Hub : Genes

CDK2AP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.3010	0.1190	5.0e-03	-0.009	NA	-0.006	NA	-0.005	0.73000	NA	5.0e-01	NA	4.9e-01
2	GTEx	Spleen	0.2810	0.1050	8.2e-04	0.013	NA	-0.006	NA	0.006	0.15000	NA	4.9e-01	NA	2.2e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.0311	0.0153	1.7e-03	0.025	0.019	0.027	0.016	0.020	0.00034	1.5e-03	1.7e-04	3.1e-03	1.2e-03
4	YFS	Blood	0.0381	0.0125	1.7e-06	0.007	0.023	0.020	0.022	0.013	0.00130	2.8e-08	2.8e-07	7.3e-08	3.9e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.7	0.5	-0.1	-0.6	-0.8
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.3	0.7	0.3	-0.4
Depressed Affect (Nagel 2018)	0.1	0.3	1.0	0.1	0.3	0.4	-1.0
Depression (Nagel 2018)	0.5	0.8	1.2	-0.9	1.0	1.1	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.1	-0.7	0.2	-0.5
Neuroticism (Nagel 2018)	0.4	0.9	2.3	0.8	0.7	-0.2	-1.5
Schizophrenia (2018)	0.3	0.6	0.9	-0.8	1.0	0.9	-0.4
Schizophrenia vs Biploar Disorder	1.6	2.1	3.8	-1.7	0.6	1.1	1.9
Worry (Nagel 2018)	0.4	0.9	1.8	0.5	1.2	-0.3	-1.3
Alzheimer’s Disease (in mother)	0.5	0.6	1.3	-0.6	1.1	0.8	-0.2
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.3	-0.0	-0.1	0.2
Alzheimer’s Disease (including proxy)	0.1	0.2	0.7	-0.3	0.8	0.3	-0.2
Crohns Disease (2017)	0.7	1.5	2.9	0.9	-1.7	-1.5	0.1
Irritable Bowel Disease (IBD)	1.1	2.7	4.1	2.0	-1.7	-1.8	-0.6
Ulcerative Colitis (UC)	1.0	1.9	4.5	2.1	-0.5	-1.5	-0.9
Major Depression (MDD)	2.2	2.7	4.7	-1.4	1.5	1.5	-2.2
Reaction Time	0.4	0.7	1.5	0.2	0.0	-1.2	1.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.4	-1.1	0.2	1.2	-0.0
Breast Cancer	0.2	0.6	1.6	0.9	1.2	-0.2	0.1
Ovarian Cancer	1.2	1.6	3.8	1.3	-0.5	-0.8	-2.0
Prostate Cancer	4.4	6.2	8.5	2.0	-2.6	-2.9	2.4
Age at First Birth	0.1	0.1	0.2	-0.0	0.4	0.2	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.3	4.6	0.1	0.6	0.5	-2.1
Coronary Artery Disease (CAD)	0.8	1.0	2.9	0.4	-0.7	-0.5	-1.7
Crohns Disease (2012)	0.1	0.1	0.3	0.5	0.1	-0.3	0.2
Mean Putamen Volume	1.7	1.9	4.5	-2.1	0.9	1.5	-0.3
Fasting Glucose	0.2	0.3	0.6	-0.3	0.2	0.5	-0.8
HbA1C	0.7	0.8	2.7	-0.4	-0.4	0.6	-1.6
HDL Cholesterol	0.2	0.3	0.4	0.6	-0.2	-0.5	0.5
LDL Cholesterol	0.5	0.8	1.4	-1.2	0.4	0.9	0.9
Lupus	0.2	0.3	0.8	-0.9	-0.2	0.3	0.4
Neuroticism (2016)	0.5	0.7	2.5	0.4	1.6	0.5	-0.1
Primary Biliary Cirrhosis	0.3	0.4	1.1	-1.1	0.2	0.6	-0.5
Rheumatoid Arthritis	2.0	2.7	5.7	1.8	-2.4	-1.3	0.4
Schizophrenia (2014)	0.4	1.0	1.8	-0.9	1.3	1.0	0.2
Triglycerides	1.2	1.9	2.9	-1.3	1.2	1.7	-1.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.5	0.0	0.5	-0.0	-1.2
Ulcerative Colitis	0.6	0.8	2.5	1.6	0.1	-0.9	0.1
