Hub : Genes

RAB3A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1758	0.0619	0.00061	0.081	NA	0.031	NA	0.071	6.7e-07	NA	1.8e-03	NA	3.1e-06
2	TCGA	Lung Adenocarcinoma	0.0378	0.0214	0.00160	0.039	0.026	0.036	NA	0.034	2.2e-05	0.00046	3.8e-05	NA	6.8e-05
3	TCGA	Lung Squamous Cell Carcinoma	0.0447	0.0303	0.00500	0.028	0.023	0.020	NA	0.023	3.7e-04	0.00110	2.0e-03	NA	1.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	0.7	-0.7	0.9	-0.7
Bipolar Disorder or Schizophrenia	0.7	1.7	2.0	-1.4	1.4	-1.1
Depressed Affect (Nagel 2018)	1.5	3.2	4.4	-1.7	1.5	-2.1
Depression (Nagel 2018)	0.1	0.2	0.3	0.0	-0.6	0.4
Intelligence (Savage-Jansen 2018)	1.4	4.2	4.4	1.9	-2.1	2.1
Neuroticism (Nagel 2018)	0.4	1.0	1.5	-0.9	0.7	-1.2
Schizophrenia (2018)	0.6	1.2	1.6	-1.2	1.1	-0.9
Schizophrenia vs Biploar Disorder	2.8	3.7	4.3	1.6	-2.0	2.1
Worry (Nagel 2018)	0.8	1.8	2.4	-1.5	1.1	-1.3
Alzheimer’s Disease (in mother)	1.0	1.2	1.6	1.3	-0.9	1.1
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.3	-0.4	0.2
Alzheimer’s Disease (including proxy)	0.9	1.3	1.7	1.3	-1.0	1.1
Crohns Disease (2017)	0.0	0.1	0.3	-0.1	-0.5	-0.1
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	-0.4	0.1	-0.0
Ulcerative Colitis (UC)	0.5	1.0	1.4	-1.2	1.2	-0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	3.4	6.5	7.2	2.4	-2.7	2.5
Verbal and Numeric Reasoning (VNR)	0.5	1.2	1.5	1.2	-0.9	1.2
Breast Cancer	0.8	2.0	2.8	1.0	-1.4	1.7
Ovarian Cancer	1.1	1.5	1.8	-1.2	1.4	-1.1
Prostate Cancer	4.2	5.8	7.5	-2.2	2.3	-2.7
Age at First Birth	1.8	2.7	3.8	1.7	-1.9	1.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	5.9	8.1	9.9	-2.7	3.1	-2.7
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.1	0.3	-0.4	-0.1	-0.5
Mean Putamen Volume	0.4	0.5	0.5	-0.7	0.7	-0.7
Fasting Glucose	2.7	3.2	3.3	1.8	-1.8	1.8
HbA1C	1.9	2.1	2.8	1.2	-1.4	1.7
HDL Cholesterol	0.3	0.5	0.7	-0.8	0.6	-0.7
LDL Cholesterol	0.7	1.1	1.7	-1.0	1.3	-0.7
Lupus	0.1	0.2	0.4	-0.6	0.3	-0.4
Neuroticism (2016)	0.4	0.6	0.8	-0.7	0.7	-0.9
Primary Biliary Cirrhosis	0.3	0.4	0.9	-0.5	0.4	-1.0
Rheumatoid Arthritis	0.4	0.6	0.8	-0.7	0.6	-0.9
Schizophrenia (2014)	0.7	1.6	2.2	-1.5	1.3	-0.9
Triglycerides	0.9	1.4	1.9	1.2	-0.9	1.4
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.1	0.2	0.4	-0.4	0.6	-0.1
Blood Eosinophil Count	2.0	15.8	19.5	3.2	-4.2	4.4
Blood Platelet Count	0.8	9.4	11.2	2.6	-3.3	3.2
Blood Red Count	0.0	0.3	0.5	0.3	-0.7	0.4
Blood White Count	0.4	2.8	4.0	1.8	-2.0	1.1
Heel T-Score	0.6	4.4	4.8	-2.0	2.2	-2.1
BMI	4.7	27.5	32.4	-5.1	5.7	-4.9
Height	0.0	0.1	0.2	0.5	-0.1	0.2
Waist Hip Ratio (WHR)	0.1	0.4	0.6	-0.2	0.8	0.7
Systolic Blood Pressure	0.3	1.5	2.2	1.5	-1.5	0.1
Smoking Status	0.0	0.0	0.0	0.1	-0.0	0.0
Allergy or Eczema	0.1	0.1	0.2	-0.4	0.4	0.3
