Best TWAS P=1.44e-16 · Best GWAS P=4.97e-18 conditioned to 0.106
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Testis | PDE4C | 0.39 | 0.44 | lasso | 2 | 0.43 | 5.8e-21 | -6.0 | -6.0 | 2.0e-09 | -0.40 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Testis | AC068499.10 | 0.38 | 0.41 | lasso | 3 | 0.40 | 6.8e-19 | -6.0 | -6.1 | 1.0e-09 | -0.41 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Thyroid | KIAA1683 | 0.11 | 0.07 | enet | 14 | 0.12 | 2.1e-09 | 3.3 | 6.5 | 9.5e-11 | 0.25 | 0.54 | 0.45 | TRUE |
| 4 | GTEx | Vagina | LRRC25 | 0.63 | 0.02 | enet | 2 | 0.04 | 5.3e-02 | 5.5 | -5.5 | 4.7e-08 | -0.18 | 0.05 | 0.10 | FALSE |
| 5 | NTR | Blood | IFI30 | 0.03 | 0.02 | lasso | 6 | 0.02 | 8.8e-08 | 7.8 | 6.3 | 2.9e-10 | 0.33 | 0.30 | 0.69 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PDE4C | 0.18 | 0.12 | enet | 17 | 0.19 | 3.3e-24 | -2.1 | -5.2 | 2.1e-07 | -0.23 | 0.91 | 0.09 | FALSE |
| 7 | YFS | Blood | MAST3 | 0.06 | 0.04 | lasso | 5 | 0.04 | 4.2e-12 | 8.4 | -8.0 | 1.4e-15 | -0.61 | 0.03 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IL12RB1 | 0.07 | 0.02 | lasso | 3 | 0.01 | 6.4e-02 | 4.9 | -5.2 | 1.9e-07 | -0.40 | 0.14 | 0.04 | FALSE |
| 9 | The Cancer Genome Atlas | Glioblastoma Multiforme | JUND | 0.17 | 0.00 | blup | 57 | 0.03 | 5.4e-02 | 5.5 | 6.5 | 8.8e-11 | 0.23 | 0.01 | 0.59 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IL12RB1 | 0.05 | 0.03 | enet | 11 | 0.05 | 2.3e-06 | -2.9 | -5.3 | 1.4e-07 | -0.41 | 0.48 | 0.40 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | JUND | 0.05 | 0.04 | lasso | 1 | 0.04 | 4.3e-05 | 5.5 | 5.5 | 4.4e-08 | 0.18 | 0.14 | 0.13 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAST3 | 0.04 | 0.02 | blup | 65 | 0.01 | 7.3e-02 | 8.4 | -6.5 | 6.2e-11 | -0.54 | 0.01 | 0.30 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | JUND | 0.11 | 0.03 | blup | 58 | 0.04 | 1.4e-03 | -3.7 | 6.0 | 2.0e-09 | 0.19 | 0.04 | 0.08 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | JUND | 0.04 | 0.03 | lasso | 2 | 0.02 | 7.9e-04 | 5.5 | 5.4 | 7.4e-08 | 0.18 | 0.19 | 0.04 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAST3 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.5e-02 | 8.1 | -8.3 | 1.4e-16 | -0.92 | 0.01 | 0.92 | TRUE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAB3A | 0.04 | 0.04 | enet | 6 | 0.04 | 3.8e-05 | -4.8 | 5.1 | 2.9e-07 | 0.41 | 0.35 | 0.06 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IL12RB1 | 0.07 | 0.04 | blup | 58 | 0.06 | 4.9e-07 | 5.1 | -6.1 | 1.3e-09 | -0.53 | 0.88 | 0.10 | FALSE |
| 18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CRTC1 | 0.33 | 0.08 | lasso | 5 | 0.12 | 3.6e-05 | -3.2 | -5.5 | 3.4e-08 | -0.01 | 0.04 | 0.52 | TRUE |
| 19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IL12RB1 | 0.10 | 0.01 | enet | 10 | 0.06 | 2.6e-03 | 2.0 | -7.0 | 2.2e-12 | -0.58 | 0.02 | 0.54 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | IL12RB1 | 0.08 | 0.04 | lasso | 3 | 0.05 | 8.9e-06 | 3.9 | -5.3 | 1.3e-07 | -0.45 | 0.42 | 0.33 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | MAST3 | 0.04 | 0.02 | lasso | 2 | 0.00 | 3.4e-01 | 8.1 | -8.2 | 2.3e-16 | -0.92 | 0.02 | 0.84 | FALSE |