Blood Eosinophil Count	0.5	3.8	8.0	-1.7	1.0	1.8	-2.8
Blood Platelet Count	0.2	2.1	4.0	-1.5	0.9	2.0	-1.1
Blood Red Count	3.0	28.7	54.0	7.2	-2.8	-7.3	1.3
Blood White Count	0.4	2.8	5.9	-0.2	2.1	0.9	-2.4
Heel T-Score	0.2	1.3	3.5	-0.7	1.9	0.4	-1.1
BMI	0.8	4.4	7.3	-1.8	1.8	1.9	-2.7
Height	8.7	167.2	338.6	-16.9	6.6	18.4	-1.2
Waist Hip Ratio (WHR)	3.7	16.8	25.7	-4.7	4.0	5.1	-1.7
Systolic Blood Pressure	1.1	5.6	11.4	3.4	-1.1	-2.8	1.5
Smoking Status	1.9	4.5	6.6	-2.4	2.2	2.6	-0.5
Allergy or Eczema	1.9	5.0	7.3	2.7	-1.0	-2.2	-2.6
Cardiovascular Disease	0.1	0.2	0.7	0.1	0.8	-0.0	0.4
Hypothyroidism (self reported)	0.1	0.2	0.6	-0.2	-0.3	0.8	-0.1
Respiratory disease	1.6	3.5	6.5	-2.0	2.5	1.7	-0.7
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.8	-0.9	1.4	1.4	-1.9
Lung FEV1/FVC ratio	0.1	0.5	1.9	-0.0	-0.3	0.4	-1.4
Lung FVC	1.7	8.4	14.4	3.2	-3.8	-2.7	1.3
Neuroticism	0.1	0.4	1.1	0.5	1.0	-0.2	-0.2
Chronotype (morning person)	0.2	0.5	1.2	0.2	0.3	-0.7	1.1
Hair Pigment	0.1	2.5	4.0	0.6	-2.0	-1.5	1.9
Tanning	0.0	0.3	0.6	-0.5	0.3	0.3	0.8
Hand grip strength (left)	0.8	2.2	3.7	-1.9	0.1	1.8	1.3
Number of treatments/medications taken	2.3	4.1	5.4	-2.1	2.2	2.3	-1.2
Average weekly spirits intake	0.8	0.9	1.3	-1.1	1.0	0.8	-0.9
Sensitivity / hurt feelings	0.4	0.8	2.7	0.2	0.4	-0.4	-1.6
Frequency of depressed mood in last 2 weeks	1.6	2.2	5.7	-0.9	2.4	1.4	-0.5
Hearing difficulty/problems: Yes	1.1	1.7	3.6	-0.3	1.9	1.4	-1.2
Relative age of first facial hair	2.7	5.6	9.0	-2.2	2.2	3.0	-2.0
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.0	-0.5	0.4	1.0	-1.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.2	-1.1	0.7	0.8	-0.4
Ever had hysterectomy (womb removed)	0.6	0.7	1.2	-0.8	0.9	1.1	0.4
Systolic blood pressure, automated reading	1.1	3.1	6.4	2.5	-1.5	-2.0	0.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.6	0.3	0.3	0.6
Angina	0.2	0.3	0.9	0.1	0.4	0.2	0.9
Medication for hormone replacement therapy	1.3	1.4	2.5	1.2	-1.6	-1.3	0.3
Vitamin and mineral supplements	1.6	2.1	2.9	0.9	-1.7	-1.4	1.7
Supplements: Zinc	1.5	1.7	3.4	-0.6	1.4	1.0	-1.8
Medication: Co-codamol	0.1	0.2	0.6	-0.1	0.2	0.8	0.0
Medication: Metformin	1.3	1.8	2.1	-1.5	1.2	1.3	-1.4
Diabetes (father)	0.5	0.7	1.5	0.7	-0.7	-0.3	-1.2
Diabetes (mother)	1.6	2.1	4.3	2.1	-0.1	-0.8	-1.8
Severe depression (siblings)	0.6	0.7	1.2	0.8	-1.1	-0.9	0.3
Pack years adult smoking proportion	1.1	1.7	6.1	-0.3	-0.7	-0.3	2.5
Impedance of leg (right)	1.1	5.5	13.1	-3.6	-0.5	2.6	1.2
Leg fat-free mass (left)	3.4	18.1	33.0	-4.9	3.5	5.7	-1.8
Trunk fat percentage	6.4	25.8	43.6	-5.5	3.7	6.6	-3.9
Hand grip strength (right)	1.9	5.2	11.4	-3.4	0.6	2.9	0.4
