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chr11:64,501,991-67,971,546

Best TWAS P=9.57e-13 · Best GWAS P=1.15e-15 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	CommonMind	Brain Pre-frontal Cortex	FIBP	0.08	0.11	enet	20	0.12	8.1e-14	5.4	7.1	9.6e-13	-0.34	1.00	0.00	TRUE
22	GTEx	Esophagus Muscularis	CTD-3074O7.5	0.22	0.02	enet	17	0.09	3.7e-06	-2.5	6.3	2.8e-10	-0.50	0.30	0.46	TRUE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	SNX32	0.14	0.09	blup	60	0.13	8.8e-15	6.1	6.3	3.6e-10	-0.16	0.01	0.99	TRUE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SNX32	0.22	0.21	enet	16	0.24	6.2e-27	6.1	5.7	9.7e-09	-0.17	0.00	1.00	TRUE
29	GTEx	Muscle Skeletal	FIBP	0.12	0.13	enet	10	0.13	2.6e-12	5.3	5.6	1.7e-08	-0.17	1.00	0.00	TRUE
89	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RPS6KB2	0.12	0.06	blup	35	0.05	5.4e-03	-4.6	5.4	5.9e-08	-0.27	0.01	0.56	TRUE
41	GTEx	Uterus	PACS1	0.21	-0.01	enet	21	0.05	3.6e-02	4.0	-5.3	1.1e-07	0.42	0.07	0.30	TRUE
79	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CTSW	0.16	0.10	enet	24	0.15	1.9e-06	5.4	-5.3	1.2e-07	0.17	0.07	0.91	TRUE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CNIH2	0.03	0.00	enet	4	0.02	6.4e-03	-4.2	5.1	2.9e-07	-0.58	0.06	0.13	TRUE
56	The Cancer Genome Atlas	Glioblastoma Multiforme	CTSW	0.16	0.18	enet	16	0.19	2.3e-06	5.7	-6.6	4.4e-11	0.23	0.04	0.92	FALSE
87	The Cancer Genome Atlas	Stomach Adenocarcinoma	SNX32	0.12	0.13	blup	60	0.13	1.2e-09	5.3	6.6	5.4e-11	-0.16	0.04	0.96	FALSE
6	GTEx	Adrenal Gland	CTSW	0.13	0.08	lasso	12	0.06	3.0e-03	5.7	-6.3	2.1e-10	0.22	0.31	0.18	FALSE
72	The Cancer Genome Atlas	Lung Adenocarcinoma	FIBP	0.02	0.01	blup	45	0.02	1.3e-03	5.6	6.2	5.7e-10	-0.25	0.04	0.61	FALSE
85	The Cancer Genome Atlas	Soft Tissue Sarcoma	SNX32	0.08	0.08	lasso	2	0.10	1.5e-06	5.5	6.2	6.3e-10	-0.21	0.04	0.96	FALSE
80	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SNX32	0.30	0.19	lasso	1	0.14	3.9e-06	6.1	6.1	8.6e-10	-0.12	0.00	1.00	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	FIBP	0.04	0.04	lasso	3	0.04	1.2e-05	6.1	6.1	8.7e-10	-0.13	0.01	0.99	FALSE
77	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SNX32	0.08	0.10	blup	60	0.11	6.0e-08	6.1	6.1	8.9e-10	-0.19	0.01	0.99	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	SNX32	0.23	0.26	lasso	7	0.25	6.4e-24	6.1	6.0	1.5e-09	-0.14	0.00	1.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SNX32	0.46	0.36	lasso	8	0.39	1.9e-50	6.1	6.0	1.7e-09	-0.16	1.00	0.00	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	FIBP	0.40	0.21	enet	26	0.29	4.3e-10	5.3	6.0	2.2e-09	-0.17	0.99	0.00	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNX32	0.15	0.17	blup	60	0.17	2.9e-34	6.1	6.0	2.3e-09	-0.16	0.00	1.00	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	EFEMP2	0.01	0.00	blup	45	0.01	3.0e-02	4.1	6.0	2.5e-09	-0.23	0.02	0.59	FALSE
