TWAS hub - EPB41L1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0709	0.033	6.9e-05	0.074	NA	0.074	NA	0.061	1.9e-06	NA	1.8e-06	NA	1.5e-05
2	GTEx	Esophagus Mucosa	0.2580	0.055	4.8e-13	0.160	NA	0.215	NA	0.215	6.9e-11	NA	1.9e-14	NA	2.1e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Sitting height	37.7	267.4	275.6	16.1	-16.6
Trunk predicted mass	35.8	204.5	204.5	14.3	-14.3
Trunk fat-free mass	35.4	203.1	204.5	14.2	-14.3
Whole body fat-free mass	34.8	198.8	198.8	14.1	-14.1
Whole body water mass	34.6	197.4	198.8	14.0	-14.1
Arm fat-free mass (right)	32.7	167.7	169.0	13.0	-12.9
Leg predicted mass (right)	32.7	174.2	176.9	13.1	-13.3
Basal metabolic rate	32.7	180.9	182.2	13.4	-13.5
Arm predicted mass (right)	32.2	164.7	168.3	13.0	-12.7
Arm predicted mass (left)	32.2	163.8	166.4	12.9	-12.7
Leg fat-free mass (right)	32.1	171.6	174.2	13.0	-13.2
Height	31.4	605.4	630.0	24.1	-25.1
Leg fat-free mass (left)	31.2	165.1	166.4	12.8	-12.9
Leg predicted mass (left)	30.9	163.8	166.4	12.7	-12.9
Arm fat-free mass (left)	30.9	156.6	159.2	12.6	-12.4
Standing height	30.7	304.2	318.6	17.0	-17.8
Comparative height size at age 10	23.9	131.3	141.6	11.9	-11.0
Weight	20.6	101.3	103.8	9.9	-10.2
Tanning	14.1	172.2	234.1	10.5	-15.3
Forced expiratory volume in 1-second (FEV1), predicted	13.8	28.7	30.4	5.2	-5.5
Hip circumference	11.6	49.8	50.3	7.0	-7.1
Impedance of leg (right)	9.6	46.3	47.4	-6.7	6.9
Hair Pigment	9.3	263.9	355.9	-13.1	18.9
Impedance of leg (left)	9.2	44.6	46.5	-6.5	6.8
Diabetes (self-reported)	8.2	12.6	12.9	3.6	-3.5
Medication: Gliclazide	8.0	9.1	10.0	2.9	-3.2
Trunk fat mass	7.6	32.6	33.5	5.6	-5.8
Peak expiratory flow (PEF)	7.3	17.0	18.5	3.9	-4.3
Lung FVC	6.9	35.0	36.7	-6.1	5.8
Waist circumference	6.7	24.6	25.9	5.1	-4.8
Arm fat mass (left)	6.5	26.7	27.3	5.1	-5.2
Hand grip strength (right)	6.4	17.3	18.2	4.0	-4.3
Relative age voice broke	6.3	9.6	10.4	-3.2	3.0
Arm fat mass (right)	6.3	25.8	26.4	5.0	-5.1
Whole body fat mass	6.3	26.3	26.4	5.1	-5.1
Impedance of whole body	6.1	31.2	32.4	-5.7	5.5
Forced vital capacity (FVC), Best measure	5.9	21.7	22.2	4.6	-4.7
Forced expiratory volume in 1-second (FEV1), Best measure	5.8	18.4	19.3	4.2	-4.4
Diabetes diagnosed by doctor	5.8	9.5	9.5	3.1	-3.1
Medication: Ventolin 100micrograms inhaler	5.5	7.1	8.7	2.4	-2.9
Knee pain experienced in last month	5.1	7.9	8.2	-2.8	2.9
Medication: Lisinopril	5.0	6.4	8.3	2.1	-2.9
HDL Cholesterol	4.9	8.2	11.6	-3.4	2.2
LDL Cholesterol	4.8	7.5	10.7	-3.3	2.1
Forced expiratory volume in 1-second (FEV1)	4.4	14.9	15.2	3.9	-3.8
Migraine (self-reported)	4.4	5.5	6.5	2.5	-2.1
Respiratory disease	4.2	9.4	10.0	3.2	-3.0
Qualifications: CSEs or equivalent	4.2	5.5	6.5	-2.6	2.1
Number of incorrect matches in round	4.2	7.0	7.8	-2.8	2.5
Forced vital capacity (FVC)	4.1	15.8	16.3	4.0	-3.9
Breast Cancer	3.9	9.3	9.5	-3.0	3.1
Eye problems/disorders: Diabetes related eye disease	3.8	4.2	4.4	2.1	-2.0
Frequency of tiredness / lethargy in last 2 weeks	3.8	6.1	7.9	2.1	-2.8
