[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr5:136,723,696-141,087,689

Best TWAS P=1.14e-13 · Best GWAS P=6.3e-20 conditioned to 3.23e-09

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBE2D2	0.05	0.02	enet	6	0.03	4.4e-04	4.7	7.4	1.1e-13	0.76	0.01	0.97	TRUE
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	BRD8	0.12	0.07	lasso	4	0.05	1.2e-03	6.9	-6.7	2.6e-11	0.03	0.00	0.98	TRUE
6	GTEx	Nerve Tibial	HARS	0.07	0.01	enet	16	0.04	1.1e-03	-4.6	5.6	2.6e-08	-0.03	0.06	0.89	TRUE
4	GTEx	Esophagus Gastroesophageal Junction	DNAJC18	0.17	0.01	lasso	10	0.04	2.0e-02	3.1	6.8	1.2e-11	0.77	0.03	0.85	FALSE
12	YFS	Blood	CXXC5	0.01	0.00	bslmm	244	0.01	2.6e-03	9.1	-6.6	3.5e-11	-0.67	0.00	0.95	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	WNT8A	0.05	0.01	blup	300	0.03	1.0e-04	-1.6	-6.6	3.9e-11	0.05	0.08	0.88	FALSE
5	GTEx	Esophagus Mucosa	TMEM173	0.10	0.03	enet	20	0.10	1.8e-07	9.1	-6.3	2.1e-10	-0.60	0.01	0.97	FALSE
8	GTEx	Vagina	PURA	0.52	0.05	enet	51	0.09	3.6e-03	5.8	-6.3	2.4e-10	-0.44	0.06	0.10	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	KDM3B	0.07	0.01	blup	307	0.03	1.0e-04	6.0	-6.1	1.1e-09	-0.03	0.06	0.90	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	FAM53C	0.13	0.06	lasso	4	0.05	4.6e-07	6.0	6.0	2.2e-09	0.05	0.99	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM53C	0.05	0.02	bslmm	291	0.03	4.1e-04	7.5	5.6	2.7e-08	-0.06	0.02	0.96	FALSE
7	GTEx	Skin Sun Exposed Lower leg	WDR55	0.04	0.01	enet	10	0.01	2.8e-02	-4.7	-5.5	3.9e-08	-0.02	0.04	0.90	FALSE
3	GTEx	Colon Transverse	TMCO6	0.15	0.06	enet	16	0.05	1.4e-03	4.4	-5.2	1.6e-07	-0.07	0.13	0.54	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	WDR55	0.10	0.03	enet	8	0.04	3.3e-09	-4.8	-5.2	2.1e-07	0.01	0.02	0.97	FALSE
13	YFS	Blood	TMCO6	0.01	0.00	blup	329	0.01	4.1e-03	-4.4	-5.2	2.2e-07	-0.03	0.06	0.91	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PCDHA2	0.04	0.03	blup	478	0.03	5.0e-05	-4.8	-5.2	2.6e-07	-0.05	0.05	0.94	FALSE