94	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CTSW	0.24	0.21	enet	21	0.24	2.9e-07	5.3	-5.9	2.9e-09	0.17	0.06	0.94	FALSE
27	GTEx	Liver	CTSW	0.27	0.03	lasso	13	0.02	1.0e-01	5.4	-5.9	3.1e-09	0.23	0.07	0.06	FALSE
13	GTEx	Breast Mammary Tissue (Male)	NEAT1	0.27	0.01	enet	29	0.03	6.3e-02	5.2	5.9	3.5e-09	-0.16	0.04	0.26	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	CTSW	0.27	0.22	lasso	12	0.22	1.9e-12	5.3	-5.9	4.2e-09	0.17	1.00	0.00	FALSE
16	GTEx	Cells Transformed fibroblasts	EFEMP2	0.06	0.06	lasso	3	0.07	7.8e-06	5.5	5.9	4.5e-09	-0.23	0.81	0.01	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	CTSW	0.25	0.39	blup	44	0.41	7.3e-91	5.3	-5.8	5.5e-09	0.17	0.12	0.88	FALSE
26	GTEx	Heart Left Ventricle	FIBP	0.12	0.09	lasso	3	0.07	9.8e-05	5.3	5.8	5.8e-09	-0.17	0.87	0.01	FALSE
50	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SNX32	0.05	0.05	blup	60	0.03	1.1e-03	6.1	5.8	6.6e-09	-0.19	0.01	0.99	FALSE
17	GTEx	Colon Transverse	CTSW	0.37	0.27	lasso	8	0.26	1.5e-12	5.3	-5.8	7.3e-09	0.17	1.00	0.00	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	SNX32	0.50	0.53	lasso	13	0.54	1.1e-81	6.1	5.8	7.4e-09	-0.13	1.00	0.00	FALSE
40	GTEx	Thyroid	PACS1	0.09	0.04	enet	16	0.09	2.8e-07	-7.8	-5.8	9.1e-09	0.79	0.02	0.98	FALSE
25	GTEx	Heart Atrial Appendage	RP11-867G23.1	0.19	0.13	lasso	5	0.11	1.6e-05	-6.0	-5.7	1.3e-08	0.66	0.11	0.81	FALSE
43	METSIM	Adipose	FIBP	0.05	0.02	blup	344	0.02	1.0e-03	5.3	5.7	1.3e-08	-0.39	0.96	0.01	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX32	0.15	0.11	blup	60	0.15	6.0e-17	6.1	5.7	1.3e-08	-0.14	0.00	1.00	FALSE
11	GTEx	Breast Mammary Tissue	CTSW	0.25	0.19	lasso	8	0.16	1.3e-08	5.3	-5.6	1.9e-08	0.13	1.00	0.00	FALSE
12	GTEx	Breast Mammary Tissue (Male)	LTBP3	0.11	-0.01	enet	26	-0.01	5.8e-01	5.5	5.6	1.9e-08	-0.08	0.03	0.25	FALSE
63	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CTSW	0.32	0.26	lasso	1	0.26	4.3e-15	5.6	-5.6	1.9e-08	0.12	0.08	0.92	FALSE
88	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CTSW	0.26	0.29	lasso	9	0.27	4.7e-10	5.3	-5.6	2.0e-08	0.14	0.11	0.89	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FIBP	0.05	0.01	blup	44	0.02	1.5e-02	6.1	5.6	2.1e-08	-0.16	0.01	0.79	FALSE
74	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CTSW	0.25	0.34	enet	14	0.34	4.1e-40	5.4	-5.6	2.3e-08	0.14	0.11	0.89	FALSE
70	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CTSW	0.63	0.41	lasso	8	0.42	1.2e-21	5.6	-5.6	2.5e-08	0.12	0.08	0.92	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	CTSW	0.06	0.03	bslmm	328	0.03	3.6e-05	5.6	-5.6	2.8e-08	0.12	0.60	0.02	FALSE
39	GTEx	Thyroid	CTSW	0.18	0.22	lasso	2	0.21	4.6e-16	5.3	-5.5	2.9e-08	0.14	1.00	0.00	FALSE
