TWAS hub - HOXB3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0990	0.0450	2.9e-04	0.062	NA	0.021	NA	0.035	8.4e-06	NA	6.7e-03	NA	0.00068
2	GTEx	Cells EBV-transformed lymphocytes	0.2760	0.1050	4.2e-03	-0.004	NA	-0.008	NA	-0.005	4.5e-01	NA	7.3e-01	NA	0.50000
3	GTEx	Esophagus Gastroesophageal Junction	0.1480	0.0650	2.0e-03	0.024	NA	0.039	NA	0.045	4.5e-02	NA	1.5e-02	NA	0.00940
4	GTEx	Muscle Skeletal	0.1271	0.0489	2.6e-05	0.020	NA	0.076	NA	0.034	3.9e-03	NA	7.0e-08	NA	0.00024
5	GTEx	Testis	0.1890	0.0760	1.9e-03	0.000	NA	0.007	NA	0.028	3.1e-01	NA	1.5e-01	NA	0.02100
6	GTEx	Whole Blood	0.1500	0.0510	5.2e-04	0.000	NA	0.004	NA	0.004	3.6e-01	NA	1.3e-01	NA	0.12000
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0494	0.0288	4.6e-03	0.010	0.022	0.022	NA	0.024	2.4e-02	0.0015	1.5e-03	NA	0.00090

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Ovarian Cancer	10.9	14.4	28.7	5.3	-2.1	5.4	3.5	0.6	3.2	-4.1
Hand grip strength (left)	7.0	18.5	33.2	5.8	-1.8	4.6	4.3	-4.4	5.0	-3.1
Mouth/teeth dental problems: Dentures	7.0	11.8	23.4	3.0	-3.5	1.0	3.3	4.8	3.6	-3.7
Hand grip strength (right)	6.6	17.9	33.4	5.8	-0.4	4.6	4.0	-4.3	5.2	-3.1
Health satisfaction	5.5	7.1	11.6	2.3	-1.2	2.8	3.1	2.8	3.4	-2.5
Exposure to tobacco smoke outside home	5.1	6.8	17.6	3.7	1.1	4.2	1.8	1.1	2.4	-2.2
Peak expiratory flow (PEF)	4.7	11.0	23.9	-4.3	1.6	-4.9	-2.4	-2.8	-4.1	1.5
Financial situation satisfaction	4.6	5.7	8.5	2.9	0.8	1.7	2.4	2.9	2.4	-2.8
Blood Red Count	4.5	43.7	76.0	8.7	-1.7	8.4	6.8	1.1	8.3	-6.3
Average weekly spirits intake	4.4	5.5	12.2	2.8	-3.5	2.3	1.7	0.8	1.5	-2.7
Overall health rating	4.1	8.8	16.5	2.4	-0.3	1.7	4.0	3.7	4.1	-2.7
Bilateral oophorectomy (both ovaries removed)	3.8	4.4	12.2	-3.0	0.2	-3.5	-1.3	1.1	-2.6	0.3
Ever had bowel cancer screening	3.8	4.5	14.9	-2.4	-0.8	-3.9	-1.3	-1.3	-0.9	2.4
Worry too long after embarrassment	3.7	6.3	15.6	2.2	0.2	2.1	4.0	2.2	1.8	-3.3
Crohns Disease (2012)	3.6	5.8	18.2	2.4	-4.3	1.0	2.4	0.1	2.6	-1.8
Blood clot in the leg (DVT)	3.6	4.7	13.8	1.6	-1.9	0.2	0.5	3.5	-0.3	-3.7
Systolic Blood Pressure	3.4	16.9	42.0	-4.3	6.5	-2.1	0.0	-1.6	-3.9	6.0
Deep venous thrombosis (DVT) (self-reported)	3.4	4.3	12.5	1.2	-2.2	-0.0	0.2	3.3	-0.5	-3.5
Frequency of tiredness / lethargy in last 2 weeks	3.3	5.4	21.6	1.1	-0.3	1.0	2.0	4.7	1.9	-2.4
Lung FEV1/FVC ratio	3.2	16.2	49.7	-6.1	1.9	-3.0	-2.8	0.9	-7.0	2.3
Systolic blood pressure, automated reading	3.2	9.3	27.6	-2.6	5.0	-0.6	0.0	-1.7	-1.5	5.3
Mouth/teeth dental problems: Loose teeth	3.2	3.8	12.0	-2.2	-0.5	-3.5	-0.4	1.3	-1.9	2.0
Family relationship satisfaction	3.0	3.7	6.5	2.5	-0.6	2.3	1.4	1.3	1.9	-2.6
Schizophrenia vs Biploar Disorder	2.9	3.8	9.6	1.5	-1.6	1.2	2.1	3.1	1.4	-2.2
Mouth/teeth dental problems	2.9	4.5	17.6	-1.7	1.3	0.1	-1.9	-4.2	-1.2	2.0
Basal cell carcinoma (self-reported)	2.9	3.4	9.3	3.0	-0.6	2.0	0.3	0.9	2.4	-1.9
Body Mass Index (BMI) (2010)	2.8	3.8	14.7	2.3	-1.1	0.8	2.1	-0.2	3.8	-0.5
Lung FVC	2.7	13.6	32.9	4.5	0.2	5.7	4.7	-2.4	0.5	-3.8
Medication: Levothyroxine sodium	2.7	4.6	8.2	2.2	-1.7	2.9	2.8	0.9	1.4	-2.2
Pulse wave Arterial Stiffness index	2.7	3.2	7.0	-2.6	-0.7	-1.2	-2.2	-0.5	-2.2	1.9
Ever used hormone-replacement therapy (HRT)	2.6	3.3	6.4	-2.5	1.0	-1.1	-2.5	-0.4	-2.5	1.4
