0.07 0.25 0.14 FALSE
63 GTEx Testis RAPGEF6 0.50 0.35 lasso 4 0.32 6.5e-15 -8.1 -8.6 1.0e-17 0.89 0.12 0.88 FALSE
64 GTEx Testis AC034220.3 0.15 0.12 lasso 9 0.12 4.4e-06 -6.9 6.9 5.6e-12 -0.12 0.85 0.06 FALSE
65 GTEx Thyroid P4HA2 0.08 0.07 enet 9 0.06 3.5e-05 8.7 7.8 7.6e-15 -0.17 0.02 0.98 FALSE
66 GTEx Thyroid PDLIM4 0.05 0.02 enet 5 0.01 3.1e-02 7.6 -7.7 1.5e-14 0.21 0.10 0.78 FALSE
67 GTEx Thyroid AC034220.3 0.29 0.29 lasso 5 0.31 4.8e-24 -6.2 5.6 2.7e-08 -0.13 1.00 0.00 FALSE
68 GTEx Thyroid P4HA2-AS1 0.08 0.06 enet 14 0.05 1.6e-04 8.7 7.8 9.5e-15 -0.16 0.02 0.97 FALSE
69 GTEx Whole Blood SLC22A4 0.07 0.05 enet 16 0.05 4.6e-05 -7.2 -7.9 2.7e-15 0.22 0.18 0.71 FALSE
70 GTEx Whole Blood SLC22A5 0.09 0.12 lasso 2 0.10 1.7e-09 8.6 -8.6 7.3e-18 0.14 0.04 0.96 FALSE
71 GTEx Whole Blood AC034220.3 0.08 0.05 enet 31 0.06 4.0e-06 8.5 -8.2 2.1e-16 0.23 0.10 0.89 FALSE
72 GTEx Whole Blood AC116366.6 0.05 0.04 lasso 17 0.03 5.7e-04 -4.3 6.0 2.0e-09 -0.19 0.41 0.29 FALSE
73 METSIM Adipose P4HA2 0.09 0.08 lasso 12 0.09 2.4e-13 8.7 8.4 4.4e-17 -0.12 0.02 0.98 FALSE
74 METSIM Adipose PDLIM4 0.05 0.04 lasso 4 0.02 2.8e-04 7.6 -7.6 3.9e-14 0.24 0.84 0.10 FALSE
75 METSIM Adipose SLC22A4 0.05 0.02 lasso 3 0.03 8.4e-06 4.1 -5.2 1.9e-07 0.16 0.94 0.02 FALSE
76 METSIM Adipose SLC22A5 0.05 0.08 lasso 1 0.08 1.0e-11 8.6 -8.6 7.2e-18 0.14 0.05 0.95 FALSE
77 NTR Blood SLC22A4 0.02 0.00 blup 423 0.01 5.2e-04 4.1 -7.0 2.0e-12 0.36 0.23 0.73 FALSE
78 ROSMAP Brain Pre-frontal Cortex PDLIM4 0.25 0.27 lasso 4 0.26 2.7e-33 -5.7 -6.3 2.3e-10 0.27 1.00 0.00 FALSE
79 ROSMAP Brain Pre-frontal Cortex SLC22A4 0.03 0.05 lasso 2 0.04 1.2e-05 -8.2 -8.7 4.3e-18 0.16 0.43 0.50 FALSE
80 YFS Blood CDC42SE2 0.14 0.05 lasso 9 0.07 3.1e-22 -8.3 6.2 4.4e-10 -0.88 0.01 0.99 FALSE
81 YFS Blood LYRM7 0.03 0.01 bslmm 243 0.01 7.0e-05 -6.3 -5.8 4.8e-09 0.69 0.24 0.54 FALSE
82 YFS Blood SLC22A4 0.10 0.12 enet 47 0.14 5.1e-42 -6.9 -5.6 2.8e-08 0.10 1.00 0.00 FALSE
83 YFS Blood SLC22A5 0.38 0.36 bslmm 430 0.37 3.0e-128 8.6 -9.3 8.5e-21 0.15 0.04 0.96 FALSE
84 The Cancer Genome Atlas Bladder Urothelial Carcinoma PDLIM4 0.05 0.01 enet 4 0.02 1.2e-02 -5.3 -5.1 2.9e-07 0.25 0.08 0.07 FALSE
85 The Cancer Genome Atlas Breast Invasive Carcinoma P4HA2 0.03 0.02 blup 47 0.03 3.1e-06 8.7 7.9 2.5e-15 -0.18 0.00 0.99 FALSE
86 The Cancer Genome Atlas Breast Invasive Carcinoma PDLIM4 0.05 0.05 lasso 4 0.05 9.0e-11 -5.7 -5.8 7.3e-09 0.29 0.99 0.01 FALSE
87 The Cancer Genome Atlas Breast Invasive Carcinoma SLC22A4 0.05 0.01 enet 7 0.02 1.6e-05 8.6 -6.4 1.6e-10 0.06 0.01 0.98 FALSE
88 The Cancer Genome Atlas Breast Invasive Carcinoma SLC22A5 0.05 0.07 enet 11 0.09 5.3e-17 -6.2 -7.4 1.2e-13 0.16 1.00 0.00 FALSE
