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chr19:17,512,412-19,190,906

Best TWAS P=1.44e-16 · Best GWAS P=4.97e-18 conditioned to 0.106

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAST3	0.02	0.02	lasso	3	0.01	1.5e-02	8.1	-8.3	1.4e-16	-0.92	0.01	0.92	TRUE
3	GTEx	Thyroid	KIAA1683	0.11	0.07	enet	14	0.12	2.1e-09	3.3	6.5	9.5e-11	0.25	0.54	0.45	TRUE
2	GTEx	Testis	AC068499.10	0.38	0.41	lasso	3	0.40	6.8e-19	-6.0	-6.1	1.0e-09	-0.41	1.00	0.00	TRUE
18	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CRTC1	0.33	0.08	lasso	5	0.12	3.6e-05	-3.2	-5.5	3.4e-08	-0.01	0.04	0.52	TRUE
21	The Cancer Genome Atlas	Thyroid Carcinoma	MAST3	0.04	0.02	lasso	2	0.00	3.4e-01	8.1	-8.2	2.3e-16	-0.92	0.02	0.84	FALSE
7	YFS	Blood	MAST3	0.06	0.04	lasso	5	0.04	4.2e-12	8.4	-8.0	1.4e-15	-0.61	0.03	0.97	FALSE
19	The Cancer Genome Atlas	Testicular Germ Cell Tumors	IL12RB1	0.10	0.01	enet	10	0.06	2.6e-03	2.0	-7.0	2.2e-12	-0.58	0.02	0.54	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAST3	0.04	0.02	blup	65	0.01	7.3e-02	8.4	-6.5	6.2e-11	-0.54	0.01	0.30	FALSE
9	The Cancer Genome Atlas	Glioblastoma Multiforme	JUND	0.17	0.00	blup	57	0.03	5.4e-02	5.5	6.5	8.8e-11	0.23	0.01	0.59	FALSE
5	NTR	Blood	IFI30	0.03	0.02	lasso	6	0.02	8.8e-08	7.8	6.3	2.9e-10	0.33	0.30	0.69	FALSE
17	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IL12RB1	0.07	0.04	blup	58	0.06	4.9e-07	5.1	-6.1	1.3e-09	-0.53	0.88	0.10	FALSE
1	GTEx	Testis	PDE4C	0.39	0.44	lasso	2	0.43	5.8e-21	-6.0	-6.0	2.0e-09	-0.40	1.00	0.00	FALSE
13	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	JUND	0.11	0.03	blup	58	0.04	1.4e-03	-3.7	6.0	2.0e-09	0.19	0.04	0.08	FALSE
11	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	JUND	0.05	0.04	lasso	1	0.04	4.3e-05	5.5	5.5	4.4e-08	0.18	0.14	0.13	FALSE
4	GTEx	Vagina	LRRC25	0.63	0.02	enet	2	0.04	5.3e-02	5.5	-5.5	4.7e-08	-0.18	0.05	0.10	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	JUND	0.04	0.03	lasso	2	0.02	7.9e-04	5.5	5.4	7.4e-08	0.18	0.19	0.04	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	IL12RB1	0.08	0.04	lasso	3	0.05	8.9e-06	3.9	-5.3	1.3e-07	-0.45	0.42	0.33	FALSE
10	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL12RB1	0.05	0.03	enet	11	0.05	2.3e-06	-2.9	-5.3	1.4e-07	-0.41	0.48	0.40	FALSE
8	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IL12RB1	0.07	0.02	lasso	3	0.01	6.4e-02	4.9	-5.2	1.9e-07	-0.40	0.14	0.04	FALSE
6	ROSMAP	Brain Pre-frontal Cortex	PDE4C	0.18	0.12	enet	17	0.19	3.3e-24	-2.1	-5.2	2.1e-07	-0.23	0.91	0.09	FALSE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB3A	0.04	0.04	enet	6	0.04	3.8e-05	-4.8	5.1	2.9e-07	0.41	0.35	0.06	FALSE