Impedance of leg (left)	2.6	12.8	32.1	-4.3	5.7	-2.3	-3.8	-0.5	-2.5	3.6
Alcohol usually taken with meals	2.6	4.2	9.8	-2.4	2.2	-0.2	-0.4	-3.1	-2.4	1.9
Asthma	2.6	5.1	14.6	2.4	0.0	2.4	0.2	-3.8	3.0	0.9
Asthma (self-reported)	2.6	5.2	15.6	2.4	0.2	2.3	0.1	-4.0	3.0	0.9
Tinnitus: Yes, now most or all of the time	2.6	3.0	6.6	2.2	-0.3	2.3	1.7	0.6	1.1	-2.6
Ever had hysterectomy (womb removed)	2.5	2.8	9.1	-1.8	1.1	-1.6	-1.4	3.0	-0.9	-0.8
Waist circumference	2.5	9.2	27.0	4.1	-2.1	0.8	2.5	2.3	5.2	-2.0
Pulse wave peak to peak time	2.5	3.0	6.7	2.6	0.3	1.2	1.6	0.4	2.2	-2.3
Alcohol drinker status: Never	2.5	3.0	8.1	1.4	-2.8	0.1	1.0	2.1	0.8	-2.2
Verbal and Numeric Reasoning (VNR)	2.3	5.6	12.5	-2.6	-1.4	-3.5	-2.9	-2.5	-0.7	1.7
Respiratory disease	2.3	5.1	13.6	3.0	-0.1	2.0	0.9	-2.9	3.7	0.3
Hearing difficulty/problems: Yes	2.3	3.4	8.0	1.4	-1.2	2.5	1.2	-0.9	2.8	-2.0
Number of children fathered	2.3	2.6	5.7	2.4	-0.3	1.6	-0.8	-1.0	1.9	-2.2
Impedance of leg (right)	2.2	10.5	25.8	-3.7	5.1	-2.3	-3.4	-0.9	-2.1	3.5
Qualifications: O levels/GCSEs or equivalent	2.2	3.4	16.2	0.1	2.5	-0.9	-0.8	-4.0	0.4	0.3
Glaucoma (self-reported)	2.2	2.6	4.5	2.1	1.6	1.9	0.3	0.4	1.5	-2.1
High cholesterol (Self-reported)	2.2	3.9	14.5	2.1	1.9	1.7	3.8	1.0	1.1	-0.0
Current tobacco smoking	2.1	3.4	13.7	-0.4	-2.7	-0.4	-0.8	3.7	-0.1	-1.3
Body mass index (BMI)	2.1	8.9	14.7	3.8	-3.0	0.5	3.6	2.9	3.5	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.6	7.0	1.9	1.6	0.9	2.6	-1.3	1.5	-0.1
Pain type(s) experienced in last month: Hip pain	2.1	2.7	4.5	1.9	-1.2	1.4	1.7	0.4	2.1	-2.1
Mean Putamen Volume	2.0	2.3	7.5	-1.8	-1.7	-0.3	-2.7	0.6	-1.5	0.2
Rheumatoid Arthritis	2.0	2.8	6.0	-1.9	-0.9	-1.3	-2.5	-0.4	-2.1	1.7
Medication for hormone replacement therapy	2.0	2.3	8.3	-1.3	1.1	-1.0	-2.9	0.9	-1.2	1.0
Happiness	2.0	2.5	4.4	1.8	-0.5	1.6	1.9	0.8	2.1	-1.6
Chest pain or discomfort	2.0	2.9	9.9	1.4	-0.3	0.2	0.2	3.1	2.3	-1.8
Smoking status: Current	2.0	3.1	11.6	-0.3	-2.7	-0.6	-1.0	3.4	-0.3	-1.2
Impedance of whole body	2.0	10.1	29.7	-4.0	5.4	-1.1	-3.0	0.6	-1.9	3.3
Chronotype (morning person)	1.9	4.3	20.0	2.0	-4.5	1.9	0.3	-1.6	-0.4	0.1
Angina	1.9	2.5	6.4	-2.5	0.2	-1.9	-0.7	0.5	-2.1	1.6
Medication: Simvastatin	1.9	2.8	9.4	0.9	1.1	1.6	3.1	1.6	1.0	1.3
Medication: Ventolin 100micrograms inhaler	1.9	2.5	6.7	2.2	0.0	2.2	-0.0	0.1	2.6	-0.9
Chronic bronchitis/emphysema (mother)	1.9	2.2	5.3	-1.1	-1.3	-2.3	-1.0	2.1	-0.3	-1.2
Angina (self-reported)	1.9	2.5	6.6	-2.6	-0.1	-2.1	-0.6	0.6	-1.9	1.4
Type 2 Diabetes (T2D) (2012)	1.8	2.0	5.4	-1.9	0.1	-1.2	0.7	0.1	-1.9	2.3
BMI	1.8	10.7	17.1	3.5	-3.8	-1.1	4.1	3.0	3.7	-2.6
Chronic bronchitis/emphysema (father)	1.8	2.2	4.8	-2.0	0.3	-2.2	-1.7	0.9	-1.5	0.5
Pain all over the body in last month	1.8	2.0	5.8	1.1	1.4	0.7	0.2	2.4	0.9	-1.9
Fluid intelligence score	1.8	3.7	7.5	-2.3	-1.5	-2.7	-2.4	-1.5	-1.6	0.5
Hypothyroidism/myxoedema (self-reported)	1.8	3.4	10.3	1.2	-2.3	2.0	3.2	0.0	-0.5	-1.8
Heart disease (mother)	1.8	2.2	8.8	0.6	1.7	-0.3	3.0	1.7	0.4	-0.5
Arm fat percentage (left)	1.8	7.3	21.2	2.7	-1.1	0.2	3.1	4.6	3.3	-1.2
Eye problems/disorders: Glaucoma	1.8	2.1	4.9	2.1	-0.0	2.2	-0.5	0.5	1.5	-1.6
Myopia	1.8	2.7	9.3	0.0	3.0	-1.5	1.4	-1.0	1.1	1.6
Crohns Disease (2017)	1.7	3.8	9.8	1.5	-3.0	1.0	1.8	-0.1	3.1	-1.3
