[Hub]/) : Traits : Leg fat-free mass (left) :

chr1:204,927,136-206,329,620

Best TWAS P=6.13e-17 · Best GWAS P=2.55e-16 conditioned to 0.145

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PM20D1 0.27 0.41 enet 15 0.41 7.8e-54 -7.1 -7.0 2.1e-12 -0.61 0.88 0.12 FALSE
2 CommonMind Brain Pre-frontal Cortex RAB7L1 0.07 0.03 enet 16 0.05 4.1e-07 7.2 -7.1 1.5e-12 -0.75 0.02 0.98 FALSE
3 CommonMind Brain Pre-frontal Cortex SLC26A9 0.13 0.16 lasso 3 0.16 3.1e-19 -7.1 -7.2 6.1e-13 -0.61 0.84 0.16 FALSE
4 GTEx Adipose Subcutaneous NUCKS1 0.11 0.10 lasso 3 0.08 9.4e-07 -7.2 7.2 6.4e-13 0.68 0.26 0.74 FALSE
5 GTEx Adipose Subcutaneous RAB7L1 0.20 0.09 lasso 4 0.18 7.6e-15 3.9 -5.8 4.8e-09 -0.70 0.19 0.81 FALSE
6 GTEx Adipose Visceral Omentum RAB7L1 0.17 0.08 enet 15 0.10 1.2e-05 4.1 -6.3 3.5e-10 -0.65 0.05 0.95 FALSE
7 GTEx Adrenal Gland NUCKS1 0.17 0.00 enet 11 0.02 6.7e-02 -7.1 5.3 1.5e-07 0.57 0.06 0.42 FALSE
8 GTEx Artery Aorta NUCKS1 0.14 0.11 lasso 3 0.08 3.7e-05 -7.1 8.2 2.4e-16 0.87 0.01 0.98 FALSE
9 GTEx Artery Aorta RAB7L1 0.43 0.20 lasso 8 0.29 1.9e-16 7.9 -7.1 1.3e-12 -0.82 0.02 0.98 FALSE
10 GTEx Artery Tibial NUCKS1 0.13 0.03 lasso 2 0.01 4.0e-02 -7.2 6.7 1.9e-11 0.60 0.14 0.62 FALSE
11 GTEx Artery Tibial RAB7L1 0.29 0.27 lasso 9 0.31 9.7e-25 7.9 -7.0 2.1e-12 -0.78 0.01 0.99 FALSE
12 GTEx Brain Caudate basal ganglia NUCKS1 0.25 0.24 lasso 3 0.25 8.1e-08 8.0 -7.8 7.9e-15 -0.87 0.01 0.98 FALSE
13 GTEx Brain Cerebellum NUCKS1 0.22 0.13 lasso 3 0.08 2.0e-03 -7.2 7.1 9.7e-13 0.64 0.21 0.29 FALSE
14 GTEx Brain Cerebellum SLC41A1 0.27 0.09 lasso 4 0.08 2.1e-03 -7.4 -7.6 3.7e-14 -0.71 0.06 0.48 FALSE
15 GTEx Brain Putamen basal ganglia NUCKS1 0.40 0.26 lasso 4 0.27 3.2e-07 -7.2 7.1 1.7e-12 0.67 0.06 0.85 FALSE
16 GTEx Breast Mammary Tissue NUCKS1 0.15 0.05 lasso 4 0.09 2.5e-05 -7.2 6.8 1.3e-11 0.65 0.18 0.79 FALSE
17 GTEx Cells Transformed fibroblasts RAB7L1 0.30 0.23 enet 19 0.36 8.6e-28 5.2 -7.3 3.1e-13 -0.83 0.04 0.96 FALSE
18 GTEx Colon Sigmoid NUCKS1 0.34 0.22 enet 20 0.21 8.3e-08 -7.1 6.7 1.5e-11 0.68 0.14 0.84 FALSE
19 GTEx Colon Transverse RAB7L1 0.14 0.05 lasso 5 0.04 7.7e-03 5.9 -6.1 1.1e-09 -0.70 0.02 0.88 FALSE
20 GTEx Esophagus Mucosa NUCKS1 0.12 0.11 enet 6 0.06 7.2e-05 7.9 8.3 1.0e-16 0.89 0.01 0.99 FALSE