Cardiovascular Disease	0.3	1.1	2.6	-0.4	0.8	-1.6
Hypothyroidism (self reported)	0.3	0.7	1.0	0.4	-1.0	1.0
Respiratory disease	0.4	0.9	1.5	-0.9	1.2	-0.7
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.1	-0.9	1.0	-1.0
Lung FEV1/FVC ratio	1.1	5.8	6.8	-2.4	2.6	-2.2
Lung FVC	0.1	0.6	1.3	-1.1	0.5	-0.6
Neuroticism	0.4	0.9	1.7	-0.8	0.7	-1.3
Chronotype (morning person)	0.2	0.4	0.9	-1.0	0.6	-0.1
Hair Pigment	0.0	0.5	1.0	-1.0	0.6	-0.4
Tanning	0.1	0.9	1.3	1.2	-0.8	0.9
Hand grip strength (left)	0.1	0.3	0.5	0.4	-0.7	0.4
Number of treatments/medications taken	0.2	0.4	0.6	-0.6	0.7	-0.5
Average weekly spirits intake	1.4	1.7	2.3	-1.5	1.3	-1.1
Sensitivity / hurt feelings	0.0	0.0	0.0	0.0	-0.1	0.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	0.4	-1.0	0.5
Hearing difficulty/problems: Yes	0.0	0.1	0.2	-0.4	0.2	0.0
Relative age of first facial hair	0.3	0.6	0.8	0.5	-0.9	0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	0.4	-0.5	0.9
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	-0.3	0.1	-0.2
Ever had hysterectomy (womb removed)	2.2	2.5	3.3	-1.6	1.8	-1.3
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.4	-0.2	-0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.3	-0.5	0.6	-0.5
Angina	0.7	0.9	1.4	1.0	-0.6	1.2
Medication for hormone replacement therapy	0.7	0.8	1.1	-0.9	0.7	-1.0
Vitamin and mineral supplements	1.7	2.3	2.5	-1.5	1.5	-1.6
Supplements: Zinc	3.0	3.2	3.6	1.8	-1.9	1.7
Medication: Co-codamol	0.4	0.4	0.6	0.8	-0.7	0.4
Medication: Metformin	1.8	2.5	2.9	-1.5	1.7	-1.5
Diabetes (father)	1.1	1.4	1.9	1.2	-0.9	1.4
Diabetes (mother)	0.9	1.2	1.6	1.3	-1.2	0.8
Severe depression (siblings)	0.1	0.1	0.2	0.3	-0.2	-0.4
Pack years adult smoking proportion	0.1	0.2	0.5	0.7	-0.2	-0.2
Impedance of leg (right)	1.3	6.1	8.3	2.2	-2.3	2.9
Leg fat-free mass (left)	1.9	10.0	10.9	-2.9	3.3	-3.3
Trunk fat percentage	3.7	14.8	18.5	-3.8	4.3	-3.3
Hand grip strength (right)	0.0	0.0	0.1	-0.3	-0.2	0.1
Townsend deprivation index at recruitment	2.5	3.5	3.8	1.8	-1.8	1.9
Current tobacco smoking	0.4	0.7	0.9	1.0	-0.8	0.7
Average weekly fortified wine intake	1.5	1.8	2.0	1.3	-1.4	1.3
Maternal smoking around birth	0.1	0.2	0.4	-0.4	0.1	-0.6
Fed-up feelings	1.7	3.0	4.2	-1.7	1.4	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	2.7	1.2	-1.6	1.6
Relative age voice broke	0.0	0.1	0.1	-0.2	-0.3	0.2
Taking other prescription medications	2.4	3.7	4.4	-1.9	2.1	-1.8
Age when periods started (menarche)	1.7	4.1	5.5	1.7	-2.0	2.3
Bilateral oophorectomy (both ovaries removed)	2.2	2.6	3.5	-1.6	1.9	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.0	-0.1	0.2	-0.1
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.0	1.2	-1.4	1.2
Qualifications: CSEs or equivalent	0.2	0.3	0.4	0.5	-0.5	0.7
