Hub : Genes

EPB41L1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.0709 0.033 6.9e-05 0.074 NA 0.074 NA 0.061 1.9e-06 NA 1.8e-06 NA 1.5e-05
2 GTEx Esophagus Mucosa 0.2580 0.055 4.8e-13 0.160 NA 0.215 NA 0.215 6.9e-11 NA 1.9e-14 NA 2.1e-14

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 2.1 3.3 3.3 1.8 -1.8
Bipolar Disorder or Schizophrenia 0.6 1.5 2.4 1.6 -0.7
Depressed Affect (Nagel 2018) 0.2 0.5 1.0 1.0 -0.2
Depression (Nagel 2018) 2.4 3.6 4.7 1.6 -2.2
Intelligence (Savage-Jansen 2018) 2.5 7.7 13.9 3.7 -1.2
Neuroticism (Nagel 2018) 0.1 0.2 0.5 -0.2 0.7
Schizophrenia (2018) 0.2 0.3 0.4 0.5 0.6
Schizophrenia vs Biploar Disorder 1.3 1.7 1.8 -1.3 1.3
Worry (Nagel 2018) 0.3 0.6 1.2 -0.2 1.1
Alzheimer’s Disease (in mother) 3.5 4.1 5.1 -2.3 1.7
Alzheimer’s Disease (in father) 2.1 2.3 2.5 -1.4 1.6
Alzheimer’s Disease (including proxy) 2.7 3.9 5.1 -2.3 1.6
Crohns Disease (2017) 0.2 0.3 0.4 0.6 -0.6
Irritable Bowel Disease (IBD) 0.8 1.8 2.7 1.6 -1.0
Ulcerative Colitis (UC) 0.8 1.5 2.5 1.6 -0.7
Major Depression (MDD) 0.1 0.1 0.1 -0.3 0.3
Reaction Time 0.7 1.4 2.7 -1.6 0.2
Verbal and Numeric Reasoning (VNR) 1.7 4.1 7.5 2.7 -0.9
Breast Cancer 3.9 9.3 9.5 -3.0 3.1
Ovarian Cancer 0.4 0.5 0.9 -0.9 0.5
Prostate Cancer 0.2 0.3 0.6 -0.8 0.0
Age at First Birth 1.6 2.3 2.6 -1.6 1.4
Bipolar Disorder (2011) 0.1 0.1 0.2 0.4 -0.2
Body Mass Index (BMI) (2010) 2.0 2.7 3.1 1.5 -1.8
Coronary Artery Disease (CAD) 3.2 3.8 4.2 1.9 -2.0
Crohns Disease (2012) 0.0 0.0 0.0 0.0 -0.2
Mean Putamen Volume 1.2 1.3 2.1 -0.8 1.4
Fasting Glucose 0.1 0.1 0.2 -0.5 0.1
HbA1C 0.1 0.1 0.2 0.5 -0.2
HDL Cholesterol 4.9 8.2 11.6 -3.4 2.2
LDL Cholesterol 4.8 7.5 10.7 -3.3 2.1
Lupus 0.9 1.4 2.2 0.8 -1.5
Neuroticism (2016) 0.2 0.3 0.3 0.5 -0.5
Primary Biliary Cirrhosis 1.1 1.6 1.8 1.2 -1.3
Rheumatoid Arthritis 0.9 1.2 1.8 -0.8 1.3
Schizophrenia (2014) 0.2 0.4 0.7 0.8 0.1
Triglycerides 0.6 1.0 1.6 -1.3 0.6
Type 2 Diabetes (T2D) (2012) 2.5 2.9 3.4 1.8 -1.6
Ulcerative Colitis 3.0 4.3 6.1 2.5 -1.6
Blood Eosinophil Count 1.2 9.5 12.3 3.5 -2.6
Blood Platelet Count 0.1 0.7 1.0 1.0 -0.7
Blood Red Count 0.8 7.3 8.7 -2.4 3.0
Blood White Count 0.3 1.9 1.9 -1.4 1.4
Heel T-Score 0.3 2.4 3.2 1.2 -1.8
BMI 2.2 12.9 13.6 3.5 -3.7
Height 31.4 605.4 630.0 24.1 -25.1
Waist Hip Ratio (WHR) 0.9 4.0 5.1 -1.7 2.3
Systolic Blood Pressure 0.3 1.3 1.6 1.3 -1.0
Smoking Status 0.3 0.8 1.4 -0.5 1.2
Allergy or Eczema 0.3 0.8 1.3 1.2 -0.6
Cardiovascular Disease 0.0 0.1 0.1 0.4 0.1
Hypothyroidism (self reported) 0.0 0.1 0.2 0.2 -0.4
Respiratory disease 4.2 9.4 10.0 3.2 -3.0
Type 2 Diabetes (T2D) (2018) 3.6 6.7 7.2 2.7 -2.5
Lung FEV1/FVC ratio 1.4 7.0 7.9 2.8 -2.5
Lung FVC 6.9 35.0 36.7 -6.1 5.8
Neuroticism 0.2 0.5 1.0 1.0 -0.2
Chronotype (morning person) 0.1 0.3 0.6 0.2 -0.8
Hair Pigment 9.3 263.9 355.9 -13.1 18.9
Tanning 14.1 172.2 234.1 10.5 -15.3
Hand grip strength (left) 3.5 9.1 11.6 2.6 -3.4
Number of treatments/medications taken 1.2 2.2 2.6 1.6 -1.4