21 GTEx Esophagus Mucosa RAB7L1 0.26 0.11 enet 34 0.18 4.5e-12 7.9 -6.0 2.0e-09 -0.62 0.03 0.97 FALSE
22 GTEx Esophagus Mucosa SLC41A1 0.17 0.09 enet 25 0.12 1.1e-08 -7.1 -5.9 3.8e-09 -0.47 0.63 0.31 FALSE
23 GTEx Esophagus Muscularis NUCKS1 0.21 0.22 lasso 5 0.20 3.6e-12 -7.4 8.0 1.1e-15 0.81 0.30 0.70 FALSE
24 GTEx Esophagus Muscularis RAB7L1 0.27 0.30 lasso 4 0.33 9.4e-21 3.9 -6.4 1.4e-10 -0.74 0.08 0.92 FALSE
25 GTEx Heart Atrial Appendage NUCKS1 0.12 0.14 enet 4 0.08 1.7e-04 7.9 8.4 6.1e-17 0.91 0.01 0.98 TRUE
26 GTEx Heart Atrial Appendage RAB7L1 0.20 0.17 enet 12 0.14 4.9e-07 7.9 -7.6 2.6e-14 -0.83 0.02 0.98 FALSE
27 GTEx Heart Left Ventricle NUCKS1 0.10 0.04 lasso 3 0.05 1.4e-03 -7.1 7.0 3.8e-12 0.68 0.15 0.45 FALSE
28 GTEx Heart Left Ventricle RAB7L1 0.33 0.09 lasso 10 0.22 4.8e-12 4.5 -5.9 3.8e-09 -0.72 0.06 0.94 FALSE
29 GTEx Lung NUCKS1 0.09 0.07 lasso 3 0.04 2.6e-04 -7.2 7.1 1.4e-12 0.67 0.14 0.85 FALSE
30 GTEx Lung RAB7L1 0.34 0.19 enet 53 0.31 7.5e-24 4.5 -7.4 1.1e-13 -0.73 0.18 0.82 FALSE
31 GTEx Muscle Skeletal RAB7L1 0.16 0.14 lasso 8 0.15 2.9e-14 4.1 -5.7 1.1e-08 -0.60 0.97 0.03 FALSE
32 GTEx Nerve Tibial NUCKS1 0.25 0.21 enet 16 0.22 7.3e-16 -7.4 7.7 1.7e-14 0.76 0.56 0.44 FALSE
33 GTEx Nerve Tibial RAB7L1 0.35 0.14 enet 68 0.22 1.8e-15 5.9 -7.5 7.1e-14 -0.68 0.03 0.97 FALSE
34 GTEx Nerve Tibial SLC41A1 0.12 0.02 lasso 4 0.05 2.5e-04 -7.1 -7.4 1.6e-13 -0.69 0.24 0.68 FALSE
35 GTEx Pancreas NUCKS1 0.16 0.00 lasso 4 0.00 4.5e-01 8.2 8.0 1.9e-15 0.88 0.01 0.90 FALSE
36 GTEx Pancreas RAB7L1 0.18 0.06 enet 12 0.06 1.1e-03 7.9 -6.6 3.5e-11 -0.62 0.02 0.92 FALSE
37 GTEx Pancreas SLC41A1 0.24 0.21 lasso 5 0.19 1.4e-08 -7.1 -7.1 1.1e-12 -0.63 0.53 0.43 FALSE
38 GTEx Pituitary NUCKS1 0.26 0.19 lasso 2 0.20 7.6e-06 -7.4 7.8 8.1e-15 0.77 0.02 0.93 FALSE
39 GTEx Prostate NUCKS1 0.38 0.23 lasso 8 0.32 7.5e-09 4.4 -6.2 4.9e-10 -0.59 0.08 0.80 FALSE
40 GTEx Skin Not Sun Exposed Suprapubic NUCKS1 0.20 0.14 lasso 4 0.13 2.0e-07 -7.2 7.4 1.0e-13 0.71 0.15 0.85 FALSE
41 GTEx Skin Not Sun Exposed Suprapubic RAB7L1 0.21 0.16 enet 17 0.17 1.8e-09 4.1 -5.7 1.2e-08 -0.62 0.33 0.66 FALSE
42 GTEx Skin Sun Exposed Lower leg NUCKS1 0.20 0.26 lasso 5 0.26 1.5e-21 -7.2 7.3 3.5e-13 0.69 0.65 0.35 FALSE
