[Hub]/) : Traits : Leg fat mass (left) :

chr20:24,230,055-26,182,690

Best TWAS P=1.39e-14 · Best GWAS P=1.57e-11 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ABHD12 0.10 0.17 blup 405 0.17 1.7e-20 5.9 7.0 3.2e-12 -0.19 0.22 0.78 FALSE
2 CommonMind Brain Pre-frontal Cortex NINL 0.19 0.17 lasso 20 0.23 1.2e-27 5.9 7.1 1.5e-12 -0.16 0.22 0.78 FALSE
3 CommonMind Brain Pre-frontal Cortex PYGB 0.10 0.05 lasso 3 0.05 6.9e-07 4.9 -5.4 7.4e-08 0.05 0.67 0.25 TRUE
4 GTEx Adipose Visceral Omentum ABHD12 0.06 0.00 lasso 8 0.00 4.6e-01 5.9 6.0 1.7e-09 -0.14 0.15 0.39 FALSE
5 GTEx Artery Aorta NINL 0.17 0.18 lasso 6 0.19 1.5e-10 5.9 6.5 9.3e-11 -0.15 0.20 0.80 FALSE
6 GTEx Artery Tibial ABHD12 0.12 0.12 enet 25 0.15 7.1e-12 5.6 5.7 1.1e-08 -0.07 0.34 0.66 FALSE
7 GTEx Brain Caudate basal ganglia ABHD12 0.09 0.05 enet 13 0.04 2.9e-02 5.9 6.0 2.1e-09 -0.15 0.17 0.50 FALSE
8 GTEx Brain Cerebellar Hemisphere PYGB 0.20 0.16 lasso 5 0.12 5.8e-04 5.4 -5.4 6.2e-08 0.14 0.18 0.47 FALSE
9 GTEx Brain Cerebellar Hemisphere NINL 0.17 0.07 enet 18 0.11 1.1e-03 5.7 5.2 1.5e-07 -0.31 0.15 0.42 FALSE
10 GTEx Brain Cerebellar Hemisphere ACSS1 0.31 0.24 lasso 3 0.16 7.1e-05 -5.1 -5.4 5.2e-08 0.23 0.19 0.05 FALSE
11 GTEx Brain Cerebellar Hemisphere ENTPD6 0.22 0.26 lasso 3 0.17 3.8e-05 5.4 -5.5 4.5e-08 0.16 0.32 0.64 FALSE
12 GTEx Brain Cerebellum ENTPD6 0.15 0.23 enet 8 0.14 4.6e-05 5.1 -5.3 1.2e-07 0.18 0.41 0.50 FALSE
13 GTEx Brain Cortex ABHD12 0.08 0.11 lasso 8 0.09 1.4e-03 6.0 5.4 6.4e-08 -0.06 0.14 0.50 FALSE
14 GTEx Breast Mammary Tissue CST7 0.10 0.00 lasso 4 0.00 7.3e-01 -4.7 5.1 2.7e-07 -0.17 0.15 0.37 FALSE
15 GTEx Breast Mammary Tissue ABHD12 0.08 0.09 lasso 5 0.09 3.3e-05 5.9 6.1 1.2e-09 -0.14 0.23 0.68 FALSE
16 GTEx Breast Mammary Tissue (Male) CST7 0.15 0.00 lasso 4 0.03 7.0e-02 -4.1 -5.7 1.2e-08 0.62 0.06 0.08 FALSE
17 GTEx Breast Mammary Tissue (Male) ABHD12 0.06 0.01 lasso 3 0.02 1.3e-01 5.0 5.8 7.0e-09 -0.13 0.05 0.11 FALSE
18 GTEx Cells EBV-transformed lymphocytes PYGB 0.38 0.08 lasso 5 0.06 7.0e-03 5.3 5.2 2.4e-07 -0.18 0.22 0.50 FALSE
19 GTEx Cells Transformed fibroblasts ABHD12 0.24 0.33 lasso 4 0.35 6.3e-27 6.0 6.1 1.3e-09 -0.16 0.18 0.82 FALSE
20 GTEx Colon Sigmoid ABHD12 0.17 0.17 lasso 15 0.17 1.0e-06 5.5 5.4 5.4e-08 -0.09 0.29 0.70 FALSE
