[Hub]/) : Traits : Leg fat mass (left) : ←

chr22:37,643,564-39,663,066

Best TWAS P=1.62e-10 · Best GWAS P=8.7e-11 conditioned to 0.416

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Artery Aorta	PLA2G6	0.10	0.02	enet	9	0.02	4.5e-02	4.1	6.4	1.6e-10	0.68	0.09	0.50	TRUE
1	GTEx	Adipose Subcutaneous	BAIAP2L2	0.11	0.03	lasso	5	0.04	1.8e-04	5.0	-5.8	4.9e-09	-0.71	0.02	0.91	TRUE
5	GTEx	Artery Aorta	AL021977.1	0.13	0.00	enet	17	0.01	8.7e-02	5.6	-6.4	1.8e-10	-0.73	0.04	0.68	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLA2G6	0.05	0.01	blup	76	0.01	7.7e-02	6.5	6.4	2.0e-10	0.83	0.01	0.86	FALSE
13	GTEx	Nerve Tibial	MAFF	0.14	0.06	lasso	3	0.05	1.2e-04	6.3	-6.2	4.5e-10	-0.98	0.01	0.98	FALSE
6	GTEx	Brain Cortex	TMEM184B	0.29	0.12	lasso	7	0.09	1.6e-03	5.6	-6.0	2.6e-09	-0.91	0.01	0.88	FALSE
8	GTEx	Cells Transformed fibroblasts	PLA2G6	0.23	0.09	lasso	9	0.10	9.9e-08	5.3	5.7	9.4e-09	0.81	0.63	0.37	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	PLA2G6	0.28	0.17	enet	13	0.18	1.3e-06	-4.6	5.6	1.6e-08	0.69	0.33	0.48	FALSE
9	GTEx	Esophagus Mucosa	PLA2G6	0.22	0.02	lasso	6	0.04	1.9e-03	5.3	5.6	1.7e-08	0.77	0.11	0.87	FALSE
4	GTEx	Artery Aorta	TMEM184B	0.17	0.07	enet	34	0.03	1.2e-02	5.6	-5.6	2.2e-08	-0.68	0.07	0.70	FALSE
2	GTEx	Artery Aorta	C22orf23	0.10	0.01	enet	24	0.02	1.6e-02	3.0	5.6	2.5e-08	0.34	0.26	0.08	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	PLA2G6	0.03	0.02	lasso	2	0.03	6.5e-04	5.5	5.5	3.2e-08	0.81	0.09	0.19	FALSE
14	GTEx	Skin Sun Exposed Lower leg	BAIAP2L2	0.09	0.09	lasso	4	0.09	5.5e-08	5.1	-5.5	3.9e-08	-0.74	0.35	0.65	FALSE
17	GTEx	Thyroid	AL021977.1	0.20	0.11	lasso	6	0.12	2.7e-09	4.1	-5.4	6.9e-08	-0.66	0.95	0.04	FALSE
12	GTEx	Nerve Tibial	PLA2G6	0.34	0.08	lasso	8	0.11	2.9e-08	-4.6	5.4	7.3e-08	0.72	0.74	0.26	FALSE
16	GTEx	Thyroid	TMEM184B	0.19	0.16	lasso	7	0.18	1.0e-13	4.2	-5.4	7.5e-08	-0.67	0.98	0.02	FALSE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ANKRD54	0.20	0.06	lasso	1	0.06	3.0e-07	-5.3	-5.3	1.1e-07	-0.17	0.00	1.00	FALSE
11	GTEx	Muscle Skeletal	DMC1	0.13	0.01	enet	17	0.04	3.3e-05	5.0	5.3	1.5e-07	0.59	0.06	0.71	FALSE
15	GTEx	Thyroid	PLA2G6	0.34	0.20	lasso	5	0.18	4.5e-14	-4.6	5.2	2.5e-07	0.67	0.98	0.02	FALSE
10	GTEx	Esophagus Muscularis	TMEM184B	0.11	0.01	enet	10	0.06	2.7e-04	3.2	-5.1	2.7e-07	-0.60	0.27	0.19	FALSE