Best TWAS P=3.09e-10 · Best GWAS P=1.18e-11 conditioned to 0.115
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | SLC25A37 | 0.13 | 0.05 | lasso | 5 | 0.04 | 3.0e-04 | -5.2 | 5.3 | 1.4e-07 | -0.12 | 0.62 | 0.16 | FALSE |
| 2 | YFS | Blood | R3HCC1 | 0.03 | 0.01 | lasso | 6 | 0.01 | 5.3e-04 | -6.1 | 6.0 | 2.5e-09 | -0.73 | 0.02 | 0.98 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STC1 | 0.04 | 0.05 | enet | 7 | 0.06 | 8.9e-12 | -5.7 | 5.8 | 8.3e-09 | -0.05 | 0.01 | 0.99 | TRUE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC25A37 | 0.11 | 0.09 | lasso | 5 | 0.09 | 7.8e-10 | -4.6 | -5.2 | 2.6e-07 | 0.07 | 0.67 | 0.32 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LOXL2 | 0.16 | 0.03 | lasso | 4 | 0.05 | 1.2e-03 | -4.9 | 5.5 | 4.0e-08 | -0.15 | 0.12 | 0.03 | TRUE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CHMP7 | 0.05 | 0.02 | blup | 89 | 0.03 | 2.5e-03 | -4.1 | -5.2 | 2.0e-07 | 0.54 | 0.04 | 0.36 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHMP7 | 0.03 | 0.03 | blup | 89 | 0.01 | 3.8e-02 | 3.1 | -5.7 | 1.4e-08 | 0.51 | 0.07 | 0.08 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | CHMP7 | 0.10 | 0.02 | lasso | 6 | 0.04 | 5.4e-05 | 3.1 | -6.3 | 3.1e-10 | 0.74 | 0.00 | 0.99 | TRUE |