Townsend deprivation index at recruitment	1.5	2.2	3.6	-1.9	1.4	1.7	0.3
Current tobacco smoking	1.7	2.7	5.5	-2.4	0.9	2.2	0.0
Average weekly fortified wine intake	0.6	0.8	1.0	-0.8	0.6	1.0	-1.0
Maternal smoking around birth	0.5	0.8	1.6	0.5	-1.1	0.1	1.3
Fed-up feelings	1.5	2.6	3.8	-1.3	1.7	2.0	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	1.9	-1.2	1.4	1.1	0.9
Relative age voice broke	1.9	2.9	3.8	-1.1	1.9	1.9	-1.8
Taking other prescription medications	4.5	7.0	10.5	-3.2	2.0	3.1	-2.0
Age when periods started (menarche)	0.9	2.2	3.6	-1.5	1.4	1.9	-1.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.7	-0.8	0.8	0.4	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.4	-0.3	0.1	-0.1	-0.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	0.7	-0.6	-0.3	-0.6
Qualifications: CSEs or equivalent	0.4	0.5	0.8	0.8	-0.5	-0.9	0.6
Serious illness, injury or assault to yourself	0.2	0.3	0.6	0.8	0.2	-0.5	-0.4
High blood pressure	0.1	0.4	0.8	-0.1	0.7	-0.4	0.9
Hayfever, allergic rhinitis or eczema	1.4	3.0	4.4	1.9	-1.0	-1.7	-2.1
Multivitamins +/- minerals	0.7	0.8	1.8	-0.5	1.3	0.9	-0.7
Stomach or abdominal pain in last month	0.1	0.2	0.3	0.1	0.5	0.2	-0.5
Supplements: Glucosamine	1.0	1.4	2.7	-1.5	0.5	1.6	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.2	0.0	-0.3	0.6
Medication: Atenolol	0.9	1.1	2.0	-1.4	0.8	1.0	-0.8
Medication: Levothyroxine sodium	1.8	3.0	5.3	-1.5	1.8	2.3	-1.1
Sitting height	1.2	8.7	16.2	-3.7	2.1	4.0	0.5
Chronic bronchitis/emphysema (father)	1.1	1.2	3.1	-0.8	0.9	0.7	-1.8
High blood pressure (mother)	0.3	0.4	0.5	-0.4	0.7	0.6	-0.6
Body mass index (BMI)	1.0	4.3	10.4	-1.0	1.9	1.5	-3.2
Impedance of leg (left)	1.1	5.3	12.0	-3.5	-0.3	2.9	0.7
Leg predicted mass (left)	3.5	18.5	33.5	-5.0	3.5	5.8	-1.8
Trunk fat mass	7.9	33.9	58.4	-6.6	4.3	7.6	-3.9
Waist circumference	6.7	24.5	38.0	-5.5	4.2	6.2	-3.6
Number of incorrect matches in round	0.3	0.5	1.3	1.2	0.1	-0.7	0.1
Past tobacco smoking	1.4	2.6	4.5	1.6	-2.1	-1.6	0.8
Alcohol usually taken with meals	1.3	2.0	7.4	0.2	-0.5	-0.7	2.7
Nervous feelings	0.1	0.2	0.5	-0.1	0.7	0.0	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.6	-0.0	1.3	0.4	0.0
Hearing difficulty/problems with background noise	1.0	1.6	4.3	1.4	0.1	-0.3	-2.1
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.4	-0.9	-0.5	-0.3
Had menopause	0.1	0.1	0.3	-0.1	-0.5	0.3	-0.4
Had other major operations	1.8	2.2	3.3	-1.7	0.8	1.8	-1.4
Forced vital capacity (FVC)	1.2	4.4	11.6	-2.5	-0.0	3.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.8	0.3	-0.8	-0.9	-0.5
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	1.9	-0.9	1.0	1.2	-1.4