Leg fat mass (left)	3.7	14.4	15.2	3.9	-3.7
Type 2 Diabetes (T2D) (2018)	3.6	6.7	7.2	2.7	-2.5
Impedance of arm (right)	3.6	16.6	18.9	-4.4	3.8
Alzheimer’s Disease (in mother)	3.5	4.1	5.1	-2.3	1.7
Hand grip strength (left)	3.5	9.1	11.6	2.6	-3.4
Diabetes (father)	3.5	4.3	4.9	1.9	-2.2
Noisy workplace	3.5	4.3	5.9	-1.6	2.4
Medication: Metformin	3.4	4.8	5.1	2.2	-2.1
Diabetes (mother)	3.4	4.4	5.2	1.9	-2.3
Average weekly beer plus cider intake	3.4	4.9	6.6	-1.8	2.6
Leg fat mass (right)	3.3	12.7	13.1	3.6	-3.5
Coronary Artery Disease (CAD)	3.2	3.8	4.2	1.9	-2.0
Impedance of arm (left)	3.2	14.6	16.1	-4.0	3.6
Tinnitus: Yes, now most or all of the time	3.2	3.7	4.3	1.8	-2.1
Medication: Atenolol	3.1	3.9	4.6	1.8	-2.1
Diastolic blood pressure, automated reading	3.1	9.5	10.1	3.2	-3.0
Ulcerative Colitis	3.0	4.3	6.1	2.5	-1.6
Alcohol usually taken with meals	3.0	4.9	6.6	2.6	-1.8
Illnesses of mother	3.0	3.7	4.5	2.1	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	3.0	4.6	5.5	2.3	-2.0
Alzheimer’s Disease (including proxy)	2.7	3.9	5.1	-2.3	1.6
Fluid intelligence score	2.7	5.6	9.8	3.1	-1.2
Chronic bronchitis/emphysema (mother)	2.7	3.1	4.3	-2.1	1.4
Angina (self-reported)	2.7	3.5	6.1	1.0	-2.5
High cholesterol (Self-reported)	2.7	4.8	6.1	-2.5	1.9
Guilty feelings	2.6	3.9	4.4	1.8	-2.1
Intelligence (Savage-Jansen 2018)	2.5	7.7	13.9	3.7	-1.2
Type 2 Diabetes (T2D) (2012)	2.5	2.9	3.4	1.8	-1.6
Angina	2.5	3.3	5.8	0.9	-2.4
Depression (Nagel 2018)	2.4	3.6	4.7	1.6	-2.2
Frequency of depressed mood in last 2 weeks	2.4	3.3	3.9	1.6	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	4.5	1.4	-2.1
Eye problems/disorders: Cataract	2.4	2.7	3.0	1.6	-1.7
Father’s age at death	2.3	3.1	4.2	-2.1	1.4
Shortness of breath walking on level ground	2.3	2.8	4.2	1.1	-2.1
Qualifications: College or University degree	2.3	7.3	7.6	2.8	-2.6
BMI	2.2	12.9	13.6	3.5	-3.7
Length of working week for main job	2.2	2.4	3.5	1.9	-1.1
Commuting to job workplace: Public transport	2.2	2.6	3.0	1.5	-1.7
Bipolar Disorder (2018)	2.1	3.3	3.3	1.8	-1.8
Alzheimer’s Disease (in father)	2.1	2.3	2.5	-1.4	1.6
Wheeze or whistling in the chest in last year	2.1	3.7	4.0	2.0	-1.9
Basal cell carcinoma (self-reported)	2.1	2.5	3.3	-1.3	1.8
Deep venous thrombosis (DVT) (self-reported)	2.1	2.6	4.4	1.0	-2.1
Body Mass Index (BMI) (2010)	2.0	2.7	3.1	1.5	-1.8
Past tobacco smoking	2.0	3.6	4.2	1.7	-2.0
Qualifications: A levels/AS levels or equivalent	2.0	4.3	5.8	2.4	-1.7
Handedness (chirality/laterality): Left-handed	2.0	2.4	2.6	-1.6	1.5
Illnesses of father: None of the above (group 1)	2.0	2.5	2.8	-1.5	1.7
Pulse rate	1.9	3.1	5.3	-1.0	2.3
Hair/balding pattern: Pattern 4	1.9	4.5	5.2	-2.3	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	3.0	1.7	-1.4
Chest pain or discomfort	1.9	2.7	4.4	2.1	-1.0
Mean time to correctly identify matches	1.8	3.4	5.8	-2.4	1.0
Heart disease (siblings)	1.8	2.3	2.8	1.7	-1.3
Verbal and Numeric Reasoning (VNR)	1.7	4.1	7.5	2.7	-0.9