21 GTEx Esophagus Gastroesophageal Junction ABHD12 0.15 0.14 lasso 13 0.14 7.0e-06 5.4 5.4 7.4e-08 -0.16 0.22 0.78 FALSE
22 GTEx Esophagus Muscularis ABHD12 0.10 0.10 enet 42 0.09 4.5e-06 5.9 5.3 1.3e-07 -0.18 0.22 0.77 FALSE
23 GTEx Heart Atrial Appendage ABHD12 0.07 0.06 enet 16 0.06 1.0e-03 5.9 5.8 7.8e-09 -0.15 0.21 0.75 FALSE
24 GTEx Heart Left Ventricle ABHD12 0.15 0.14 lasso 10 0.12 4.0e-07 5.9 6.4 1.9e-10 -0.18 0.19 0.81 FALSE
25 GTEx Heart Left Ventricle NINL 0.08 0.03 enet 11 0.05 1.1e-03 5.6 5.2 1.8e-07 0.01 0.39 0.38 TRUE
26 GTEx Liver ABHD12 0.20 0.20 lasso 19 0.15 7.3e-05 5.9 5.8 7.8e-09 -0.15 0.24 0.74 FALSE
27 GTEx Liver APMAP 0.20 -0.01 lasso 9 0.00 3.8e-01 5.9 5.9 3.0e-09 -0.26 0.14 0.33 FALSE
28 GTEx Lung ABHD12 0.06 0.00 lasso 6 0.00 2.7e-01 5.8 6.4 1.8e-10 -0.12 0.18 0.49 FALSE
29 GTEx Nerve Tibial PYGB 0.26 0.15 enet 11 0.14 5.7e-10 4.8 -5.3 1.1e-07 0.09 0.97 0.03 FALSE
30 GTEx Nerve Tibial ABHD12 0.24 0.44 lasso 11 0.44 5.1e-34 5.9 -5.7 1.5e-08 0.16 0.24 0.76 FALSE
31 GTEx Pancreas ENTPD6 0.11 0.05 enet 23 0.05 5.0e-03 5.8 -6.1 9.1e-10 0.15 0.21 0.65 FALSE
32 GTEx Pituitary ABHD12 0.27 0.31 enet 25 0.31 1.8e-08 5.9 6.5 7.2e-11 -0.14 0.24 0.76 FALSE
33 GTEx Skin Not Sun Exposed Suprapubic PYGB 0.12 0.13 enet 13 0.14 4.2e-08 4.9 -5.8 8.4e-09 0.28 0.65 0.17 FALSE
34 GTEx Skin Sun Exposed Lower leg ABHD12 0.07 0.03 lasso 10 0.05 7.3e-05 5.1 6.2 4.6e-10 -0.19 0.32 0.64 FALSE
35 GTEx Spleen PYGB 0.15 0.09 lasso 6 0.04 2.6e-02 5.9 5.4 7.1e-08 -0.14 0.20 0.57 FALSE
36 GTEx Testis ABHD12 0.21 0.18 enet 25 0.23 1.1e-10 5.9 6.1 8.6e-10 -0.14 0.20 0.80 FALSE
37 GTEx Thyroid ABHD12 0.05 0.04 lasso 5 0.03 3.9e-03 5.9 -5.9 4.5e-09 0.16 0.23 0.70 FALSE
38 GTEx Thyroid NINL 0.13 0.18 enet 17 0.20 6.2e-15 -3.2 -5.8 7.7e-09 0.19 0.68 0.32 FALSE
39 ROSMAP Brain Pre-frontal Cortex PYGB 0.20 0.10 bslmm 414 0.11 3.2e-14 5.8 -6.1 1.2e-09 0.07 0.30 0.70 FALSE
40 ROSMAP Brain Pre-frontal Cortex ABHD12 0.26 0.35 enet 35 0.42 7.9e-58 5.6 6.1 8.9e-10 -0.14 0.27 0.73 FALSE
41 ROSMAP Brain Pre-frontal Cortex NINL 0.19 0.19 enet 18 0.25 2.1e-32 5.9 5.3 9.6e-08 -0.07 0.20 0.80 FALSE
42 ROSMAP Brain Pre-frontal Cortex ENTPD6 0.32 0.10 bslmm 432 0.12 1.8e-15 5.8 7.7 1.4e-14 -0.70 0.21 0.79 TRUE
43 YFS Blood ABHD12 0.15 0.35 bslmm 390 0.34 2.2e-118 6.0 6.2 4.7e-10 -0.16 0.18 0.82 TRUE
