Best TWAS P=1.47e-11 · Best GWAS P=8.64e-11 conditioned to 1.11e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | GPRC5B | 0.07 | 0.04 | lasso | 4 | 0.03 | 1.3e-03 | -6.1 | 6.8 | 1.5e-11 | 0.31 | 0.08 | 0.78 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | THUMPD1 | 0.13 | 0.16 | enet | 16 | 0.16 | 4.2e-12 | -5.1 | -5.3 | 1.4e-07 | 0.04 | 0.16 | 0.84 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | KNOP1 | 0.51 | 0.44 | enet | 22 | 0.56 | 5.3e-24 | -4.5 | -5.3 | 1.1e-07 | -0.27 | 0.71 | 0.29 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | AC002550.5 | 0.62 | 0.54 | enet | 35 | 0.63 | 4.4e-29 | -3.7 | -5.5 | 4.8e-08 | -0.27 | 0.99 | 0.01 | FALSE |
| 5 | GTEx | Testis | AC004381.6 | 0.18 | 0.10 | lasso | 7 | 0.08 | 1.8e-04 | -5.2 | -5.3 | 1.3e-07 | 0.04 | 0.12 | 0.72 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IQCK | 0.03 | 0.03 | lasso | 3 | 0.02 | 7.2e-04 | -5.2 | -5.5 | 3.1e-08 | -0.25 | 0.04 | 0.92 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | ACSM3 | 0.06 | 0.04 | blup | 43 | 0.03 | 5.9e-04 | -5.2 | 5.2 | 1.9e-07 | -0.05 | 0.01 | 0.96 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | GPRC5B | 0.06 | 0.01 | blup | 38 | 0.01 | 2.4e-02 | -3.7 | -6.0 | 2.2e-09 | -0.43 | 0.01 | 0.10 | FALSE |