Fed-up feelings	1.7	3.1	10.4	0.8	-0.7	1.7	1.3	3.2	1.0	-2.2
Sitting height	1.7	12.0	35.0	-3.4	-2.1	-1.9	-5.1	-5.9	-0.3	1.7
Leg predicted mass (left)	1.7	9.2	35.9	2.9	-6.0	0.3	0.8	-0.6	3.0	-3.2
Arm fat percentage (right)	1.7	6.8	20.9	2.4	-1.1	-0.3	3.0	4.6	3.2	-0.8
Medication: Blood pressure	1.7	3.0	7.2	-2.2	0.4	-2.7	0.4	1.2	-1.2	2.4
Arm predicted mass (right)	1.7	8.7	37.5	2.2	-6.1	-0.2	-0.5	-2.1	2.3	-3.0
Illnesses of siblings: Diabetes	1.7	2.1	5.5	-2.2	-0.4	-1.3	-1.2	0.8	-0.5	2.4
Arm fat-free mass (left)	1.7	8.6	41.3	2.0	-6.4	-0.8	-0.4	-1.9	2.2	-2.4
Cholesterol lowering medication	1.7	2.5	7.0	0.3	2.4	0.7	2.6	-1.0	0.5	1.6
Intelligence (Savage-Jansen 2018)	1.6	4.8	11.9	-1.7	-1.1	-2.8	-2.4	-3.5	0.6	1.9
Coronary Artery Disease (CAD)	1.6	1.9	6.2	0.2	1.2	-0.3	2.5	0.9	-0.1	-2.1
Frequency of depressed mood in last 2 weeks	1.6	2.3	6.0	1.1	-1.4	0.7	0.6	1.5	1.8	-2.5
Leg fat-free mass (left)	1.6	8.7	34.3	2.8	-5.9	0.2	0.8	-0.6	2.9	-3.1
Arm fat mass (right)	1.6	6.7	12.2	2.7	-3.1	-0.2	2.4	3.0	3.5	-1.6
Arm fat-free mass (right)	1.6	8.2	37.8	1.9	-6.2	-0.5	-0.5	-2.3	1.9	-2.6
Leg fat-free mass (right)	1.6	8.7	34.6	2.7	-5.9	0.5	0.8	-0.6	2.7	-3.3
Whole body water mass	1.6	9.2	41.5	2.2	-6.4	-0.4	-0.3	-1.9	2.3	-3.0
Leg predicted mass (right)	1.6	8.8	34.2	2.7	-5.8	0.6	0.8	-0.6	2.8	-3.3
Arm fat mass (left)	1.6	6.5	11.2	2.8	-2.9	0.1	2.3	3.1	3.4	-1.8
Diastolic blood pressure, automated reading	1.6	5.0	19.9	1.8	1.3	1.6	4.5	-0.8	2.4	0.8
Arm predicted mass (left)	1.6	8.0	39.3	1.7	-6.3	-1.0	-0.5	-1.9	1.9	-2.3
Age at First Birth	1.5	2.1	7.2	-2.0	0.6	-1.5	-0.4	-0.4	-0.8	2.7
Fasting Glucose	1.5	1.8	8.1	-0.4	2.0	0.5	0.1	-0.2	-0.0	2.8
Schizophrenia (2014)	1.5	3.3	9.7	1.2	-1.4	2.3	0.6	3.1	1.2	-1.7
Hypothyroidism (self reported)	1.5	3.4	9.8	0.8	-2.6	1.2	3.1	1.0	-0.9	-1.9
Diabetes (father)	1.5	1.8	5.9	-0.2	-0.4	0.1	2.2	2.4	-0.2	-1.3
Impedance of arm (right)	1.5	7.0	21.5	-3.2	4.6	-1.0	-2.0	1.2	-1.1	3.1
Hip circumference	1.5	6.3	14.8	2.5	-3.8	-0.2	1.1	1.9	3.7	-2.1
Medication: Amlodipine	1.5	2.1	9.0	-1.2	1.1	-3.0	1.2	0.0	-0.6	1.3
Wheeze or whistling in the chest in last year	1.5	2.6	7.0	2.4	0.8	2.0	-0.1	-0.7	2.6	-0.7
Whole body fat-free mass	1.5	8.8	40.4	2.0	-6.4	-0.4	-0.4	-2.0	2.2	-2.8
Guilty feelings	1.5	2.2	4.5	1.2	0.9	2.0	1.6	-0.6	2.1	-1.4
Basal metabolic rate	1.5	8.3	36.6	2.3	-6.0	-0.4	-0.0	-1.4	2.6	-2.8
Waist Hip Ratio (WHR)	1.4	6.4	15.3	3.2	3.0	2.4	1.8	0.4	3.9	-0.9
Type 2 Diabetes (T2D) (2018)	1.4	2.7	11.0	-1.3	0.3	-1.8	-0.6	3.3	-1.5	-0.5
Medication: Metformin	1.4	2.0	5.3	-1.5	0.6	-1.1	-1.5	2.3	-1.4	0.8
Trunk fat-free mass	1.4	8.0	35.3	1.4	-5.9	-1.0	-1.2	-3.0	1.4	-2.4
Worrier / anxious feelings	1.4	2.6	7.3	1.1	2.7	1.5	2.4	-0.2	1.1	-0.4
Illnesses of mother	1.4	1.7	4.9	-0.1	-1.1	1.1	-2.2	-2.1	-0.1	0.3
Impedance of arm (left)	1.4	6.3	24.9	-2.7	5.0	-0.2	-2.0	1.3	-1.0	2.2
Trunk predicted mass	1.4	8.0	35.6	1.4	-6.0	-1.1	-1.1	-2.9	1.4	-2.4
Forced vital capacity (FVC), Best measure	1.4	5.3	10.0	2.2	-2.0	2.8	1.7	-3.2	1.0	-2.6
Migraine (self-reported)	1.4	1.7	4.9	0.8	-2.2	1.0	1.4	-0.2	1.1	-1.7
Risk taking	1.4	2.1	5.6	1.5	-2.4	0.1	-1.3	1.4	0.7	-1.6
Pain experienced in last month	1.4	2.3	8.0	-0.3	2.1	-0.6	-0.4	-1.8	-0.4	2.8
Alzheimer’s Disease (in mother)	1.3	1.5	6.4	-0.1	2.5	-0.3	-0.7	0.7	-0.4	-1.8
