[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr5:129,797,129-132,839,137

Best TWAS P=2.48e-27 · Best GWAS P=5.09e-20 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Adipose Subcutaneous	HINT1	0.10	0.07	enet	16	0.06	8.8e-06	-8.8	-10.8	2.5e-27	0.53	0.05	0.94	TRUE
56	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	8.9	-9.0	2.6e-19	0.42	0.05	0.95	TRUE
91	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	-7.1	-7.6	4.0e-14	0.34	0.07	0.93	TRUE
31	GTEx	Esophagus Gastroesophageal Junction	SEPT8	0.22	0.08	lasso	12	0.10	2.2e-04	-6.6	7.2	6.6e-13	-0.24	0.36	0.48	TRUE
22	GTEx	Breast Mammary Tissue	SLC22A5	0.10	0.02	enet	16	0.06	4.5e-04	8.8	-6.4	1.5e-10	0.57	0.26	0.64	TRUE
1	CommonMind	Brain Pre-frontal Cortex	PDLIM4	0.11	0.18	lasso	5	0.18	8.0e-21	-5.9	-6.2	4.3e-10	0.19	1.00	0.00	TRUE
50	GTEx	Pancreas	P4HA2-AS1	0.16	0.16	lasso	5	0.16	3.2e-07	-5.0	5.8	4.9e-09	-0.71	0.47	0.46	TRUE
12	GTEx	Artery Tibial	HINT1	0.11	0.04	enet	18	0.06	1.0e-05	-8.3	-10.4	2.6e-25	0.64	0.07	0.88	FALSE
8	GTEx	Artery Aorta	HINT1	0.07	0.07	enet	8	0.06	4.7e-04	-8.5	-9.6	7.7e-22	0.51	0.09	0.52	FALSE
83	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	8.8	-9.5	3.0e-21	0.48	0.06	0.94	FALSE
11	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	8.9	9.4	7.7e-21	-0.59	0.01	0.99	FALSE
61	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	8.9	9.1	6.9e-20	-0.53	0.04	0.96	FALSE
33	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	8.8	-9.1	1.2e-19	0.54	0.04	0.96	FALSE
26	GTEx	Cells Transformed fibroblasts	HINT1	0.10	0.06	lasso	2	0.05	2.1e-04	-8.2	-9.0	1.8e-19	0.55	0.07	0.90	FALSE
58	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	8.8	8.9	4.2e-19	-0.46	0.08	0.80	FALSE
7	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	8.9	8.9	6.3e-19	-0.54	0.02	0.98	FALSE
32	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	8.9	8.9	8.2e-19	-0.49	0.02	0.98	FALSE
10	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	8.7	8.8	1.1e-18	-0.53	0.05	0.90	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	SLC22A4	0.03	0.05	lasso	2	0.04	1.2e-05	-8.4	-8.8	1.1e-18	0.40	0.48	0.44	FALSE
70	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	8.8	-8.8	2.0e-18	0.46	0.06	0.94	FALSE
76	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	8.8	-8.8	2.0e-18	0.46	0.09	0.91	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	8.9	8.8	2.2e-18	-0.59	0.00	1.00	FALSE
15	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	8.9	8.7	2.9e-18	-0.46	0.02	0.98	FALSE
46	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	7.9	8.7	3.1e-18	-0.60	0.05	0.94	FALSE
73	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	8.9	8.7	5.2e-18	-0.71	0.02	0.98	FALSE
40	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	8.8	-8.6	6.8e-18	0.49	0.08	0.92	FALSE
57	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	8.6	-8.6	7.1e-18	0.48	0.13	0.87	FALSE
35	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	8.9	8.6	9.7e-18	-0.52	0.05	0.95	FALSE
