Hub : Genes

ELK4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.0645 0.0284 0.0080 0.039 NA 0.056 NA 0.063 9.7e-05 NA 3.2e-06 NA 8.0e-07
2 TCGA Prostate Adenocarcinoma 0.0612 0.0270 0.0018 -0.001 0.023 -0.001 NA 0.003 4.7e-01 0.0018 4.7e-01 NA 1.3e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.5 0.7 0.9 -0.9 0.7
Bipolar Disorder or Schizophrenia 0.7 1.6 2.3 -1.0 1.5
Depressed Affect (Nagel 2018) 0.9 1.8 2.8 -1.7 0.9
Depression (Nagel 2018) 0.0 0.0 0.1 0.2 -0.3
Intelligence (Savage-Jansen 2018) 3.4 10.5 16.5 2.1 -4.1
Neuroticism (Nagel 2018) 0.6 1.5 1.7 -1.1 1.3
Schizophrenia (2018) 0.5 1.0 1.7 -0.5 1.3
Schizophrenia vs Biploar Disorder 0.6 0.8 0.9 0.9 0.8
Worry (Nagel 2018) 1.7 3.7 6.3 -1.0 2.5
Alzheimer’s Disease (in mother) 0.2 0.2 0.4 0.1 0.6
Alzheimer’s Disease (in father) 0.2 0.2 0.3 0.3 -0.6
Alzheimer’s Disease (including proxy) 0.1 0.2 0.3 0.5 -0.2
Crohns Disease (2017) 1.2 2.6 4.4 -0.9 2.1
Irritable Bowel Disease (IBD) 1.5 3.7 4.8 -1.6 2.2
Ulcerative Colitis (UC) 1.4 2.7 3.4 -1.4 1.8
Major Depression (MDD) 0.6 0.8 1.4 -1.2 0.4
Reaction Time 2.9 5.5 5.5 -2.3 2.3
Verbal and Numeric Reasoning (VNR) 2.1 5.1 9.9 0.5 -3.2
Breast Cancer 0.4 0.9 1.8 -1.4 -0.2
Ovarian Cancer 0.5 0.7 1.2 -1.1 0.4
Prostate Cancer 1.7 2.4 4.8 0.2 -2.2
Age at First Birth 0.1 0.1 0.2 -0.5 -0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 -0.1 0.2
Body Mass Index (BMI) (2010) 6.4 8.8 15.2 3.9 -1.5
Coronary Artery Disease (CAD) 0.3 0.4 0.6 -0.4 0.8
Crohns Disease (2012) 0.9 1.4 1.5 -1.1 1.2
Mean Putamen Volume 0.6 0.7 1.1 1.1 0.6
Fasting Glucose 0.8 0.9 1.7 -0.3 -1.3
HbA1C 1.7 1.9 3.9 2.0 0.1
HDL Cholesterol 3.0 5.1 6.0 -2.0 2.5
LDL Cholesterol 0.9 1.5 2.9 -1.7 -0.1
Lupus 0.4 0.6 0.9 -1.0 -0.5
Neuroticism (2016) 0.1 0.2 0.3 -0.6 0.2
Primary Biliary Cirrhosis 0.7 0.9 1.8 -0.3 1.3
Rheumatoid Arthritis 0.4 0.5 0.9 -0.2 1.0
Schizophrenia (2014) 0.4 0.9 1.3 -0.8 1.1
Triglycerides 0.3 0.4 0.7 0.4 -0.8
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.5 0.7 -0.3
Ulcerative Colitis 0.6 0.8 1.1 -1.1 0.8
Blood Eosinophil Count 0.4 2.7 4.8 -0.8 -2.2
Blood Platelet Count 0.2 2.7 5.4 0.2 -2.3
Blood Red Count 0.2 1.6 2.6 1.6 0.8
Blood White Count 0.4 2.7 5.4 -2.3 0.3
Heel T-Score 0.0 0.4 0.7 -0.3 -0.8
BMI 0.5 3.1 6.2 0.0 -2.5
Height 2.4 46.3 46.5 6.8 -6.8
Waist Hip Ratio (WHR) 0.0 0.2 0.4 0.2 0.6
Systolic Blood Pressure 0.2 1.2 2.4 -1.6 -0.3
Smoking Status 0.5 1.3 1.8 -1.4 0.9
Allergy or Eczema 0.1 0.2 0.4 0.6 0.3
Cardiovascular Disease 3.4 11.1 20.6 -4.5 1.2
Hypothyroidism (self reported) 0.3 0.6 1.2 -1.1 0.1
Respiratory disease 0.0 0.0 0.0 0.2 -0.0
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.2 -0.4 0.1
Lung FEV1/FVC ratio 2.3 11.5 17.6 2.4 -4.2
Lung FVC 0.1 0.7 1.4 0.1 1.2
Neuroticism 1.8 4.4 5.3 -2.3 1.9
Chronotype (morning person) 0.1 0.2 0.2 -0.4 0.5
Hair Pigment 0.6 16.7 19.0 -4.4 3.8
Tanning 0.0 0.6 1.0 -0.4 -1.0
Hand grip strength (left) 6.1 16.1 20.0 3.5 -4.5