Height	1.3	24.3	83.4	-3.9	-4.3	-3.4	-9.1	-6.4	0.4	0.4
Qualifications: CSEs or equivalent	1.3	1.7	5.8	0.1	2.4	-0.9	1.2	1.5	-0.8	-0.9
Number of incorrect matches in round	1.3	2.2	7.1	-1.3	2.7	-0.2	1.4	1.5	0.2	1.5
Forced vital capacity (FVC)	1.3	4.9	13.0	1.8	-1.5	3.0	0.5	-3.6	0.3	-2.5
Allergy	1.3	2.9	7.1	-2.3	1.0	-2.7	-1.0	0.4	-2.0	1.4
Neuroticism score	1.3	2.8	4.6	1.0	0.3	2.0	2.2	2.0	1.6	-1.7
Hair/balding pattern: Pattern 3	1.3	2.0	6.5	0.4	1.4	-0.4	2.0	-2.5	0.3	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.2	-1.4	-1.5	-1.4	-1.1	0.6	-1.2	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	8.5	-0.2	-2.9	-1.2	0.3	-0.8	0.3	-1.0
Medication: Cholesterol lowering	1.3	2.1	5.3	1.4	0.6	1.3	2.1	2.3	0.3	0.7
Medication: Lansoprazole	1.3	1.5	2.6	-1.1	1.1	0.2	-1.4	-1.1	-1.6	1.4
Lung cancer (father)	1.3	1.6	2.8	-1.7	-1.7	-0.4	-1.5	1.1	-1.3	0.0
Exposure to tobacco smoke at home	1.3	1.5	3.6	0.4	-0.1	1.9	-1.1	1.9	-0.3	-1.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.8	-1.1	1.3	-0.5	-1.6	-1.5	-0.8	1.7
Diabetes diagnosed by doctor	1.3	2.2	6.5	-1.3	0.2	-1.9	-0.6	2.5	-1.8	-0.1
Medication: Paracetamol	1.3	2.0	7.3	-0.2	-2.7	0.8	0.8	1.0	1.0	-1.9
Supplements: Calcium	1.3	1.4	3.1	-0.2	1.4	-0.2	1.5	-1.4	0.8	1.8
Schizophrenia (2018)	1.2	2.4	6.5	0.9	-0.5	2.3	0.9	2.6	1.4	-1.2
Irritable Bowel Disease (IBD)	1.2	2.8	9.2	1.5	-1.6	0.9	1.3	0.3	3.0	-1.7
Neuroticism	1.2	2.9	6.2	1.0	-0.1	1.0	2.3	2.5	1.7	-1.9
Sensitivity / hurt feelings	1.2	2.1	6.8	-0.1	0.9	1.9	0.5	2.6	-1.0	-1.4
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	5.3	-0.0	-2.3	0.5	-0.8	1.0	1.5	-1.1
Townsend deprivation index at recruitment	1.2	1.7	6.0	1.7	1.3	1.2	-0.1	0.3	2.5	0.4
Supplements: Glucosamine	1.2	1.5	3.9	-1.4	-0.0	-0.3	-2.0	-0.9	-1.0	1.8
Medication: Atenolol	1.2	1.6	5.3	-0.3	-0.7	-0.9	1.6	-1.2	-0.4	2.3
Hearing difficulty/problems with background noise	1.2	1.9	6.0	0.6	-0.5	1.0	2.5	1.3	1.8	-0.9
Weight	1.2	5.9	21.4	2.2	-4.6	-0.7	0.7	0.5	3.2	-1.8
Time employed in main current job	1.2	1.4	4.3	0.9	-2.1	1.1	-0.6	-0.5	1.3	-1.1
Standing height	1.2	12.2	34.8	-2.8	-3.6	-2.3	-5.9	-4.9	0.1	-0.2
Medication: Ibuprofen	1.2	1.5	7.2	-0.0	-2.7	-0.5	0.8	-0.4	0.7	-1.2
Had major operations	1.2	1.4	4.3	-0.2	-1.4	1.9	-0.1	2.1	0.2	-0.4
Back pain experienced in last month	1.2	1.7	5.5	-0.5	1.3	-0.7	0.4	2.3	-0.4	-1.9
Breast cancer (self-reported)	1.2	1.4	3.8	-1.9	0.0	-1.2	0.3	-0.2	-1.9	1.0
Wears glasses or contact lenses	1.2	1.4	4.4	-0.7	-0.1	-0.0	-1.0	-2.1	0.3	1.9
Prostate Cancer	1.1	1.6	4.6	-2.1	0.2	-1.5	-1.3	0.1	-0.6	1.5
Blood Platelet Count	1.1	12.2	26.3	-4.9	3.0	-5.1	-2.8	-0.9	-1.2	4.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.1	0.9	-0.9	0.6	0.4	1.4	1.7	-1.8
Financial difficulties in last 2 years	1.1	1.5	6.1	1.0	0.1	0.0	0.5	2.5	0.8	-1.7
Noisy workplace	1.1	1.3	4.3	1.5	0.1	0.0	2.1	-0.3	1.5	-0.1
Medication for pain relief, constipation, heartburn	1.1	1.8	6.0	0.1	2.4	0.3	-1.6	-1.6	-0.6	1.2
Comparative height size at age 10	1.1	5.9	26.6	-0.7	-5.2	-0.7	-2.0	-3.0	0.8	0.3
Number of full sisters	1.1	1.4	3.6	1.0	-0.5	0.1	0.7	1.7	1.9	-1.1
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.9	1.5	-1.5	1.1	1.7	0.6	0.1	-0.6
Qualifications: nursing, teaching	1.1	1.7	6.5	-1.0	0.2	-1.7	-2.5	0.4	-1.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	4.0	0.9	-0.6	0.0	1.2	2.0	1.0	-1.1
