TWAS hub - PHF23

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pancreas	0.260	0.0830	3.8e-03	-0.007	NA	0.003	NA	-0.004	0.9200	NA	2.2e-01	NA	5.2e-01
2	GTEx	Skin Sun Exposed Lower leg	0.089	0.0370	6.6e-03	0.010	NA	0.001	NA	0.004	0.0420	NA	2.4e-01	NA	1.5e-01
3	YFS	Blood	0.034	0.0112	2.7e-05	0.006	0.013	0.016	0.022	0.017	0.0029	2.3e-05	5.2e-06	5.9e-08	1.6e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3
Hypothyroidism/myxoedema (self-reported)	3.9	7.7	23.1	4.8	-0.1
Lupus	3.8	5.8	14.6	3.8	-1.7
Medication: Ventolin 100micrograms inhaler	3.7	4.7	13.8	-3.7	0.6
Arm fat-free mass (left)	3.6	18.5	31.8	4.9	-5.6
Arm predicted mass (left)	3.6	18.5	30.6	5.0	-5.5
Arm fat-free mass (right)	3.5	17.7	30.2	4.8	-5.5
Arm predicted mass (right)	3.5	17.9	30.8	4.8	-5.5
Medication: Levothyroxine sodium	3.3	5.6	15.5	3.9	1.1
Blood clot in the leg (DVT)	3.3	4.3	8.4	2.9	-2.1
Chest pain or discomfort	3.2	4.6	8.3	-2.9	2.3
Asthma (self-reported)	3.2	6.4	15.9	-4.0	-1.8
Deep venous thrombosis (DVT) (self-reported)	3.1	4.0	7.6	2.8	-2.1
Leg fat mass (right)	3.0	11.7	23.4	4.8	-3.4
Mother’s age at death	3.0	3.7	8.6	-1.6	2.9
Hypothyroidism (self reported)	2.9	6.8	18.6	4.3	1.3
Ever unenthusiastic/disinterested for a whole week	2.9	3.5	5.5	2.3	-2.3
Hip circumference	2.9	12.6	22.5	4.7	-3.9
Osteoporosis (self-reported)	2.8	3.5	7.8	-1.6	2.8
Basal metabolic rate	2.8	15.3	25.3	4.5	-5.0
Leg fat mass (left)	2.8	10.8	21.9	4.7	-3.2
Weight	2.7	13.4	20.3	4.5	-4.4
Asthma	2.7	5.4	12.0	-3.5	-2.0
Trunk predicted mass	2.6	14.6	25.6	4.3	-5.1
Whole body water mass	2.6	14.8	26.0	4.3	-5.1
Respiratory disease	2.5	5.6	16.7	-4.1	-0.4
Trunk fat-free mass	2.5	14.4	25.2	4.2	-5.0
Father’s age at death	2.5	3.4	5.4	-2.3	2.1
Whole body fat-free mass	2.5	14.2	24.2	4.3	-4.9
Illnesses of siblings: Diabetes	2.4	3.0	4.5	2.1	2.1
Diastolic blood pressure, automated reading	2.4	7.6	18.3	4.3	-2.1
Commuting to job workplace: Cycle	2.4	2.9	5.2	-2.3	1.9
Basal cell carcinoma (self-reported)	2.4	2.8	4.9	-2.2	1.9
Whole body fat mass	2.3	9.4	19.7	4.4	-2.9
Sitting height	2.2	15.7	28.8	5.4	-4.3
Leg predicted mass (left)	2.2	11.4	19.2	3.9	-4.4
HbA1C	2.1	2.3	4.8	1.5	2.2
Leg fat-free mass (left)	2.1	11.2	18.8	3.9	-4.3
Arm fat mass (right)	2.1	8.6	17.9	4.2	-2.8
Allergy	2.0	4.6	12.0	1.4	3.5
Qualifications: A levels/AS levels or equivalent	2.0	4.4	10.6	-3.3	1.6
Supplements: Vitamin C	2.0	2.3	4.0	-1.7	2.0
Arm fat mass (left)	2.0	8.1	15.9	4.0	-2.9
Illnesses of father: None of the above (group 1)	1.9	2.4	4.1	-1.7	2.0
Trunk fat mass	1.8	7.9	17.3	4.2	-2.5
Impedance of arm (right)	1.8	8.3	16.9	-2.8	4.1
Leg fat percentage (right)	1.8	6.6	15.4	3.9	-2.1
Leg predicted mass (right)	1.8	9.6	17.1	3.4	-4.1
Average weekly champagne plus white wine intake	1.8	2.4	5.7	1.3	-2.4
Medication: Lisinopril	1.8	2.3	4.1	-1.6	2.0
Alzheimer’s Disease (in father)	1.7	1.8	2.8	1.7	-1.6
Supplements: Zinc	1.7	1.9	5.6	-0.2	2.4
Body mass index (BMI)	1.7	7.1	13.0	3.6	-2.9