Qualifications: None of the above	0.1	0.2	0.5	0.5	0.1	0.2	0.7
Financial difficulties in last 2 years	1.5	2.0	4.2	-0.8	2.0	1.5	-1.0
Mouth/teeth dental problems	0.5	0.7	1.7	1.3	-0.5	-0.6	-0.8
Heart attack	0.1	0.1	0.3	0.1	0.5	-0.3	0.3
Allergy	0.5	1.2	4.1	-0.0	-0.9	0.2	2.0
Pain all over the body in last month	1.2	1.2	2.1	-0.1	1.4	0.9	-1.4
Diabetes (self-reported)	2.5	3.9	4.9	-1.6	2.2	1.9	-2.1
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	5.2	2.3	-1.2	-2.0	-0.9
Medication: Ramipril	0.4	0.6	1.5	1.2	-0.1	-0.6	0.5
Medication: Simvastatin	0.4	0.6	1.8	-0.7	0.1	0.5	-1.4
Fluid intelligence score	0.1	0.3	1.0	-0.0	-1.0	-0.1	-0.4
Illnesses of siblings	0.1	0.2	0.5	0.1	-0.7	0.1	-0.5
Neuroticism score	0.1	0.3	0.9	-0.1	0.9	-0.0	-0.5
Weight	6.3	31.2	54.0	-6.5	4.2	7.3	-3.2
Impedance of arm (right)	0.4	1.7	2.7	-1.0	-0.8	1.6	1.7
Arm fat percentage (right)	1.3	5.3	8.0	-1.9	1.7	2.6	-2.8
Trunk fat-free mass	3.8	21.5	39.1	-5.8	3.3	6.2	-1.4
Hip circumference	4.4	19.0	34.0	-5.1	2.7	5.8	-2.9
Time employed in main current job	2.6	3.0	4.0	-2.0	1.2	1.9	-1.7
Alcohol intake versus 10 years previously	0.6	0.9	2.0	-0.7	0.7	0.7	-1.4
Father’s age at death	1.1	1.5	2.0	-1.4	0.6	1.4	-1.3
Worrier / anxious feelings	0.5	0.9	3.0	0.1	0.7	-0.3	-1.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.5	0.4	0.7	0.6	-1.2
Falls in the last year	6.4	8.7	9.7	-2.6	3.0	3.1	-3.0
Hair/balding pattern: Pattern 3	1.1	1.6	2.9	1.0	1.7	-0.4	-1.6
Number of live births	0.9	1.3	2.2	1.5	-1.0	-0.7	-1.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.9	-0.8	-1.3	1.7	0.0
Pulse rate	0.4	0.7	1.3	0.7	-0.0	-1.1	1.1
Happiness	2.8	3.4	4.7	-1.7	2.2	1.7	-1.7
Noisy workplace	1.0	1.3	1.9	-1.4	1.3	1.2	-0.4
Qualifications: A levels/AS levels or equivalent	2.0	4.5	7.0	2.6	-2.1	-2.5	-0.3
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.9	4.4	-2.0	1.4	2.1	-0.9
Mouth/teeth dental problems: Dentures	1.4	2.3	5.2	-2.3	0.9	1.8	0.2
Asthma	0.9	1.7	3.3	-1.6	1.8	1.0	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.5	0.1	-0.5	0.1	-0.7
Medication: Cholesterol lowering	0.3	0.4	1.2	0.4	-1.1	-0.4	0.5
Depression (self-reported)	1.9	2.3	4.9	-2.2	1.1	1.6	-0.4
Medication: Lansoprazole	0.6	0.6	2.5	0.2	0.2	0.0	-1.6
Prospective memory result	0.5	0.6	1.2	-0.4	-0.0	0.9	-1.1
Lung cancer (father)	1.1	1.3	2.6	-1.6	0.6	1.5	-0.3
Illnesses of mother	1.0	1.2	2.6	-0.9	-1.2	0.1	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.3	9.8	-2.7	-0.4	3.1	-0.3
Pulse wave Arterial Stiffness index	2.3	2.6	4.2	2.0	-1.4	-1.9	0.8
Impedance of arm (left)	0.8	3.6	8.5	-2.4	0.1	2.9	0.5
Arm fat mass (right)	2.9	11.8	18.1	-3.5	2.7	4.3	-3.0