Medication: Gliclazide	1.1	1.3	5.5	-1.2	-0.5	-0.5	0.7	2.4	-1.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	6.8	1.4	0.9	2.0	1.7	-0.3	-0.1	-2.6
Fractured/broken bones in last 5 years	1.1	1.4	3.2	-1.0	-1.8	-0.9	-0.9	1.8	-0.3	0.7
Major Depression (MDD)	1.0	1.3	2.3	-1.0	-1.5	-1.5	-0.8	1.5	-0.7	-0.4
Primary Biliary Cirrhosis	1.0	1.4	4.5	0.6	-2.1	0.8	1.1	0.2	1.5	-1.0
Blood White Count	1.0	7.2	14.2	-2.1	2.9	-3.7	-2.9	3.8	-0.5	1.0
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.1	-0.7	-0.3	1.3	-0.4	1.8	-0.8	-1.2
Trunk fat percentage	1.0	4.0	12.2	1.2	-1.4	-0.4	1.2	3.5	3.3	0.1
Serious illness, injury or assault to yourself	1.0	1.3	2.7	0.6	-0.9	0.2	1.1	1.2	1.6	-1.6
High blood pressure	1.0	2.8	10.4	-1.4	1.1	-1.1	2.1	0.1	-0.5	3.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.9	1.6	0.6	2.0	0.6	0.7	0.7	-1.0
Father’s age at death	1.0	1.3	4.4	-1.1	0.0	-1.2	-0.7	-2.1	-0.5	1.3
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	9.3	1.3	-0.2	2.8	0.7	-3.0	-0.3	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	6.5	1.6	-0.9	2.5	1.9	-1.9	-0.1	-2.4
Loud music exposure frequency	1.0	1.1	3.6	0.3	-1.9	1.1	-0.9	-1.0	-0.0	-0.8
Medication: Paracetamol	1.0	1.6	8.7	-1.4	-3.0	-0.2	-0.2	0.2	-0.2	-0.7
Body fat percentage	1.0	4.1	13.9	1.4	-1.3	-0.9	1.5	3.7	2.9	-0.1
Comparative body size at age 10	1.0	2.7	8.2	2.3	-2.9	-0.7	0.8	-1.7	1.3	0.4
Eye problems/disorders: None of the above	1.0	1.2	4.7	-1.1	-0.0	-2.2	-0.9	-0.3	-1.3	0.3
Whole body fat mass	1.0	4.1	9.5	1.8	-2.8	-0.7	1.3	2.4	3.1	-0.6
Leg fat mass (right)	1.0	3.9	8.8	2.1	-2.7	-0.7	1.4	1.9	3.0	-0.8
Medication: Aspirin	1.0	1.3	4.6	-0.5	1.1	-1.1	0.8	2.1	-0.9	0.7
Loneliness, isolation	1.0	1.4	5.2	0.5	-0.2	1.5	0.3	2.3	0.1	-1.3
Long-standing illness, disability or infirmity	1.0	1.5	3.5	1.4	0.2	1.2	0.5	1.4	1.9	-1.2
Friendships satisfaction	1.0	1.3	4.0	1.0	-0.1	1.4	0.3	2.0	0.6	-1.3
Illnesses of father: None of the above (group 1)	1.0	1.2	2.5	-0.2	0.8	0.8	-1.4	-1.6	0.4	1.5
Illnesses of father: High blood pressure	1.0	1.3	4.4	0.4	2.1	-1.2	1.4	-0.3	0.8	-0.6
Ever depressed for a whole week	1.0	1.2	4.9	0.8	-2.2	1.0	0.3	1.2	0.4	-0.7
Depressed Affect (Nagel 2018)	0.9	1.8	5.3	0.8	-0.9	0.6	0.3	2.2	0.7	-2.3
Smoking Status	0.9	2.2	5.8	-0.1	-2.4	-0.8	-1.4	2.3	0.1	-1.5
Cardiovascular Disease	0.9	3.0	9.2	0.0	2.7	-0.7	3.0	0.2	-0.2	2.0
Average weekly fortified wine intake	0.9	1.0	3.6	-0.7	-0.2	-0.6	0.0	-1.9	-0.5	1.6
Maternal smoking around birth	0.9	1.3	2.8	-1.6	0.5	-1.7	-0.6	1.2	-1.4	-0.5
Trunk fat mass	0.9	3.9	11.0	1.4	-2.8	-0.7	0.7	2.3	3.3	-0.4
Diabetes (self-reported)	0.9	1.4	3.3	-0.9	0.1	-1.5	-0.6	1.8	-1.7	-0.2
Illnesses of siblings	0.9	1.3	2.2	1.3	-1.5	-0.3	-0.5	-1.2	1.5	-1.3
Pulse wave reflection index	0.9	1.1	2.7	-0.9	-1.6	-1.1	-1.2	-0.5	-1.0	-0.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.2	0.7	-1.3	1.1	-0.8	-1.6	0.7	-1.8
Birth weight	0.9	2.0	5.4	1.4	0.0	0.4	1.5	-1.3	2.3	1.6
Leg fat percentage (right)	0.9	3.1	8.0	1.7	-0.8	-1.1	1.6	2.8	2.6	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.1	1.3	-2.0	-0.1	-0.1	-0.3	2.0	-1.7
Osteoporosis (self-reported)	0.9	1.1	4.4	-0.9	-2.1	-0.9	-0.6	0.9	0.5	0.7
Medication: Aspirin	0.9	1.2	4.9	-0.4	0.8	-1.4	0.3	2.2	-0.6	0.5