Number of treatments/medications taken 5.2 9.3 12.4 -3.5 2.5
Average weekly spirits intake 0.1 0.1 0.1 0.1 0.4
Sensitivity / hurt feelings 1.4 2.4 4.3 -2.1 -0.8
Frequency of depressed mood in last 2 weeks 0.0 0.0 0.0 0.0 0.2
Hearing difficulty/problems: Yes 2.0 3.1 6.2 2.5 -0.2
Relative age of first facial hair 0.1 0.1 0.3 -0.2 0.5
Other serious medical condition/disability diagnosed by doctor 2.7 3.5 6.5 -0.7 2.5
Ever used hormone-replacement therapy (HRT) 2.1 2.6 3.8 -1.9 1.2
Ever had hysterectomy (womb removed) 0.4 0.5 0.9 -1.0 0.1
Systolic blood pressure, automated reading 0.5 1.6 2.9 -1.7 0.5
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.0 -0.2 0.2
Angina 1.4 1.9 2.8 -1.0 1.7
Medication for hormone replacement therapy 0.4 0.4 0.6 -0.8 -0.5
Vitamin and mineral supplements 1.2 1.6 3.1 0.2 -1.8
Supplements: Zinc 0.5 0.5 0.9 1.0 0.3
Medication: Co-codamol 0.5 0.6 0.8 -0.9 -0.7
Medication: Metformin 0.1 0.2 0.2 -0.4 0.4
Diabetes (father) 0.3 0.4 0.8 0.9 0.1
Diabetes (mother) 0.1 0.1 0.2 0.2 -0.4
Severe depression (siblings) 4.5 5.0 6.4 -1.9 2.5
Pack years adult smoking proportion 0.1 0.2 0.2 0.4 -0.5
Impedance of leg (right) 1.9 9.1 14.1 -2.0 3.8
Leg fat-free mass (left) 4.0 20.9 34.5 2.7 -5.9
Trunk fat percentage 0.2 0.7 1.4 -1.2 0.1
Hand grip strength (right) 7.4 20.2 24.7 4.0 -5.0
Townsend deprivation index at recruitment 0.3 0.4 0.7 -0.3 0.8
Current tobacco smoking 1.0 1.6 3.1 -1.8 0.1
Average weekly fortified wine intake 2.2 2.5 4.4 -2.1 0.8
Maternal smoking around birth 1.6 2.3 2.8 -1.7 -1.3
Fed-up feelings 0.2 0.3 0.4 -0.6 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.3 -0.6 -1.1
Relative age voice broke 0.0 0.0 0.0 0.0 0.0
Taking other prescription medications 1.6 2.5 3.1 -1.8 1.4
Age when periods started (menarche) 1.9 4.5 6.5 -2.6 1.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.6 -1.3 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.3 5.9 -0.8 -2.4
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 1.3 -0.9 -1.2
Qualifications: CSEs or equivalent 0.9 1.1 2.1 -0.4 1.4
Serious illness, injury or assault to yourself 4.8 5.8 11.1 -0.7 3.3
High blood pressure 3.6 9.9 15.6 -4.0 2.1
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.1 1.0 0.4
Multivitamins +/- minerals 3.5 4.5 8.9 -0.4 3.0
Stomach or abdominal pain in last month 0.7 0.9 1.8 -1.3 -0.2
Supplements: Glucosamine 1.8 2.3 4.5 -2.1 0.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.6 -0.7 -0.8
Medication: Atenolol 3.2 4.0 6.7 -2.6 1.1
Medication: Levothyroxine sodium 0.5 0.8 1.4 -1.2 0.4
Sitting height 4.8 34.4 48.7 4.5 -7.0
Chronic bronchitis/emphysema (father) 1.1 1.2 2.3 -1.5 0.4
High blood pressure (mother) 1.7 2.4 2.8 -1.7 1.4
Body mass index (BMI) 0.4 1.8 2.8 -1.0 -1.7
Impedance of leg (left) 1.8 8.6 14.5 -1.6 3.8
Leg predicted mass (left) 4.0 21.0 34.8 2.7 -5.9
Trunk fat mass 0.3 1.5 3.0 -0.1 -1.7
Waist circumference 0.5 1.8 3.2 0.6 -1.8
Number of incorrect matches in round 5.0 8.2 13.2 -1.8 3.6