Serious illness, injury or assault to yourself	0.1	0.1	0.1	-0.3	-0.1	-0.3
High blood pressure	0.0	0.1	0.2	0.3	-0.1	-0.5
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.4	0.1	-0.0	0.6
Multivitamins +/- minerals	0.0	0.0	0.1	0.1	-0.2	0.3
Stomach or abdominal pain in last month	0.3	0.4	0.6	0.4	-0.7	0.7
Supplements: Glucosamine	0.0	0.0	0.0	-0.2	-0.0	-0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.1	0.0	-0.2
Medication: Atenolol	0.1	0.1	0.1	0.3	-0.0	0.3
Medication: Levothyroxine sodium	0.4	0.6	0.9	0.7	-0.8	0.9
Sitting height	0.5	3.5	3.7	-1.9	1.9	-1.8
Chronic bronchitis/emphysema (father)	0.1	0.2	0.3	-0.4	0.5	-0.0
High blood pressure (mother)	0.1	0.1	0.3	0.3	-0.0	-0.5
Body mass index (BMI)	5.0	21.2	23.9	-4.5	4.9	-4.4
Impedance of leg (left)	1.4	6.6	8.1	2.3	-2.6	2.9
Leg predicted mass (left)	1.9	10.1	11.1	-2.9	3.3	-3.3
Trunk fat mass	4.5	19.5	23.1	-4.4	4.8	-4.0
Waist circumference	4.3	15.7	19.5	-3.9	4.4	-3.6
Number of incorrect matches in round	2.7	4.6	5.4	2.0	-2.3	2.1
Past tobacco smoking	1.3	2.4	2.7	-1.6	1.4	-1.6
Alcohol usually taken with meals	2.1	3.3	3.8	1.7	-2.0	1.8
Nervous feelings	0.4	0.7	1.0	-0.9	0.7	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.6	1.0	-1.2	0.6
Hearing difficulty/problems with background noise	3.1	4.9	5.7	2.1	-2.4	2.1
Hair/balding pattern: Pattern 2	0.3	0.3	0.4	0.4	-0.7	0.6
Had menopause	0.5	0.6	1.0	-1.0	0.6	-0.7
Had other major operations	0.1	0.1	0.1	0.3	0.3	0.3
Forced vital capacity (FVC)	0.2	0.9	1.4	0.8	-1.2	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.5	0.5	-0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.3	-0.5	0.5	-0.4
Qualifications: None of the above	0.0	0.1	0.1	-0.3	0.3	-0.1
Financial difficulties in last 2 years	0.6	0.8	0.9	0.8	-0.9	1.0
Mouth/teeth dental problems	5.5	8.4	8.8	2.8	-2.9	3.0
Heart attack	0.0	0.0	0.0	0.1	-0.2	0.0
Allergy	0.0	0.1	0.1	0.1	-0.3	-0.3
Pain all over the body in last month	1.1	1.1	2.4	0.6	-0.9	1.5
Diabetes (self-reported)	0.2	0.3	0.3	-0.5	0.6	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	0.3	-0.2	0.7
Medication: Ramipril	0.0	0.1	0.1	-0.3	0.1	-0.2
Medication: Simvastatin	1.0	1.4	1.6	1.1	-1.3	1.2
Fluid intelligence score	0.5	1.1	1.3	1.1	-0.9	1.1
Illnesses of siblings	0.4	0.6	0.8	0.9	-0.8	0.6
Neuroticism score	0.1	0.2	0.4	-0.4	-0.0	-0.7
Weight	3.7	18.3	20.5	-4.1	4.5	-4.2
Impedance of arm (right)	2.5	11.9	13.0	3.4	-3.3	3.6
Arm fat percentage (right)	4.6	18.1	22.2	-4.2	4.7	-3.8
Trunk fat-free mass	1.5	8.9	10.6	-2.7	2.9	-3.3
Hip circumference	4.3	18.4	19.4	-4.1	4.4	-4.3
Time employed in main current job	1.0	1.1	1.6	1.1	-1.3	0.7
Alcohol intake versus 10 years previously	0.5	0.8	1.0	0.8	-1.0	0.9
Father’s age at death	0.8	1.1	1.5	-1.0	1.2	-1.0