Average weekly spirits intake 0.0 0.0 0.1 -0.2 -0.2
Sensitivity / hurt feelings 1.7 2.9 4.8 -2.2 1.0
Frequency of depressed mood in last 2 weeks 2.4 3.3 3.9 1.6 -2.0
Hearing difficulty/problems: Yes 0.3 0.5 0.7 -0.8 0.5
Relative age of first facial hair 1.2 2.4 2.7 -1.6 1.4
Other serious medical condition/disability diagnosed by doctor 0.0 0.1 0.1 -0.3 -0.2
Ever used hormone-replacement therapy (HRT) 0.0 0.0 0.0 -0.1 -0.0
Ever had hysterectomy (womb removed) 0.3 0.3 0.6 -0.2 0.8
Systolic blood pressure, automated reading 0.2 0.6 0.9 0.5 -0.9
Eye problems/disorders: Diabetes related eye disease 3.8 4.2 4.4 2.1 -2.0
Angina 2.5 3.3 5.8 0.9 -2.4
Medication for hormone replacement therapy 0.5 0.6 0.8 -0.6 0.9
Vitamin and mineral supplements 0.5 0.6 0.7 0.8 -0.8
Supplements: Zinc 0.5 0.6 1.1 1.0 -0.2
Medication: Co-codamol 0.1 0.1 0.1 0.3 -0.2
Medication: Metformin 3.4 4.8 5.1 2.2 -2.1
Diabetes (father) 3.5 4.3 4.9 1.9 -2.2
Diabetes (mother) 3.4 4.4 5.2 1.9 -2.3
Severe depression (siblings) 0.8 0.8 1.0 -1.0 0.9
Pack years adult smoking proportion 1.4 2.2 2.6 1.6 -1.3
Impedance of leg (right) 9.6 46.3 47.4 -6.7 6.9
Leg fat-free mass (left) 31.2 165.1 166.4 12.8 -12.9
Trunk fat percentage 1.1 4.4 5.1 1.9 -2.3
Hand grip strength (right) 6.4 17.3 18.2 4.0 -4.3
Townsend deprivation index at recruitment 0.0 0.0 0.0 -0.2 0.2
Current tobacco smoking 0.0 0.0 0.1 0.3 -0.1
Average weekly fortified wine intake 0.0 0.0 0.0 -0.2 0.0
Maternal smoking around birth 0.1 0.1 0.1 0.2 0.4
Fed-up feelings 1.5 2.8 4.1 2.0 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 2.4 3.2 4.5 1.4 -2.1
Relative age voice broke 6.3 9.6 10.4 -3.2 3.0
Taking other prescription medications 0.5 0.7 0.8 0.9 -0.8
Age when periods started (menarche) 1.6 3.9 4.5 -2.1 1.8
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.7 -0.1 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.2 0.4 -0.5
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 -0.1 -0.3
Qualifications: CSEs or equivalent 4.2 5.5 6.5 -2.6 2.1
Serious illness, injury or assault to yourself 0.0 0.1 0.1 -0.2 -0.2
High blood pressure 0.2 0.5 0.9 0.9 -0.4
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.1 0.3 -0.0
Multivitamins +/- minerals 0.1 0.1 0.2 -0.5 0.3
Stomach or abdominal pain in last month 0.0 0.1 0.1 0.3 0.1
Supplements: Glucosamine 0.2 0.3 0.3 -0.6 0.5
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.1 -1.1 0.3
Medication: Atenolol 3.1 3.9 4.6 1.8 -2.1
Medication: Levothyroxine sodium 0.2 0.3 0.6 0.3 -0.8
Sitting height 37.7 267.4 275.6 16.1 -16.6
Chronic bronchitis/emphysema (father) 0.7 0.8 1.5 -0.5 1.2
High blood pressure (mother) 0.1 0.1 0.2 0.1 -0.4
Body mass index (BMI) 1.5 6.5 6.8 2.6 -2.5
Impedance of leg (left) 9.2 44.6 46.5 -6.5 6.8
Leg predicted mass (left) 30.9 163.8 166.4 12.7 -12.9
Trunk fat mass 7.6 32.6 33.5 5.6 -5.8
Waist circumference 6.7 24.6 25.9 5.1 -4.8
Number of incorrect matches in round 4.2 7.0 7.8 -2.8 2.5
