[Hub]/) : Traits : Arm fat-free mass (right) : ← →

chr17:6,444,676-8,161,149

Best TWAS P=2.23e-13 · Best GWAS P=3.08e-16 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Esophagus Mucosa	CHRNB1	0.19	0.11	lasso	2	0.13	7.3e-09	7.4	7.3	2.2e-13	0.29	0.56	0.44	TRUE
33	The Cancer Genome Atlas	Thyroid Carcinoma	SHBG	0.04	0.00	blup	59	0.02	4.4e-03	-4.2	-6.6	3.6e-11	-0.46	0.04	0.08	TRUE
2	CommonMind	Brain Pre-frontal Cortex	EIF5A	0.20	0.12	bslmm	446	0.10	1.2e-12	-4.1	-6.2	4.9e-10	-0.05	1.00	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CHRNB1	0.09	0.06	lasso	2	0.08	9.8e-10	7.4	6.2	5.9e-10	0.16	0.49	0.51	TRUE
22	The Cancer Genome Atlas	Glioblastoma Multiforme	AMAC1L3	0.14	0.12	lasso	3	0.12	1.8e-04	5.9	-6.1	1.0e-09	-0.25	0.01	0.88	TRUE
6	GTEx	Breast Mammary Tissue (Male)	CHRNB1	0.28	-0.01	lasso	6	0.02	9.6e-02	7.4	6.0	2.2e-09	0.20	0.07	0.08	TRUE
9	GTEx	Esophagus Mucosa	ZBTB4	0.12	0.10	lasso	2	0.08	8.0e-06	5.7	5.6	2.0e-08	0.26	0.96	0.00	TRUE
19	YFS	Blood	PHF23	0.03	0.01	bslmm	450	0.02	5.9e-08	6.3	-5.5	3.8e-08	0.05	0.87	0.01	TRUE
23	The Cancer Genome Atlas	Glioblastoma Multiforme	EIF5A	0.26	0.10	blup	51	0.05	9.7e-03	4.4	-5.4	6.6e-08	0.14	0.04	0.08	TRUE
16	METSIM	Adipose	NEURL4	0.06	0.00	blup	454	0.01	8.2e-03	-1.1	-5.4	7.1e-08	-0.02	0.11	0.02	TRUE
12	GTEx	Skin Not Sun Exposed Suprapubic	CHRNB1	0.17	0.15	lasso	3	0.16	7.4e-09	7.4	7.2	7.5e-13	0.29	0.69	0.31	FALSE
4	GTEx	Adipose Visceral Omentum	CHRNB1	0.29	0.14	lasso	5	0.14	1.0e-07	7.4	7.1	1.3e-12	0.27	0.62	0.36	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	TNFSF12-TNFSF13	0.03	0.00	lasso	4	0.01	2.9e-02	-5.1	-7.0	2.7e-12	-0.45	0.01	0.66	FALSE
21	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHRNB1	0.07	0.04	blup	57	0.05	1.6e-03	7.4	7.0	3.2e-12	0.34	0.00	0.90	FALSE
30	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHRNB1	0.06	0.00	blup	57	0.03	4.5e-03	3.6	6.9	6.3e-12	0.34	0.00	0.77	FALSE
18	YFS	Blood	CHRNB1	0.04	0.02	lasso	5	0.04	8.5e-12	7.2	6.8	1.2e-11	0.31	0.66	0.34	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	CHRNB1	0.11	0.08	lasso	6	0.08	7.8e-11	7.4	6.7	1.9e-11	0.30	0.63	0.37	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHRNB1	0.05	0.04	blup	57	0.04	6.1e-05	6.1	6.7	1.9e-11	0.23	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Lung Adenocarcinoma	CHRNB1	0.03	0.02	blup	57	0.02	7.8e-04	7.2	6.5	7.0e-11	0.36	0.00	0.99	FALSE
15	GTEx	Whole Blood	TNFSF12	0.09	0.03	enet	24	0.04	1.9e-04	-5.2	-6.5	1.0e-10	-0.43	0.44	0.43	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNB1	0.06	0.06	enet	10	0.06	1.0e-11	7.2	6.2	5.9e-10	0.32	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHRNB1	0.18	0.09	enet	10	0.10	4.9e-11	7.4	6.1	1.3e-09	0.30	0.00	1.00	FALSE
7	GTEx	Cells Transformed fibroblasts	CHRNB1	0.28	0.11	enet	25	0.18	2.9e-13	7.4	6.0	2.0e-09	0.46	0.63	0.37	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	CHRNB1	0.09	0.02	blup	57	0.05	2.6e-05	-3.6	6.0	2.6e-09	0.23	0.11	0.75	FALSE
14	GTEx	Stomach	CHRNB1	0.28	0.19	lasso	4	0.23	2.0e-11	7.4	5.7	1.5e-08	0.15	0.56	0.43	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	SENP3	0.07	0.04	enet	9	0.03	2.7e-04	3.2	5.7	1.5e-08	0.20	0.22	0.41	FALSE
11	GTEx	Muscle Skeletal	EIF5A	0.14	0.06	enet	35	0.05	4.2e-06	-4.0	-5.6	2.4e-08	-0.02	0.96	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	POLR2A	0.08	0.07	lasso	4	0.07	1.9e-08	5.4	5.5	3.9e-08	0.18	1.00	0.00	FALSE
13	GTEx	Skin Sun Exposed Lower leg	CHRNB1	0.19	0.12	enet	13	0.12	3.0e-10	5.7	5.5	5.1e-08	0.22	1.00	0.00	FALSE
10	GTEx	Esophagus Muscularis	ZBTB4	0.13	0.06	lasso	2	0.05	6.3e-04	5.5	5.4	8.2e-08	0.26	0.29	0.23	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	TNFSF12-TNFSF13	0.07	0.01	enet	17	0.03	4.4e-04	-5.1	-5.4	8.3e-08	-0.08	0.03	0.08	FALSE
5	GTEx	Artery Tibial	TNFSF12	0.11	0.06	lasso	2	0.05	1.2e-04	5.4	5.3	8.6e-08	0.52	0.26	0.67	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHRNB1	0.06	0.07	lasso	6	0.07	1.8e-08	3.9	5.3	1.5e-07	0.28	0.54	0.46	FALSE