Impedance of arm (left)	1.7	8.0	15.5	-2.9	3.9
Wheeze or whistling in the chest in last year	1.7	3.0	8.4	-2.9	-0.7
Leg fat-free mass (right)	1.7	9.3	17.1	3.3	-4.1
BMI	1.6	9.1	20.2	4.5	-2.7
Gout (self-reported)	1.6	2.2	5.9	0.8	2.4
Waist Hip Ratio (WHR)	1.5	6.8	10.8	-3.3	3.1
Shortness of breath walking on level ground	1.5	1.8	5.2	-0.3	-2.3
Medication: Allopurinol	1.5	2.0	5.4	0.8	2.3
Leg pain on walking	1.5	1.9	5.4	0.5	-2.3
Cholesterol lowering medication	1.5	2.3	4.2	-2.0	-1.6
Depressed Affect (Nagel 2018)	1.4	2.8	7.5	1.0	-2.7
Maternal smoking around birth	1.4	2.0	4.2	1.3	-2.0
Medication: Ramipril	1.4	1.9	5.5	0.3	-2.3
Body fat percentage	1.4	5.5	14.1	3.8	-1.6
Leg fat percentage (left)	1.4	5.1	12.5	3.5	-1.7
Hayfever, allergic rhinitis or eczema	1.3	2.9	7.5	-1.1	-2.7
Heart attack	1.3	1.7	4.7	-0.6	-2.2
Alcohol intake frequency.	1.3	3.0	8.5	0.8	-2.9
Hearing aid user	1.3	1.4	2.4	-1.4	1.5
High cholesterol (Self-reported)	1.3	2.3	4.4	-1.6	-2.1
Heart attack/myocardial infarction (self-reported)	1.3	1.6	4.4	-0.7	-2.1
Primary Biliary Cirrhosis	1.2	1.7	5.0	2.2	-0.4
Trunk fat percentage	1.2	4.8	12.6	3.6	-1.3
Current tobacco smoking	1.2	2.0	5.8	0.5	-2.4
Hearing difficulty/problems with background noise	1.2	1.8	2.8	-1.7	1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.2	1.8	-0.8
Eye problems/disorders: Cataract	1.2	1.3	3.2	-0.9	-1.8
Neuroticism (Nagel 2018)	1.1	2.7	7.4	0.8	-2.7
Ovarian Cancer	1.1	1.5	2.8	1.3	-1.7
Ulcerative Colitis	1.1	1.6	4.1	0.9	-2.0
Medication: Atenolol	1.1	1.4	3.6	1.9	0.8
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	5.0	-2.2	-0.5
Illnesses of father: Heart disease	1.1	1.5	3.8	0.8	-1.9
Alcohol drinker status: Never	1.1	1.3	3.4	0.8	-1.8
Ever depressed for a whole week	1.1	1.4	3.7	1.9	-0.7
Neuroticism (2016)	1.0	1.4	3.6	-1.9	0.7
Blood Eosinophil Count	1.0	7.6	11.8	-3.3	-3.4
Heel T-Score	1.0	7.7	15.1	-3.9	2.9
Relative age of first facial hair	1.0	2.2	4.0	2.0	-1.6
Medication: Co-codamol	1.0	1.1	1.8	1.2	-1.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	1.9	1.4	-1.2
Illnesses of siblings	1.0	1.4	2.9	-1.2	-1.7
Medication: Lansoprazole	1.0	1.2	3.5	-0.1	-1.9
Comparative height size at age 10	1.0	5.5	9.7	3.1	-2.6
Supplements: Calcium	1.0	1.1	2.9	-0.6	1.7
Bipolar Disorder (2018)	0.9	1.5	2.7	-1.6	-1.3
Reaction Time	0.9	1.6	3.8	1.0	-2.0
Breast Cancer	0.9	2.2	6.0	-2.4	0.8
Diabetes (father)	0.9	1.2	3.0	1.7	0.7
Relative age voice broke	0.9	1.4	3.8	0.5	-2.0
Falls in the last year	0.9	1.3	2.6	1.1	-1.6
Loud music exposure frequency	0.9	1.0	2.9	0.3	1.7
Commuting to job workplace: Car/motor vehicle	0.9	1.1	3.1	0.4	-1.8
Breast cancer (self-reported)	0.9	1.0	3.0	0.3	-1.7
Smoking status: Current	0.9	1.5	4.1	0.5	-2.0
Number of self-reported non-cancer illnesses	0.9	1.5	2.5	1.4	-1.6
Impedance of whole body	0.9	4.8	9.7	-2.2	3.1
LDL Cholesterol	0.8	1.2	3.4	-1.8	-0.5
Height	0.8	15.3	32.1	3.7	-5.7
Supplements: Glucosamine	0.8	1.0	1.8	-1.1	1.3
Waist circumference	0.8	3.1	5.4	2.3	-2.0