Past tobacco smoking 0.7 1.2 1.8 0.8 -1.4
Alcohol usually taken with meals 0.3 0.5 0.5 0.7 0.7
Nervous feelings 0.4 0.8 1.0 -0.8 1.0
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 2.1 -1.2 1.4
Hearing difficulty/problems with background noise 2.2 3.6 5.0 2.2 -1.5
Hair/balding pattern: Pattern 2 2.4 3.1 5.2 2.3 -1.0
Had menopause 4.6 5.7 9.0 -1.5 3.0
Had other major operations 0.7 0.8 1.6 -1.3 0.1
Forced vital capacity (FVC) 1.5 5.7 8.5 2.9 -1.7
Heel bone mineral density (BMD) T-score, automated (right) 2.4 5.6 10.7 -0.7 -3.3
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.0 0.8 -1.0
Qualifications: None of the above 2.0 4.4 8.6 -2.9 0.3
Financial difficulties in last 2 years 0.8 1.1 2.2 -0.1 1.5
Mouth/teeth dental problems 1.5 2.3 4.1 2.0 -0.8
Heart attack 2.5 3.2 6.4 -2.5 -0.0
Allergy 0.2 0.4 0.6 -0.8 0.4
Pain all over the body in last month 0.7 0.8 0.9 0.9 -0.8
Diabetes (self-reported) 0.3 0.5 0.8 -0.5 0.9
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 2.5 1.2 -1.6
Medication: Ramipril 1.3 1.7 2.6 -1.6 0.9
Medication: Simvastatin 2.6 3.8 4.2 -2.0 1.9
Fluid intelligence score 1.4 2.8 5.3 0.5 -2.3
Illnesses of siblings 1.1 1.6 2.1 1.1 -1.4
Neuroticism score 2.2 4.6 5.3 -2.3 2.0
Weight 2.1 10.3 18.3 1.5 -4.3
Impedance of arm (right) 1.8 8.5 16.2 -0.9 4.0
Arm fat percentage (right) 0.2 0.8 1.6 -1.3 -0.1
Trunk fat-free mass 5.1 29.4 44.4 3.8 -6.7
Hip circumference 1.2 5.1 9.9 0.4 -3.1
Time employed in main current job 0.2 0.2 0.3 -0.4 -0.5
Alcohol intake versus 10 years previously 0.1 0.1 0.2 0.2 -0.4
Father’s age at death 0.4 0.5 0.8 0.9 -0.4
Worrier / anxious feelings 1.9 3.6 4.0 -2.0 1.8
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 3.2 -1.8 -0.7
Falls in the last year 0.4 0.5 0.6 0.7 -0.7
Hair/balding pattern: Pattern 3 0.8 1.2 1.3 -1.1 1.1
Number of live births 0.2 0.3 0.3 -0.5 0.6
Forced expiratory volume in 1-second (FEV1) 2.4 8.1 8.7 3.0 -2.7
Pulse rate 0.3 0.5 0.8 -0.5 -0.9
Happiness 0.6 0.8 1.5 0.2 -1.2
Noisy workplace 1.5 1.8 3.6 -0.1 1.9
Qualifications: A levels/AS levels or equivalent 0.9 1.9 2.8 1.7 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.4 0.4 0.6
Mouth/teeth dental problems: Dentures 1.4 2.3 4.4 -2.1 -0.5
Asthma 0.2 0.3 0.3 -0.5 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.2 -1.1 0.9
Medication: Cholesterol lowering 3.3 5.1 8.0 -2.8 1.5
Depression (self-reported) 0.8 1.0 1.4 -1.2 0.8
Medication: Lansoprazole 3.0 3.4 6.4 0.6 2.5
Prospective memory result 0.3 0.4 0.7 -0.4 0.8
Lung cancer (father) 0.8 0.9 0.9 -0.9 1.0
Illnesses of mother 0.1 0.2 0.2 0.4 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.5 4.7 6.8 2.6 -1.6
Pulse wave Arterial Stiffness index 2.1 2.5 4.3 -2.1 0.8
Impedance of arm (left) 1.4 6.5 12.6 -0.6 3.5
Arm fat mass (right) 0.7 2.8 5.7 -0.0 -2.4
Trunk predicted mass 5.3 30.1 45.7 3.8 -6.8
Standing height 3.4 34.2 39.2 5.4 -6.3
Length of working week for main job 1.1 1.3 1.6 1.3 -1.0
