[Hub]/) : Traits : Leg fat mass (left) : ← →

chr18:20,082,830-21,863,589

Best TWAS P=2.42e-21 · Best GWAS P=9.72e-20 conditioned to 0.317

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
37	GTEx	Testis	C18orf8	0.12	0.07	lasso	6	0.08	1.9e-04	-8.9	-9.5	2.4e-21	0.92	0.03	0.90	TRUE
5	GTEx	Adipose Subcutaneous	C18orf8	0.17	0.16	enet	13	0.16	2.6e-13	-8.9	-9.3	1.7e-20	0.98	0.02	0.98	FALSE
12	GTEx	Brain Cerebellar Hemisphere	C18orf8	0.27	0.34	enet	19	0.34	1.3e-09	-8.9	-9.2	2.9e-20	0.98	0.02	0.98	FALSE
26	GTEx	Esophagus Muscularis	NPC1	0.11	0.07	enet	4	0.09	7.3e-06	-8.9	-9.2	5.1e-20	0.97	0.02	0.98	FALSE
11	GTEx	Brain Caudate basal ganglia	C18orf8	0.15	0.16	enet	11	0.11	5.9e-04	-9.0	-9.2	5.6e-20	0.96	0.02	0.96	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	NPC1	0.15	0.08	lasso	4	0.12	2.3e-07	-8.9	-9.1	6.6e-20	0.94	0.03	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C18orf8	0.26	0.35	lasso	6	0.40	1.9e-52	-9.0	-9.1	7.1e-20	0.93	0.02	0.98	FALSE
13	GTEx	Brain Cerebellum	C18orf8	0.23	0.18	enet	13	0.21	9.9e-07	-8.9	-9.1	9.0e-20	0.91	0.02	0.98	FALSE
16	GTEx	Brain Cortex	C18orf8	0.19	0.18	lasso	5	0.13	1.8e-04	-9.1	-9.1	1.1e-19	1.00	0.02	0.96	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	C18orf8	0.21	0.27	enet	6	0.23	6.9e-13	-8.9	-9.0	1.7e-19	0.98	0.03	0.97	FALSE
35	GTEx	Skin Sun Exposed Lower leg	C18orf8	0.35	0.33	enet	23	0.36	1.7e-30	-9.0	-9.0	2.1e-19	0.96	0.02	0.98	FALSE
24	GTEx	Esophagus Mucosa	NPC1	0.09	0.04	lasso	3	0.05	1.5e-04	-8.6	-9.0	2.8e-19	0.93	0.04	0.94	FALSE
31	GTEx	Nerve Tibial	NPC1	0.19	0.12	lasso	6	0.16	1.1e-11	7.6	-8.9	4.1e-19	0.90	0.04	0.96	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	NPC1	0.07	0.08	lasso	3	0.10	1.6e-11	7.6	-8.9	4.6e-19	0.88	0.05	0.95	FALSE
36	GTEx	Skin Sun Exposed Lower leg	NPC1	0.23	0.18	lasso	3	0.27	1.8e-22	-8.6	-8.9	5.7e-19	0.90	0.22	0.78	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NPC1	0.03	0.04	lasso	2	0.05	4.2e-06	-8.3	-8.9	6.1e-19	0.93	0.03	0.97	FALSE
27	GTEx	Heart Left Ventricle	NPC1	0.19	0.15	enet	12	0.17	1.6e-09	-8.9	-8.9	7.8e-19	0.93	0.04	0.96	FALSE
32	GTEx	Pancreas	NPC1	0.33	0.14	lasso	7	0.12	1.1e-05	-8.9	-8.7	2.7e-18	0.95	0.02	0.97	FALSE
8	GTEx	Adipose Visceral Omentum	NPC1	0.20	0.19	lasso	3	0.17	2.9e-09	-8.6	-8.7	3.8e-18	0.92	0.23	0.77	FALSE
6	GTEx	Adipose Subcutaneous	NPC1	0.27	0.27	enet	12	0.30	2.4e-25	-8.6	-8.7	4.0e-18	0.94	0.37	0.63	FALSE
30	GTEx	Nerve Tibial	C18orf8	0.16	0.07	enet	21	0.09	3.9e-07	-8.2	-8.6	7.6e-18	0.90	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	NPC1	0.03	0.03	blup	69	0.04	2.9e-09	-8.9	-8.6	7.6e-18	0.86	0.03	0.97	FALSE
21	GTEx	Breast Mammary Tissue (Female)	NPC1	0.43	0.24	lasso	3	0.27	1.1e-08	-8.2	-8.6	8.7e-18	0.94	0.02	0.98	FALSE
19	GTEx	Breast Mammary Tissue	NPC1	0.27	0.13	enet	27	0.19	5.0e-10	-8.6	-8.5	1.5e-17	0.88	0.03	0.97	FALSE
17	GTEx	Brain Frontal Cortex BA9	C18orf8	0.42	0.30	enet	12	0.08	3.4e-03	-8.9	-8.5	1.6e-17	0.96	0.02	0.98	FALSE
28	GTEx	Lung	NPC1	0.11	0.06	enet	11	0.04	2.3e-04	-9.0	-8.5	1.9e-17	0.95	0.02	0.98	FALSE