Arm fat percentage (right)	0.8	3.1	8.4	2.9	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	1.7	1.2	-1.3
Standing height	0.8	7.5	14.9	2.7	-3.9
Number of children fathered	0.8	0.9	2.4	-0.4	1.5
Pulse wave peak to peak time	0.8	0.9	2.2	1.5	0.7
Emphysema/chronic bronchitis	0.8	0.9	1.8	-1.4	-0.9
Migraine (self-reported)	0.8	1.0	2.9	-1.7	0.4
Family relationship satisfaction	0.8	0.9	1.5	-1.1	-1.2
Arm fat percentage (left)	0.8	3.3	8.9	3.0	-1.0
Mood swings	0.8	1.5	2.4	1.4	-1.6
Friendships satisfaction	0.8	1.0	3.1	-1.8	-0.2
Miserableness	0.8	1.4	3.1	1.0	-1.8
Ever taken oral contraceptive pill	0.8	0.9	2.6	0.5	-1.6
Commuting to job workplace: Public transport	0.8	0.9	1.8	-1.0	1.3
Alcohol drinker status: Previous	0.8	0.9	2.1	0.7	-1.4
Irritable Bowel Disease (IBD)	0.7	1.8	5.2	2.3	0.1
Prostate Cancer	0.7	0.9	2.6	1.6	0.4
Blood Platelet Count	0.7	8.5	14.7	-3.3	-3.8
Blood Red Count	0.7	6.5	17.1	4.1	-1.5
Allergy or Eczema	0.7	1.8	3.6	-1.3	-1.9
Lung FVC	0.7	3.4	9.8	-0.7	3.1
Neuroticism	0.7	1.6	4.8	-0.1	-2.2
Ever had hysterectomy (womb removed)	0.7	0.8	1.5	1.2	0.8
Medication: Metformin	0.7	0.9	2.7	-1.6	-0.3
Townsend deprivation index at recruitment	0.7	0.9	1.6	1.3	1.1
Fed-up feelings	0.7	1.3	2.3	1.2	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.6	-0.8	-1.6
Prospective memory result	0.7	0.9	2.1	1.5	-0.7
Pulse wave Arterial Stiffness index	0.7	0.8	1.4	-1.2	-1.0
Tense / ‘highly strung’	0.7	1.2	2.1	-1.4	1.2
Smoking status: Previous	0.7	1.0	3.1	-0.1	1.8
Irritability	0.7	1.2	3.6	-1.9	0.0
Verbal and Numeric Reasoning (VNR)	0.6	1.3	3.6	0.6	-1.9
Hearing difficulty/problems: Yes	0.6	0.9	1.6	-1.1	1.3
Medication: Simvastatin	0.6	1.0	2.4	-0.7	-1.6
Hair/balding pattern: Pattern 3	0.6	0.9	2.2	1.5	-0.7
Happiness	0.6	0.7	2.0	-1.4	0.0
Depression (self-reported)	0.6	0.8	1.5	0.8	-1.2
Medication: Ibuprofen	0.6	0.7	1.4	0.9	-1.2
Medication: Omeprazole	0.6	0.7	1.5	-0.8	1.2
Knee pain experienced in last month	0.6	0.9	2.2	0.7	-1.5
Osteoarthritis (self-reported)	0.6	0.8	2.2	1.5	-0.0
Medication: Gliclazide	0.6	0.6	1.9	-0.0	-1.4
Illnesses of father: High blood pressure	0.6	0.8	2.2	1.5	-0.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.5	0.8	1.2
Bipolar Disorder or Schizophrenia	0.5	1.1	2.0	-1.4	1.2
Crohns Disease (2017)	0.5	1.2	3.6	1.9	0.0
Crohns Disease (2012)	0.5	0.9	1.9	1.4	0.8
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.9	0.2	-1.4
Severe depression (siblings)	0.5	0.6	1.8	0.2	-1.3
Average weekly fortified wine intake	0.5	0.6	1.7	-1.3	0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	1.3	0.4
Chronic bronchitis/emphysema (father)	0.5	0.5	1.5	-1.2	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.3	1.1	-1.0
Had other major operations	0.5	0.6	1.1	1.1	0.8
Lung cancer (father)	0.5	0.6	1.6	-0.4	1.3
Hair/balding pattern: Pattern 4	0.5	1.1	3.3	-0.1	1.8
Peak expiratory flow (PEF)	0.5	1.1	2.6	1.6	-0.8
Headache pain in last month	0.5	0.8	2.2	-1.5	-0.6