Sensitivity / hurt feelings	1.7	2.9	4.8	-2.2	1.0
Medication: Simvastatin	1.7	2.5	4.0	-2.0	1.0
Blood clot in the leg (DVT)	1.7	2.3	3.5	1.0	-1.9
Smoking status: Previous	1.7	2.5	2.7	-1.5	1.6
Mineral and other dietary supplements	1.7	2.3	3.3	1.2	-1.8
Age at First Birth	1.6	2.3	2.6	-1.6	1.4
Age when periods started (menarche)	1.6	3.9	4.5	-2.1	1.8
Hair/balding pattern: Pattern 2	1.6	2.0	3.9	-0.4	2.0
Fed-up feelings	1.5	2.8	4.1	2.0	-1.2
Body mass index (BMI)	1.5	6.5	6.8	2.6	-2.5
Family relationship satisfaction	1.5	1.8	2.3	1.5	-1.2
Average weekly champagne plus white wine intake	1.5	2.1	2.6	1.6	-1.3
Pack years of smoking	1.5	2.1	2.3	1.5	-1.4
Lung FEV1/FVC ratio	1.4	7.0	7.9	2.8	-2.5
Pack years adult smoking proportion	1.4	2.2	2.6	1.6	-1.3
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	4.0	2.0	-0.6
Schizophrenia vs Biploar Disorder	1.3	1.7	1.8	-1.3	1.3
Qualifications: None of the above	1.3	2.8	3.4	-1.9	1.5
Alcohol intake versus 10 years previously	1.3	2.0	3.1	1.8	-0.9
Asthma (self-reported)	1.3	2.5	3.6	1.9	-1.2
Myopia	1.3	1.8	2.3	1.5	-1.2
Mean Putamen Volume	1.2	1.3	2.1	-0.8	1.4
Blood Eosinophil Count	1.2	9.5	12.3	3.5	-2.6
Number of treatments/medications taken	1.2	2.2	2.6	1.6	-1.4
Relative age of first facial hair	1.2	2.4	2.7	-1.6	1.4
Time employed in main current job	1.2	1.3	2.5	-1.6	0.5
Asthma	1.2	2.4	3.1	1.7	-1.3
Medication for pain relief, constipation, heartburn	1.2	2.0	2.8	-1.1	1.7
Heart disease (mother)	1.2	1.5	2.8	0.5	-1.7
Mother’s age at death	1.2	1.5	1.7	-1.3	1.2
Commuting to job workplace: Cycle	1.2	1.4	2.4	0.7	-1.6
Primary Biliary Cirrhosis	1.1	1.6	1.8	1.2	-1.3
Trunk fat percentage	1.1	4.4	5.1	1.9	-2.3
Commuting to job workplace: Walk	1.1	1.2	1.5	0.9	-1.2
Ever taken oral contraceptive pill	1.1	1.2	1.2	-1.1	1.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.1	1.5	-0.6
Pulse wave reflection index	1.0	1.3	2.3	0.4	-1.5
Exposure to tobacco smoke outside home	1.0	1.4	1.9	1.4	-0.9
Illnesses of siblings: Diabetes	1.0	1.3	1.8	1.3	-0.9
Mood swings	1.0	1.9	2.8	1.7	-1.0
Irritability	1.0	1.7	2.4	-1.0	1.5
Unable to work because of sickness or disability	1.0	1.2	1.8	-1.3	0.8
Vascular/heart problems diagnosed by doctor	1.0	2.8	3.1	-1.8	1.6
Lupus	0.9	1.4	2.2	0.8	-1.5
Rheumatoid Arthritis	0.9	1.2	1.8	-0.8	1.3
Waist Hip Ratio (WHR)	0.9	4.0	5.1	-1.7	2.3
Pain all over the body in last month	0.9	1.0	1.4	0.7	-1.2
Medication: Ramipril	0.9	1.1	1.3	1.1	-1.0
Birth weight	0.9	2.0	3.1	1.0	-1.7
Leg pain on walking	0.9	1.1	2.1	0.4	-1.4
Breast cancer (self-reported)	0.9	1.1	1.9	1.4	-0.5
Medication: Blood pressure	0.9	1.8	2.7	1.6	-0.9
Irritable Bowel Disease (IBD)	0.8	1.8	2.7	1.6	-1.0
Ulcerative Colitis (UC)	0.8	1.5	2.5	1.6	-0.7
Blood Red Count	0.8	7.3	8.7	-2.4	3.0
Severe depression (siblings)	0.8	0.8	1.0	-1.0	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	1.7	1.3	-0.8
Had menopause	0.8	1.0	1.9	1.4	-0.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.3	0.8	-1.2