Trunk predicted mass	3.8	21.8	39.4	-5.9	3.3	6.3	-1.4
Standing height	9.0	89.3	174.2	-12.4	5.4	13.2	-0.4
Length of working week for main job	0.2	0.2	0.5	-0.2	0.7	0.3	0.5
Exposure to tobacco smoke at home	0.1	0.1	0.5	0.1	0.1	-0.1	0.7
Breastfed as a baby	0.0	0.1	0.1	-0.1	0.2	0.3	-0.3
Tense / ‘highly strung’	0.5	0.8	1.5	-0.8	1.2	0.9	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.4	5.4	-1.9	2.3	2.1	-0.7
Hair/balding pattern: Pattern 4	0.9	2.1	3.1	1.8	-1.3	-1.8	0.7
Birth weight of first child	0.2	0.4	0.6	0.8	-0.5	-0.3	-0.8
Peak expiratory flow (PEF)	0.4	1.0	2.6	-0.8	-0.9	1.6	-0.2
Pulse wave reflection index	2.4	2.9	4.6	1.5	-2.1	-2.0	0.9
Ever highly irritable/argumentative for 2 days	2.0	2.4	4.6	-0.3	2.1	0.5	-2.1
Loud music exposure frequency	2.3	2.5	4.0	-2.0	0.9	1.9	-1.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.4	0.2	-0.7	-0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.5	0.4	-0.0	0.2
Blood clot in the leg (DVT)	0.2	0.3	0.8	-0.9	0.4	0.2	0.5
Medication: Paracetamol	0.8	1.4	2.9	-0.3	1.7	0.7	-1.4
Headache pain in last month	0.3	0.4	1.1	1.0	-0.4	-0.7	-0.0
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.1	-1.5	0.8	1.2	-1.1
Glaucoma (self-reported)	0.8	1.0	1.9	-1.4	1.0	1.0	-0.2
Gout (self-reported)	0.4	0.5	1.7	-0.5	0.3	0.4	-1.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.4	0.0	0.3	1.2	-0.9
Medication: Amlodipine	0.7	0.9	2.0	1.0	-0.2	-0.8	1.4
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.9	-1.7	0.0	1.2	-0.4
Birth weight	0.5	1.1	1.6	-1.3	1.1	1.2	-0.5
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.7	0.5	-0.0	-0.4	0.8
High blood pressure (siblings)	0.4	0.6	2.1	-0.5	1.4	0.2	0.1
Forced vital capacity (FVC), Best measure	2.5	9.2	20.2	-4.0	0.6	4.5	-0.4
Body fat percentage	4.7	18.5	29.6	-4.7	3.2	5.4	-3.5
Leg fat percentage (right)	2.7	9.9	13.3	-3.6	2.3	3.6	-2.8
Arm fat-free mass (right)	5.5	28.4	47.1	-6.7	4.0	6.9	-2.2
Exposure to tobacco smoke outside home	0.2	0.3	0.7	-0.3	0.6	0.3	-0.9
Comparative body size at age 10	0.4	1.0	2.3	0.5	1.1	0.1	-1.5
Number of full brothers	2.1	2.6	4.4	2.1	-1.5	-1.9	0.7
Worry too long after embarrassment	0.5	0.8	1.1	0.5	-0.9	-0.9	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.1	0.1	-0.1	-1.0
Wheeze or whistling in the chest in last year	1.4	2.6	4.2	-1.4	2.1	1.2	-1.6
Number of children fathered	1.4	1.6	6.1	0.1	-0.4	0.1	-2.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.7	-0.2	0.8	0.2	-0.3
Age at first live birth	0.1	0.2	0.8	-0.3	0.3	0.9	0.2
Pulse wave peak to peak time	4.5	5.3	8.7	-3.0	1.8	2.9	-0.9
Health satisfaction	3.1	4.0	8.7	-1.8	1.3	1.5	-2.9
