[Hub]/) : Traits : Arm fat percentage (left) :

chr4:2,152,449-3,943,984

Best TWAS P=1.15e-10 · Best GWAS P=2.96e-09 conditioned to 0.192

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous GRK4 0.30 0.39 lasso 6 0.41 1.2e-35 -5.1 5.5 3.5e-08 -0.97 0.05 0.95 FALSE
2 GTEx Adipose Visceral Omentum GRK4 0.32 0.38 lasso 4 0.40 5.5e-22 -5.2 5.3 1.1e-07 -0.97 0.07 0.93 FALSE
3 GTEx Adrenal Gland GRK4 0.38 0.25 lasso 5 0.29 5.1e-11 -5.2 6.1 8.7e-10 -0.88 0.13 0.87 FALSE
4 GTEx Artery Aorta GRK4 0.29 0.38 enet 11 0.40 1.3e-23 -5.1 5.5 3.5e-08 -0.96 0.07 0.93 FALSE
5 GTEx Artery Coronary GRK4 0.27 0.24 lasso 3 0.22 6.7e-08 -5.2 5.3 1.5e-07 -0.93 0.04 0.96 FALSE
6 GTEx Artery Tibial GRK4 0.34 0.35 lasso 4 0.35 1.1e-28 -5.1 5.2 1.7e-07 -0.92 0.19 0.81 FALSE
7 GTEx Brain Cortex GRK4 0.25 0.26 lasso 4 0.25 1.7e-07 -5.2 5.3 1.4e-07 -0.91 0.18 0.81 FALSE
8 GTEx Breast Mammary Tissue GRK4 0.27 0.32 enet 11 0.32 5.3e-17 -5.1 5.3 1.4e-07 -0.95 0.12 0.88 FALSE
9 GTEx Breast Mammary Tissue (Female) GRK4 0.23 0.24 lasso 3 0.24 1.1e-07 -5.2 5.3 1.3e-07 -0.97 0.06 0.94 FALSE
10 GTEx Cells Transformed fibroblasts NOP14 0.12 0.06 enet 11 0.09 2.9e-07 -4.4 6.1 9.3e-10 -0.77 0.07 0.93 TRUE
11 GTEx Cells Transformed fibroblasts GRK4 0.32 0.35 lasso 7 0.37 3.1e-29 -5.2 5.3 1.1e-07 -0.97 0.03 0.97 FALSE
12 GTEx Colon Sigmoid GRK4 0.26 0.30 lasso 2 0.28 2.6e-10 -5.2 5.2 2.5e-07 -0.92 0.05 0.94 FALSE
13 GTEx Colon Transverse GRK4 0.27 0.25 enet 18 0.25 2.4e-12 -5.2 6.0 1.8e-09 -0.95 0.02 0.98 FALSE
14 GTEx Esophagus Gastroesophageal Junction GRK4 0.37 0.23 lasso 9 0.22 2.2e-08 -5.5 5.5 3.6e-08 -0.96 0.02 0.98 FALSE
15 GTEx Esophagus Mucosa GRK4 0.28 0.35 lasso 4 0.34 3.1e-23 -5.1 5.2 2.4e-07 -0.92 0.18 0.82 FALSE
16 GTEx Esophagus Muscularis GRK4 0.29 0.30 enet 7 0.30 2.5e-18 -5.1 5.2 1.8e-07 -0.92 0.17 0.82 FALSE
17 GTEx Lung ADD1 0.09 0.02 enet 6 0.01 3.5e-02 3.7 5.6 2.5e-08 -0.71 0.24 0.57 FALSE
18 GTEx Lung GRK4 0.26 0.36 lasso 4 0.36 3.3e-29 -5.1 5.4 8.3e-08 -0.95 0.12 0.88 FALSE
19 GTEx Lung HTT 0.06 0.00 lasso 4 0.00 5.8e-01 -5.1 5.7 1.0e-08 -0.81 0.08 0.52 FALSE
20 GTEx Nerve Tibial GRK4 0.29 0.38 lasso 3 0.39 4.6e-29 -5.1 5.2 2.0e-07 -0.94 0.16 0.84 FALSE
21 GTEx Ovary GRK4 0.25 0.19 lasso 8 0.18 3.6e-05 -5.2 5.6 2.5e-08 -0.87 0.08 0.72 FALSE
22 GTEx Pituitary GRK4 0.17 0.00 enet 6 -0.01 5.6e-01 -5.9 5.8 8.8e-09 -0.99 0.03 0.74 FALSE
23 GTEx Skin Not Sun Exposed Suprapubic GRK4 0.38 0.43 lasso 4 0.42 9.6e-25 -5.2 5.3 1.1e-07 -0.94 0.14 0.86 FALSE
24 GTEx Stomach GRK4 0.22 0.19 lasso 7 0.19 2.6e-09 -5.5 5.6 2.5e-08 -0.96 0.05 0.95 FALSE
25 GTEx Thyroid GRK4 0.50 0.47 lasso 9 0.48 6.4e-41 -5.2 5.3 1.2e-07 -0.95 0.10 0.90 FALSE
26 GTEx Thyroid NOP14-AS1 0.18 0.09 lasso 8 0.11 1.3e-08 -5.2 5.4 7.7e-08 -0.94 0.09 0.90 FALSE