Number of self-reported non-cancer illnesses	0.9	1.6	3.5	1.0	0.7	1.8	1.9	0.1	1.8	0.0
Commuting to job workplace: Public transport	0.9	1.0	5.6	0.6	-2.4	0.3	0.6	-0.4	0.8	-0.3
Supplements: Fish oil (including cod liver oil)	0.9	1.1	3.2	0.9	0.9	0.4	0.9	-1.4	-0.1	1.8
Ever smoked	0.9	1.5	9.4	0.0	-3.1	-0.8	-0.7	-0.2	0.1	0.1
Number of operations (self-reported)	0.9	1.3	5.2	-1.3	-0.3	-0.4	-0.8	2.3	-0.6	0.8
Leg fat mass (left)	0.9	3.4	7.1	1.9	-2.6	-0.8	1.3	2.0	2.7	-0.8
Bipolar Disorder or Schizophrenia	0.8	2.0	7.7	0.6	-0.3	2.8	0.6	1.7	1.4	-0.6
Ulcerative Colitis (UC)	0.8	1.5	4.5	1.2	0.1	1.1	0.5	0.6	1.6	-2.1
Lupus	0.8	1.2	5.2	-0.2	0.3	2.3	-0.5	-0.2	-0.5	1.7
Hair Pigment	0.8	23.7	37.1	2.6	-2.4	5.4	-5.9	4.8	-5.5	-6.1
Relative age of first facial hair	0.8	1.6	3.2	0.8	-1.3	1.1	-1.2	0.5	-1.7	-1.8
Pack years adult smoking proportion	0.8	1.2	3.1	1.1	-0.2	0.1	1.8	1.6	0.9	0.4
Had menopause	0.8	1.0	3.5	-1.3	-0.2	-1.0	-1.9	0.2	-0.5	0.6
Tense / ‘highly strung’	0.8	1.3	3.0	1.3	-0.1	1.5	0.7	-0.9	1.7	-1.0
Leg pain on walking	0.8	1.0	4.4	0.2	-2.1	1.1	0.6	0.9	-0.0	-0.2
Average weekly red wine intake	0.8	1.1	4.0	-0.0	2.0	0.5	-0.5	-1.7	-0.7	-0.2
Eye problems/disorders: Cataract	0.8	0.9	2.2	0.9	-0.9	1.5	0.6	-1.0	0.6	0.6
Mother’s age at death	0.8	1.0	2.9	0.2	1.4	-0.6	-1.7	-0.0	-1.2	-0.3
Medication: Lisinopril	0.8	1.0	2.2	-0.0	1.5	-1.3	0.0	-0.7	-1.4	0.9
Alcohol drinker status: Previous	0.8	0.9	4.0	-0.3	0.7	-0.8	0.1	2.0	-0.6	-0.9
Depression (Nagel 2018)	0.7	1.1	3.8	0.2	-0.6	-0.5	0.2	1.1	1.3	-1.9
Neuroticism (Nagel 2018)	0.7	1.6	3.5	0.6	0.2	1.6	1.5	1.4	0.8	-1.9
Reaction Time	0.7	1.3	4.9	2.2	-1.2	1.4	0.4	-0.6	0.3	-0.4
HbA1C	0.7	0.8	2.5	-1.2	0.2	-0.4	-0.1	-0.6	-1.6	1.0
Neuroticism (2016)	0.7	1.0	4.1	-2.0	0.6	-0.9	0.3	0.3	-1.1	0.6
Number of treatments/medications taken	0.7	1.3	4.5	-0.3	-2.1	-0.0	1.4	1.1	0.8	0.7
Severe depression (siblings)	0.7	0.8	1.6	-1.0	1.3	-0.8	-1.0	0.7	-0.4	0.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.3	-1.5	0.3	-1.0	-1.4	0.6	-0.4	0.1
High blood pressure (mother)	0.7	1.0	5.5	0.0	-0.0	-0.0	2.3	1.2	-0.5	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	5.0	1.4	2.2	0.9	-0.7	-1.6	0.4	-0.6
Medication: Ramipril	0.7	1.0	3.3	-0.2	0.8	-1.0	1.8	0.6	1.0	0.7
Number of live births	0.7	1.0	2.0	0.8	-0.8	-1.4	0.4	1.4	0.5	-1.1
Breastfed as a baby	0.7	0.9	3.0	-0.0	0.8	-0.4	-1.7	-1.5	-0.2	0.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	-0.2	-1.3	0.4	-0.9	1.0	-0.7	-1.3
Medication: Allopurinol	0.7	1.0	2.6	-1.5	0.2	-0.2	-0.9	-1.6	-0.1	1.1
Medication: Seretide 50 evohaler	0.7	0.8	3.1	0.1	-1.8	-0.2	-0.9	-0.8	0.8	-0.5
Pulse rate, automated reading	0.7	2.4	6.2	0.3	1.3	1.4	2.5	-0.2	2.1	1.6
Age at last live birth	0.7	1.0	3.2	0.1	-0.2	-0.5	1.1	-0.9	1.2	1.8
Hypertension (Self-reported)	0.7	2.0	7.8	-1.3	0.7	-1.2	1.7	0.4	-0.3	2.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.0	-0.9	1.1	-0.3	-0.6	1.5	-1.7	-0.2
Average weekly champagne plus white wine intake	0.7	1.0	2.7	-1.0	-1.0	-0.7	-1.6	-1.2	-0.7	0.1
Leg fat percentage (left)	0.7	2.6	8.6	1.2	-0.4	-1.2	1.3	2.9	2.1	-0.1
Average weekly beer plus cider intake	0.7	1.1	6.3	-0.5	-0.5	0.6	-2.5	0.1	0.2	0.5
Vascular/heart problems diagnosed by doctor	0.7	1.9	5.0	1.0	-1.3	0.9	-2.1	-0.5	0.4	-2.2