Medication: Amlodipine	0.5	0.7	1.2	0.9	-1.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.5	-1.2	0.5
Medication: Seretide 50 evohaler	0.5	0.6	1.9	-1.4	-0.2
Medication: Aspirin	0.5	0.7	1.6	1.3	0.7
Qualifications: nursing, teaching	0.5	0.7	1.9	-1.4	-0.5
Commuting to job workplace: Walk	0.5	0.5	1.3	0.5	1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.5	-0.1	-1.6
Medication: Aspirin	0.5	0.7	1.7	1.3	0.6
Medication: Atorvastatin	0.5	0.7	1.8	-1.4	0.4
Age started oral contraceptive pill	0.5	0.6	1.8	-0.3	1.4
Heart disease (siblings)	0.5	0.6	1.6	-0.5	1.3
Depression (Nagel 2018)	0.4	0.6	1.7	-0.4	-1.3
Worry (Nagel 2018)	0.4	0.9	2.6	0.3	-1.6
Ulcerative Colitis (UC)	0.4	0.8	2.0	1.4	0.6
Mean Putamen Volume	0.4	0.5	1.0	0.7	1.0
Cardiovascular Disease	0.4	1.3	3.5	0.6	-1.9
Sensitivity / hurt feelings	0.4	0.6	1.7	1.3	-0.4
Systolic blood pressure, automated reading	0.4	1.1	3.2	1.8	0.3
Diabetes (mother)	0.4	0.6	1.6	0.2	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.5	-0.4	1.6
Alcohol usually taken with meals	0.4	0.6	1.8	-1.3	0.3
Nervous feelings	0.4	0.8	2.2	-0.4	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.4	-0.3	1.5
Qualifications: None of the above	0.4	0.8	2.4	1.5	0.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.5	1.6	-1.2
Illnesses of mother	0.4	0.5	0.9	1.0	-0.8
Exposure to tobacco smoke at home	0.4	0.4	1.3	0.1	1.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.1	-1.0	0.6
Glaucoma (self-reported)	0.4	0.4	1.1	-0.4	1.1
High blood pressure (siblings)	0.4	0.5	1.0	1.0	0.7
Number of full brothers	0.4	0.5	1.2	0.6	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.2	1.1	-0.7
Eye problems/disorders: None of the above	0.4	0.4	0.7	0.9	0.7
Medication: Blood pressure	0.4	0.7	2.2	1.5	-0.1
Number of full sisters	0.4	0.4	0.9	0.7	-0.9
Had major operations	0.4	0.5	0.8	0.9	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.7	-0.1	-1.6
Average weekly red wine intake	0.4	0.5	0.9	-0.9	0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.3	0.4	1.1
Back pain experienced in last month	0.4	0.5	1.2	-0.6	-1.1
Guilty feelings	0.4	0.6	1.5	0.5	-1.2
Wears glasses or contact lenses	0.4	0.4	0.7	-0.9	0.8
Financial situation satisfaction	0.4	0.5	1.3	0.5	-1.1
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.9	-0.5	-1.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	-0.4	1.2
Myopia	0.4	0.6	1.0	-1.0	0.9
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.3	0.3	-1.5
Schizophrenia (2018)	0.3	0.6	1.7	-0.3	1.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	0.0	1.0
Age at First Birth	0.3	0.4	0.9	0.6	0.9
HDL Cholesterol	0.3	0.5	1.4	1.2	-0.2
Blood White Count	0.3	2.0	5.6	-2.4	-0.7
Smoking Status	0.3	0.8	2.0	0.6	-1.4
Number of treatments/medications taken	0.3	0.5	0.8	0.9	-0.9
Medication for hormone replacement therapy	0.3	0.3	0.8	0.4	-0.9
Vitamin and mineral supplements	0.3	0.4	1.1	1.0	-0.1
Hand grip strength (right)	0.3	0.8	2.0	-1.4	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	1.0	0.1	-1.0