Exposure to tobacco smoke at home 0.6 0.7 1.3 -1.1 0.2
Breastfed as a baby 2.1 2.6 5.1 0.1 2.3
Tense / ‘highly strung’ 2.4 4.0 6.6 -1.2 2.6
Seen doctor (GP) for nerves, anxiety, tension or depression 2.2 3.3 3.4 -1.8 1.8
Hair/balding pattern: Pattern 4 0.3 0.8 0.8 -0.8 -0.9
Birth weight of first child 0.8 1.4 2.3 1.5 -0.7
Peak expiratory flow (PEF) 4.2 9.6 9.7 3.1 -3.1
Pulse wave reflection index 3.2 4.0 6.4 -1.3 2.5
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.5 -0.7 0.2
Loud music exposure frequency 1.2 1.3 2.6 1.6 -0.0
Qualifications: O levels/GCSEs or equivalent 3.3 5.3 8.5 2.9 -1.4
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.3 -0.2 1.1
Blood clot in the leg (DVT) 0.5 0.7 1.3 -0.1 -1.2
Medication: Paracetamol 2.2 3.6 4.3 -1.7 2.1
Headache pain in last month 1.1 1.9 3.4 -1.8 0.7
Medication for cholesterol, blood pressure or diabetes 2.9 4.7 7.2 2.7 -1.5
Glaucoma (self-reported) 3.4 4.0 7.0 -1.1 2.6
Gout (self-reported) 0.8 1.1 2.2 -0.1 1.5
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.1 -0.3 0.4
Medication: Amlodipine 3.1 4.3 7.1 -2.7 1.2
Medication: Ventolin 100micrograms inhaler 2.0 2.5 4.1 -2.0 1.0
Birth weight 3.7 8.1 14.7 3.8 -1.2
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.6 -1.2 -0.5
High blood pressure (siblings) 2.6 3.7 6.9 -2.6 0.8
Forced vital capacity (FVC), Best measure 1.4 5.2 9.1 3.0 -1.1
Body fat percentage 0.3 1.1 2.2 -1.5 0.1
Leg fat percentage (right) 0.6 2.3 4.3 -2.1 0.5
Arm fat-free mass (right) 4.5 23.2 37.8 2.9 -6.2
Exposure to tobacco smoke outside home 0.1 0.2 0.3 -0.1 -0.6
Comparative body size at age 10 1.9 5.4 9.2 1.2 -3.0
Number of full brothers 0.6 0.7 0.8 0.9 0.8
Worry too long after embarrassment 0.0 0.1 0.1 0.2 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.3 -1.2 0.2
Wheeze or whistling in the chest in last year 1.0 1.8 2.0 -1.4 1.3
Number of children fathered 0.2 0.2 0.3 -0.4 0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 2.1 -0.9 1.5
Age at first live birth 0.8 1.5 2.5 1.6 -0.7
Pulse wave peak to peak time 3.5 4.1 6.6 2.6 -1.3
Health satisfaction 2.4 3.1 3.5 -1.9 1.7
Shortness of breath walking on level ground 0.1 0.1 0.2 0.4 -0.2
Qualifications: College or University degree 1.6 5.0 9.9 3.1 -0.4
Eye problems/disorders: None of the above 1.2 1.3 2.1 0.7 -1.5
Mouth/teeth dental problems: Loose teeth 2.6 3.0 5.7 -2.4 -0.6
Emphysema/chronic bronchitis 0.0 0.0 0.0 0.2 -0.1
Medication for pain relief, constipation, heartburn 6.9 11.8 12.5 3.3 -3.5
Neck or shoulder pain in last month 1.2 1.7 3.3 0.4 -1.8
Medication: Blood pressure 2.4 4.2 6.1 -2.5 1.5
Angina (self-reported) 1.8 2.4 3.2 -1.2 1.8
Migraine (self-reported) 2.4 3.0 5.7 -2.4 0.6
Medication: Ibuprofen 0.3 0.3 0.6 -0.3 0.7
Medication: Allopurinol 0.8 1.0 1.4 0.8 1.2
Medication: Omeprazole 0.3 0.3 0.6 -0.8 0.2
Medication: Seretide 50 evohaler 0.4 0.5 1.0 0.1 -1.0
Mean time to correctly identify matches 1.7 3.3 4.5 -1.4 2.1
