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chr17:27,200,734-30,884,028

Best TWAS P=1.27e-31 · Best GWAS P=6.67e-36 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	NF1	0.06	0.01	blup	410	0.04	1.1e-05	7.64	6.8	1.0e-11	-0.20	0.95	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	TEFM	0.12	0.02	lasso	14	0.05	1.0e-03	1.15	-6.2	4.1e-10	0.21	0.08	0.09	FALSE
3	GTEx	Artery Aorta	ABHD15	0.20	0.03	enet	36	0.06	2.9e-04	-5.10	-7.8	4.4e-15	0.08	0.03	0.57	TRUE
4	GTEx	Artery Aorta	TEFM	0.13	0.02	enet	34	0.03	5.8e-03	1.16	-6.7	1.7e-11	0.57	0.15	0.78	FALSE
5	GTEx	Artery Aorta	CRLF3	0.12	0.03	enet	33	0.06	3.8e-04	1.18	-7.6	3.8e-14	0.53	0.25	0.70	TRUE
6	GTEx	Artery Tibial	RP11-848P1.7	0.54	0.00	lasso	10	0.02	7.3e-03	-7.07	-11.7	1.3e-31	0.47	0.02	0.06	TRUE
7	GTEx	Brain Cerebellar Hemisphere	CRLF3	0.38	0.35	enet	26	0.35	6.0e-10	2.45	-5.8	5.6e-09	0.32	0.97	0.01	FALSE
8	GTEx	Brain Cerebellum	CRLF3	0.52	0.12	lasso	27	0.20	1.3e-06	-10.82	-9.6	7.9e-22	0.56	0.09	0.74	FALSE
9	GTEx	Breast Mammary Tissue	CRLF3	0.10	0.10	lasso	3	0.05	9.6e-04	3.05	-5.3	1.1e-07	0.31	0.09	0.62	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	EVI2A	0.13	0.03	lasso	4	0.01	1.5e-01	7.64	-8.2	2.7e-16	0.17	0.16	0.04	FALSE
11	GTEx	Cells Transformed fibroblasts	OMG	0.06	0.02	lasso	2	0.01	2.5e-02	7.67	7.7	1.6e-14	-0.22	0.14	0.07	FALSE
12	GTEx	Colon Transverse	CRLF3	0.16	0.07	lasso	6	0.05	1.5e-03	1.18	-5.2	1.7e-07	0.42	0.15	0.64	FALSE
13	GTEx	Esophagus Muscularis	BLMH	0.15	0.02	lasso	8	0.01	1.0e-01	-3.78	5.9	3.6e-09	-0.13	0.04	0.46	TRUE
14	GTEx	Esophagus Muscularis	CRLF3	0.17	0.12	lasso	6	0.18	5.1e-11	2.45	-7.4	1.2e-13	0.46	0.94	0.05	FALSE
15	GTEx	Muscle Skeletal	TP53I13	0.08	0.02	lasso	4	0.02	2.2e-03	-5.10	6.0	1.7e-09	-0.08	0.06	0.49	TRUE
16	GTEx	Nerve Tibial	CRLF3	0.38	0.16	lasso	14	0.19	3.0e-13	2.51	-6.1	9.2e-10	0.38	1.00	0.00	FALSE
17	GTEx	Ovary	CRLF3	0.21	0.14	lasso	4	0.11	1.0e-03	2.45	-6.2	5.0e-10	0.40	0.06	0.58	FALSE
18	GTEx	Pituitary	SUZ12P	0.29	0.23	lasso	9	0.32	6.0e-09	2.45	-6.1	1.3e-09	0.40	0.86	0.07	TRUE
19	GTEx	Spleen	EVI2A	0.22	0.12	lasso	4	0.07	8.3e-03	7.89	-7.8	8.6e-15	0.17	0.11	0.05	FALSE
20	GTEx	Spleen	OMG	0.41	0.10	enet	26	0.08	4.5e-03	7.67	7.3	3.1e-13	-0.23	0.64	0.03	FALSE
21	GTEx	Testis	CRLF3	0.26	0.19	enet	23	0.17	3.8e-08	2.55	-5.5	4.2e-08	0.38	0.99	0.00	FALSE
22	GTEx	Thyroid	COPRS	0.17	0.00	enet	43	0.01	1.2e-01	0.97	-5.3	1.3e-07	0.13	0.04	0.23	FALSE
23	GTEx	Thyroid	CRLF3	0.10	0.04	enet	35	0.08	1.1e-06	2.51	-6.0	2.6e-09	0.38	0.91	0.05	FALSE
24	GTEx	Whole Blood	EVI2A	0.07	0.04	lasso	4	0.04	2.6e-04	7.85	-8.0	1.5e-15	0.14	0.89	0.00	FALSE
25	METSIM	Adipose	CTD-2349P21.5	0.02	0.00	bslmm	252	0.01	3.0e-03	-9.01	-7.1	1.5e-12	0.33	0.04	0.31	FALSE
26	METSIM	Adipose	NF1	0.04	0.00	blup	396	0.01	5.5e-03	8.54	8.0	1.0e-15	-0.30	0.80	0.02	FALSE
