Best TWAS P=1.31e-09 · Best GWAS P=1.62e-08 conditioned to 0.922
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | BAIAP2L2 | 0.11 | 0.03 | lasso | 5 | 0.04 | 1.8e-04 | 4.6 | -5.9 | 3.2e-09 | -0.75 | 0.03 | 0.86 | TRUE |
2 | GTEx | Artery Aorta | C22orf23 | 0.10 | 0.01 | enet | 24 | 0.02 | 1.6e-02 | 2.8 | 5.4 | 8.7e-08 | 0.34 | 0.25 | 0.10 | FALSE |
3 | GTEx | Artery Aorta | PLA2G6 | 0.10 | 0.02 | enet | 9 | 0.02 | 4.5e-02 | 3.2 | 5.4 | 5.2e-08 | 0.67 | 0.08 | 0.59 | FALSE |
4 | GTEx | Artery Aorta | TMEM184B | 0.17 | 0.07 | enet | 34 | 0.03 | 1.2e-02 | 4.9 | -5.2 | 2.2e-07 | -0.67 | 0.06 | 0.73 | FALSE |
5 | GTEx | Artery Aorta | AL021977.1 | 0.13 | 0.00 | enet | 17 | 0.01 | 8.7e-02 | 5.2 | -6.1 | 1.3e-09 | -0.73 | 0.03 | 0.74 | TRUE |
6 | GTEx | Brain Cortex | TMEM184B | 0.29 | 0.12 | lasso | 7 | 0.09 | 1.6e-03 | 4.9 | -5.4 | 7.7e-08 | -0.90 | 0.01 | 0.88 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | ANKRD54 | 0.11 | 0.09 | lasso | 4 | 0.09 | 5.3e-07 | -5.1 | -5.2 | 1.8e-07 | -0.20 | 0.14 | 0.83 | FALSE |
8 | GTEx | Nerve Tibial | MAFF | 0.14 | 0.06 | lasso | 3 | 0.05 | 1.2e-04 | 5.6 | -5.5 | 3.6e-08 | -0.99 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLA2G6 | 0.05 | 0.01 | blup | 76 | 0.01 | 7.7e-02 | 5.6 | 5.8 | 6.6e-09 | 0.85 | 0.01 | 0.84 | FALSE |