43 GTEx Skin Sun Exposed Lower leg RAB7L1 0.18 0.20 lasso 3 0.22 2.1e-18 4.1 -5.3 1.0e-07 -0.61 0.95 0.05 FALSE
44 GTEx Skin Sun Exposed Lower leg SLC45A3 0.08 0.00 lasso 5 0.00 3.6e-01 7.9 6.3 3.6e-10 0.68 0.01 0.91 FALSE
45 GTEx Spleen RAB7L1 0.31 0.00 lasso 7 0.00 2.8e-01 3.8 -5.7 1.5e-08 -0.58 0.06 0.46 FALSE
46 GTEx Stomach NUCKS1 0.21 0.11 lasso 8 0.15 1.1e-07 -7.4 8.1 5.5e-16 0.82 0.03 0.97 FALSE
47 GTEx Stomach RAB7L1 0.22 0.11 lasso 5 0.12 2.7e-06 5.9 -6.3 3.7e-10 -0.70 0.07 0.91 FALSE
48 GTEx Testis NUCKS1 0.16 0.16 enet 15 0.16 1.3e-07 -7.3 7.6 3.0e-14 0.73 0.39 0.59 FALSE
49 GTEx Testis RAB7L1 0.41 0.21 lasso 13 0.26 9.2e-12 4.1 -6.6 3.5e-11 -0.73 0.26 0.73 FALSE
50 GTEx Thyroid NUCKS1 0.26 0.16 lasso 6 0.19 1.8e-14 -7.3 8.3 1.4e-16 0.84 0.15 0.85 FALSE
51 GTEx Thyroid RAB7L1 0.23 0.15 lasso 6 0.15 1.3e-11 4.1 -5.2 2.4e-07 -0.54 0.61 0.39 FALSE
52 GTEx Whole Blood RAB7L1 0.14 0.11 lasso 5 0.10 3.1e-09 3.8 -5.8 5.4e-09 -0.63 0.41 0.59 FALSE
53 METSIM Adipose NUCKS1 0.05 0.02 lasso 6 0.01 4.3e-03 -7.3 8.1 5.3e-16 0.81 0.08 0.88 FALSE
54 METSIM Adipose PM20D1 0.25 0.30 bslmm 377 0.31 8.4e-47 -7.1 6.7 2.4e-11 0.59 0.88 0.12 FALSE
55 METSIM Adipose RAB7L1 0.08 0.04 bslmm 401 0.05 8.6e-08 8.0 -5.5 4.2e-08 -0.64 0.01 0.99 FALSE
56 NTR Blood RAB7L1 0.03 0.01 bslmm 385 0.02 1.9e-07 4.2 -5.6 2.8e-08 -0.63 0.06 0.94 FALSE
57 YFS Blood NUCKS1 0.15 0.24 lasso 4 0.25 1.4e-80 -7.2 8.0 8.6e-16 0.80 0.64 0.36 FALSE
58 YFS Blood RAB7L1 0.06 0.07 lasso 6 0.06 1.1e-19 8.0 -8.3 7.3e-17 -0.89 0.01 0.99 FALSE
59 YFS Blood SLC41A1 0.06 0.05 enet 15 0.05 2.6e-17 -7.2 -7.3 3.0e-13 -0.70 0.65 0.35 FALSE
60 The Cancer Genome Atlas Bladder Urothelial Carcinoma PM20D1 0.22 0.26 lasso 5 0.26 1.7e-22 -7.2 6.8 1.5e-11 0.60 0.00 1.00 FALSE
61 The Cancer Genome Atlas Bladder Urothelial Carcinoma RAB7L1 0.11 0.07 blup 46 0.07 1.4e-06 7.2 -6.5 5.8e-11 -0.69 0.01 0.99 FALSE
62 The Cancer Genome Atlas Breast Invasive Carcinoma PM20D1 0.24 0.37 lasso 5 0.39 4.9e-85 -7.1 6.3 2.6e-10 0.54 0.00 1.00 FALSE
63 The Cancer Genome Atlas Breast Invasive Carcinoma RAB7L1 0.02 0.02 enet 5 0.02 3.1e-04 5.9 -7.2 5.1e-13 -0.84 0.01 0.98 FALSE
64 The Cancer Genome Atlas Colon Adenocarcinoma PM20D1 0.26 0.13 enet 14 0.16 9.7e-10 4.4 5.3 1.0e-07 0.52 0.01 0.99 FALSE