Past tobacco smoking 2.0 3.6 4.2 1.7 -2.0
Alcohol usually taken with meals 3.0 4.9 6.6 2.6 -1.8
Nervous feelings 0.3 0.5 0.9 -0.3 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 1.7 1.3 -0.8
Hearing difficulty/problems with background noise 0.2 0.3 0.6 -0.0 -0.8
Hair/balding pattern: Pattern 2 1.6 2.0 3.9 -0.4 2.0
Had menopause 0.8 1.0 1.9 1.4 -0.4
Had other major operations 0.0 0.0 0.1 -0.2 -0.3
Forced vital capacity (FVC) 4.1 15.8 16.3 4.0 -3.9
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.3 0.5 -0.5
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 2.1 1.5 -0.6
Qualifications: None of the above 1.3 2.8 3.4 -1.9 1.5
Financial difficulties in last 2 years 0.7 0.9 1.1 0.9 -1.0
Mouth/teeth dental problems 0.1 0.1 0.2 0.5 -0.2
Heart attack 0.5 0.6 1.0 1.0 -0.4
Allergy 0.7 1.6 1.8 -1.4 1.2
Pain all over the body in last month 0.9 1.0 1.4 0.7 -1.2
Diabetes (self-reported) 8.2 12.6 12.9 3.6 -3.5
Hayfever/allergic rhinitis (self-reported) 0.0 0.0 0.1 -0.1 -0.3
Medication: Ramipril 0.9 1.1 1.3 1.1 -1.0
Medication: Simvastatin 1.7 2.5 4.0 -2.0 1.0
Fluid intelligence score 2.7 5.6 9.8 3.1 -1.2
Illnesses of siblings 0.1 0.1 0.2 -0.4 0.3
Neuroticism score 0.3 0.7 1.1 1.1 -0.4
Weight 20.6 101.3 103.8 9.9 -10.2
Impedance of arm (right) 3.6 16.6 18.9 -4.4 3.8
Arm fat percentage (right) 0.2 0.9 1.0 0.9 -1.0
Trunk fat-free mass 35.4 203.1 204.5 14.2 -14.3
Hip circumference 11.6 49.8 50.3 7.0 -7.1
Time employed in main current job 1.2 1.3 2.5 -1.6 0.5
Alcohol intake versus 10 years previously 1.3 2.0 3.1 1.8 -0.9
Father’s age at death 2.3 3.1 4.2 -2.1 1.4
Worrier / anxious feelings 0.0 0.0 0.1 0.1 0.3
Frequency of tiredness / lethargy in last 2 weeks 3.8 6.1 7.9 2.1 -2.8
Falls in the last year 0.4 0.5 0.5 0.7 -0.7
Hair/balding pattern: Pattern 3 0.0 0.0 0.1 -0.2 0.2
Number of live births 0.1 0.2 0.2 -0.3 0.5
Forced expiratory volume in 1-second (FEV1) 4.4 14.9 15.2 3.9 -3.8
Pulse rate 1.9 3.1 5.3 -1.0 2.3
Happiness 0.6 0.8 1.5 1.2 -0.2
Noisy workplace 3.5 4.3 5.9 -1.6 2.4
Qualifications: A levels/AS levels or equivalent 2.0 4.3 5.8 2.4 -1.7
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.3 -0.6 0.4
Mouth/teeth dental problems: Dentures 0.0 0.0 0.0 -0.0 0.1
Asthma 1.2 2.4 3.1 1.7 -1.3
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.1 -0.2 -0.4
Medication: Cholesterol lowering 0.5 0.8 1.2 -1.1 0.6
Depression (self-reported) 0.2 0.3 0.5 -0.1 0.7
Medication: Lansoprazole 0.6 0.7 1.4 -1.2 0.2
Prospective memory result 0.3 0.3 0.6 -0.8 0.2
Lung cancer (father) 0.5 0.6 1.1 -0.1 -1.1
Illnesses of mother 3.0 3.7 4.5 2.1 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 5.8 18.4 19.3 4.2 -4.4
Pulse wave Arterial Stiffness index 0.1 0.1 0.1 0.4 -0.3
Impedance of arm (left) 3.2 14.6 16.1 -4.0 3.6
Arm fat mass (right) 6.3 25.8 26.4 5.0 -5.1
Trunk predicted mass 35.8 204.5 204.5 14.3 -14.3
Standing height 30.7 304.2 318.6 17.0 -17.8
Length of working week for main job 2.2 2.4 3.5 1.9 -1.1
