TWAS hub - ELK4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0645	0.0284	0.0080	0.039	NA	0.056	NA	0.063	9.7e-05	NA	3.2e-06	NA	8.0e-07
2	TCGA	Prostate Adenocarcinoma	0.0612	0.0270	0.0018	-0.001	0.023	-0.001	NA	0.003	4.7e-01	0.0018	4.7e-01	NA	1.3e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hand grip strength (right)	7.4	20.2	24.7	4.0	-5.0
Medication for pain relief, constipation, heartburn	6.9	11.8	12.5	3.3	-3.5
Body Mass Index (BMI) (2010)	6.4	8.8	15.2	3.9	-1.5
Hand grip strength (left)	6.1	16.1	20.0	3.5	-4.5
Medication: Aspirin	5.7	7.4	9.1	-3.0	2.4
Trunk predicted mass	5.3	30.1	45.7	3.8	-6.8
Medication: Aspirin	5.3	7.0	7.3	-2.6	2.7
Number of treatments/medications taken	5.2	9.3	12.4	-3.5	2.5
Ever had prostate specific antigen (PSA) test	5.2	6.0	10.4	1.3	-3.2
Trunk fat-free mass	5.1	29.4	44.4	3.8	-6.7
Comparative height size at age 10	5.1	27.8	30.4	5.0	-5.5
Number of incorrect matches in round	5.0	8.2	13.2	-1.8	3.6
Whole body fat-free mass	5.0	28.5	45.0	3.5	-6.7
Whole body water mass	4.9	27.9	44.8	3.3	-6.7
Mother’s age at death	4.9	6.2	8.2	2.9	-2.0
Serious illness, injury or assault to yourself	4.8	5.8	11.1	-0.7	3.3
Sitting height	4.8	34.4	48.7	4.5	-7.0
Had menopause	4.6	5.7	9.0	-1.5	3.0
Severe depression (siblings)	4.5	5.0	6.4	-1.9	2.5
Arm fat-free mass (right)	4.5	23.2	37.8	2.9	-6.2
Arm predicted mass (right)	4.4	22.6	37.3	2.8	-6.1
Basal metabolic rate	4.4	24.4	39.9	3.0	-6.3
Leg predicted mass (right)	4.3	22.8	36.0	3.1	-6.0
Vascular/heart problems diagnosed by doctor	4.3	11.6	17.2	4.2	-2.4
Peak expiratory flow (PEF)	4.2	9.6	9.7	3.1	-3.1
Leg fat-free mass (right)	4.2	22.7	35.3	3.2	-5.9
Osteoarthritis (self-reported)	4.1	5.4	8.9	-3.0	-1.4
Leg fat-free mass (left)	4.0	20.9	34.5	2.7	-5.9
Leg predicted mass (left)	4.0	21.0	34.8	2.7	-5.9
Arm fat-free mass (left)	4.0	20.3	33.4	2.7	-5.8
Arm predicted mass (left)	3.9	19.6	32.8	2.5	-5.7
Average weekly red wine intake	3.8	5.6	9.9	-1.1	3.2
Birth weight	3.7	8.1	14.7	3.8	-1.2
High blood pressure	3.6	9.9	15.6	-4.0	2.1
High cholesterol (Self-reported)	3.6	6.4	12.1	-3.5	0.8
Multivitamins +/- minerals	3.5	4.5	8.9	-0.4	3.0
Pulse wave peak to peak time	3.5	4.1	6.6	2.6	-1.3
Intelligence (Savage-Jansen 2018)	3.4	10.5	16.5	2.1	-4.1
Cardiovascular Disease	3.4	11.1	20.6	-4.5	1.2
Standing height	3.4	34.2	39.2	5.4	-6.3
Glaucoma (self-reported)	3.4	4.0	7.0	-1.1	2.6
Hypertension (Self-reported)	3.4	9.5	16.2	-4.0	1.7
Eye problems/disorders: Glaucoma	3.4	4.0	7.3	-0.8	2.7
Age started oral contraceptive pill	3.4	4.2	8.1	-0.6	2.9
Medication: Cholesterol lowering	3.3	5.1	8.0	-2.8	1.5
Qualifications: O levels/GCSEs or equivalent	3.3	5.3	8.5	2.9	-1.4
Medication: Atenolol	3.2	4.0	6.7	-2.6	1.1
Pulse wave reflection index	3.2	4.0	6.4	-1.3	2.5
Medication: Amlodipine	3.1	4.3	7.1	-2.7	1.2
Medication: Bendroflumethiazide	3.1	4.6	8.8	-3.0	0.7
HDL Cholesterol	3.0	5.1	6.0	-2.0	2.5
Medication: Lansoprazole	3.0	3.4	6.4	0.6	2.5
Reaction Time	2.9	5.5	5.5	-2.3	2.3