Headache pain in last month	0.8	1.4	1.9	0.9	-1.4
Eye problems/disorders: None of the above	0.8	0.9	1.2	-0.8	1.1
Friendships satisfaction	0.8	1.0	1.8	1.3	-0.3
Hearing aid user	0.8	1.0	1.8	-1.4	-0.2
Medication: Atorvastatin	0.8	0.9	1.0	-1.0	0.9
Reaction Time	0.7	1.4	2.7	-1.6	0.2
Chronic bronchitis/emphysema (father)	0.7	0.8	1.5	-0.5	1.2
Financial difficulties in last 2 years	0.7	0.9	1.1	0.9	-1.0
Allergy	0.7	1.6	1.8	-1.4	1.2
Medication: Allopurinol	0.7	1.0	1.2	0.8	-1.1
Osteoarthritis (self-reported)	0.7	0.9	1.0	-1.0	0.9
Medication: Aspirin	0.7	0.9	0.9	0.9	-1.0
Number of self-reported non-cancer illnesses	0.7	1.2	1.5	1.0	-1.2
Bipolar Disorder or Schizophrenia	0.6	1.5	2.4	1.6	-0.7
Triglycerides	0.6	1.0	1.6	-1.3	0.6
Happiness	0.6	0.8	1.5	1.2	-0.2
Medication: Lansoprazole	0.6	0.7	1.4	-1.2	0.2
Exposure to tobacco smoke at home	0.6	0.7	1.3	0.2	-1.1
Leg fat percentage (right)	0.6	2.2	2.7	-1.3	1.6
Pulse wave peak to peak time	0.6	0.7	0.8	0.8	-0.9
Health satisfaction	0.6	0.8	1.2	0.7	-1.1
Medication: Blood pressure	0.6	1.1	1.6	1.3	-0.8
Pulse rate, automated reading	0.6	2.0	2.5	-1.2	1.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.3	-0.3	1.1
Medication: Aspirin	0.6	0.8	1.0	0.8	-1.0
Back pain experienced in last month	0.6	0.8	1.3	-1.2	0.6
Ever depressed for a whole week	0.6	0.7	1.1	-1.0	0.5
Pain experienced in last month	0.6	1.1	1.2	1.1	-0.9
Medication for hormone replacement therapy	0.5	0.6	0.8	-0.6	0.9
Vitamin and mineral supplements	0.5	0.6	0.7	0.8	-0.8
Supplements: Zinc	0.5	0.6	1.1	1.0	-0.2
Taking other prescription medications	0.5	0.7	0.8	0.9	-0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	-1.1	0.3
Heart attack	0.5	0.6	1.0	1.0	-0.4
Medication: Cholesterol lowering	0.5	0.8	1.2	-1.1	0.6
Lung cancer (father)	0.5	0.6	1.1	-0.1	-1.1
Birth weight of first child	0.5	0.9	1.2	-0.8	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.5	-1.2	0.8
Cholesterol lowering medication	0.5	0.8	1.0	-1.0	0.8
Ovarian Cancer	0.4	0.5	0.9	-0.9	0.5
Falls in the last year	0.4	0.5	0.5	0.7	-0.7
Medication: Paracetamol	0.4	0.7	0.7	0.8	-0.8
High blood pressure (siblings)	0.4	0.5	0.5	0.7	-0.7
Comparative body size at age 10	0.4	1.2	1.6	0.9	-1.2
Number of full brothers	0.4	0.6	1.0	0.4	-1.0
Medication: Omeprazole	0.4	0.5	0.9	-0.9	0.2
Medication: Seretide 50 evohaler	0.4	0.4	0.4	0.7	-0.6
Illnesses of father: Heart disease	0.4	0.5	0.9	1.0	-0.2
Qualifications: nursing, teaching	0.4	0.7	1.1	1.0	-0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.6	0.6	-0.7	0.8
Alcohol drinker status: Never	0.4	0.5	1.0	-0.2	1.0
Leg fat percentage (left)	0.4	1.6	2.1	-1.0	1.5
Risk taking	0.4	0.6	0.9	0.6	-0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	0.9	-0.4
Alcohol drinker status: Previous	0.4	0.4	0.8	-0.9	0.2
Worry (Nagel 2018)	0.3	0.6	1.2	-0.2	1.1
Blood White Count	0.3	1.9	1.9	-1.4	1.4
Heel T-Score	0.3	2.4	3.2	1.2	-1.8
Systolic Blood Pressure	0.3	1.3	1.6	1.3	-1.0
Smoking Status	0.3	0.8	1.4	-0.5	1.2