69	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNX32	0.15	0.27	enet	23	0.26	6.1e-30	6.1	5.5	3.3e-08	-0.14	0.00	1.00	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SNX32	0.15	0.14	enet	8	0.15	2.5e-16	4.1	5.5	3.4e-08	-0.16	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CTSW	0.31	0.32	lasso	4	0.34	1.8e-39	5.4	-5.5	3.7e-08	0.13	0.10	0.90	FALSE
35	GTEx	Skin Sun Exposed Lower leg	RP11-867G23.1	0.06	0.06	enet	7	0.02	1.3e-02	5.3	-5.5	4.0e-08	0.69	0.26	0.48	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CFL1	0.04	0.00	bslmm	350	0.02	3.3e-03	3.2	-5.5	4.2e-08	0.41	0.08	0.28	FALSE
55	The Cancer Genome Atlas	Colon Adenocarcinoma	SNX32	0.11	0.08	enet	5	0.07	9.7e-05	5.2	5.5	4.3e-08	-0.14	0.00	0.99	FALSE
32	GTEx	Prostate	CTSW	0.29	0.26	lasso	8	0.26	2.9e-07	5.3	-5.5	4.8e-08	0.13	0.57	0.03	FALSE
34	GTEx	Skin Sun Exposed Lower leg	CTSW	0.19	0.19	lasso	6	0.18	1.1e-14	5.3	-5.5	4.9e-08	0.13	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	CTSW	0.13	0.14	blup	44	0.14	7.0e-16	5.3	-5.5	5.1e-08	0.11	0.06	0.94	FALSE
76	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CTSW	0.20	0.23	lasso	9	0.23	1.5e-15	5.3	-5.5	5.1e-08	0.13	0.09	0.91	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	CTSW	0.23	0.29	lasso	7	0.29	1.0e-33	5.4	-5.5	5.2e-08	0.13	0.09	0.91	FALSE
86	The Cancer Genome Atlas	Stomach Adenocarcinoma	CTSW	0.24	0.35	lasso	7	0.36	3.0e-27	5.6	-5.4	5.2e-08	0.15	0.07	0.93	FALSE
78	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CTSW	0.30	0.23	lasso	11	0.24	1.7e-10	5.3	-5.4	5.4e-08	0.14	0.06	0.94	FALSE
49	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CTSW	0.12	0.16	enet	12	0.17	5.6e-14	5.3	-5.4	5.5e-08	0.18	0.11	0.89	FALSE
4	GTEx	Adipose Subcutaneous	CTSW	0.30	0.18	lasso	6	0.16	3.9e-13	5.3	-5.4	5.8e-08	0.13	1.00	0.00	FALSE
30	GTEx	Nerve Tibial	CTSW	0.22	0.19	lasso	7	0.18	1.3e-12	5.3	-5.4	5.8e-08	0.13	1.00	0.00	FALSE
15	GTEx	Cells Transformed fibroblasts	FIBP	0.20	0.13	lasso	5	0.17	1.7e-12	5.3	5.4	6.6e-08	-0.13	1.00	0.00	FALSE
91	The Cancer Genome Atlas	Thyroid Carcinoma	CTSW	0.25	0.37	lasso	8	0.37	5.2e-38	5.4	-5.4	6.7e-08	0.14	0.12	0.88	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	CTSW	0.29	0.49	enet	12	0.49	3.4e-58	5.3	-5.4	6.9e-08	0.13	0.12	0.88	FALSE
5	GTEx	Adipose Visceral Omentum	CTSW	0.22	0.20	lasso	11	0.19	5.1e-10	5.3	-5.4	7.8e-08	0.15	1.00	0.00	FALSE
83	The Cancer Genome Atlas	Rectum Adenocarcinoma	CTSW	0.21	0.05	blup	39	0.07	9.1e-03	5.3	-5.4	8.3e-08	0.16	0.04	0.47	FALSE
31	GTEx	Pancreas	CTSW	0.13	0.11	lasso	3	0.08	4.0e-04	5.3	-5.4	8.4e-08	0.12	0.33	0.03	FALSE
36	GTEx	Spleen	CTSW	0.30	0.31	lasso	2	0.26	1.9e-07	5.3	-5.4	8.5e-08	0.13	0.97	0.00	FALSE
