[Hub]/) : Traits : Arm predicted mass (right) : ← →

chr17:6,444,676-8,161,149

Best TWAS P=9.87e-13 · Best GWAS P=2.16e-16 conditioned to 3.4e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CHRNB1	0.09	0.06	lasso	2	0.08	9.8e-10	7.1	5.9	3.8e-09	0.16	0.88	0.12	FALSE
2	CommonMind	Brain Pre-frontal Cortex	EIF5A	0.20	0.12	bslmm	446	0.10	1.2e-12	-4.1	-6.1	9.4e-10	-0.05	1.00	0.00	TRUE
3	CommonMind	Brain Pre-frontal Cortex	POLR2A	0.08	0.07	lasso	4	0.07	1.9e-08	5.4	5.5	5.2e-08	0.18	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	CHRNB1	0.29	0.14	lasso	5	0.14	1.0e-07	7.1	6.9	4.5e-12	0.27	0.89	0.07	FALSE
5	GTEx	Artery Tibial	TNFSF12	0.11	0.06	lasso	2	0.05	1.2e-04	5.4	5.5	5.1e-08	0.52	0.26	0.67	FALSE
6	GTEx	Breast Mammary Tissue (Male)	CHRNB1	0.28	-0.01	lasso	6	0.02	9.6e-02	7.1	5.9	4.4e-09	0.20	0.07	0.07	FALSE
7	GTEx	Cells Transformed fibroblasts	CHRNB1	0.28	0.11	enet	25	0.18	2.9e-13	7.1	5.8	7.1e-09	0.46	0.91	0.09	FALSE
8	GTEx	Cells Transformed fibroblasts	TNFSF12	0.25	0.22	lasso	8	0.20	7.4e-15	-5.3	-5.2	2.0e-07	-0.30	1.00	0.00	FALSE
9	GTEx	Esophagus Mucosa	CHRNB1	0.19	0.11	lasso	2	0.13	7.3e-09	7.1	7.1	9.9e-13	0.29	0.91	0.09	TRUE
10	GTEx	Esophagus Mucosa	ZBTB4	0.12	0.10	lasso	2	0.08	8.0e-06	5.6	5.5	3.4e-08	0.26	0.96	0.00	FALSE
11	GTEx	Esophagus Muscularis	ZBTB4	0.13	0.06	lasso	2	0.05	6.3e-04	5.5	5.3	8.8e-08	0.26	0.29	0.22	FALSE
12	GTEx	Muscle Skeletal	EIF5A	0.14	0.06	enet	35	0.05	4.2e-06	-4.1	-5.8	7.3e-09	-0.02	0.96	0.00	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	CHRNB1	0.17	0.15	lasso	3	0.16	7.4e-09	7.1	7.0	3.1e-12	0.29	0.94	0.05	FALSE
14	GTEx	Skin Sun Exposed Lower leg	CHRNB1	0.19	0.12	enet	13	0.12	3.0e-10	5.6	5.3	1.2e-07	0.22	1.00	0.00	FALSE
15	GTEx	Stomach	CHRNB1	0.28	0.19	lasso	4	0.23	2.0e-11	7.1	5.3	8.7e-08	0.15	0.89	0.09	FALSE
16	GTEx	Whole Blood	TNFSF12	0.09	0.03	enet	24	0.04	1.9e-04	-5.3	-6.5	6.8e-11	-0.43	0.44	0.42	TRUE
17	METSIM	Adipose	NEURL4	0.06	0.00	blup	454	0.01	8.2e-03	-1.0	-5.3	1.2e-07	-0.02	0.11	0.02	TRUE
18	ROSMAP	Brain Pre-frontal Cortex	CHRNB1	0.11	0.08	lasso	6	0.08	7.8e-11	7.1	6.5	9.7e-11	0.30	0.93	0.07	FALSE
19	YFS	Blood	CHRNB1	0.04	0.02	lasso	5	0.04	8.5e-12	6.9	6.6	4.9e-11	0.31	0.94	0.06	FALSE
20	YFS	Blood	PHF23	0.03	0.01	bslmm	450	0.02	5.9e-08	6.4	-5.5	2.8e-08	0.05	0.87	0.02	TRUE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNB1	0.06	0.06	enet	10	0.06	1.0e-11	6.9	6.1	1.2e-09	0.32	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHRNB1	0.07	0.04	blup	57	0.05	1.6e-03	7.1	6.8	1.3e-11	0.34	0.00	0.90	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	TNFSF12-TNFSF13	0.07	0.05	lasso	3	0.02	1.9e-02	-5.2	-5.3	1.3e-07	-0.22	0.08	0.04	FALSE
24	The Cancer Genome Atlas	Glioblastoma Multiforme	AMAC1L3	0.14	0.12	lasso	3	0.12	1.8e-04	5.7	-5.9	4.2e-09	-0.25	0.01	0.88	FALSE
25	The Cancer Genome Atlas	Glioblastoma Multiforme	EIF5A	0.26	0.10	blup	51	0.05	9.7e-03	4.5	-5.3	8.9e-08	0.14	0.04	0.11	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHRNB1	0.06	0.07	lasso	6	0.07	1.8e-08	3.9	5.2	1.7e-07	0.28	0.53	0.47	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHRNB1	0.05	0.04	blup	57	0.04	6.1e-05	5.9	6.5	1.1e-10	0.23	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	TNFSF12-TNFSF13	0.07	0.01	enet	17	0.03	4.4e-04	-5.3	-5.5	4.3e-08	-0.08	0.03	0.08	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	CHRNB1	0.03	0.02	blup	57	0.02	7.8e-04	6.9	6.4	1.3e-10	0.36	0.00	0.99	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHRNB1	0.18	0.09	enet	10	0.10	4.9e-11	7.1	6.0	2.7e-09	0.30	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	TNFSF12-TNFSF13	0.03	0.00	lasso	4	0.01	2.9e-02	-5.3	-7.1	1.0e-12	-0.45	0.01	0.66	FALSE
32	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHRNB1	0.06	0.00	blup	57	0.03	4.5e-03	3.4	6.7	2.0e-11	0.34	0.00	0.77	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	CHRNB1	0.09	0.02	blup	57	0.05	2.6e-05	-3.7	5.9	3.9e-09	0.23	0.11	0.75	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	SENP3	0.07	0.04	enet	9	0.03	2.7e-04	3.4	5.8	6.2e-09	0.20	0.17	0.56	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	SHBG	0.04	0.00	blup	59	0.02	4.4e-03	-4.6	-6.9	5.2e-12	-0.46	0.04	0.08	FALSE