Allergy or Eczema	0.3	0.8	1.3	1.2	-0.6
Hearing difficulty/problems: Yes	0.3	0.5	0.7	-0.8	0.5
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.2	0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.7	-0.1	0.9
Nervous feelings	0.3	0.5	0.9	-0.3	0.9
Neuroticism score	0.3	0.7	1.1	1.1	-0.4
Prospective memory result	0.3	0.3	0.6	-0.8	0.2
Gout (self-reported)	0.3	0.4	0.8	0.4	-0.9
Medication: Ibuprofen	0.3	0.4	0.7	0.3	-0.8
Overall health rating	0.3	0.6	0.8	0.9	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.5	-0.7	0.4
Arm fat percentage (left)	0.3	1.2	1.2	1.1	-1.1
Long-standing illness, disability or infirmity	0.3	0.4	0.6	0.6	-0.7
Financial situation satisfaction	0.3	0.4	0.4	0.6	-0.6
Eye problems/disorders: Glaucoma	0.3	0.3	0.6	-0.8	0.2
Medication: Paracetamol	0.3	0.4	0.5	0.7	-0.5
Illnesses of father: High blood pressure	0.3	0.3	0.6	0.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	-0.3	-0.9
Depressed Affect (Nagel 2018)	0.2	0.5	1.0	1.0	-0.2
Schizophrenia (2018)	0.2	0.3	0.4	0.5	0.6
Crohns Disease (2017)	0.2	0.3	0.4	0.6	-0.6
Prostate Cancer	0.2	0.3	0.6	-0.8	0.0
Neuroticism (2016)	0.2	0.3	0.3	0.5	-0.5
Schizophrenia (2014)	0.2	0.4	0.7	0.8	0.1
Neuroticism	0.2	0.5	1.0	1.0	-0.2
Systolic blood pressure, automated reading	0.2	0.6	0.9	0.5	-0.9
High blood pressure	0.2	0.5	0.9	0.9	-0.4
Supplements: Glucosamine	0.2	0.3	0.3	-0.6	0.5
Medication: Levothyroxine sodium	0.2	0.3	0.6	0.3	-0.8
Hearing difficulty/problems with background noise	0.2	0.3	0.6	-0.0	-0.8
Arm fat percentage (right)	0.2	0.9	1.0	0.9	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	-0.6	0.4
Depression (self-reported)	0.2	0.3	0.5	-0.1	0.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	0.0	-0.7
Glaucoma (self-reported)	0.2	0.2	0.4	0.1	-0.6
Medication: Amlodipine	0.2	0.2	0.4	0.2	0.7
Body fat percentage	0.2	0.6	0.6	0.8	-0.8
Number of children fathered	0.2	0.3	0.3	-0.6	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.5	-0.3	0.7
Age at first live birth	0.2	0.3	0.5	-0.3	0.7
Had major operations	0.2	0.2	0.3	-0.5	-0.3
Loneliness, isolation	0.2	0.2	0.4	0.7	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	-0.7	0.4
Medication for cholesterol	0.2	0.4	0.4	-0.5	-0.7
Osteoporosis (self-reported)	0.2	0.2	0.4	-0.1	-0.6
Miserableness	0.2	0.3	0.5	0.7	0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.3	0.4	-0.6
Medication: Bendroflumethiazide	0.2	0.4	0.5	0.7	0.5
Ever smoked	0.2	0.3	0.5	-0.4	0.7
Age started oral contraceptive pill	0.2	0.2	0.3	-0.3	0.5
Supplements: Calcium	0.2	0.2	0.3	0.3	-0.6
Neuroticism (Nagel 2018)	0.1	0.2	0.5	-0.2	0.7
Major Depression (MDD)	0.1	0.1	0.1	-0.3	0.3
Bipolar Disorder (2011)	0.1	0.1	0.2	0.4	-0.2
Fasting Glucose	0.1	0.1	0.2	-0.5	0.1
HbA1C	0.1	0.1	0.2	0.5	-0.2
Blood Platelet Count	0.1	0.7	1.0	1.0	-0.7
Chronotype (morning person)	0.1	0.3	0.6	0.2	-0.8
Medication: Co-codamol	0.1	0.1	0.1	0.3	-0.2
Maternal smoking around birth	0.1	0.1	0.1	0.2	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.2	0.4	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	-0.1	-0.3