Medication for cholesterol, blood pressure or diabetes	2.9	4.7	7.2	2.7	-1.5
Other serious medical condition/disability diagnosed by doctor	2.7	3.5	6.5	-0.7	2.5
Age at last live birth	2.7	3.9	5.7	2.4	-1.4
Irritability	2.7	4.5	7.7	-2.8	1.2
Medication: Simvastatin	2.6	3.8	4.2	-2.0	1.9
High blood pressure (siblings)	2.6	3.7	6.9	-2.6	0.8
Mouth/teeth dental problems: Loose teeth	2.6	3.0	5.7	-2.4	-0.6
Heart attack	2.5	3.2	6.4	-2.5	-0.0
Height	2.4	46.3	46.5	6.8	-6.8
Hair/balding pattern: Pattern 2	2.4	3.1	5.2	2.3	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.6	10.7	-0.7	-3.3
Forced expiratory volume in 1-second (FEV1)	2.4	8.1	8.7	3.0	-2.7
Tense / ‘highly strung’	2.4	4.0	6.6	-1.2	2.6
Health satisfaction	2.4	3.1	3.5	-1.9	1.7
Medication: Blood pressure	2.4	4.2	6.1	-2.5	1.5
Migraine (self-reported)	2.4	3.0	5.7	-2.4	0.6
Medication for cholesterol	2.4	3.6	7.2	2.7	-0.2
Lung FEV1/FVC ratio	2.3	11.5	17.6	2.4	-4.2
Mood swings	2.3	4.1	5.4	-2.3	1.7
Ever taken oral contraceptive pill	2.3	2.5	2.8	-1.5	1.7
Average weekly fortified wine intake	2.2	2.5	4.4	-2.1	0.8
Hearing difficulty/problems with background noise	2.2	3.6	5.0	2.2	-1.5
Neuroticism score	2.2	4.6	5.3	-2.3	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.3	3.4	-1.8	1.8
Medication: Paracetamol	2.2	3.6	4.3	-1.7	2.1
Verbal and Numeric Reasoning (VNR)	2.1	5.1	9.9	0.5	-3.2
Ever used hormone-replacement therapy (HRT)	2.1	2.6	3.8	-1.9	1.2
Weight	2.1	10.3	18.3	1.5	-4.3
Pulse wave Arterial Stiffness index	2.1	2.5	4.3	-2.1	0.8
Breastfed as a baby	2.1	2.6	5.1	0.1	2.3
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	4.5	2.1	-2.1
Number of self-reported non-cancer illnesses	2.1	3.6	5.5	-2.3	1.3
Tinnitus: Yes, now most or all of the time	2.1	2.5	4.4	0.7	-2.1
Medication: Paracetamol	2.1	3.3	4.9	-1.3	2.2
Hearing difficulty/problems: Yes	2.0	3.1	6.2	2.5	-0.2
Qualifications: None of the above	2.0	4.4	8.6	-2.9	0.3
Medication: Ventolin 100micrograms inhaler	2.0	2.5	4.1	-2.0	1.0
Impedance of leg (right)	1.9	9.1	14.1	-2.0	3.8
Age when periods started (menarche)	1.9	4.5	6.5	-2.6	1.6
Worrier / anxious feelings	1.9	3.6	4.0	-2.0	1.8
Comparative body size at age 10	1.9	5.4	9.2	1.2	-3.0
Osteoporosis (self-reported)	1.9	2.4	3.9	2.0	0.9
Impedance of whole body	1.9	9.8	18.1	-1.2	4.2
Neuroticism	1.8	4.4	5.3	-2.3	1.9
Supplements: Glucosamine	1.8	2.3	4.5	-2.1	0.4
Impedance of leg (left)	1.8	8.6	14.5	-1.6	3.8
Impedance of arm (right)	1.8	8.5	16.2	-0.9	4.0
Angina (self-reported)	1.8	2.4	3.2	-1.2	1.8
Illness, injury, bereavement, stress in last 2 years	1.8	2.1	3.7	-0.7	-1.9
Mineral and other dietary supplements	1.8	2.4	3.6	1.1	-1.9
Heart attack/myocardial infarction (self-reported)	1.8	2.3	4.6	-2.1	-0.1
Worry (Nagel 2018)	1.7	3.7	6.3	-1.0	2.5
Prostate Cancer	1.7	2.4	4.8	0.2	-2.2
HbA1C	1.7	1.9	3.9	2.0	0.1
High blood pressure (mother)	1.7	2.4	2.8	-1.7	1.4
Mean time to correctly identify matches	1.7	3.3	4.5	-1.4	2.1
Medication: Blood pressure	1.7	3.2	5.7	-2.4	0.9