Qualifications: CSEs or equivalent	0.3	0.3	0.9	0.3	-1.0
High blood pressure (mother)	0.3	0.4	0.8	0.9	0.6
Number of incorrect matches in round	0.3	0.4	0.8	0.9	0.7
Past tobacco smoking	0.3	0.5	1.5	-0.2	-1.2
Forced vital capacity (FVC)	0.3	1.2	2.9	1.7	-0.8
Number of live births	0.3	0.4	0.7	-0.8	-0.6
Exposure to tobacco smoke outside home	0.3	0.4	0.9	-0.5	1.0
Comparative body size at age 10	0.3	0.9	2.6	1.6	-0.1
Health satisfaction	0.3	0.4	1.2	0.3	-1.1
Medication for pain relief, constipation, heartburn	0.3	0.6	1.8	-1.3	0.1
Pulse rate, automated reading	0.3	0.9	1.6	-1.2	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.7	-0.9	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.1	-0.3	1.1
Long-standing illness, disability or infirmity	0.3	0.4	0.7	0.7	-0.8
Medication for cholesterol	0.3	0.5	1.5	0.2	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.9	-0.1	1.0
Ever smoked	0.3	0.6	1.3	-0.7	1.1
Number of operations (self-reported)	0.3	0.4	1.2	1.1	-0.2
Risk taking	0.3	0.5	1.0	-1.0	-0.7
Pack years of smoking	0.3	0.5	1.3	-1.2	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.2	0.6	0.3	-0.8
Major Depression (MDD)	0.2	0.2	0.6	-0.8	-0.0
Fasting Glucose	0.2	0.3	0.8	-0.0	0.9
Rheumatoid Arthritis	0.2	0.3	0.8	0.9	-0.2
Systolic Blood Pressure	0.2	1.2	2.7	1.6	-0.9
Hair Pigment	0.2	5.2	14.1	3.8	-1.2
Average weekly spirits intake	0.2	0.2	0.6	-0.8	0.1
Pack years adult smoking proportion	0.2	0.3	0.5	-0.7	-0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.7	0.6
Stomach or abdominal pain in last month	0.2	0.3	0.7	0.4	-0.8
Impedance of leg (left)	0.2	0.9	2.4	-0.6	1.5
Fluid intelligence score	0.2	0.4	1.3	0.2	-1.1
Time employed in main current job	0.2	0.2	0.5	-0.7	0.2
Medication: Cholesterol lowering	0.2	0.3	0.8	-0.5	-0.9
Pulse wave reflection index	0.2	0.2	0.4	-0.4	-0.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.8	0.1	-0.9
Age at first live birth	0.2	0.3	0.9	-0.1	1.0
Qualifications: College or University degree	0.2	0.6	1.7	-1.3	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.8	-0.1	0.9
Suffer from ‘nerves’	0.2	0.3	0.7	-0.9	0.4
Ever had bowel cancer screening	0.2	0.2	0.3	-0.5	0.5
Mineral and other dietary supplements	0.2	0.3	0.8	0.0	-0.9
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	-0.7	0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.0	0.8
Alzheimer’s Disease (in mother)	0.1	0.2	0.3	-0.4	0.5
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.4	0.4
Schizophrenia (2014)	0.1	0.2	0.4	-0.6	-0.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.4	-0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.6	-0.6
Lung FEV1/FVC ratio	0.1	0.4	1.3	0.0	-1.1
Hand grip strength (left)	0.1	0.2	0.5	-0.7	0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	0.5	0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.4	0.7	-0.2
Impedance of leg (right)	0.1	0.4	1.1	-0.1	1.1
Taking other prescription medications	0.1	0.1	0.2	-0.3	-0.5