65 The Cancer Genome Atlas Colon Adenocarcinoma RAB7L1 0.17 0.14 blup 46 0.14 1.7e-08 -7.3 -6.8 1.3e-11 -0.61 0.08 0.92 FALSE
66 The Cancer Genome Atlas Esophageal Carcinoma RAB7L1 0.14 0.03 blup 46 0.07 2.5e-03 2.6 -5.4 5.9e-08 -0.66 0.02 0.51 FALSE
67 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PM20D1 0.19 0.25 lasso 5 0.25 3.0e-28 -7.1 6.8 1.2e-11 0.59 0.00 1.00 FALSE
68 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RAB7L1 0.09 0.13 lasso 6 0.13 3.6e-14 7.2 -7.9 2.9e-15 -0.82 0.22 0.78 FALSE
69 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SLC45A3 0.08 0.00 blup 80 0.03 5.5e-04 3.4 -6.7 2.0e-11 -0.59 0.01 0.84 FALSE
70 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PM20D1 0.29 0.35 enet 18 0.35 5.1e-41 -7.1 6.5 1.0e-10 0.55 0.00 1.00 FALSE
71 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RAB7L1 0.09 0.08 enet 11 0.08 1.7e-09 8.0 -7.7 1.2e-14 -0.82 0.00 1.00 FALSE
72 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PM20D1 0.19 0.19 enet 4 0.19 4.5e-11 -7.1 7.0 2.4e-12 0.62 0.00 1.00 FALSE
73 The Cancer Genome Atlas Brain Lower Grade Glioma PM20D1 0.41 0.43 enet 20 0.44 9.2e-55 -7.1 6.7 3.0e-11 0.59 0.00 1.00 FALSE
74 The Cancer Genome Atlas Brain Lower Grade Glioma RAB7L1 0.09 0.08 lasso 2 0.07 1.1e-08 8.0 -8.1 8.3e-16 -0.89 0.00 1.00 FALSE
75 The Cancer Genome Atlas Lung Adenocarcinoma PM20D1 0.31 0.39 enet 16 0.41 5.1e-52 -7.1 6.8 1.2e-11 0.59 0.00 1.00 FALSE
76 The Cancer Genome Atlas Lung Adenocarcinoma RAB7L1 0.02 0.02 enet 5 0.03 4.6e-04 7.2 -6.7 2.7e-11 -0.66 0.02 0.71 FALSE
77 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PM20D1 0.26 0.34 lasso 3 0.34 1.9e-40 -7.1 6.5 1.1e-10 0.55 0.00 1.00 FALSE
78 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RAB7L1 0.06 0.05 enet 6 0.06 2.6e-07 5.9 -6.9 4.9e-12 -0.74 0.44 0.52 FALSE
79 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma PM20D1 0.12 0.13 blup 47 0.12 9.1e-09 -7.1 6.1 1.3e-09 0.53 0.00 1.00 FALSE
80 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RAB7L1 0.06 0.06 blup 46 0.06 5.2e-05 -7.1 -7.6 2.5e-14 -0.75 0.10 0.87 FALSE
81 The Cancer Genome Atlas Pancreatic Adenocarcinoma PM20D1 0.32 0.34 lasso 2 0.34 9.7e-15 -7.2 7.2 4.6e-13 0.65 0.00 1.00 FALSE