44 YFS Blood NINL 0.04 0.03 lasso 8 0.03 2.8e-10 5.8 5.7 1.2e-08 -0.07 0.37 0.63 FALSE
45 The Cancer Genome Atlas Bladder Urothelial Carcinoma ABHD12 0.04 0.00 blup 77 0.02 6.6e-03 5.8 5.5 4.8e-08 -0.17 0.04 0.53 FALSE
46 The Cancer Genome Atlas Breast Invasive Carcinoma PYGB 0.08 0.02 enet 7 0.03 1.7e-07 5.5 -5.6 2.1e-08 0.06 0.74 0.24 FALSE
47 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma PYGB 0.08 0.04 blup 74 0.06 1.0e-03 5.9 -6.0 1.6e-09 0.14 0.14 0.47 TRUE
48 The Cancer Genome Atlas Colon Adenocarcinoma NINL 0.20 0.06 lasso 4 0.08 2.7e-05 4.9 5.7 9.8e-09 -0.04 0.05 0.90 FALSE
49 The Cancer Genome Atlas Glioblastoma Multiforme ABHD12 0.14 0.10 lasso 5 0.13 1.1e-04 5.5 5.7 1.1e-08 -0.15 0.06 0.89 FALSE
50 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ABHD12 0.04 0.03 blup 77 0.04 4.0e-05 6.0 5.8 7.7e-09 -0.16 0.05 0.95 FALSE
51 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ABHD12 0.03 0.01 blup 77 0.01 8.7e-03 4.3 5.9 3.5e-09 -0.14 0.06 0.75 FALSE
52 The Cancer Genome Atlas Brain Lower Grade Glioma ABHD12 0.04 0.06 blup 77 0.06 2.2e-07 5.9 6.1 1.3e-09 -0.15 0.06 0.94 FALSE
53 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ABHD12 0.07 0.05 blup 77 0.05 2.4e-03 5.9 5.6 2.0e-08 -0.15 0.05 0.84 FALSE
54 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ABHD12 0.08 0.09 blup 80 0.09 1.7e-06 5.9 5.6 1.8e-08 -0.12 0.06 0.94 FALSE
55 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ENTPD6 0.07 0.07 lasso 1 0.04 9.2e-03 5.4 -5.4 5.5e-08 0.15 0.09 0.07 FALSE
56 The Cancer Genome Atlas Prostate Adenocarcinoma ABHD12 0.03 0.02 lasso 4 0.03 5.8e-04 -5.4 5.6 2.5e-08 -0.17 0.07 0.75 FALSE
57 The Cancer Genome Atlas Prostate Adenocarcinoma PYGB 0.21 0.13 enet 5 0.17 2.0e-17 4.3 -5.3 9.7e-08 0.09 0.99 0.01 FALSE
58 The Cancer Genome Atlas Testicular Germ Cell Tumors NINL 0.11 0.03 blup 81 0.07 2.1e-03 -5.4 -5.3 8.9e-08 0.16 0.03 0.68 FALSE
59 The Cancer Genome Atlas Thyroid Carcinoma ENTPD6 0.16 0.14 lasso 4 0.13 1.2e-12 5.4 -5.4 7.5e-08 0.16 0.74 0.26 FALSE
60 The Cancer Genome Atlas Thyroid Carcinoma NINL 0.08 0.14 lasso 11 0.13 2.9e-12 5.9 -5.7 1.0e-08 0.16 0.02 0.98 FALSE
61 The Cancer Genome Atlas Thyroid Carcinoma PYGB 0.10 0.08 lasso 7 0.07 1.4e-07 4.9 -5.7 1.5e-08 0.10 0.79 0.20 FALSE