Shortness of breath walking on level ground	0.9	1.0	1.7	-0.9	1.3	1.2	0.6
Qualifications: College or University degree	0.0	0.1	0.2	-0.1	-0.5	0.0	0.3
Eye problems/disorders: None of the above	0.1	0.2	0.4	-0.1	0.5	0.3	0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.1	1.1	-0.7	-1.1	0.4
Emphysema/chronic bronchitis	0.2	0.2	0.5	-0.7	0.2	0.5	-0.1
Medication for pain relief, constipation, heartburn	1.6	2.8	4.7	1.1	-1.9	-1.3	2.2
Neck or shoulder pain in last month	2.5	3.6	5.2	-2.3	1.7	2.3	-1.2
Medication: Blood pressure	0.9	1.5	3.1	1.8	0.1	-1.2	1.2
Angina (self-reported)	0.2	0.3	1.2	0.3	0.2	0.1	1.1
Migraine (self-reported)	0.2	0.3	0.7	0.4	0.8	-0.2	-0.5
Medication: Ibuprofen	0.3	0.3	0.8	-0.3	-0.1	0.7	-0.9
Medication: Allopurinol	0.4	0.6	1.1	0.5	-1.1	-0.4	-0.8
Medication: Omeprazole	0.4	0.5	1.9	-0.3	-0.1	0.3	-1.4
Medication: Seretide 50 evohaler	1.2	1.4	2.3	-1.4	1.1	1.5	-0.3
Mean time to correctly identify matches	0.1	0.2	0.4	-0.5	0.5	-0.2	0.6
Heart disease (mother)	1.2	1.5	2.2	1.5	-0.4	-1.2	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.1	1.0	-0.6	-1.2	1.5
Whole body fat mass	6.5	26.9	45.0	-5.9	3.9	6.7	-3.5
Leg fat mass (right)	4.2	16.3	25.1	-4.6	3.2	5.0	-3.0
Arm predicted mass (right)	5.2	26.8	45.2	-6.5	3.9	6.7	-2.1
Pulse rate, automated reading	0.2	0.6	1.3	0.3	0.7	-1.2	0.6
Alcohol intake frequency.	0.3	0.6	2.3	-0.4	-0.1	0.3	-1.5
Comparative height size at age 10	6.1	33.6	62.7	-7.8	3.0	7.9	1.3
Number of full sisters	1.8	2.2	5.4	2.3	-1.2	-1.4	0.3
Suffer from ‘nerves’	1.3	2.1	4.0	1.9	-0.3	-2.0	0.7
Overall health rating	2.2	4.8	11.5	-1.3	2.1	1.2	-3.4
Chest pain or discomfort	0.1	0.1	0.3	0.1	0.0	-0.5	0.3
Had major operations	1.5	1.7	5.1	-0.7	0.8	0.9	-2.3
Age at last live birth	0.2	0.3	0.4	0.6	-0.5	0.3	-0.6
Family relationship satisfaction	0.1	0.2	0.3	-0.6	0.1	0.0	-0.5
Leg pain on walking	0.7	0.9	3.3	-0.2	0.3	0.5	-1.8
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.3	-1.2	2.1	1.0	0.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.4	-1.1	0.1	1.2	-0.6
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.6	0.3	-1.3	-1.2	0.9
Medication: Aspirin	0.3	0.4	0.8	-0.9	0.6	0.7	0.1
Supplements: Vitamin C	1.0	1.2	3.0	-0.4	0.5	1.2	-1.7
Knee pain experienced in last month	5.0	7.7	9.7	-3.1	3.0	3.0	-1.7
Hypertension (Self-reported)	0.2	0.6	1.3	-0.1	1.1	-0.2	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.8	-0.8	-0.4	0.6	-1.7
Illnesses of father: Heart disease	1.6	2.2	3.0	1.3	-1.3	-1.6	1.7
Illnesses of siblings: Diabetes	0.3	0.3	0.9	0.9	-0.1	-0.6	0.3
Smoking status: Previous	1.2	1.7	4.1	-0.9	2.0	1.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	5.5	11.3	20.8	-4.6	2.0	4.5	0.1