Maternal smoking around birth	1.6	2.3	2.8	-1.7	-1.3
Taking other prescription medications	1.6	2.5	3.1	-1.8	1.4
Qualifications: College or University degree	1.6	5.0	9.9	3.1	-0.4
Medication: Gliclazide	1.6	1.9	2.0	-1.3	1.4
Average weekly beer plus cider intake	1.6	2.3	2.3	-1.5	1.5
Irritable Bowel Disease (IBD)	1.5	3.7	4.8	-1.6	2.2
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	5.9	-0.8	-2.4
Forced vital capacity (FVC)	1.5	5.7	8.5	2.9	-1.7
Mouth/teeth dental problems	1.5	2.3	4.1	2.0	-0.8
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	2.5	1.2	-1.6
Noisy workplace	1.5	1.8	3.6	-0.1	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	6.8	2.6	-1.6
Ulcerative Colitis (UC)	1.4	2.7	3.4	-1.4	1.8
Sensitivity / hurt feelings	1.4	2.4	4.3	-2.1	-0.8
Angina	1.4	1.9	2.8	-1.0	1.7
Fluid intelligence score	1.4	2.8	5.3	0.5	-2.3
Mouth/teeth dental problems: Dentures	1.4	2.3	4.4	-2.1	-0.5
Impedance of arm (left)	1.4	6.5	12.6	-0.6	3.5
Forced vital capacity (FVC), Best measure	1.4	5.2	9.1	3.0	-1.1
Knee pain experienced in last month	1.4	2.1	3.9	-2.0	0.6
Miserableness	1.4	2.4	2.5	-1.6	1.5
Medication: Ramipril	1.3	1.7	2.6	-1.6	0.9
Overall health rating	1.3	2.9	5.6	-2.4	0.4
Crohns Disease (2017)	1.2	2.6	4.4	-0.9	2.1
Vitamin and mineral supplements	1.2	1.6	3.1	0.2	-1.8
Hip circumference	1.2	5.1	9.9	0.4	-3.1
Loud music exposure frequency	1.2	1.3	2.6	1.6	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.1	-0.9	1.5
Eye problems/disorders: None of the above	1.2	1.3	2.1	0.7	-1.5
Neck or shoulder pain in last month	1.2	1.7	3.3	0.4	-1.8
Breast cancer (self-reported)	1.2	1.4	1.6	1.1	1.3
Wears glasses or contact lenses	1.2	1.3	1.6	1.0	1.3
Ever smoked	1.2	2.0	4.0	-0.1	2.0
Number of operations (self-reported)	1.2	1.7	3.5	-1.9	0.2
Commuting to job workplace: Cycle	1.2	1.4	2.6	-1.6	0.5
Chronic bronchitis/emphysema (father)	1.1	1.2	2.3	-1.5	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	2.1	-1.2	1.4
Illnesses of siblings	1.1	1.6	2.1	1.1	-1.4
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	3.2	-1.8	-0.7
Length of working week for main job	1.1	1.3	1.6	1.3	-1.0
Headache pain in last month	1.1	1.9	3.4	-1.8	0.7
Leg pain on walking	1.1	1.4	2.8	-1.7	-0.2
Average weekly champagne plus white wine intake	1.1	1.5	3.0	1.7	0.2
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.8	-1.7	-0.4
Illnesses of father: High blood pressure	1.1	1.3	2.2	-0.7	-1.5
Cholesterol lowering medication	1.1	1.6	2.6	-1.6	0.9
Current tobacco smoking	1.0	1.6	3.1	-1.8	0.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	1.3	-0.9	-1.2
Wheeze or whistling in the chest in last year	1.0	1.8	2.0	-1.4	1.3
Handedness (chirality/laterality): Left-handed	1.0	1.1	1.3	-1.1	1.0
Long-standing illness, disability or infirmity	1.0	1.5	1.9	-1.4	1.0
Risk taking	1.0	1.4	1.9	-1.4	0.9
Pain experienced in last month	1.0	1.7	3.2	1.8	0.4
Basal cell carcinoma (self-reported)	1.0	1.2	2.3	0.1	1.5