98	The Cancer Genome Atlas	Lung Adenocarcinoma	LYRM7	0.03	0.01	enet	10	0.02	7.5e-04	-5.9	8.6	1.0e-17	-0.53	0.01	0.90	FALSE
63	GTEx	Testis	RAPGEF6	0.50	0.35	lasso	4	0.32	6.5e-15	-7.9	-8.4	5.5e-17	0.42	0.92	0.08	FALSE
71	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	8.6	-8.4	6.4e-17	0.25	0.16	0.84	FALSE
19	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	-7.3	8.3	7.9e-17	-0.51	0.13	0.76	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	8.8	-8.3	1.4e-16	0.37	0.11	0.81	FALSE
9	GTEx	Artery Aorta	AC034220.3	0.08	0.06	lasso	3	0.05	1.1e-03	-7.1	8.2	2.4e-16	-0.40	0.52	0.21	FALSE
85	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	8.9	8.2	2.8e-16	-0.70	0.00	1.00	FALSE
106	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	-4.7	8.2	2.8e-16	-0.35	0.78	0.13	FALSE
27	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	-7.2	-8.1	6.6e-16	0.31	0.54	0.46	FALSE
65	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	8.9	8.0	9.1e-16	-0.44	0.02	0.98	FALSE
69	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	-7.2	-8.0	9.3e-16	0.23	0.23	0.63	FALSE
103	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	-7.1	-8.0	1.0e-15	0.47	0.12	0.88	FALSE
68	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	8.9	8.0	1.3e-15	-0.40	0.02	0.97	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	-7.2	-8.0	1.6e-15	0.44	0.29	0.71	FALSE
99	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC22A5	0.06	0.03	lasso	4	0.02	9.3e-04	-7.2	-7.9	2.9e-15	0.23	0.06	0.73	FALSE
66	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	7.9	-7.9	3.0e-15	0.48	0.12	0.74	FALSE
74	METSIM	Adipose	PDLIM4	0.05	0.04	lasso	4	0.02	2.8e-04	8.0	-7.9	3.6e-15	0.45	0.84	0.10	FALSE
107	The Cancer Genome Atlas	Thyroid Carcinoma	HINT1	0.07	0.04	lasso	2	0.01	1.8e-02	-7.9	-7.9	3.7e-15	0.50	0.00	0.98	FALSE
38	GTEx	Heart Left Ventricle	AC034220.3	0.25	0.22	lasso	6	0.25	8.6e-14	-7.1	7.8	4.2e-15	-0.36	0.98	0.02	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	8.8	-7.8	6.9e-15	0.51	0.11	0.78	FALSE
43	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	-7.1	7.8	6.9e-15	-0.58	0.03	0.97	FALSE
42	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	-6.1	7.7	1.3e-14	-0.33	0.14	0.42	FALSE
62	GTEx	Testis	PDLIM4	0.15	0.07	enet	8	0.05	2.5e-03	-7.3	7.7	1.6e-14	-0.51	0.25	0.13	FALSE
88	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A5	0.05	0.07	enet	11	0.09	5.3e-17	-6.4	-7.7	2.0e-14	0.31	1.00	0.00	FALSE
89	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	-7.2	-7.6	2.2e-14	0.35	0.03	0.91	FALSE
30	GTEx	Colon Transverse	AC034220.3	0.30	0.15	lasso	3	0.11	8.4e-06	-7.1	7.6	2.6e-14	-0.45	0.93	0.03	FALSE
108	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	6.0	7.6	2.9e-14	-0.39	0.06	0.07	FALSE
14	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	8.6	-7.6	3.0e-14	0.40	0.12	0.88	FALSE
60	GTEx	Stomach	AC034220.3	0.17	0.15	enet	21	0.16	4.2e-08	-6.4	7.6	3.4e-14	-0.30	1.00	0.00	FALSE