Heart disease (mother) 0.1 0.2 0.2 -0.4 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.2 -0.3 0.4
Whole body fat mass 0.5 2.1 4.1 -0.3 -2.0
Leg fat mass (right) 0.6 2.2 4.0 -0.6 -2.0
Arm predicted mass (right) 4.4 22.6 37.3 2.8 -6.1
Pulse rate, automated reading 0.9 2.9 4.3 1.2 -2.1
Alcohol intake frequency. 0.5 1.1 1.7 -0.7 -1.3
Comparative height size at age 10 5.1 27.8 30.4 5.0 -5.5
Number of full sisters 0.3 0.3 0.5 -0.4 0.7
Suffer from ‘nerves’ 0.4 0.7 1.3 0.2 1.1
Overall health rating 1.3 2.9 5.6 -2.4 0.4
Chest pain or discomfort 0.4 0.5 0.7 -0.6 -0.9
Had major operations 0.0 0.0 0.1 0.1 -0.2
Age at last live birth 2.7 3.9 5.7 2.4 -1.4
Family relationship satisfaction 0.1 0.1 0.2 -0.4 -0.3
Leg pain on walking 1.1 1.4 2.8 -1.7 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.3 -1.5 0.1
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.3 0.3 0.5
Illness, injury, bereavement, stress in last 2 years 1.8 2.1 3.7 -0.7 -1.9
Medication: Aspirin 5.3 7.0 7.3 -2.6 2.7
Supplements: Vitamin C 0.1 0.1 0.2 0.1 0.4
Knee pain experienced in last month 1.4 2.1 3.9 -2.0 0.6
Hypertension (Self-reported) 3.4 9.5 16.2 -4.0 1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 1.1 1.0 0.0
Illnesses of father: Heart disease 0.4 0.5 0.8 0.5 0.9
Illnesses of siblings: Diabetes 0.5 0.6 1.1 0.1 1.1
Smoking status: Previous 0.9 1.3 2.2 -0.6 1.5
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.4 4.5 2.1 -2.1
Whole body fat-free mass 5.0 28.5 45.0 3.5 -6.7
Leg fat-free mass (right) 4.2 22.7 35.3 3.2 -5.9
Arm fat percentage (left) 0.2 0.8 1.5 -1.2 -0.3
Average weekly red wine intake 3.8 5.6 9.9 -1.1 3.2
Handedness (chirality/laterality): Left-handed 1.0 1.1 1.3 -1.1 1.0
Mood swings 2.3 4.1 5.4 -2.3 1.7
Loneliness, isolation 0.4 0.5 1.1 -1.0 -0.0
Long-standing illness, disability or infirmity 1.0 1.5 1.9 -1.4 1.0
Ever had bowel cancer screening 0.1 0.1 0.1 -0.3 -0.3
Diabetes diagnosed by doctor 0.2 0.4 0.6 -0.4 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.6 0.8 -0.2
Friendships satisfaction 0.4 0.5 0.8 -0.9 -0.5
Qualifications: nursing, teaching 0.5 0.8 1.4 1.2 -0.4
Commuting to job workplace: Walk 0.1 0.1 0.3 0.0 0.5
Eye problems/disorders: Cataract 0.3 0.4 0.8 0.0 0.9
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.7 -0.8 0.3
Medication for cholesterol 2.4 3.6 7.2 2.7 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 1.7 1.3 -0.7
Back pain experienced in last month 0.7 1.1 2.1 -0.1 -1.5
Mineral and other dietary supplements 1.8 2.4 3.6 1.1 -1.9
Breast cancer (self-reported) 1.2 1.4 1.6 1.1 1.3
Asthma (self-reported) 0.0 0.1 0.1 -0.3 -0.3
Osteoporosis (self-reported) 1.9 2.4 3.9 2.0 0.9
Osteoarthritis (self-reported) 4.1 5.4 8.9 -3.0 -1.4
Medication: Aspirin 5.7 7.4 9.1 -3.0 2.4
Medication: Gliclazide 1.6 1.9 2.0 -1.3 1.4
Illnesses of father: None of the above (group 1) 0.5 0.7 1.3 -0.1 -1.2