Depressed Affect (Nagel 2018)	0.9	1.8	2.8	-1.7	0.9
Crohns Disease (2012)	0.9	1.4	1.5	-1.1	1.2
LDL Cholesterol	0.9	1.5	2.9	-1.7	-0.1
Qualifications: CSEs or equivalent	0.9	1.1	2.1	-0.4	1.4
Qualifications: A levels/AS levels or equivalent	0.9	1.9	2.8	1.7	-1.0
Pulse rate, automated reading	0.9	2.9	4.3	1.2	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.3	-1.5	0.1
Smoking status: Previous	0.9	1.3	2.2	-0.6	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.7	1.3	-0.7
Fasting Glucose	0.8	0.9	1.7	-0.3	-1.3
Financial difficulties in last 2 years	0.8	1.1	2.2	-0.1	1.5
Hair/balding pattern: Pattern 3	0.8	1.2	1.3	-1.1	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.2	-1.1	0.9
Depression (self-reported)	0.8	1.0	1.4	-1.2	0.8
Lung cancer (father)	0.8	0.9	0.9	-0.9	1.0
Birth weight of first child	0.8	1.4	2.3	1.5	-0.7
Gout (self-reported)	0.8	1.1	2.2	-0.1	1.5
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.6	-1.2	-0.5
Age at first live birth	0.8	1.5	2.5	1.6	-0.7
Medication: Allopurinol	0.8	1.0	1.4	0.8	1.2
Fractured/broken bones in last 5 years	0.8	1.0	2.0	0.2	-1.4
Alcohol drinker status: Previous	0.8	1.0	1.5	-1.2	0.7
Bipolar Disorder or Schizophrenia	0.7	1.6	2.3	-1.0	1.5
Primary Biliary Cirrhosis	0.7	0.9	1.8	-0.3	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.3	-0.6	-1.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.6	-1.3	-0.2
Stomach or abdominal pain in last month	0.7	0.9	1.8	-1.3	-0.2
Past tobacco smoking	0.7	1.2	1.8	0.8	-1.4
Had other major operations	0.7	0.8	1.6	-1.3	0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.0	0.8	-1.0
Pain all over the body in last month	0.7	0.8	0.9	0.9	-0.8
Arm fat mass (right)	0.7	2.8	5.7	-0.0	-2.4
Back pain experienced in last month	0.7	1.1	2.1	-0.1	-1.5
Smoking status: Current	0.7	1.0	2.1	-1.4	-0.1
Medication: Atorvastatin	0.7	0.8	1.3	-1.1	0.6
Unable to work because of sickness or disability	0.7	0.9	1.3	-1.1	0.8
Neuroticism (Nagel 2018)	0.6	1.5	1.7	-1.1	1.3
Schizophrenia vs Biploar Disorder	0.6	0.8	0.9	0.9	0.8
Major Depression (MDD)	0.6	0.8	1.4	-1.2	0.4
Mean Putamen Volume	0.6	0.7	1.1	1.1	0.6
Ulcerative Colitis	0.6	0.8	1.1	-1.1	0.8
Hair Pigment	0.6	16.7	19.0	-4.4	3.8
Happiness	0.6	0.8	1.5	0.2	-1.2
Exposure to tobacco smoke at home	0.6	0.7	1.3	-1.1	0.2
Leg fat percentage (right)	0.6	2.3	4.3	-2.1	0.5
Number of full brothers	0.6	0.7	0.8	0.9	0.8
Leg fat mass (right)	0.6	2.2	4.0	-0.6	-2.0
Arm fat mass (left)	0.6	2.5	5.0	-0.0	-2.2
Financial situation satisfaction	0.6	0.8	1.3	1.1	-0.5
Bipolar Disorder (2018)	0.5	0.7	0.9	-0.9	0.7
Schizophrenia (2018)	0.5	1.0	1.7	-0.5	1.3
Ovarian Cancer	0.5	0.7	1.2	-1.1	0.4
BMI	0.5	3.1	6.2	0.0	-2.5
Smoking Status	0.5	1.3	1.8	-1.4	0.9
Systolic blood pressure, automated reading	0.5	1.6	2.9	-1.7	0.5
Supplements: Zinc	0.5	0.5	0.9	1.0	0.3
Medication: Co-codamol	0.5	0.6	0.8	-0.9	-0.7
Medication: Levothyroxine sodium	0.5	0.8	1.4	-1.2	0.4
Waist circumference	0.5	1.8	3.2	0.6	-1.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.3	-0.2	1.1