Whole body fat-free mass	3.8	21.8	39.6	-5.7	3.5	6.3	-1.7
Leg fat-free mass (right)	3.2	17.3	31.8	-4.6	3.5	5.6	-1.9
Arm fat percentage (left)	2.2	8.7	11.3	-2.6	2.4	3.3	-3.4
Average weekly red wine intake	1.2	1.7	3.2	1.7	-0.3	-1.8	0.8
Handedness (chirality/laterality): Left-handed	2.0	2.3	3.6	1.3	-1.4	-1.9	1.4
Mood swings	0.2	0.4	0.8	-0.4	0.4	0.6	-0.9
Loneliness, isolation	0.7	0.9	2.0	-0.4	1.4	1.2	0.2
Long-standing illness, disability or infirmity	3.6	5.5	7.6	-2.7	2.5	2.8	-0.9
Ever had bowel cancer screening	1.0	1.2	2.1	-1.4	0.6	1.5	0.3
Diabetes diagnosed by doctor	1.4	2.3	3.8	-1.2	1.4	1.4	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.4	-0.1	-0.3	0.3
Friendships satisfaction	0.6	0.8	2.5	-0.5	1.6	0.6	0.3
Qualifications: nursing, teaching	1.8	2.8	5.9	0.9	-2.4	-1.5	1.5
Commuting to job workplace: Walk	1.1	1.2	3.0	1.7	0.1	-1.0	0.8
Eye problems/disorders: Cataract	0.7	0.8	1.4	0.9	-0.9	-0.3	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	0.6	-0.6	-0.8	-0.2
Medication for cholesterol	0.8	1.2	2.6	1.6	-0.9	-1.0	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.7	1.6	-0.3	-0.9	0.6
Back pain experienced in last month	2.7	4.0	6.2	-2.5	1.5	2.3	-1.5
Mineral and other dietary supplements	0.2	0.3	0.7	0.5	-0.2	-0.8	0.3
Breast cancer (self-reported)	0.3	0.4	0.8	-0.3	0.9	0.5	0.6
Asthma (self-reported)	0.8	1.5	2.8	-1.6	1.7	0.9	-0.0
Osteoporosis (self-reported)	0.5	0.6	1.6	-1.3	0.2	0.9	0.2
Osteoarthritis (self-reported)	1.7	2.3	3.2	-1.5	0.9	1.6	-1.8
Medication: Aspirin	0.4	0.6	1.0	-0.9	1.0	0.6	0.1
Medication: Gliclazide	0.6	0.7	1.4	-1.0	0.1	0.6	-1.2
Illnesses of father: None of the above (group 1)	0.9	1.1	1.8	-1.1	1.1	1.3	-0.1
Smoking status: Current	1.5	2.4	4.7	-2.2	0.8	2.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.2	0.8	-1.5	-0.7	-0.3
Whole body water mass	3.8	21.5	38.9	-5.7	3.5	6.2	-1.7
Leg predicted mass (right)	3.2	17.3	31.9	-4.6	3.5	5.7	-2.0
Arm fat mass (left)	3.3	13.5	20.6	-3.9	2.9	4.5	-3.2
Number of self-reported non-cancer illnesses	2.0	3.5	8.2	-1.4	2.9	1.8	-1.0
Average weekly champagne plus white wine intake	0.8	1.1	2.2	-1.4	-0.2	1.5	-0.3
Miserableness	0.8	1.5	2.4	1.3	-1.3	-1.5	0.2
Guilty feelings	0.3	0.4	1.3	0.5	0.3	0.2	-1.1
Wears glasses or contact lenses	1.6	1.8	4.8	-0.3	1.2	0.9	-2.2
Ever taken oral contraceptive pill	0.0	0.0	0.0	0.1	0.1	-0.1	-0.2
Hearing aid user	0.3	0.3	0.6	0.6	-0.2	-0.7	0.8
Mother’s age at death	0.3	0.4	0.8	-0.2	0.4	0.9	-0.7
Financial situation satisfaction	1.1	1.4	2.6	-1.4	0.9	1.6	0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.1	0.6	-0.2	-0.4