Worrier / anxious feelings	0.6	1.2	1.9	-1.4	0.7	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.8	-0.9	0.5	-0.9
Falls in the last year	0.7	0.9	1.5	0.7	-1.2	0.9
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	0.0	0.1	0.2
Number of live births	0.5	0.6	1.0	-0.8	1.0	-0.5
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.0	-0.1	-0.2	0.1
Pulse rate	0.1	0.1	0.2	-0.3	0.2	-0.4
Happiness	0.9	1.1	1.7	1.2	-1.3	0.4
Noisy workplace	0.0	0.0	0.0	-0.2	0.0	-0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	-0.0	-0.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.1	-1.0	1.0	-0.8
Mouth/teeth dental problems: Dentures	6.3	10.7	11.5	-3.1	3.4	-3.3
Asthma	0.6	1.1	1.5	-1.1	1.2	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	-0.9	0.5	-0.3
Medication: Cholesterol lowering	0.0	0.0	0.0	-0.0	-0.0	0.2
Depression (self-reported)	0.3	0.4	0.4	-0.6	0.6	-0.6
Medication: Lansoprazole	0.0	0.0	0.1	-0.0	0.3	0.2
Prospective memory result	1.0	1.2	1.5	1.2	-1.2	0.8
Lung cancer (father)	2.4	2.8	3.1	-1.5	1.7	-1.8
Illnesses of mother	0.1	0.1	0.1	-0.3	0.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	-0.7	0.3	-0.5
Pulse wave Arterial Stiffness index	0.8	0.9	1.1	-0.8	1.0	-1.0
Impedance of arm (left)	1.9	8.9	10.7	2.9	-2.8	3.3
Arm fat mass (right)	4.7	19.2	22.2	-4.3	4.7	-4.1
Trunk predicted mass	1.5	8.8	10.4	-2.7	2.9	-3.2
Standing height	0.0	0.0	0.1	0.2	-0.1	-0.1
Length of working week for main job	3.7	4.1	4.5	-2.0	2.1	-2.0
Exposure to tobacco smoke at home	1.1	1.2	1.9	1.2	-1.4	0.6
Breastfed as a baby	0.5	0.6	0.7	-0.9	0.7	-0.8
Tense / ‘highly strung’	0.0	0.1	0.1	-0.2	0.0	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.0	-0.9	1.0	-1.0
Hair/balding pattern: Pattern 4	0.6	1.5	2.3	-1.0	1.1	-1.5
Birth weight of first child	0.4	0.7	1.1	-0.9	1.1	-0.5
Peak expiratory flow (PEF)	0.0	0.0	0.1	-0.3	0.1	-0.1
Pulse wave reflection index	3.3	4.0	4.6	-2.2	2.0	-1.9
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.1	-0.3	-0.5
Loud music exposure frequency	2.4	2.6	4.1	-1.3	1.5	-2.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	1.4	-1.0	1.2	-1.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	-0.2	0.4	-0.6
Blood clot in the leg (DVT)	0.0	0.1	0.1	-0.3	0.3	-0.0
Medication: Paracetamol	0.7	1.1	1.6	-0.9	0.9	-1.3
Headache pain in last month	0.7	1.1	2.0	-0.9	0.8	-1.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	-0.4	0.3	-0.5
Glaucoma (self-reported)	0.0	0.0	0.1	-0.0	-0.0	0.3
Gout (self-reported)	7.4	10.2	11.4	-2.9	3.3	-3.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	0.1	-0.5	0.9
Medication: Amlodipine	0.1	0.1	0.2	-0.1	0.4	-0.4
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.0	0.0	0.1	0.0
Birth weight	0.5	1.2	1.6	-1.1	1.3	-0.9
Chronic bronchitis/emphysema (mother)	3.1	3.6	5.0	-2.2	1.7	-1.7
