[Hub]/) : Traits : Leg predicted mass (left) :

chr3:8,706,520-11,999,795

Best TWAS P=1.82e-12 · Best GWAS P=6.24e-12 conditioned to 0.000101

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous CRELD1 0.46 0.16 enet 51 0.27 2.2e-22 -6.0 -5.7 1.2e-08 0.07 0.02 0.98 FALSE
2 GTEx Adipose Subcutaneous AC034193.5 0.08 0.07 lasso 4 0.07 2.2e-06 5.2 5.4 7.3e-08 0.00 0.50 0.47 FALSE
3 GTEx Adipose Visceral Omentum CRELD1 0.19 0.12 lasso 4 0.10 4.1e-06 -6.0 -5.8 9.1e-09 -0.02 0.02 0.93 FALSE
4 GTEx Artery Aorta CRELD1 0.30 0.07 lasso 7 0.12 2.4e-07 -6.0 -5.3 9.2e-08 0.03 0.02 0.98 FALSE
5 GTEx Artery Aorta AC034193.5 0.12 0.01 lasso 3 0.00 1.6e-01 5.4 5.4 5.9e-08 -0.01 0.17 0.39 FALSE
6 GTEx Artery Aorta RP11-1020A11.1 0.15 0.01 lasso 3 0.00 4.0e-01 -6.0 -6.7 2.4e-11 -0.03 0.03 0.58 FALSE
7 GTEx Artery Tibial AC034193.5 0.10 0.08 lasso 1 0.06 1.2e-05 5.3 5.3 9.2e-08 -0.02 0.38 0.60 FALSE
8 GTEx Breast Mammary Tissue CRELD1 0.25 0.19 lasso 6 0.18 2.2e-09 -6.0 -5.8 8.9e-09 -0.02 0.02 0.98 FALSE
9 GTEx Cells EBV-transformed lymphocytes CYCSP10 0.19 0.01 lasso 5 -0.01 6.6e-01 5.3 -5.4 6.9e-08 0.01 0.07 0.15 FALSE
10 GTEx Cells Transformed fibroblasts CRELD1 0.39 0.19 enet 39 0.28 4.5e-21 -6.0 -6.2 4.3e-10 0.04 0.02 0.98 FALSE
11 GTEx Cells Transformed fibroblasts AC034193.5 0.12 0.05 lasso 3 0.05 1.2e-04 5.3 5.3 9.4e-08 -0.03 0.40 0.57 FALSE
12 GTEx Cells Transformed fibroblasts HRH1 0.20 0.00 lasso 3 0.01 1.1e-01 6.9 -5.8 5.4e-09 -0.77 0.01 0.93 TRUE
13 GTEx Cells Transformed fibroblasts RP11-1020A11.1 0.20 0.10 enet 67 0.09 1.9e-07 -6.0 -5.9 4.1e-09 0.01 0.02 0.98 FALSE
14 GTEx Esophagus Mucosa VHL 0.14 0.00 lasso 1 0.00 2.9e-01 5.3 -5.3 8.9e-08 0.02 0.08 0.35 FALSE
15 GTEx Esophagus Muscularis CRELD1 0.21 0.10 lasso 1 0.08 1.7e-05 -6.0 -6.0 2.3e-09 -0.02 0.02 0.96 FALSE
16 GTEx Skin Not Sun Exposed Suprapubic AC034193.5 0.15 0.09 enet 11 0.08 3.3e-05 5.3 5.7 1.3e-08 0.02 0.40 0.50 FALSE
17 GTEx Skin Sun Exposed Lower leg AC034193.5 0.09 0.11 lasso 2 0.09 8.7e-08 5.3 5.3 9.9e-08 -0.02 0.42 0.58 FALSE
18 GTEx Testis CRELD1 0.22 0.22 lasso 8 0.26 1.1e-11 5.3 -7.0 1.8e-12 0.00 0.14 0.86 TRUE
19 GTEx Thyroid THUMPD3 0.24 0.10 lasso 7 0.10 4.6e-08 4.3 -5.2 1.5e-07 0.02 0.02 0.88 TRUE
20 GTEx Thyroid CIDECP 0.11 0.12 lasso 2 0.11 1.1e-08 5.2 5.2 1.5e-07 0.00 0.49 0.51 FALSE
21 GTEx Thyroid BRK1 0.08 0.05 lasso 3 0.04 6.8e-04 5.3 -5.5 3.7e-08 0.01 0.30 0.69 FALSE
22 METSIM Adipose BRK1 0.04 0.02 bslmm 559 0.01 8.9e-03 4.9 -5.7 9.4e-09 -0.04 0.15 0.68 FALSE
23 ROSMAP Brain Pre-frontal Cortex AC022007.5 0.05 0.02 blup 515 0.03 2.8e-04 5.9 6.0 2.3e-09 0.02 0.04 0.96 FALSE
24 YFS Blood FANCD2 0.04 0.04 lasso 1 0.04 7.7e-13 5.8 -5.8 6.3e-09 -0.06 0.04 0.96 FALSE
25 YFS Blood PRRT3 0.08 0.02 bslmm 469 0.04 7.4e-13 -6.0 -5.2 2.0e-07 -0.03 0.02 0.98 FALSE
26 The Cancer Genome Atlas Breast Invasive Carcinoma C3orf10 0.01 0.01 blup 49 0.01 9.4e-03 4.8 -5.2 2.0e-07 0.02 0.08 0.31 FALSE
27 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C3orf10 0.03 0.05 lasso 5 0.04 3.4e-05 5.3 -5.3 8.7e-08 -0.01 0.08 0.91 FALSE
28 The Cancer Genome Atlas Prostate Adenocarcinoma CIDECP 0.04 0.02 blup 33 0.03 3.8e-04 5.4 5.8 4.8e-09 0.00 0.04 0.90 FALSE
29 The Cancer Genome Atlas Prostate Adenocarcinoma LOC401052 0.06 0.07 enet 6 0.06 3.5e-07 6.0 -5.9 3.1e-09 -0.05 0.01 0.99 FALSE
30 The Cancer Genome Atlas Thyroid Carcinoma C3orf10 0.05 0.02 blup 49 0.04 9.3e-05 4.9 -5.4 8.2e-08 -0.03 0.12 0.86 FALSE