27	METSIM	Adipose	TEFM	0.08	0.06	blup	246	0.06	8.8e-10	-12.51	-7.8	5.7e-15	0.57	0.00	1.00	TRUE
28	YFS	Blood	EVI2A	0.03	0.05	lasso	4	0.04	1.0e-13	7.89	-7.9	2.9e-15	0.10	1.00	0.00	FALSE
29	YFS	Blood	EVI2B	0.01	0.00	blup	339	0.00	6.4e-02	-0.42	7.1	1.2e-12	-0.26	0.07	0.02	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EVI2A	0.03	0.03	blup	37	0.03	2.3e-03	7.88	-7.8	4.7e-15	0.10	0.02	0.78	FALSE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	OMG	0.02	0.02	blup	31	0.02	3.2e-03	7.88	-8.3	1.5e-16	0.15	0.02	0.83	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	EVI2A	0.03	0.03	blup	38	0.03	6.9e-07	7.79	-8.1	6.9e-16	0.12	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	GOSR1	0.02	0.01	enet	4	0.01	1.7e-02	-7.10	7.2	5.9e-13	-0.27	0.01	0.83	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	OMG	0.03	0.04	lasso	1	0.04	1.1e-08	7.81	-7.8	5.6e-15	0.23	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC37B2	0.09	0.00	enet	11	0.03	7.3e-03	3.47	-6.2	4.8e-10	0.47	0.01	0.26	TRUE
36	The Cancer Genome Atlas	Esophageal Carcinoma	OMG	0.09	0.09	blup	31	0.11	2.0e-04	7.90	-8.3	1.1e-16	0.18	0.02	0.91	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EVI2A	0.04	0.00	blup	37	0.01	1.1e-02	7.84	-6.2	4.5e-10	0.00	0.01	0.51	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	OMG	0.02	0.02	blup	31	0.03	6.9e-04	7.88	-8.2	1.6e-16	0.17	0.02	0.89	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	EVI2A	0.03	0.03	blup	38	0.04	3.0e-05	7.83	-8.3	1.4e-16	0.16	0.04	0.96	FALSE
40	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	NF1	0.04	0.03	blup	111	0.03	1.3e-02	7.87	8.1	5.6e-16	-0.19	0.08	0.50	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	EVI2A	0.04	0.06	blup	38	0.06	3.0e-07	7.76	-8.2	2.3e-16	0.15	0.07	0.93	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	OMG	0.05	0.03	lasso	5	0.04	3.6e-05	7.74	-6.9	4.8e-12	0.10	0.03	0.93	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EVI2A	0.03	0.03	lasso	1	0.02	2.4e-03	7.59	-7.6	3.1e-14	0.10	0.02	0.66	FALSE
44	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GOSR1	0.15	0.00	blup	56	0.04	1.1e-03	-3.37	6.4	2.0e-10	-0.35	0.04	0.20	FALSE
45	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	OMG	0.05	0.03	blup	32	0.03	5.6e-03	7.67	-7.3	2.0e-13	0.25	0.02	0.69	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	EVI2A	0.08	0.12	lasso	3	0.12	1.3e-12	8.54	-8.3	8.4e-17	0.12	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	EVI2A	0.05	0.03	enet	7	0.04	4.8e-04	4.02	-6.7	2.2e-11	0.13	0.04	0.60	FALSE
48	The Cancer Genome Atlas	Stomach Adenocarcinoma	SUZ12P	0.05	0.05	blup	29	0.04	5.1e-04	3.05	-5.5	2.9e-08	0.32	0.16	0.16	TRUE
49	The Cancer Genome Atlas	Thyroid Carcinoma	OMG	0.02	0.01	blup	32	0.02	4.8e-03	7.67	-8.2	1.6e-16	0.18	0.02	0.86	FALSE