37	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	-7.1	7.6	3.7e-14	-0.42	0.71	0.29	FALSE
29	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	8.8	-7.6	4.0e-14	0.36	0.18	0.70	FALSE
101	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	-6.4	-7.5	4.4e-14	0.29	0.04	0.96	FALSE
16	GTEx	Brain Caudate basal ganglia	AC034220.3	0.41	0.45	enet	19	0.46	8.8e-15	-7.1	7.5	9.0e-14	-0.42	0.98	0.02	FALSE
59	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	-6.7	-7.5	9.0e-14	0.23	0.11	0.37	FALSE
41	GTEx	Muscle Skeletal	AC034220.3	0.27	0.23	lasso	9	0.24	9.1e-24	-7.1	7.5	9.6e-14	-0.39	1.00	0.00	FALSE
45	GTEx	Nerve Tibial	AC034220.3	0.15	0.11	lasso	5	0.10	1.9e-07	-7.1	7.3	2.7e-13	-0.44	0.99	0.00	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	AC034220.3	0.24	0.24	enet	34	0.24	3.7e-07	-7.2	7.3	3.4e-13	-0.39	0.89	0.05	FALSE
48	GTEx	Ovary	AC004041.2	0.21	-0.01	lasso	2	-0.01	7.7e-01	-5.7	7.3	3.4e-13	-0.19	0.06	0.28	FALSE
34	GTEx	Esophagus Mucosa	AC034220.3	0.08	0.03	lasso	3	0.05	4.7e-04	-7.3	7.3	3.6e-13	-0.42	0.95	0.03	FALSE
3	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	8.6	-7.2	4.1e-13	0.35	0.09	0.86	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	-7.2	-7.2	5.6e-13	0.21	0.02	0.70	FALSE
93	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A4	0.03	0.03	lasso	1	0.02	3.5e-03	-7.2	-7.2	7.2e-13	0.42	0.35	0.27	FALSE
6	GTEx	Adrenal Gland	AC034220.3	0.12	0.11	lasso	16	0.08	7.7e-04	-7.1	7.2	7.6e-13	-0.40	0.70	0.09	FALSE
4	GTEx	Adipose Subcutaneous	AC034220.3	0.11	0.11	lasso	10	0.09	4.8e-08	-7.1	7.1	1.1e-12	-0.42	0.99	0.01	FALSE
5	GTEx	Adipose Visceral Omentum	AC034220.3	0.10	0.09	lasso	7	0.08	7.3e-05	-7.1	7.1	1.2e-12	-0.42	0.49	0.19	FALSE
64	GTEx	Testis	AC034220.3	0.15	0.12	lasso	9	0.12	4.4e-06	-7.1	7.1	1.3e-12	-0.42	0.85	0.06	FALSE
92	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDLIM4	0.09	0.02	lasso	6	0.05	4.5e-06	-5.7	-7.1	1.3e-12	0.18	0.19	0.65	FALSE
96	The Cancer Genome Atlas	Brain Lower Grade Glioma	HINT1	0.06	0.03	enet	5	0.03	5.2e-04	-5.8	-7.1	1.4e-12	0.38	0.08	0.41	FALSE
77	NTR	Blood	SLC22A4	0.02	0.00	blup	423	0.01	5.2e-04	4.4	-7.1	1.5e-12	0.41	0.32	0.62	FALSE
28	GTEx	Colon Sigmoid	AC034220.3	0.18	0.11	lasso	12	0.06	3.7e-03	-7.3	7.0	2.5e-12	-0.42	0.21	0.28	FALSE
51	GTEx	Pituitary	AC034220.3	0.25	0.22	lasso	12	0.18	3.1e-05	-6.3	7.0	2.6e-12	-0.30	0.69	0.06	FALSE
102	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDLIM4	0.32	0.36	enet	13	0.37	3.8e-40	-5.7	-7.0	3.6e-12	0.26	1.00	0.00	FALSE
17	GTEx	Brain Cortex	AC034220.3	0.43	0.39	lasso	15	0.17	2.4e-05	-7.1	6.9	5.9e-12	-0.42	0.95	0.04	FALSE
49	GTEx	Pancreas	P4HA2	0.22	0.21	lasso	13	0.20	5.3e-09	-5.0	6.7	1.7e-11	-0.76	0.51	0.48	FALSE
36	GTEx	Esophagus Muscularis	AC034220.3	0.12	0.08	enet	20	0.07	3.8e-05	-7.1	6.7	1.8e-11	-0.41	0.78	0.14	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	PDLIM4	0.25	0.27	lasso	4	0.26	2.7e-33	-6.1	-6.7	1.9e-11	0.26	1.00	0.00	FALSE