27 GTEx Uterus GRK4 0.31 0.24 enet 29 0.32 2.5e-07 -5.5 5.7 1.4e-08 -0.88 0.02 0.94 FALSE
28 GTEx Vagina GRK4 0.27 0.12 lasso 4 0.11 1.6e-03 -5.3 5.5 3.9e-08 -0.89 0.06 0.66 FALSE
29 GTEx Whole Blood HTT 0.10 0.00 enet 15 0.03 1.4e-03 5.0 6.5 1.2e-10 -0.40 0.09 0.50 TRUE
30 METSIM Adipose GRK4 0.20 0.26 lasso 6 0.25 9.9e-38 -5.1 5.3 1.1e-07 -0.94 0.18 0.81 FALSE
31 ROSMAP Brain Pre-frontal Cortex GRK4 0.12 0.14 lasso 4 0.14 1.8e-17 -5.1 5.5 4.1e-08 -0.95 0.03 0.97 FALSE
32 The Cancer Genome Atlas Bladder Urothelial Carcinoma GRK4 0.09 0.10 lasso 4 0.14 1.4e-11 -5.1 5.3 1.4e-07 -0.91 0.17 0.82 FALSE
33 The Cancer Genome Atlas Breast Invasive Carcinoma GRK4 0.11 0.17 lasso 7 0.18 6.7e-36 -5.1 5.4 6.1e-08 -0.97 0.09 0.91 FALSE
34 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma GRK4 0.09 0.12 blup 76 0.12 1.7e-06 -5.1 5.6 2.2e-08 -0.93 0.05 0.94 FALSE
35 The Cancer Genome Atlas Colon Adenocarcinoma GRK4 0.18 0.23 blup 76 0.21 3.8e-12 -5.2 5.3 1.2e-07 -0.93 0.07 0.93 FALSE
36 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GRK4 0.09 0.18 lasso 5 0.20 1.5e-22 -5.9 5.9 3.1e-09 -0.95 0.01 0.99 FALSE
37 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma GRK4 0.16 0.18 lasso 6 0.20 1.9e-11 -4.7 5.4 7.3e-08 -0.88 0.18 0.82 FALSE
38 The Cancer Genome Atlas Lung Adenocarcinoma C4orf44 0.03 0.04 lasso 4 0.05 2.9e-06 -4.9 5.5 5.0e-08 -0.36 0.01 0.98 FALSE
39 The Cancer Genome Atlas Lung Squamous Cell Carcinoma GRK4 0.10 0.14 enet 16 0.14 4.6e-15 -5.2 5.2 1.6e-07 -0.93 0.10 0.90 FALSE
40 The Cancer Genome Atlas Pancreatic Adenocarcinoma GRK4 0.23 0.32 lasso 5 0.31 1.0e-13 -5.2 5.3 1.4e-07 -0.93 0.10 0.90 FALSE
41 The Cancer Genome Atlas Prostate Adenocarcinoma GRK4 0.12 0.13 lasso 6 0.14 6.0e-15 -5.1 5.4 5.2e-08 -0.96 0.05 0.95 FALSE
42 The Cancer Genome Atlas Rectum Adenocarcinoma GRK4 0.27 0.10 blup 76 0.13 7.3e-04 -5.2 5.5 3.3e-08 -0.87 0.05 0.70 FALSE
43 The Cancer Genome Atlas Soft Tissue Sarcoma GRK4 0.08 0.07 blup 77 0.09 4.4e-06 -5.1 5.9 2.8e-09 -0.90 0.08 0.92 FALSE
44 The Cancer Genome Atlas Soft Tissue Sarcoma SH3BP2 0.08 0.03 blup 53 0.02 2.8e-02 5.0 5.8 8.8e-09 -0.39 0.01 0.36 FALSE
45 The Cancer Genome Atlas Stomach Adenocarcinoma GRK4 0.17 0.24 lasso 6 0.24 1.2e-17 -5.2 5.6 2.6e-08 -0.96 0.09 0.91 FALSE
46 The Cancer Genome Atlas Testicular Germ Cell Tumors GRK4 0.08 0.09 lasso 1 0.06 4.2e-03 -5.1 5.2 2.6e-07 -0.91 0.04 0.62 FALSE
47 The Cancer Genome Atlas Thyroid Carcinoma C4orf10 0.18 0.06 lasso 3 0.07 2.2e-07 -5.5 5.4 6.0e-08 -0.94 0.00 1.00 FALSE
48 The Cancer Genome Atlas Thyroid Carcinoma GRK4 0.22 0.39 lasso 6 0.38 4.1e-39 -5.2 5.2 1.9e-07 -0.92 0.16 0.83 FALSE
49 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma GRK4 0.11 0.12 lasso 1 0.10 8.4e-04 -5.7 5.7 1.3e-08 -0.98 0.02 0.88 FALSE