Blood clot in the leg (DVT)	0.5	0.7	1.3	-0.1	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.3	-1.2	0.2
Whole body fat mass	0.5	2.1	4.1	-0.3	-2.0
Alcohol intake frequency.	0.5	1.1	1.7	-0.7	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.1	1.0	0.0
Illnesses of siblings: Diabetes	0.5	0.6	1.1	0.1	1.1
Qualifications: nursing, teaching	0.5	0.8	1.4	1.2	-0.4
Illnesses of father: None of the above (group 1)	0.5	0.7	1.3	-0.1	-1.2
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.3	-0.3	1.1
Leg fat percentage (left)	0.5	1.8	3.4	-1.8	0.5
Myopia	0.5	0.7	0.9	1.0	0.6
Leg fat mass (left)	0.5	2.1	3.9	-0.5	-2.0
Breast Cancer	0.4	0.9	1.8	-1.4	-0.2
Lupus	0.4	0.6	0.9	-1.0	-0.5
Rheumatoid Arthritis	0.4	0.5	0.9	-0.2	1.0
Schizophrenia (2014)	0.4	0.9	1.3	-0.8	1.1
Blood Eosinophil Count	0.4	2.7	4.8	-0.8	-2.2
Blood White Count	0.4	2.7	5.4	-2.3	0.3
Ever had hysterectomy (womb removed)	0.4	0.5	0.9	-1.0	0.1
Medication for hormone replacement therapy	0.4	0.4	0.6	-0.8	-0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.6	-0.7	-0.8
Body mass index (BMI)	0.4	1.8	2.8	-1.0	-1.7
Nervous feelings	0.4	0.8	1.0	-0.8	1.0
Father’s age at death	0.4	0.5	0.8	0.9	-0.4
Falls in the last year	0.4	0.5	0.6	0.7	-0.7
Medication: Seretide 50 evohaler	0.4	0.5	1.0	0.1	-1.0
Suffer from ‘nerves’	0.4	0.7	1.3	0.2	1.1
Chest pain or discomfort	0.4	0.5	0.7	-0.6	-0.9
Illnesses of father: Heart disease	0.4	0.5	0.8	0.5	0.9
Loneliness, isolation	0.4	0.5	1.1	-1.0	-0.0
Friendships satisfaction	0.4	0.5	0.8	-0.9	-0.5
Hearing aid user	0.4	0.4	0.8	-0.9	0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.1	0.0	-1.1
Coronary Artery Disease (CAD)	0.3	0.4	0.6	-0.4	0.8
Triglycerides	0.3	0.4	0.7	0.4	-0.8
Hypothyroidism (self reported)	0.3	0.6	1.2	-1.1	0.1
Diabetes (father)	0.3	0.4	0.8	0.9	0.1
Townsend deprivation index at recruitment	0.3	0.4	0.7	-0.3	0.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	1.0	0.4
Trunk fat mass	0.3	1.5	3.0	-0.1	-1.7
Alcohol usually taken with meals	0.3	0.5	0.5	0.7	0.7
Diabetes (self-reported)	0.3	0.5	0.8	-0.5	0.9
Pulse rate	0.3	0.5	0.8	-0.5	-0.9
Prospective memory result	0.3	0.4	0.7	-0.4	0.8
Hair/balding pattern: Pattern 4	0.3	0.8	0.8	-0.8	-0.9
Body fat percentage	0.3	1.1	2.2	-1.5	0.1
Medication: Ibuprofen	0.3	0.3	0.6	-0.3	0.7
Medication: Omeprazole	0.3	0.3	0.6	-0.8	0.2
Number of full sisters	0.3	0.3	0.5	-0.4	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	0.8	-0.2
Eye problems/disorders: Cataract	0.3	0.4	0.8	0.0	0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.7	-0.8	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.8	0.9	0.6
Ever depressed for a whole week	0.3	0.3	0.5	-0.4	-0.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.1	0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.3	0.3	-0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.5	0.7	-0.3
Blood Platelet Count	0.2	2.7	5.4	0.2	-2.3
Blood Red Count	0.2	1.6	2.6	1.6	0.8