Exposure to tobacco smoke at home 0.6 0.7 1.3 0.2 -1.1
Breastfed as a baby 0.0 0.0 0.0 0.1 -0.1
Tense / ‘highly strung’ 0.1 0.1 0.2 -0.0 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 3.0 4.6 5.5 2.3 -2.0
Hair/balding pattern: Pattern 4 1.9 4.5 5.2 -2.3 2.0
Birth weight of first child 0.5 0.9 1.2 -0.8 1.1
Peak expiratory flow (PEF) 7.3 17.0 18.5 3.9 -4.3
Pulse wave reflection index 1.0 1.3 2.3 0.4 -1.5
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.4 0.0 -0.7
Loud music exposure frequency 0.0 0.0 0.1 0.2 -0.1
Qualifications: O levels/GCSEs or equivalent 1.4 2.2 4.0 2.0 -0.6
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 1.3 0.8 -1.2
Blood clot in the leg (DVT) 1.7 2.3 3.5 1.0 -1.9
Medication: Paracetamol 0.4 0.7 0.7 0.8 -0.8
Headache pain in last month 0.8 1.4 1.9 0.9 -1.4
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.2 -0.1 0.5
Glaucoma (self-reported) 0.2 0.2 0.4 0.1 -0.6
Gout (self-reported) 0.3 0.4 0.8 0.4 -0.9
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.4 0.4 -0.6
Medication: Amlodipine 0.2 0.2 0.4 0.2 0.7
Medication: Ventolin 100micrograms inhaler 5.5 7.1 8.7 2.4 -2.9
Birth weight 0.9 2.0 3.1 1.0 -1.7
Chronic bronchitis/emphysema (mother) 2.7 3.1 4.3 -2.1 1.4
High blood pressure (siblings) 0.4 0.5 0.5 0.7 -0.7
Forced vital capacity (FVC), Best measure 5.9 21.7 22.2 4.6 -4.7
Body fat percentage 0.2 0.6 0.6 0.8 -0.8
Leg fat percentage (right) 0.6 2.2 2.7 -1.3 1.6
Arm fat-free mass (right) 32.7 167.7 169.0 13.0 -12.9
Exposure to tobacco smoke outside home 1.0 1.4 1.9 1.4 -0.9
Comparative body size at age 10 0.4 1.2 1.6 0.9 -1.2
Number of full brothers 0.4 0.6 1.0 0.4 -1.0
Worry too long after embarrassment 0.0 0.0 0.1 -0.0 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.9 2.4 3.0 1.7 -1.4
Wheeze or whistling in the chest in last year 2.1 3.7 4.0 2.0 -1.9
Number of children fathered 0.2 0.3 0.3 -0.6 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.5 -0.3 0.7
Age at first live birth 0.2 0.3 0.5 -0.3 0.7
Pulse wave peak to peak time 0.6 0.7 0.8 0.8 -0.9
Health satisfaction 0.6 0.8 1.2 0.7 -1.1
Shortness of breath walking on level ground 2.3 2.8 4.2 1.1 -2.1
Qualifications: College or University degree 2.3 7.3 7.6 2.8 -2.6
Eye problems/disorders: None of the above 0.8 0.9 1.2 -0.8 1.1
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.0 -0.1 0.2
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.5 0.1
Medication for pain relief, constipation, heartburn 1.2 2.0 2.8 -1.1 1.7
Neck or shoulder pain in last month 0.1 0.1 0.2 0.5 -0.0
Medication: Blood pressure 0.6 1.1 1.6 1.3 -0.8
Angina (self-reported) 2.7 3.5 6.1 1.0 -2.5
Migraine (self-reported) 4.4 5.5 6.5 2.5 -2.1
Medication: Ibuprofen 0.3 0.4 0.7 0.3 -0.8
Medication: Allopurinol 0.7 1.0 1.2 0.8 -1.1
Medication: Omeprazole 0.4 0.5 0.9 -0.9 0.2
Medication: Seretide 50 evohaler 0.4 0.4 0.4 0.7 -0.6
Mean time to correctly identify matches 1.8 3.4 5.8 -2.4 1.0