High blood pressure (siblings)	0.4	0.6	0.7	-0.8	0.6	-0.8
Forced vital capacity (FVC), Best measure	0.0	0.2	0.4	0.2	-0.6	0.2
Body fat percentage	4.3	17.1	21.1	-4.1	4.6	-3.6
Leg fat percentage (right)	4.8	17.4	21.2	-4.3	4.6	-3.6
Arm fat-free mass (right)	2.8	14.3	15.2	-3.7	3.8	-3.9
Exposure to tobacco smoke outside home	0.1	0.1	0.1	0.2	-0.3	-0.2
Comparative body size at age 10	1.2	3.4	5.3	-1.6	1.5	-2.3
Number of full brothers	0.1	0.1	0.2	0.1	-0.1	0.4
Worry too long after embarrassment	0.1	0.2	0.5	0.1	-0.7	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.1	0.2	-0.5
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.2	0.5	-0.0
Number of children fathered	1.0	1.1	1.4	-1.0	1.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	-0.0	-0.1	-0.3
Age at first live birth	3.0	5.4	6.1	2.5	-2.4	2.0
Pulse wave peak to peak time	0.8	0.9	1.1	0.8	-1.0	1.1
Health satisfaction	2.7	3.5	5.0	-1.6	1.7	-2.2
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.2	0.5	-0.2
Qualifications: College or University degree	1.2	3.8	5.4	1.9	-2.3	1.5
Eye problems/disorders: None of the above	0.2	0.2	0.2	0.4	-0.5	0.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	0.9	0.8	-0.9	0.8
Emphysema/chronic bronchitis	0.5	0.6	0.8	0.8	-0.6	0.9
Medication for pain relief, constipation, heartburn	0.4	0.7	0.8	0.9	-0.9	0.7
Neck or shoulder pain in last month	0.2	0.3	0.6	0.5	-0.7	0.5
Medication: Blood pressure	0.0	0.0	0.0	0.1	0.0	0.2
Angina (self-reported)	0.4	0.5	0.8	0.8	-0.4	0.9
Migraine (self-reported)	1.0	1.3	2.6	-0.9	1.6	-0.7
Medication: Ibuprofen	0.2	0.2	0.5	-0.7	0.5	-0.1
Medication: Allopurinol	2.3	3.0	3.3	-1.5	1.8	-1.8
Medication: Omeprazole	0.1	0.1	0.1	-0.2	0.2	0.3
Medication: Seretide 50 evohaler	0.4	0.4	0.8	0.5	-0.3	0.9
Mean time to correctly identify matches	0.9	1.7	2.1	1.1	-1.4	1.3
Heart disease (mother)	0.0	0.0	0.1	0.1	-0.1	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.0	0.0	0.3
Whole body fat mass	4.8	20.1	23.7	-4.4	4.9	-4.1
Leg fat mass (right)	5.6	21.9	25.6	-4.7	5.1	-4.3
Arm predicted mass (right)	2.0	10.0	10.7	-3.0	3.2	-3.3
Pulse rate, automated reading	0.1	0.2	0.3	0.2	-0.5	0.5
Alcohol intake frequency.	0.5	1.1	1.2	1.1	-1.1	1.0
Comparative height size at age 10	0.2	1.2	1.5	-0.8	1.2	-1.2
Number of full sisters	4.3	5.2	5.9	2.2	-2.2	2.4
Suffer from ‘nerves’	0.5	0.8	1.1	0.7	-0.9	1.1
Overall health rating	0.2	0.3	0.5	0.6	-0.7	0.3
Chest pain or discomfort	0.2	0.3	0.6	0.3	-0.6	0.8
Had major operations	2.5	2.9	3.6	-1.6	1.9	-1.6
Age at last live birth	3.0	4.4	5.3	2.3	-2.2	1.8
Family relationship satisfaction	0.5	0.6	1.1	1.0	-0.8	0.1
Leg pain on walking	1.9	2.4	4.2	-1.4	1.1	-2.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	-0.5	0.8	0.2
