Best TWAS P=1.14e-13 · Best GWAS P=6.3e-20 conditioned to 3.23e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FAM53C | 0.05 | 0.02 | bslmm | 291 | 0.03 | 4.1e-04 | 7.5 | 5.6 | 2.7e-08 | -0.06 | 0.02 | 0.96 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PCDHA2 | 0.04 | 0.03 | blup | 478 | 0.03 | 5.0e-05 | -4.8 | -5.2 | 2.6e-07 | -0.05 | 0.05 | 0.94 | FALSE |
| 3 | GTEx | Colon Transverse | TMCO6 | 0.15 | 0.06 | enet | 16 | 0.05 | 1.4e-03 | 4.4 | -5.2 | 1.6e-07 | -0.07 | 0.13 | 0.54 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | DNAJC18 | 0.17 | 0.01 | lasso | 10 | 0.04 | 2.0e-02 | 3.1 | 6.8 | 1.2e-11 | 0.77 | 0.03 | 0.85 | FALSE |
| 5 | GTEx | Esophagus Mucosa | TMEM173 | 0.10 | 0.03 | enet | 20 | 0.10 | 1.8e-07 | 9.1 | -6.3 | 2.1e-10 | -0.60 | 0.01 | 0.97 | FALSE |
| 6 | GTEx | Nerve Tibial | HARS | 0.07 | 0.01 | enet | 16 | 0.04 | 1.1e-03 | -4.6 | 5.6 | 2.6e-08 | -0.03 | 0.06 | 0.89 | TRUE |
| 7 | GTEx | Skin Sun Exposed Lower leg | WDR55 | 0.04 | 0.01 | enet | 10 | 0.01 | 2.8e-02 | -4.7 | -5.5 | 3.9e-08 | -0.02 | 0.04 | 0.90 | FALSE |
| 8 | GTEx | Vagina | PURA | 0.52 | 0.05 | enet | 51 | 0.09 | 3.6e-03 | 5.8 | -6.3 | 2.4e-10 | -0.44 | 0.06 | 0.10 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | WNT8A | 0.05 | 0.01 | blup | 300 | 0.03 | 1.0e-04 | -1.6 | -6.6 | 3.9e-11 | 0.05 | 0.08 | 0.88 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | FAM53C | 0.13 | 0.06 | lasso | 4 | 0.05 | 4.6e-07 | 6.0 | 6.0 | 2.2e-09 | 0.05 | 0.99 | 0.00 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | KDM3B | 0.07 | 0.01 | blup | 307 | 0.03 | 1.0e-04 | 6.0 | -6.1 | 1.1e-09 | -0.03 | 0.06 | 0.90 | FALSE |
| 12 | YFS | Blood | CXXC5 | 0.01 | 0.00 | bslmm | 244 | 0.01 | 2.6e-03 | 9.1 | -6.6 | 3.5e-11 | -0.67 | 0.00 | 0.95 | FALSE |
| 13 | YFS | Blood | TMCO6 | 0.01 | 0.00 | blup | 329 | 0.01 | 4.1e-03 | -4.4 | -5.2 | 2.2e-07 | -0.03 | 0.06 | 0.91 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | WDR55 | 0.10 | 0.03 | enet | 8 | 0.04 | 3.3e-09 | -4.8 | -5.2 | 2.1e-07 | 0.01 | 0.02 | 0.97 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | UBE2D2 | 0.05 | 0.02 | enet | 6 | 0.03 | 4.4e-04 | 4.7 | 7.4 | 1.1e-13 | 0.76 | 0.01 | 0.97 | TRUE |
| 16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | BRD8 | 0.12 | 0.07 | lasso | 4 | 0.05 | 1.2e-03 | 6.9 | -6.7 | 2.6e-11 | 0.03 | 0.00 | 0.98 | TRUE |