Pack years of smoking	0.7	1.0	2.9	0.9	-0.2	0.1	1.7	1.7	0.8	0.3
Worry (Nagel 2018)	0.6	1.3	5.4	0.6	1.0	1.1	2.3	0.1	1.0	-0.6
Alzheimer’s Disease (in father)	0.6	0.7	3.4	-0.6	-1.9	-0.1	-0.8	-0.7	-0.2	-0.1
LDL Cholesterol	0.6	1.0	1.4	1.2	0.3	1.1	1.2	-0.6	1.0	-1.1
Age when periods started (menarche)	0.6	1.3	3.1	-1.8	0.9	-1.3	-0.6	0.1	-1.6	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.5	1.7	1.9	0.5	-0.3	-1.3	1.0	-0.4
Hayfever, allergic rhinitis or eczema	0.6	1.4	4.7	1.3	-0.3	2.2	0.8	0.6	1.0	-1.1
Past tobacco smoking	0.6	1.2	6.2	-0.3	2.5	0.4	1.2	0.2	-0.3	0.2
Qualifications: None of the above	0.6	1.2	6.2	0.1	0.4	0.5	1.3	2.5	-0.0	0.2
Alcohol intake versus 10 years previously	0.6	0.9	2.0	0.8	1.4	-1.1	0.8	0.1	0.6	1.2
Length of working week for main job	0.6	0.7	1.5	0.5	-0.9	1.2	0.7	0.1	1.1	-0.6
Hair/balding pattern: Pattern 4	0.6	1.4	6.4	-1.0	0.7	-0.6	-0.1	2.5	0.9	0.9
Headache pain in last month	0.6	1.1	5.1	-0.0	-2.2	0.3	0.3	0.5	0.1	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.6	0.2	-1.1	-0.1	0.1	1.2	-0.1	-1.6
Age at first live birth	0.6	1.1	3.6	-0.2	0.1	-0.3	-0.6	-1.9	0.9	1.7
Shortness of breath walking on level ground	0.6	0.7	1.8	0.4	0.2	-0.4	0.7	1.1	0.8	-1.4
Mean time to correctly identify matches	0.6	1.1	3.8	2.0	0.1	1.3	-0.1	-1.3	0.8	0.3
Supplements: Vitamin C	0.6	0.7	2.7	0.3	0.6	1.7	0.2	-0.9	0.4	0.5
Hearing aid user	0.6	0.7	1.4	1.0	-0.5	0.9	0.8	-0.6	1.2	-0.8
Medication: Bendroflumethiazide	0.6	0.9	2.5	-1.2	1.0	-1.6	0.5	1.0	-0.2	0.1
Medication: Atorvastatin	0.6	0.7	1.7	0.9	0.8	1.3	1.1	-0.6	0.3	0.0
Irritability	0.6	1.1	2.0	1.0	-0.5	1.4	1.4	0.2	1.2	-1.0
Ulcerative Colitis	0.5	0.7	1.9	0.8	0.1	1.0	0.1	-0.6	1.4	-1.0
Blood Eosinophil Count	0.5	4.1	20.1	-1.8	0.5	-1.3	-4.5	-0.7	-1.5	0.9
Allergy or Eczema	0.5	1.2	2.7	1.4	-0.2	1.6	0.1	1.1	0.4	-1.6
Supplements: Zinc	0.5	0.5	1.4	0.5	-0.8	0.7	-0.8	-0.2	-0.6	-1.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	0.7	0.7	1.2	-0.1	0.9	0.2	-0.6
Multivitamins +/- minerals	0.5	0.6	2.4	-0.6	-0.7	-0.7	0.2	0.4	-1.6	0.5
Falls in the last year	0.5	0.6	2.6	-0.1	-0.8	-0.8	0.2	1.6	-0.1	-0.7
Pulse rate	0.5	0.8	2.9	0.6	-0.1	0.9	1.7	1.0	0.6	-0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.7	-1.6	-0.1	-1.3	-1.0	-1.1	-0.3	1.2
Depression (self-reported)	0.5	0.7	1.6	-1.2	0.1	-1.3	-0.3	-0.9	-0.2	0.7
Birth weight of first child	0.5	0.9	2.3	-0.2	-1.5	0.8	-1.1	-1.2	0.2	0.8
High blood pressure (siblings)	0.5	0.8	1.6	-0.9	1.1	-0.1	0.5	1.1	-1.3	0.4
Number of full brothers	0.5	0.6	1.1	0.9	-0.8	0.6	0.5	1.1	0.4	-1.0
Qualifications: College or University degree	0.5	1.7	4.7	-1.1	0.4	-1.4	-1.3	-2.2	-0.5	1.4
Suffer from ‘nerves’	0.5	0.9	2.3	-1.5	0.6	-0.9	-1.0	-0.3	-1.2	-0.1
Illnesses of father: Heart disease	0.5	0.6	2.0	1.0	-0.2	-0.3	1.4	0.7	-0.4	-0.9
Mood swings	0.5	0.8	2.3	0.2	-1.5	1.2	-0.5	-0.5	0.9	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.4	0.2	-1.2	-0.7	-0.2	0.6	0.1	-1.2
Mineral and other dietary supplements	0.5	0.7	3.0	-0.7	0.2	0.0	-0.9	1.0	0.0	-1.7
Age started oral contraceptive pill	0.5	0.6	2.0	0.5	0.9	-0.0	0.2	-1.4	1.0	-0.4
Unable to work because of sickness or disability	0.5	0.7	1.4	0.3	0.7	-0.5	1.2	0.7	1.0	1.0
Alzheimer’s Disease (including proxy)	0.4	0.5	2.9	0.6	0.2	0.0	0.0	0.2	0.4	-1.7