Multivitamins +/- minerals	0.1	0.1	0.2	-0.5	0.3
High blood pressure (mother)	0.1	0.1	0.2	0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.3	0.5	-0.5
Mouth/teeth dental problems	0.1	0.1	0.2	0.5	-0.2
Illnesses of siblings	0.1	0.1	0.2	-0.4	0.3
Number of live births	0.1	0.2	0.2	-0.3	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	-0.2	-0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	0.4	-0.3
Tense / ‘highly strung’	0.1	0.1	0.2	-0.0	0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	-0.1	0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.4	0.4	-0.6
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.5	0.1
Neck or shoulder pain in last month	0.1	0.1	0.2	0.5	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.5	-0.0
Suffer from ‘nerves’	0.1	0.1	0.1	0.3	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.3	0.4
Supplements: Vitamin C	0.1	0.1	0.2	0.1	-0.5
Hypertension (Self-reported)	0.1	0.3	0.5	0.7	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.2	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.2	0.5	-0.3
Number of operations (self-reported)	0.1	0.2	0.3	-0.6	0.2
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.5	-0.2
Crohns Disease (2012)	0.0	0.0	0.0	0.0	-0.2
Cardiovascular Disease	0.0	0.1	0.1	0.4	0.1
Hypothyroidism (self reported)	0.0	0.1	0.2	0.2	-0.4
Average weekly spirits intake	0.0	0.0	0.1	-0.2	-0.2
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.1	-0.3	-0.2
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	-0.1	-0.0
Townsend deprivation index at recruitment	0.0	0.0	0.0	-0.2	0.2
Current tobacco smoking	0.0	0.0	0.1	0.3	-0.1
Average weekly fortified wine intake	0.0	0.0	0.0	-0.2	0.0
Serious illness, injury or assault to yourself	0.0	0.1	0.1	-0.2	-0.2
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	0.3	-0.0
Stomach or abdominal pain in last month	0.0	0.1	0.1	0.3	0.1
Had other major operations	0.0	0.0	0.1	-0.2	-0.3
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	-0.1	-0.3
Worrier / anxious feelings	0.0	0.0	0.1	0.1	0.3
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	-0.2	0.2
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	-0.0	0.1
Breastfed as a baby	0.0	0.0	0.0	0.1	-0.1
Loud music exposure frequency	0.0	0.0	0.1	0.2	-0.1
Worry too long after embarrassment	0.0	0.0	0.1	-0.0	-0.3
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.1	0.2
Alcohol intake frequency.	0.0	0.1	0.1	0.3	0.3
Number of full sisters	0.0	0.0	0.1	0.0	-0.2
Age at last live birth	0.0	0.0	0.0	0.2	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.0	-0.1	0.2
Average weekly red wine intake	0.0	0.0	0.1	0.1	-0.2
Ever had bowel cancer screening	0.0	0.0	0.1	0.2	-0.0
Smoking status: Current	0.0	0.0	0.0	0.0	0.2
Wears glasses or contact lenses	0.0	0.0	0.1	0.3	0.0
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	0.2	0.1

Hub : Genes

EPB41L1

Models

Trait associations