Best TWAS P=8.78e-09 · Best GWAS P=5.38e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | DMXL2 | 0.17 | 0.13 | lasso | 3 | 0.06 | 4.2e-03 | 5.4 | 5.3 | 1.5e-07 | -0.45 | 0.22 | 0.57 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | DMXL2 | 0.06 | 0.06 | lasso | 3 | 0.05 | 5.9e-05 | 5.3 | -5.3 | 1.3e-07 | 0.28 | 0.32 | 0.60 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | TMOD2 | 0.09 | 0.10 | enet | 8 | 0.10 | 3.0e-08 | -5.6 | -5.7 | 1.3e-08 | 0.99 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Muscle Skeletal | LYSMD2 | 0.23 | 0.23 | lasso | 4 | 0.21 | 1.6e-20 | -5.7 | 5.7 | 1.1e-08 | -0.97 | 0.04 | 0.96 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | TMOD3 | 0.05 | 0.07 | enet | 13 | 0.07 | 6.4e-05 | -5.8 | 5.4 | 7.9e-08 | -0.98 | 0.05 | 0.94 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | TMOD3 | 0.07 | 0.07 | enet | 22 | 0.06 | 6.0e-06 | -5.6 | 5.8 | 8.8e-09 | -0.99 | 0.03 | 0.97 | TRUE |
| 7 | GTEx | Thyroid | MAPK6 | 0.04 | 0.02 | lasso | 4 | 0.01 | 8.8e-02 | -4.5 | 5.1 | 2.9e-07 | -0.92 | 0.14 | 0.73 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | TMOD2 | 0.02 | 0.01 | blup | 78 | 0.02 | 2.3e-03 | -4.8 | -5.5 | 2.9e-08 | 0.98 | 0.04 | 0.84 | FALSE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TMOD2 | 0.13 | 0.10 | lasso | 2 | 0.07 | 1.0e-03 | 5.2 | -5.3 | 1.2e-07 | 0.73 | 0.03 | 0.71 | FALSE |