90	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A4	0.02	0.02	lasso	1	0.02	3.0e-03	-6.6	-6.6	3.5e-11	0.20	0.12	0.53	FALSE
52	GTEx	Prostate	AC034220.3	0.38	0.37	lasso	5	0.37	3.0e-10	-7.1	6.6	5.1e-11	-0.40	0.95	0.04	FALSE
95	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC22A4	0.04	0.03	blup	108	0.01	7.1e-02	-6.4	-6.5	7.6e-11	0.18	0.12	0.15	FALSE
87	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	8.8	-6.4	1.3e-10	0.35	0.01	0.98	FALSE
104	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A5	0.12	0.05	lasso	4	0.08	1.8e-08	-5.0	-6.4	2.0e-10	0.17	0.96	0.00	FALSE
72	GTEx	Whole Blood	AC116366.6	0.05	0.04	lasso	17	0.03	5.7e-04	-4.5	6.2	7.4e-10	-0.39	0.42	0.26	FALSE
23	GTEx	Breast Mammary Tissue (Female)	SLC22A5	0.04	-0.01	lasso	3	0.01	1.3e-01	-3.7	-6.2	7.6e-10	0.54	0.05	0.18	FALSE
86	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM4	0.05	0.05	lasso	4	0.05	9.0e-11	-6.1	-6.1	8.4e-10	0.19	0.99	0.01	FALSE
105	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC22A5	0.05	0.01	blup	92	0.02	1.1e-02	-6.5	-6.1	9.5e-10	0.13	0.09	0.14	FALSE
25	GTEx	Cells Transformed fibroblasts	PDLIM4	0.08	0.09	lasso	1	0.07	6.4e-06	-6.1	-6.1	1.1e-09	0.19	0.82	0.03	FALSE
80	YFS	Blood	CDC42SE2	0.14	0.05	lasso	9	0.07	3.1e-22	-8.1	6.0	1.8e-09	-0.25	0.36	0.64	FALSE
18	GTEx	Brain Frontal Cortex BA9	AC034220.3	0.31	0.20	lasso	14	0.21	3.3e-06	-7.3	5.8	8.3e-09	-0.41	0.64	0.22	FALSE
67	GTEx	Thyroid	AC034220.3	0.29	0.29	lasso	5	0.31	4.8e-24	-6.4	5.8	9.1e-09	-0.14	1.00	0.00	FALSE
82	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	-7.1	-5.7	1.5e-08	0.33	1.00	0.00	FALSE
81	YFS	Blood	LYRM7	0.03	0.01	bslmm	243	0.01	7.0e-05	-6.1	-5.6	1.9e-08	0.16	0.52	0.02	FALSE
39	GTEx	Liver	AC034220.3	0.30	0.16	lasso	6	0.16	3.9e-05	-7.1	5.6	2.0e-08	-0.31	0.59	0.04	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	SLC22A5	0.15	0.00	enet	24	0.05	1.4e-02	-7.3	5.6	2.7e-08	-0.60	0.06	0.50	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A4	0.13	0.00	lasso	4	0.01	7.1e-02	-2.7	-5.6	2.8e-08	0.54	0.14	0.16	FALSE
84	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PDLIM4	0.05	0.01	enet	4	0.02	1.2e-02	-5.7	-5.5	3.8e-08	0.13	0.08	0.07	FALSE
75	METSIM	Adipose	SLC22A4	0.05	0.02	lasso	3	0.03	8.4e-06	4.4	-5.5	4.4e-08	0.34	0.94	0.02	FALSE
47	GTEx	Ovary	PDLIM4	0.25	0.22	enet	10	0.05	2.1e-02	-4.3	5.4	5.4e-08	-0.22	0.36	0.20	FALSE
100	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A4	0.04	0.01	blup	111	0.03	3.0e-04	-1.1	-5.4	8.5e-08	0.17	0.05	0.75	FALSE
44	GTEx	Nerve Tibial	LYRM7	0.05	0.02	enet	11	0.04	7.0e-04	-5.7	5.3	1.2e-07	-0.36	0.33	0.40	FALSE
13	GTEx	Artery Tibial	LYRM7	0.10	0.03	lasso	3	0.04	3.1e-04	-6.0	5.3	1.3e-07	-0.34	0.51	0.08	FALSE
94	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CDC42SE2	0.10	0.07	lasso	1	0.06	2.6e-04	-5.2	5.2	2.3e-07	-0.33	0.07	0.53	FALSE
97	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PDLIM4	0.08	0.03	blup	67	0.05	2.4e-03	-6.3	-5.1	2.7e-07	0.11	0.04	0.36	FALSE