Commuting to job workplace: Car/motor vehicle	2.5	2.9	4.4	-1.6	1.3	-2.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.5	0.7	-0.6	0.4
Medication: Aspirin	0.1	0.2	0.3	0.5	-0.3	0.4
Supplements: Vitamin C	3.4	4.1	4.5	2.0	-2.1	1.9
Knee pain experienced in last month	0.2	0.2	0.4	-0.5	0.2	-0.6
Hypertension (Self-reported)	0.0	0.1	0.3	0.5	-0.3	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.0	-0.1	0.1	0.0
Illnesses of father: Heart disease	0.7	0.9	1.5	1.1	-1.2	0.4
Illnesses of siblings: Diabetes	2.7	3.3	3.9	-1.6	1.8	-2.0
Smoking status: Previous	0.1	0.1	0.3	0.3	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.0	0.9	-0.7	1.0
Whole body fat-free mass	1.7	9.7	11.2	-2.9	3.1	-3.3
Leg fat-free mass (right)	1.5	7.8	9.2	-2.5	2.8	-3.0
Arm fat percentage (left)	5.3	21.2	25.6	-4.6	5.1	-4.1
Average weekly red wine intake	0.8	1.2	1.6	1.0	-1.3	1.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.7	0.8	-0.8	0.7
Mood swings	0.8	1.5	2.7	-1.0	0.9	-1.6
Loneliness, isolation	0.0	0.0	0.1	-0.2	0.1	-0.3
Long-standing illness, disability or infirmity	0.7	1.0	1.1	1.1	-0.9	1.0
Ever had bowel cancer screening	0.7	0.9	1.0	-1.0	1.0	-0.8
Diabetes diagnosed by doctor	0.1	0.2	0.3	-0.3	0.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	0.1	-0.3	0.0
Friendships satisfaction	0.2	0.3	0.5	0.6	-0.7	0.1
Qualifications: nursing, teaching	0.0	0.0	0.0	0.1	-0.2	0.2
Commuting to job workplace: Walk	0.1	0.1	0.1	-0.4	0.3	0.1
Eye problems/disorders: Cataract	0.2	0.2	0.4	-0.6	0.6	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.9	-0.8	0.5	-1.0
Medication for cholesterol	1.4	2.2	3.4	1.2	-1.3	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.2	-0.5	0.3	-0.4
Back pain experienced in last month	0.3	0.4	0.8	-0.5	0.5	-0.9
Mineral and other dietary supplements	0.0	0.0	0.1	0.2	-0.0	0.3
Breast cancer (self-reported)	0.4	0.5	0.8	-0.7	0.9	-0.5
Asthma (self-reported)	0.3	0.5	0.8	-0.7	0.9	-0.6
Osteoporosis (self-reported)	0.0	0.0	0.1	0.3	-0.1	0.3
Osteoarthritis (self-reported)	3.3	4.3	4.8	-2.2	2.1	-1.9
Medication: Aspirin	0.1	0.1	0.3	-0.2	0.5	-0.3
Medication: Gliclazide	1.5	1.7	2.1	-1.3	1.4	-1.1
Illnesses of father: None of the above (group 1)	0.7	0.9	1.6	0.7	-0.7	1.3
Smoking status: Current	0.3	0.4	0.6	0.8	-0.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.6	-0.8	0.1	-0.6
Whole body water mass	1.7	9.6	11.0	-2.9	3.1	-3.3
Leg predicted mass (right)	1.4	7.3	8.6	-2.4	2.7	-2.9
Arm fat mass (left)	5.0	20.4	23.9	-4.4	4.9	-4.2
Number of self-reported non-cancer illnesses	1.9	3.3	4.6	-1.6	2.1	-1.7
Average weekly champagne plus white wine intake	0.0	0.0	0.0	0.0	0.1	-0.1
Miserableness	0.3	0.6	1.1	-0.7	0.3	-1.0
Guilty feelings	0.1	0.2	0.3	0.3	-0.6	0.3
Wears glasses or contact lenses	0.8	0.9	1.3	-1.2	0.9	-0.8