37	GTEx	Stomach	CTSW	0.18	0.20	lasso	7	0.19	1.7e-09	5.3	-5.3	8.7e-08	0.13	1.00	0.00	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	FIBP	0.13	0.13	lasso	3	0.15	5.8e-19	5.3	5.3	9.4e-08	-0.13	1.00	0.00	FALSE
8	GTEx	Artery Coronary	FIBP	0.13	0.01	lasso	5	0.04	1.3e-02	5.3	5.3	9.7e-08	-0.18	0.16	0.19	FALSE
84	The Cancer Genome Atlas	Soft Tissue Sarcoma	CTSW	0.18	0.22	lasso	3	0.22	4.1e-13	5.3	-5.3	9.7e-08	0.13	0.12	0.88	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CTSW	0.23	0.25	lasso	6	0.25	3.2e-28	5.3	-5.3	9.9e-08	0.13	0.13	0.87	FALSE
9	GTEx	Artery Tibial	CTSW	0.12	0.09	enet	22	0.11	1.2e-08	5.3	-5.3	1.1e-07	0.16	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Glioblastoma Multiforme	SNX32	0.13	0.05	blup	60	0.09	1.1e-03	6.1	5.3	1.2e-07	-0.20	0.01	0.91	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	SNX32	0.07	0.08	lasso	4	0.10	2.0e-10	5.4	5.3	1.2e-07	-0.14	0.01	0.99	FALSE
7	GTEx	Artery Aorta	CTSW	0.29	0.26	lasso	7	0.25	3.2e-14	5.3	-5.3	1.3e-07	0.14	1.00	0.00	FALSE
90	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SNX32	0.23	0.15	blup	60	0.12	6.3e-05	6.1	5.3	1.3e-07	-0.11	0.00	1.00	FALSE
10	GTEx	Brain Cortex	PACS1	0.19	0.11	lasso	9	0.08	2.9e-03	4.7	-5.3	1.4e-07	0.60	0.26	0.29	FALSE
23	GTEx	Heart Atrial Appendage	KLC2	0.10	0.04	lasso	8	0.09	1.1e-04	4.5	-5.3	1.4e-07	0.56	0.27	0.42	FALSE
38	GTEx	Testis	FIBP	0.21	0.22	lasso	5	0.19	6.5e-09	5.3	5.2	1.5e-07	-0.13	1.00	0.00	FALSE
44	METSIM	Adipose	KLC2	0.06	0.06	blup	323	0.05	1.2e-08	4.5	-5.3	1.5e-07	0.53	1.00	0.00	FALSE
19	GTEx	Esophagus Muscularis	FIBP	0.11	0.04	lasso	4	0.04	1.2e-03	3.5	5.2	1.7e-07	-0.17	0.69	0.02	FALSE
20	GTEx	Esophagus Muscularis	CTSW	0.29	0.32	lasso	5	0.32	2.9e-20	5.3	-5.2	1.7e-07	0.11	1.00	0.00	FALSE
18	GTEx	Esophagus Mucosa	CTSW	0.32	0.19	lasso	6	0.17	1.3e-11	5.3	-5.2	1.8e-07	0.13	1.00	0.00	FALSE
24	GTEx	Heart Atrial Appendage	PTPRCAP	0.14	0.11	lasso	10	0.09	5.1e-05	-4.5	5.2	2.0e-07	-0.27	0.03	0.91	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFEMP2	0.04	0.02	lasso	5	0.02	1.4e-05	4.6	5.2	2.1e-07	-0.26	0.16	0.82	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	CTSW	0.40	0.34	enet	14	0.36	4.3e-22	5.4	-5.2	2.3e-07	0.09	0.08	0.92	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	CDK2AP2	0.03	0.02	enet	11	0.03	1.6e-04	-3.7	5.2	2.4e-07	-0.21	0.09	0.73	FALSE
28	GTEx	Lung	CTSW	0.33	0.20	lasso	8	0.21	3.2e-16	5.3	-5.2	2.5e-07	0.11	1.00	0.00	FALSE
21	GTEx	Esophagus Muscularis	YIF1A	0.11	0.05	enet	11	0.04	2.4e-03	4.4	-5.2	2.7e-07	0.57	0.82	0.16	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	FIBP	0.04	0.00	blup	45	0.02	8.0e-03	3.5	5.1	2.7e-07	-0.14	0.02	0.22	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SNX32	0.11	0.06	blup	60	0.09	1.3e-05	5.3	5.1	3.0e-07	-0.10	0.02	0.98	FALSE
42	METSIM	Adipose	CTSW	0.13	0.12	lasso	10	0.12	3.9e-17	5.3	-5.1	3.1e-07	0.11	1.00	0.00	FALSE