82 The Cancer Genome Atlas Pancreatic Adenocarcinoma RAB7L1 0.09 0.04 blup 46 0.04 1.2e-02 8.0 -8.2 3.1e-16 -0.87 0.00 0.97 FALSE
83 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma PM20D1 0.34 0.13 enet 20 0.21 9.7e-09 2.9 5.4 8.5e-08 0.37 0.02 0.98 FALSE
84 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma RAB7L1 0.17 0.13 lasso 2 0.11 4.4e-05 7.9 -8.0 1.5e-15 -0.87 0.00 0.99 FALSE
85 The Cancer Genome Atlas Prostate Adenocarcinoma ELK4 0.06 0.00 blup 81 0.02 1.8e-03 3.8 -5.9 4.4e-09 -0.61 0.00 0.79 FALSE
86 The Cancer Genome Atlas Prostate Adenocarcinoma NUCKS1 0.04 0.05 lasso 2 0.03 1.5e-04 -7.1 7.2 5.2e-13 0.70 0.23 0.60 FALSE
87 The Cancer Genome Atlas Prostate Adenocarcinoma PM20D1 0.16 0.14 enet 15 0.16 5.6e-16 -7.1 5.8 6.6e-09 0.51 0.01 0.99 FALSE
88 The Cancer Genome Atlas Prostate Adenocarcinoma RAB7L1 0.12 0.12 lasso 2 0.12 3.8e-12 7.9 -8.2 3.4e-16 -0.89 0.00 1.00 FALSE
89 The Cancer Genome Atlas Rectum Adenocarcinoma PM20D1 0.17 0.02 blup 47 0.01 2.2e-01 -7.2 5.5 4.6e-08 0.46 0.00 0.76 FALSE
90 The Cancer Genome Atlas Soft Tissue Sarcoma PM20D1 0.23 0.24 lasso 4 0.24 1.2e-14 -7.1 6.8 7.6e-12 0.59 0.00 1.00 FALSE
91 The Cancer Genome Atlas Skin Cutaneous Melanoma PM20D1 0.17 0.11 lasso 3 0.07 5.0e-03 -7.1 7.0 2.9e-12 0.61 0.00 0.88 FALSE
92 The Cancer Genome Atlas Stomach Adenocarcinoma RAB7L1 0.07 0.04 blup 46 0.07 1.2e-05 -7.2 -7.7 1.6e-14 -0.79 0.00 0.99 FALSE
93 The Cancer Genome Atlas Testicular Germ Cell Tumors PM20D1 0.42 0.34 lasso 3 0.34 6.9e-13 -7.1 6.6 4.6e-11 0.59 0.00 1.00 FALSE
94 The Cancer Genome Atlas Testicular Germ Cell Tumors SLC41A1 0.13 0.03 blup 55 0.03 2.6e-02 -7.3 6.5 8.1e-11 0.62 0.05 0.41 FALSE
95 The Cancer Genome Atlas Thyroid Carcinoma NUCKS1 0.07 0.07 blup 59 0.07 1.3e-07 -7.3 5.5 3.3e-08 0.46 0.56 0.43 FALSE
96 The Cancer Genome Atlas Thyroid Carcinoma PM20D1 0.26 0.40 lasso 4 0.41 2.0e-42 -7.1 6.9 4.6e-12 0.60 0.00 1.00 FALSE
97 The Cancer Genome Atlas Thyroid Carcinoma RAB7L1 0.13 0.17 enet 15 0.21 3.6e-20 7.9 -8.0 1.3e-15 -0.81 0.00 1.00 FALSE
98 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma NUCKS1 0.11 0.02 blup 58 0.09 1.9e-03 5.9 7.5 4.3e-14 0.77 0.02 0.67 FALSE
99 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma PM20D1 0.19 0.09 lasso 4 0.12 4.2e-04 -7.2 6.2 7.4e-10 0.55 0.00 0.96 FALSE