[Hub]/) : Traits : Arm fat-free mass (left) :

chr5:136,723,696-140,767,031

Best TWAS P=6.18e-14 · Best GWAS P=8.11e-18 conditioned to 1.33e-07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DNAJC18 0.09 0.10 bslmm 260 0.10 2.5e-12 3.7 6.0 1.9e-09 0.41 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex FAM53C 0.05 0.02 bslmm 291 0.03 4.1e-04 7.2 5.6 2.4e-08 -0.06 0.03 0.92 FALSE
3 GTEx Cells EBV-transformed lymphocytes DNAJC18 0.26 0.09 lasso 2 0.12 9.7e-05 4.2 5.9 3.3e-09 0.49 0.11 0.55 FALSE
4 GTEx Cells Transformed fibroblasts CD14 0.09 0.05 lasso 4 0.06 2.7e-05 -3.8 -5.2 2.1e-07 -0.05 0.16 0.73 FALSE
5 GTEx Colon Transverse DNAJC18 0.37 -0.01 lasso 5 0.01 1.1e-01 4.2 5.8 5.1e-09 0.39 0.06 0.06 FALSE
6 GTEx Esophagus Gastroesophageal Junction DNAJC18 0.17 0.01 lasso 10 0.04 2.0e-02 4.2 7.2 8.2e-13 0.77 0.03 0.83 FALSE
7 GTEx Esophagus Mucosa TMEM173 0.10 0.03 enet 20 0.10 1.8e-07 8.6 -5.6 2.3e-08 -0.60 0.01 0.96 FALSE
8 GTEx Esophagus Muscularis DNAJC18 0.22 0.10 lasso 6 0.13 3.2e-08 4.2 5.7 1.1e-08 0.40 0.56 0.10 FALSE
9 GTEx Esophagus Muscularis TMEM173 0.24 0.00 lasso 6 0.06 1.5e-04 4.2 -5.3 1.1e-07 -0.40 0.76 0.07 FALSE
10 GTEx Nerve Tibial HARS 0.07 0.01 enet 16 0.04 1.1e-03 -4.4 5.4 5.8e-08 -0.03 0.12 0.74 TRUE
11 GTEx Skin Sun Exposed Lower leg WDR55 0.04 0.01 enet 10 0.01 2.8e-02 -4.4 -5.2 2.5e-07 -0.02 0.10 0.72 FALSE
12 GTEx Spleen DNAJC18 0.30 0.13 lasso 5 0.20 6.5e-06 4.2 5.3 8.6e-08 0.47 0.14 0.52 FALSE
13 GTEx Vagina PURA 0.52 0.05 enet 51 0.09 3.6e-03 5.2 -6.0 2.2e-09 -0.44 0.06 0.10 FALSE
14 ROSMAP Brain Pre-frontal Cortex WNT8A 0.05 0.01 blup 300 0.03 1.0e-04 -2.0 -6.8 1.2e-11 0.05 0.10 0.84 TRUE
15 ROSMAP Brain Pre-frontal Cortex KDM3B 0.07 0.01 blup 307 0.03 1.0e-04 4.8 -5.5 4.3e-08 -0.03 0.12 0.81 FALSE
16 YFS Blood CXXC5 0.01 0.00 bslmm 244 0.01 2.6e-03 8.6 -6.7 2.3e-11 -0.67 0.00 0.95 FALSE
17 YFS Blood TMCO6 0.01 0.00 blup 329 0.01 4.1e-03 -4.4 -5.2 2.4e-07 -0.03 0.13 0.79 FALSE
18 The Cancer Genome Atlas Breast Invasive Carcinoma TMEM173 0.02 0.03 blup 7 0.03 4.6e-07 4.5 -5.4 6.0e-08 -0.40 0.07 0.92 FALSE
19 The Cancer Genome Atlas Colon Adenocarcinoma WDR55 0.09 0.08 enet 12 0.12 1.5e-07 -4.5 -5.2 2.4e-07 -0.05 0.02 0.93 FALSE
20 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma UBE2D2 0.05 0.02 enet 6 0.03 4.4e-04 5.0 7.5 6.2e-14 0.76 0.01 0.97 TRUE
21 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma BRD8 0.12 0.07 lasso 4 0.05 1.2e-03 6.7 -6.4 1.3e-10 0.03 0.00 0.98 FALSE
22 The Cancer Genome Atlas Prostate Adenocarcinoma EGR1 0.02 0.01 blup 41 0.02 1.9e-03 -4.6 -5.2 2.1e-07 -0.04 0.11 0.08 FALSE