Heart disease (mother) 1.2 1.5 2.8 0.5 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 -0.5 -0.0
Whole body fat mass 6.3 26.3 26.4 5.1 -5.1
Leg fat mass (right) 3.3 12.7 13.1 3.6 -3.5
Arm predicted mass (right) 32.2 164.7 168.3 13.0 -12.7
Pulse rate, automated reading 0.6 2.0 2.5 -1.2 1.6
Alcohol intake frequency. 0.0 0.1 0.1 0.3 0.3
Comparative height size at age 10 23.9 131.3 141.6 11.9 -11.0
Number of full sisters 0.0 0.0 0.1 0.0 -0.2
Suffer from ‘nerves’ 0.1 0.1 0.1 0.3 0.4
Overall health rating 0.3 0.6 0.8 0.9 -0.5
Chest pain or discomfort 1.9 2.7 4.4 2.1 -1.0
Had major operations 0.2 0.2 0.3 -0.5 -0.3
Age at last live birth 0.0 0.0 0.0 0.2 -0.0
Family relationship satisfaction 1.5 1.8 2.3 1.5 -1.2
Leg pain on walking 0.9 1.1 2.1 0.4 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.5 -0.7 0.4
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 0.3 0.4
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.3 -0.3 1.1
Medication: Aspirin 0.6 0.8 1.0 0.8 -1.0
Supplements: Vitamin C 0.1 0.1 0.2 0.1 -0.5
Knee pain experienced in last month 5.1 7.9 8.2 -2.8 2.9
Hypertension (Self-reported) 0.1 0.3 0.5 0.7 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.0 -0.1 0.2
Illnesses of father: Heart disease 0.4 0.5 0.9 1.0 -0.2
Illnesses of siblings: Diabetes 1.0 1.3 1.8 1.3 -0.9
Smoking status: Previous 1.7 2.5 2.7 -1.5 1.6
Forced expiratory volume in 1-second (FEV1), predicted 13.8 28.7 30.4 5.2 -5.5
Whole body fat-free mass 34.8 198.8 198.8 14.1 -14.1
Leg fat-free mass (right) 32.1 171.6 174.2 13.0 -13.2
Arm fat percentage (left) 0.3 1.2 1.2 1.1 -1.1
Average weekly red wine intake 0.0 0.0 0.1 0.1 -0.2
Handedness (chirality/laterality): Left-handed 2.0 2.4 2.6 -1.6 1.5
Mood swings 1.0 1.9 2.8 1.7 -1.0
Loneliness, isolation 0.2 0.2 0.4 0.7 -0.1
Long-standing illness, disability or infirmity 0.3 0.4 0.6 0.6 -0.7
Ever had bowel cancer screening 0.0 0.0 0.1 0.2 -0.0
Diabetes diagnosed by doctor 5.8 9.5 9.5 3.1 -3.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.2 0.4
Friendships satisfaction 0.8 1.0 1.8 1.3 -0.3
Qualifications: nursing, teaching 0.4 0.7 1.1 1.0 -0.5
Commuting to job workplace: Walk 1.1 1.2 1.5 0.9 -1.2
Eye problems/disorders: Cataract 2.4 2.7 3.0 1.6 -1.7
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 -0.7 0.4
Medication for cholesterol 0.2 0.4 0.4 -0.5 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.2 0.5 -0.3
Back pain experienced in last month 0.6 0.8 1.3 -1.2 0.6
Mineral and other dietary supplements 1.7 2.3 3.3 1.2 -1.8
Breast cancer (self-reported) 0.9 1.1 1.9 1.4 -0.5
Asthma (self-reported) 1.3 2.5 3.6 1.9 -1.2
Osteoporosis (self-reported) 0.2 0.2 0.4 -0.1 -0.6
Osteoarthritis (self-reported) 0.7 0.9 1.0 -1.0 0.9
Medication: Aspirin 0.7 0.9 0.9 0.9 -1.0
Medication: Gliclazide 8.0 9.1 10.0 2.9 -3.2
Illnesses of father: None of the above (group 1) 2.0 2.5 2.8 -1.5 1.7
Smoking status: Current 0.0 0.0 0.0 0.0 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.5 -1.2 0.8