Ever taken oral contraceptive pill	0.0	0.0	0.0	0.0	-0.0	-0.1
Hearing aid user	0.1	0.2	0.2	0.4	-0.4	0.3
Mother’s age at death	3.5	4.3	5.2	2.3	-1.9	2.0
Financial situation satisfaction	0.6	0.8	0.8	0.9	-0.9	0.8
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.3	-0.7	0.3
Commuting to job workplace: Public transport	0.3	0.4	0.5	-0.6	0.7	-0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	0.3	-0.3	0.6
Medication: Blood pressure	0.1	0.1	0.2	0.4	-0.2	-0.4
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.8	-0.9	0.6	-0.7
Supplements: Fish oil (including cod liver oil)	0.5	0.7	0.9	0.8	-0.9	0.7
High cholesterol (Self-reported)	0.0	0.0	0.1	-0.2	0.2	0.0
Medication: Bendroflumethiazide	0.1	0.2	0.5	-0.3	0.2	-0.7
Medication: Paracetamol	0.4	0.6	1.0	-0.6	0.7	-1.0
Medication: Lisinopril	0.1	0.2	0.3	-0.4	0.3	-0.6
Medication: Atorvastatin	0.7	0.9	1.3	-0.9	1.1	-0.8
Illnesses of father: High blood pressure	2.8	3.5	4.8	-1.5	1.8	-2.2
Alcohol drinker status: Never	2.9	3.5	4.0	1.8	-1.8	2.0
Ever smoked	5.6	9.9	11.4	3.4	-3.1	3.0
Basal metabolic rate	2.0	11.1	12.0	-3.1	3.4	-3.5
Leg fat percentage (left)	4.9	17.9	21.1	-4.3	4.6	-3.7
Arm fat-free mass (left)	1.9	9.6	10.6	-3.0	3.1	-3.3
Number of operations (self-reported)	2.0	2.9	4.1	-1.4	2.0	-1.7
Average weekly beer plus cider intake	3.0	4.3	5.2	-1.7	2.3	-2.1
Irritability	0.2	0.3	0.4	0.6	-0.5	0.5
Risk taking	0.3	0.4	0.8	0.6	-0.9	0.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.7	0.8	-0.5	0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.4	-0.4	0.1
Age started oral contraceptive pill	0.1	0.1	0.2	0.2	-0.4	0.1
Diastolic blood pressure, automated reading	0.4	1.2	2.0	-0.6	1.1	-1.4
Ever depressed for a whole week	0.1	0.1	0.3	0.1	-0.0	-0.5
Unable to work because of sickness or disability	0.1	0.1	0.2	0.2	-0.5	0.2
Commuting to job workplace: Cycle	2.3	2.8	3.2	1.8	-1.7	1.5
Myopia	0.5	0.7	0.9	-0.9	1.0	-0.7
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.3	-0.5	0.3	0.3
Cholesterol lowering medication	0.0	0.1	0.1	0.4	-0.2	0.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.8	-0.9	0.7	-0.4
Pain experienced in last month	0.1	0.2	0.3	0.6	-0.3	0.4
Supplements: Calcium	3.9	4.3	4.7	2.2	-2.1	2.0
Basal cell carcinoma (self-reported)	0.6	0.8	1.2	-0.5	0.9	-1.1
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	0.0	-0.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	-0.4	0.5	-0.2
Heart disease (siblings)	0.0	0.0	0.1	-0.3	0.1	0.1
Alcohol drinker status: Previous	0.0	0.0	0.1	0.2	-0.1	-0.2
Pack years of smoking	0.1	0.2	0.5	0.7	-0.2	-0.2
Impedance of whole body	2.1	10.7	12.7	3.1	-3.1	3.6
Leg fat mass (left)	5.8	22.8	26.3	-4.8	5.1	-4.4
Arm predicted mass (left)	1.8	9.0	9.8	-2.9	3.0	-3.1