High blood pressure	0.1	0.2	0.6	0.8	0.3
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	0.3	0.6
Had menopause	0.1	0.1	0.4	0.2	0.6
Diabetes (self-reported)	0.1	0.2	0.5	-0.7	-0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	-0.7	0.1
Neuroticism score	0.1	0.1	0.3	-0.4	-0.6
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.5	-0.3
Worrier / anxious feelings	0.1	0.1	0.4	-0.2	-0.6
Pulse rate	0.1	0.2	0.6	-0.8	-0.2
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	0.7	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	1.1	1.1	-0.5
Length of working week for main job	0.1	0.1	0.4	0.6	-0.1
Breastfed as a baby	0.1	0.2	0.5	-0.7	-0.1
Birth weight of first child	0.1	0.2	0.6	0.1	-0.8
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	-0.5	0.2
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.4	0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	0.5	0.7	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.3	-0.5	-0.5
Mean time to correctly identify matches	0.1	0.3	0.6	0.5	-0.8
Heart disease (mother)	0.1	0.1	0.3	0.1	-0.5
Age at last live birth	0.1	0.1	0.2	-0.1	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.2	-0.5
Hypertension (Self-reported)	0.1	0.4	1.1	1.1	0.1
Medication: Blood pressure	0.1	0.1	0.3	0.1	-0.5
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.6	0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.2	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	-0.8	0.1
Pain experienced in last month	0.1	0.1	0.3	-0.1	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.1	-0.2	0.2
Chronotype (morning person)	0.0	0.0	0.1	0.2	-0.2
Tanning	0.0	0.0	0.0	0.2	0.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.2	0.1
Angina	0.0	0.0	0.0	-0.2	-0.1
Age when periods started (menarche)	0.0	0.0	0.1	0.0	-0.3
Serious illness, injury or assault to yourself	0.0	0.0	0.0	-0.1	0.1
Multivitamins +/- minerals	0.0	0.0	0.0	-0.2	-0.2
Financial difficulties in last 2 years	0.0	0.1	0.2	-0.4	-0.0
Mouth/teeth dental problems	0.0	0.0	0.1	0.3	0.1
Pain all over the body in last month	0.0	0.1	0.2	0.4	-0.0
Noisy workplace	0.0	0.0	0.0	-0.0	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.1	0.1	0.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.0	0.3
Medication: Paracetamol	0.0	0.0	0.0	-0.1	-0.1
Birth weight	0.0	0.0	0.0	-0.1	0.2
Worry too long after embarrassment	0.0	0.0	0.1	-0.3	0.1
Neck or shoulder pain in last month	0.0	0.0	0.0	-0.0	-0.1
Angina (self-reported)	0.0	0.0	0.1	0.1	-0.2
Overall health rating	0.0	0.0	0.1	0.3	-0.1
Loneliness, isolation	0.0	0.1	0.2	-0.1	-0.4
Diabetes diagnosed by doctor	0.0	0.0	0.1	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.3	-0.1	0.5
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.1	0.3	-0.3
Medication: Paracetamol	0.0	0.0	0.0	-0.1	-0.1
Average weekly beer plus cider intake	0.0	0.1	0.1	0.3	0.3
Unable to work because of sickness or disability	0.0	0.0	0.1	0.4	0.0

Hub : Genes

PHF23

Models

Trait associations