Systolic Blood Pressure	0.2	1.2	2.4	-1.6	-0.3
Trunk fat percentage	0.2	0.7	1.4	-1.2	0.1
Fed-up feelings	0.2	0.3	0.4	-0.6	-0.5
Allergy	0.2	0.4	0.6	-0.8	0.4
Arm fat percentage (right)	0.2	0.8	1.6	-1.3	-0.1
Time employed in main current job	0.2	0.2	0.3	-0.4	-0.5
Number of live births	0.2	0.3	0.3	-0.5	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.4	0.4	0.6
Asthma	0.2	0.3	0.3	-0.5	-0.6
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	-0.7	0.2
Number of children fathered	0.2	0.2	0.3	-0.4	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.3	0.3	0.5
Arm fat percentage (left)	0.2	0.8	1.5	-1.2	-0.3
Diabetes diagnosed by doctor	0.2	0.4	0.6	-0.4	0.8
Guilty feelings	0.2	0.3	0.4	-0.6	-0.5
Supplements: Calcium	0.2	0.2	0.3	-0.6	0.4
Heart disease (siblings)	0.2	0.2	0.4	-0.0	0.6
Pack years of smoking	0.2	0.3	0.5	0.4	-0.7
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	0.5	-0.2
Age at First Birth	0.1	0.1	0.2	-0.5	-0.3
Neuroticism (2016)	0.1	0.2	0.3	-0.6	0.2
Allergy or Eczema	0.1	0.2	0.4	0.6	0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.4	0.1
Lung FVC	0.1	0.7	1.4	0.1	1.2
Chronotype (morning person)	0.1	0.2	0.2	-0.4	0.5
Average weekly spirits intake	0.1	0.1	0.1	0.1	0.4
Relative age of first facial hair	0.1	0.1	0.3	-0.2	0.5
Medication: Metformin	0.1	0.2	0.2	-0.4	0.4
Diabetes (mother)	0.1	0.1	0.2	0.2	-0.4
Pack years adult smoking proportion	0.1	0.2	0.2	0.4	-0.5
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.2	-0.4
Illnesses of mother	0.1	0.2	0.2	0.4	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.1	-0.3	0.4
Exposure to tobacco smoke outside home	0.1	0.2	0.3	-0.1	-0.6
Shortness of breath walking on level ground	0.1	0.1	0.2	0.4	-0.2
Heart disease (mother)	0.1	0.2	0.2	-0.4	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.2	-0.3	0.4
Family relationship satisfaction	0.1	0.1	0.2	-0.4	-0.3
Supplements: Vitamin C	0.1	0.1	0.2	0.1	0.4
Ever had bowel cancer screening	0.1	0.1	0.1	-0.3	-0.3
Commuting to job workplace: Walk	0.1	0.1	0.3	0.0	0.5
Commuting to job workplace: Public transport	0.1	0.2	0.2	0.4	0.3
Medication: Lisinopril	0.1	0.1	0.2	-0.1	-0.4
Diastolic blood pressure, automated reading	0.1	0.2	0.4	-0.6	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.2	-0.3	-0.4
Depression (Nagel 2018)	0.0	0.0	0.1	0.2	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	-0.1	0.2
Heel T-Score	0.0	0.4	0.7	-0.3	-0.8
Waist Hip Ratio (WHR)	0.0	0.2	0.4	0.2	0.6
Respiratory disease	0.0	0.0	0.0	0.2	-0.0
Tanning	0.0	0.6	1.0	-0.4	-1.0
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	0.0	0.2
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.2	0.2
Relative age voice broke	0.0	0.0	0.0	0.0	0.0
Worry too long after embarrassment	0.0	0.1	0.1	0.2	0.3
Emphysema/chronic bronchitis	0.0	0.0	0.0	0.2	-0.1
Had major operations	0.0	0.0	0.1	0.1	-0.2
Asthma (self-reported)	0.0	0.1	0.1	-0.3	-0.3
Alcohol drinker status: Never	0.0	0.1	0.1	-0.2	-0.3

Hub : Genes

ELK4

Models

Trait associations