43	The Cancer Genome Atlas	Esophageal Carcinoma	NPC1	0.16	0.10	lasso	3	0.10	3.7e-04	7.6	-8.5	2.8e-17	0.81	0.05	0.64	FALSE
38	GTEx	Thyroid	NPC1	0.20	0.10	enet	25	0.13	2.3e-10	-8.9	-8.4	4.3e-17	0.90	0.02	0.98	FALSE
25	GTEx	Esophagus Muscularis	C18orf8	0.14	0.13	lasso	3	0.10	8.0e-07	7.6	-8.3	7.1e-17	0.79	0.08	0.92	FALSE
14	GTEx	Brain Cerebellum	NPC1	0.20	0.10	enet	9	0.12	1.9e-04	-8.9	-8.3	1.3e-16	0.93	0.02	0.94	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	NPC1	0.04	0.03	blup	70	0.05	9.4e-06	-8.9	-8.1	5.7e-16	0.90	0.03	0.97	FALSE
41	METSIM	Adipose	NPC1	0.06	0.05	enet	18	0.05	6.4e-08	-9.1	-8.1	6.1e-16	0.89	0.02	0.98	FALSE
7	GTEx	Adipose Visceral Omentum	C18orf8	0.18	0.11	enet	10	0.04	4.5e-03	-8.9	-8.0	1.3e-15	0.89	0.02	0.98	FALSE
10	GTEx	Artery Tibial	NPC1	0.26	0.07	enet	31	0.11	3.7e-09	7.6	-7.9	3.7e-15	0.82	0.07	0.93	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	NPC1	0.05	0.02	blup	65	0.03	9.9e-04	-8.3	-7.8	4.6e-15	0.73	0.04	0.60	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RIOK3	0.02	0.01	bslmm	348	0.00	1.8e-01	-6.5	-7.7	1.1e-14	0.69	0.12	0.22	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	C18orf8	0.07	0.05	lasso	5	0.03	9.5e-05	7.6	-7.6	2.3e-14	0.72	0.27	0.71	FALSE
9	GTEx	Artery Tibial	C18orf8	0.18	0.12	lasso	3	0.10	1.5e-08	7.6	-7.5	8.8e-14	0.70	0.97	0.03	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NPC1	0.08	0.07	lasso	3	0.08	5.2e-10	7.6	-7.1	1.3e-12	0.71	0.80	0.20	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NPC1	0.05	0.02	blup	66	0.03	1.4e-04	-8.3	-7.1	1.8e-12	0.74	0.22	0.48	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	TMEM241	0.17	0.02	lasso	6	-0.01	5.6e-01	-8.9	-6.8	1.1e-11	0.76	0.03	0.69	FALSE
29	GTEx	Nerve Tibial	TMEM241	0.16	0.04	enet	10	0.07	1.8e-05	-6.5	-6.6	5.0e-11	0.50	0.60	0.16	FALSE
39	GTEx	Vagina	NPC1	0.27	0.09	lasso	7	0.14	4.9e-04	-5.8	-6.4	1.4e-10	0.57	0.11	0.57	FALSE
15	GTEx	Brain Cortex	TMEM241	0.37	0.12	enet	19	0.22	1.3e-06	2.4	-6.2	6.0e-10	0.74	0.05	0.93	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	C18orf45	0.04	0.02	lasso	3	0.03	2.7e-04	5.6	-6.0	2.3e-09	0.60	0.02	0.97	FALSE
49	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NPC1	0.14	0.01	enet	14	0.08	3.3e-04	-8.3	-5.9	2.8e-09	0.70	0.03	0.77	FALSE
40	METSIM	Adipose	C18orf8	0.08	0.02	enet	23	0.04	1.0e-06	7.5	-5.9	4.6e-09	0.56	0.22	0.73	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	NPC1	0.19	0.13	lasso	5	0.11	1.1e-04	-4.5	-5.7	1.3e-08	0.72	0.06	0.87	FALSE
4	GTEx	Adipose Subcutaneous	TMEM241	0.07	0.00	enet	12	0.01	4.1e-02	-6.5	-5.6	2.4e-08	0.58	0.14	0.61	FALSE
52	The Cancer Genome Atlas	Stomach Adenocarcinoma	NPC1	0.06	0.01	enet	6	0.05	2.2e-04	-5.8	-5.5	3.3e-08	0.63	0.07	0.38	FALSE
20	GTEx	Breast Mammary Tissue (Male)	NPC1	0.15	0.12	lasso	7	0.16	2.0e-04	-1.9	-5.3	1.1e-07	0.53	0.05	0.53	FALSE
51	The Cancer Genome Atlas	Soft Tissue Sarcoma	C18orf45	0.08	0.06	blup	114	0.06	1.7e-04	-6.0	-5.3	1.1e-07	0.49	0.02	0.96	FALSE
22	GTEx	Cells Transformed fibroblasts	NPC1	0.26	0.24	lasso	8	0.24	5.7e-18	-4.5	-5.3	1.4e-07	0.69	1.00	0.00	FALSE