89 The Cancer Genome Atlas Colon Adenocarcinoma SLC22A5 0.08 0.04 blup 92 0.07 1.2e-04 -7.2 -7.5 7.7e-14 0.18 0.03 0.91 FALSE
90 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SLC22A4 0.02 0.02 lasso 1 0.02 3.0e-03 -6.4 -6.4 1.2e-10 0.15 0.13 0.51 FALSE
91 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SLC22A5 0.06 0.05 blup 93 0.08 1.2e-09 -7.0 -7.4 1.6e-13 0.14 0.07 0.93 TRUE
92 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PDLIM4 0.09 0.02 lasso 6 0.05 4.5e-06 -5.3 -6.8 9.7e-12 0.22 0.18 0.67 FALSE
93 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SLC22A4 0.03 0.03 lasso 1 0.02 3.5e-03 -7.0 -7.0 2.5e-12 0.13 0.34 0.30 FALSE
94 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CDC42SE2 0.10 0.07 lasso 1 0.06 2.6e-04 -5.6 5.6 2.4e-08 -0.80 0.02 0.84 FALSE
95 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SLC22A4 0.04 0.03 blup 108 0.01 7.1e-02 -6.2 -6.3 2.7e-10 0.17 0.12 0.17 FALSE
96 The Cancer Genome Atlas Brain Lower Grade Glioma HINT1 0.06 0.03 enet 5 0.03 5.2e-04 -6.1 -7.3 2.7e-13 0.74 0.08 0.41 FALSE
97 The Cancer Genome Atlas Lung Adenocarcinoma LYRM7 0.03 0.01 enet 10 0.02 7.5e-04 -6.2 8.6 5.6e-18 -0.74 0.01 0.88 FALSE
98 The Cancer Genome Atlas Lung Adenocarcinoma SLC22A5 0.06 0.03 lasso 4 0.02 9.3e-04 -7.2 -7.8 4.7e-15 0.21 0.06 0.74 FALSE
99 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SLC22A4 0.04 0.01 blup 111 0.03 3.0e-04 -1.2 -5.3 9.6e-08 0.10 0.05 0.78 FALSE
100 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SLC22A5 0.05 0.03 blup 93 0.05 1.9e-06 -6.2 -7.4 1.6e-13 0.13 0.04 0.96 FALSE
101 The Cancer Genome Atlas Prostate Adenocarcinoma PDLIM4 0.32 0.36 enet 13 0.37 3.8e-40 -5.3 -6.6 4.6e-11 0.28 1.00 0.00 FALSE
102 The Cancer Genome Atlas Prostate Adenocarcinoma SLC22A4 0.09 0.07 blup 108 0.09 3.0e-09 -7.0 -7.8 6.1e-15 0.20 0.10 0.90 FALSE
103 The Cancer Genome Atlas Prostate Adenocarcinoma SLC22A5 0.12 0.05 lasso 4 0.08 1.8e-08 -4.9 -6.2 5.1e-10 0.22 0.96 0.00 FALSE
104 The Cancer Genome Atlas Stomach Adenocarcinoma SLC22A5 0.05 0.01 blup 92 0.02 1.1e-02 -6.3 -6.0 2.2e-09 0.18 0.09 0.14 FALSE
105 The Cancer Genome Atlas Thyroid Carcinoma C5orf56 0.06 0.04 blup 98 0.03 1.3e-03 -4.5 7.9 2.1e-15 -0.21 0.78 0.12 FALSE
106 The Cancer Genome Atlas Thyroid Carcinoma HINT1 0.07 0.04 lasso 2 0.01 1.8e-02 -8.0 -8.0 1.6e-15 0.57 0.00 0.98 FALSE
107 The Cancer Genome Atlas Thyroid Carcinoma IRF1 0.05 0.02 blup 83 0.03 1.5e-03 5.9 7.3 2.3e-13 -0.14 0.06 0.08 FALSE
108 The Cancer Genome Atlas Thyroid Carcinoma P4HA2 0.21 0.35 enet 10 0.35 4.7e-35 8.7 8.5 2.0e-17 -0.25 0.00 1.00 FALSE
109 The Cancer Genome Atlas Thyroid Carcinoma SLC22A5 0.03 0.02 lasso 1 0.01 2.6e-02 -7.2 -7.2 5.2e-13 0.16 0.02 0.70 FALSE