Whole body water mass 34.6 197.4 198.8 14.0 -14.1
Leg predicted mass (right) 32.7 174.2 176.9 13.1 -13.3
Arm fat mass (left) 6.5 26.7 27.3 5.1 -5.2
Number of self-reported non-cancer illnesses 0.7 1.2 1.5 1.0 -1.2
Average weekly champagne plus white wine intake 1.5 2.1 2.6 1.6 -1.3
Miserableness 0.2 0.3 0.5 0.7 0.1
Guilty feelings 2.6 3.9 4.4 1.8 -2.1
Wears glasses or contact lenses 0.0 0.0 0.1 0.3 0.0
Ever taken oral contraceptive pill 1.1 1.2 1.2 -1.1 1.1
Hearing aid user 0.8 1.0 1.8 -1.4 -0.2
Mother’s age at death 1.2 1.5 1.7 -1.3 1.2
Financial situation satisfaction 0.3 0.4 0.4 0.6 -0.6
Tinnitus: Yes, now most or all of the time 3.2 3.7 4.3 1.8 -2.1
Commuting to job workplace: Public transport 2.2 2.6 3.0 1.5 -1.7
Eye problems/disorders: Glaucoma 0.3 0.3 0.6 -0.8 0.2
Medication: Blood pressure 0.9 1.8 2.7 1.6 -0.9
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.3 0.4 -0.6
Supplements: Fish oil (including cod liver oil) 0.4 0.6 0.6 -0.7 0.8
High cholesterol (Self-reported) 2.7 4.8 6.1 -2.5 1.9
Medication: Bendroflumethiazide 0.2 0.4 0.5 0.7 0.5
Medication: Paracetamol 0.3 0.4 0.5 0.7 -0.5
Medication: Lisinopril 5.0 6.4 8.3 2.1 -2.9
Medication: Atorvastatin 0.8 0.9 1.0 -1.0 0.9
Illnesses of father: High blood pressure 0.3 0.3 0.6 0.2 -0.8
Alcohol drinker status: Never 0.4 0.5 1.0 -0.2 1.0
Ever smoked 0.2 0.3 0.5 -0.4 0.7
Basal metabolic rate 32.7 180.9 182.2 13.4 -13.5
Leg fat percentage (left) 0.4 1.6 2.1 -1.0 1.5
Arm fat-free mass (left) 30.9 156.6 159.2 12.6 -12.4
Number of operations (self-reported) 0.1 0.2 0.3 -0.6 0.2
Average weekly beer plus cider intake 3.4 4.9 6.6 -1.8 2.6
Irritability 1.0 1.7 2.4 -1.0 1.5
Risk taking 0.4 0.6 0.9 0.6 -0.9
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.0 0.2 0.1
Fractured/broken bones in last 5 years 0.1 0.1 0.2 -0.5 -0.2
Age started oral contraceptive pill 0.2 0.2 0.3 -0.3 0.5
Diastolic blood pressure, automated reading 3.1 9.5 10.1 3.2 -3.0
Ever depressed for a whole week 0.6 0.7 1.1 -1.0 0.5
Unable to work because of sickness or disability 1.0 1.2 1.8 -1.3 0.8
Commuting to job workplace: Cycle 1.2 1.4 2.4 0.7 -1.6
Myopia 1.3 1.8 2.3 1.5 -1.2
Vascular/heart problems diagnosed by doctor 1.0 2.8 3.1 -1.8 1.6
Cholesterol lowering medication 0.5 0.8 1.0 -1.0 0.8
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.7 -0.3 -0.9
Pain experienced in last month 0.6 1.1 1.2 1.1 -0.9
Supplements: Calcium 0.2 0.2 0.3 0.3 -0.6
Basal cell carcinoma (self-reported) 2.1 2.5 3.3 -1.3 1.8
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.8 0.9 -0.4
Deep venous thrombosis (DVT) (self-reported) 2.1 2.6 4.4 1.0 -2.1
Heart disease (siblings) 1.8 2.3 2.8 1.7 -1.3
Alcohol drinker status: Previous 0.4 0.4 0.8 -0.9 0.2
Pack years of smoking 1.5 2.1 2.3 1.5 -1.4
Impedance of whole body 6.1 31.2 32.4 -5.7 5.5
Leg fat mass (left) 3.7 14.4 15.2 3.9 -3.7
Arm predicted mass (left) 32.2 163.8 166.4 12.9 -12.7