Bipolar Disorder (2011)	0.4	0.4	1.6	0.1	-0.4	1.3	-0.4	-0.8	0.2	0.0
Triglycerides	0.4	0.6	1.7	-0.5	-0.8	1.1	-1.3	-0.4	0.8	0.0
Medication: Co-codamol	0.4	0.5	2.3	-0.4	-1.5	-0.2	0.3	0.8	0.4	-0.5
Diabetes (mother)	0.4	0.5	2.1	-0.0	1.5	1.0	0.0	0.1	0.2	-0.7
Taking other prescription medications	0.4	0.6	1.5	-0.2	-0.8	1.0	0.6	1.2	0.6	0.1
Nervous feelings	0.4	0.7	3.3	-0.5	0.2	0.2	1.8	-0.2	0.4	1.0
Heart attack	0.4	0.5	1.4	-0.3	-0.2	-0.1	0.8	0.7	-1.2	-0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.1	0.4	-0.8	0.1	-0.0	0.6	-0.6	-1.4
Gout (self-reported)	0.4	0.6	2.1	-0.6	-0.1	0.1	-0.6	-1.4	0.5	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.6	-0.0	-0.8	-0.4	-0.6	-0.8	1.3	-0.6
Emphysema/chronic bronchitis	0.4	0.5	1.4	-0.9	0.4	-0.1	-0.6	0.7	0.3	-1.2
Neck or shoulder pain in last month	0.4	0.5	2.3	-0.3	-0.6	0.1	0.7	1.5	0.0	-0.5
Alcohol intake frequency.	0.4	0.9	2.6	1.1	-0.9	-0.7	1.1	1.6	0.3	-0.3
Knee pain experienced in last month	0.4	0.6	2.0	0.3	-1.0	-0.0	0.7	1.4	0.2	-0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.9	-1.0	-0.4	0.1	-0.5	1.4	0.1	0.3
Miserableness	0.4	0.8	2.4	0.6	0.7	0.3	0.2	0.9	1.1	-1.5
Commuting to job workplace: Cycle	0.4	0.5	2.2	-0.7	1.5	-0.4	-0.5	0.2	-0.4	-0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.8	-0.4	-0.1	-0.2	1.0	0.7	-1.3	-0.5
Bipolar Disorder (2018)	0.3	0.4	2.4	-0.1	0.1	1.5	-0.0	-0.4	0.5	0.5
Heel T-Score	0.3	2.3	9.0	-0.6	2.3	-0.6	-3.0	-0.2	-1.1	-0.0
Tanning	0.3	4.0	12.4	1.4	1.4	0.0	0.8	-3.2	3.5	0.9
Relative age voice broke	0.3	0.5	1.8	-0.6	-0.1	0.5	-0.5	0.5	-1.3	-0.6
Stomach or abdominal pain in last month	0.3	0.4	0.9	-0.3	-0.2	-0.8	1.0	1.0	0.3	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	3.0	-0.3	-0.2	0.3	0.1	-0.1	0.6	-1.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	-0.0	-0.8	0.5	-1.0	0.4	-0.8	-0.1
Prospective memory result	0.3	0.3	1.2	0.1	-0.1	0.4	0.6	-0.4	0.7	1.1
Medication: Omeprazole	0.3	0.4	1.1	-0.7	0.2	-0.4	0.4	-0.9	-0.3	1.0
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.3	0.2	0.5	-0.4	-0.1	0.5	-0.7	-1.2
Commuting to job workplace: Walk	0.3	0.3	0.9	0.9	0.3	0.2	0.6	-0.7	0.5	-0.3
Medication for cholesterol	0.3	0.5	1.5	0.2	-0.9	0.1	-0.7	-0.7	-0.2	-1.2
Ever taken oral contraceptive pill	0.3	0.4	0.9	-0.1	-0.8	-0.5	-0.9	-0.9	0.2	0.3
Medication: Blood pressure	0.3	0.6	2.2	-0.3	0.4	-0.0	1.1	0.2	0.2	1.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	-0.7	-0.6	-0.7	0.1	0.2	-0.8	0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	-0.6	0.8	0.1	0.6	-1.0	0.2	0.2
Heart disease (siblings)	0.3	0.4	1.3	-0.6	0.9	-0.3	0.1	0.4	-1.1	-0.1
Vitamin and mineral supplements	0.2	0.2	0.8	-0.3	0.9	-0.7	-0.4	-0.2	0.2	0.1
Had other major operations	0.2	0.2	0.6	-0.3	-0.8	-0.0	-0.0	0.4	0.8	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	1.2	-0.1	0.6	-0.1	0.0	1.1	0.3	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.4	0.2	1.2	-0.3	0.5	-0.2	0.3	0.3
Smoking status: Previous	0.2	0.3	0.6	0.5	-0.4	0.1	-0.8	-0.6	0.8	0.2
Osteoarthritis (self-reported)	0.2	0.3	0.5	0.1	-0.6	0.7	-0.2	-0.6	0.6	0.1
Breast Cancer	0.1	0.1	0.3	0.2	0.1	-0.5	-0.5	-0.5	0.4	0.1
HDL Cholesterol	0.1	0.1	0.9	0.1	0.2	-0.1	0.2	-0.0	-0.9	-0.1
Hair/balding pattern: Pattern 2	0.1	0.2	0.8	0.4	0.1	-0.3	-0.1	0.5	0.0	-0.9

Hub : Genes

HOXB3

Models

Trait associations