Commuting to job workplace: Public transport	0.3	0.3	0.9	-0.3	0.9	0.5	0.4
Eye problems/disorders: Glaucoma	1.0	1.2	2.9	-1.7	0.7	1.1	-0.0
Medication: Blood pressure	0.9	1.8	2.7	-1.6	1.4	1.1	1.1
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.3	-0.8	1.1	1.3	-1.5
Supplements: Fish oil (including cod liver oil)	0.9	1.2	4.0	-0.3	-0.1	0.9	-2.0
High cholesterol (Self-reported)	0.8	1.5	2.1	-1.4	1.1	1.5	0.9
Medication: Bendroflumethiazide	0.6	0.9	2.3	-0.8	0.4	0.5	1.5
Medication: Paracetamol	0.7	1.1	2.9	-0.5	1.7	0.7	-0.8
Medication: Lisinopril	0.6	0.8	1.5	1.0	-0.5	-1.2	0.6
Medication: Atorvastatin	0.2	0.3	0.8	-0.3	0.1	0.6	0.9
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.1	0.3	-0.6	-0.4
Alcohol drinker status: Never	0.5	0.6	1.0	-0.1	-1.0	-0.7	0.9
Ever smoked	1.6	2.7	4.2	-1.8	1.7	2.0	-0.6
Basal metabolic rate	4.3	23.8	42.8	-5.9	3.7	6.5	-2.1
Leg fat percentage (left)	3.0	10.8	14.1	-3.5	2.4	3.8	-3.4
Arm fat-free mass (left)	4.3	21.9	37.6	-6.0	3.4	6.1	-1.8
Number of operations (self-reported)	2.6	3.8	4.6	-2.1	1.7	2.0	-1.9
Average weekly beer plus cider intake	0.7	1.0	3.3	-0.1	1.8	0.4	-0.6
Irritability	1.1	1.9	2.8	-1.3	1.7	1.6	-0.5
Risk taking	0.1	0.2	0.3	0.1	-0.6	0.2	0.5
Ever had prostate specific antigen (PSA) test	2.8	3.2	7.7	-1.2	1.4	1.3	-2.8
Fractured/broken bones in last 5 years	0.2	0.3	0.7	-0.4	0.4	0.3	0.8
Age started oral contraceptive pill	0.9	1.1	2.1	-1.5	0.4	0.9	1.1
Diastolic blood pressure, automated reading	0.3	1.0	1.4	0.8	-1.2	-1.1	0.8
Ever depressed for a whole week	1.6	2.0	3.2	-1.5	1.2	1.8	-1.1
Unable to work because of sickness or disability	0.8	1.0	1.4	-1.2	0.8	0.9	1.1
Commuting to job workplace: Cycle	0.6	0.7	2.6	-0.5	0.0	-0.2	1.6
Myopia	1.5	2.2	4.0	2.0	-0.8	-2.0	0.6
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.9	-0.1	-1.0	0.4	-0.8
Cholesterol lowering medication	1.4	2.0	2.5	-1.4	1.6	1.2	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.0	-0.3	0.3	0.6	-1.4
Pain experienced in last month	3.6	6.0	9.1	2.6	-2.6	-3.0	1.3
Supplements: Calcium	0.6	0.6	1.3	0.8	-1.1	-0.5	-0.6
Basal cell carcinoma (self-reported)	0.1	0.2	0.4	0.3	0.1	-0.2	-0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.2	0.5	-0.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	-0.9	0.2	0.5	0.3
Heart disease (siblings)	0.2	0.3	0.6	-0.5	0.4	0.8	-0.5
Alcohol drinker status: Previous	0.8	0.9	3.5	0.3	-0.0	-0.1	-1.9
Pack years of smoking	1.0	1.4	4.7	-0.3	-1.0	-0.2	2.2
Impedance of whole body	1.0	5.0	9.7	-3.1	0.1	3.1	0.8
Leg fat mass (left)	4.5	17.4	26.6	-4.6	3.2	5.2	-3.4
Arm predicted mass (left)	4.0	20.5	36.4	-5.7	3.1	6.0	-1.8