Smoking status: Current 0.7 1.0 2.1 -1.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 0.8 0.9 0.6
Whole body water mass 4.9 27.9 44.8 3.3 -6.7
Leg predicted mass (right) 4.3 22.8 36.0 3.1 -6.0
Arm fat mass (left) 0.6 2.5 5.0 -0.0 -2.2
Number of self-reported non-cancer illnesses 2.1 3.6 5.5 -2.3 1.3
Average weekly champagne plus white wine intake 1.1 1.5 3.0 1.7 0.2
Miserableness 1.4 2.4 2.5 -1.6 1.5
Guilty feelings 0.2 0.3 0.4 -0.6 -0.5
Wears glasses or contact lenses 1.2 1.3 1.6 1.0 1.3
Ever taken oral contraceptive pill 2.3 2.5 2.8 -1.5 1.7
Hearing aid user 0.4 0.4 0.8 -0.9 0.2
Mother’s age at death 4.9 6.2 8.2 2.9 -2.0
Financial situation satisfaction 0.6 0.8 1.3 1.1 -0.5
Tinnitus: Yes, now most or all of the time 2.1 2.5 4.4 0.7 -2.1
Commuting to job workplace: Public transport 0.1 0.2 0.2 0.4 0.3
Eye problems/disorders: Glaucoma 3.4 4.0 7.3 -0.8 2.7
Medication: Blood pressure 1.7 3.2 5.7 -2.4 0.9
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.8 -1.7 -0.4
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.3 -0.3 1.1
High cholesterol (Self-reported) 3.6 6.4 12.1 -3.5 0.8
Medication: Bendroflumethiazide 3.1 4.6 8.8 -3.0 0.7
Medication: Paracetamol 2.1 3.3 4.9 -1.3 2.2
Medication: Lisinopril 0.1 0.1 0.2 -0.1 -0.4
Medication: Atorvastatin 0.7 0.8 1.3 -1.1 0.6
Illnesses of father: High blood pressure 1.1 1.3 2.2 -0.7 -1.5
Alcohol drinker status: Never 0.0 0.1 0.1 -0.2 -0.3
Ever smoked 1.2 2.0 4.0 -0.1 2.0
Basal metabolic rate 4.4 24.4 39.9 3.0 -6.3
Leg fat percentage (left) 0.5 1.8 3.4 -1.8 0.5
Arm fat-free mass (left) 4.0 20.3 33.4 2.7 -5.8
Number of operations (self-reported) 1.2 1.7 3.5 -1.9 0.2
Average weekly beer plus cider intake 1.6 2.3 2.3 -1.5 1.5
Irritability 2.7 4.5 7.7 -2.8 1.2
Risk taking 1.0 1.4 1.9 -1.4 0.9
Ever had prostate specific antigen (PSA) test 5.2 6.0 10.4 1.3 -3.2
Fractured/broken bones in last 5 years 0.8 1.0 2.0 0.2 -1.4
Age started oral contraceptive pill 3.4 4.2 8.1 -0.6 2.9
Diastolic blood pressure, automated reading 0.1 0.2 0.4 -0.6 -0.2
Ever depressed for a whole week 0.3 0.3 0.5 -0.4 -0.7
Unable to work because of sickness or disability 0.7 0.9 1.3 -1.1 0.8
Commuting to job workplace: Cycle 1.2 1.4 2.6 -1.6 0.5
Myopia 0.5 0.7 0.9 1.0 0.6
Vascular/heart problems diagnosed by doctor 4.3 11.6 17.2 4.2 -2.4
Cholesterol lowering medication 1.1 1.6 2.6 -1.6 0.9
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.2 -0.3 -0.4
Pain experienced in last month 1.0 1.7 3.2 1.8 0.4
Supplements: Calcium 0.2 0.2 0.3 -0.6 0.4
Basal cell carcinoma (self-reported) 1.0 1.2 2.3 0.1 1.5
Heart attack/myocardial infarction (self-reported) 1.8 2.3 4.6 -2.1 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.1 0.0 -1.1
Heart disease (siblings) 0.2 0.2 0.4 -0.0 0.6
Alcohol drinker status: Previous 0.8 1.0 1.5 -1.2 0.7
Pack years of smoking 0.2 0.3 0.5 0.4 -0.7
Impedance of whole body 1.9 9.8 18.1 -1.2 4.2
Leg fat mass (left) 0.5 2.1 3.9 -0.5 -2.0
Arm predicted mass (left) 3.9 19.6 32.8 2.5 -5.7