[Hub]/) : Traits : Arm predicted mass (left) :

chr5:136,723,696-141,087,689

Best TWAS P=4.15e-14 · Best GWAS P=1.62e-17 conditioned to 3.82e-07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DNAJC18 0.09 0.10 bslmm 260 0.10 2.5e-12 4.1 6.3 3.6e-10 0.41 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex FAM53C 0.05 0.02 bslmm 291 0.03 4.1e-04 6.7 5.2 2.1e-07 -0.06 0.03 0.92 FALSE
3 CommonMind Brain Pre-frontal Cortex PCDHA2 0.04 0.03 blup 478 0.03 5.0e-05 -4.8 -5.2 1.5e-07 -0.05 0.09 0.90 FALSE
4 GTEx Artery Tibial PROB1 0.06 0.09 enet 10 0.08 5.9e-07 4.6 -5.3 1.0e-07 -0.39 0.89 0.05 FALSE
5 GTEx Cells EBV-transformed lymphocytes DNAJC18 0.26 0.09 lasso 2 0.12 9.7e-05 4.6 6.2 5.5e-10 0.49 0.10 0.60 FALSE
6 GTEx Cells Transformed fibroblasts HARS2 0.04 0.01 enet 15 0.02 1.1e-02 4.3 -5.2 2.4e-07 -0.07 0.12 0.69 FALSE
7 GTEx Cells Transformed fibroblasts CD14 0.09 0.05 lasso 4 0.06 2.7e-05 -3.8 -5.3 1.5e-07 -0.05 0.18 0.75 FALSE
8 GTEx Colon Transverse TMCO6 0.15 0.06 enet 16 0.05 1.4e-03 4.5 -5.5 5.0e-08 -0.07 0.16 0.53 FALSE
9 GTEx Colon Transverse DNAJC18 0.37 -0.01 lasso 5 0.01 1.1e-01 4.6 5.8 5.4e-09 0.39 0.06 0.06 FALSE
10 GTEx Esophagus Gastroesophageal Junction DNAJC18 0.17 0.01 lasso 10 0.04 2.0e-02 4.5 7.3 2.3e-13 0.77 0.03 0.83 FALSE
11 GTEx Esophagus Mucosa TMEM173 0.10 0.03 enet 20 0.10 1.8e-07 8.5 -5.5 3.4e-08 -0.60 0.01 0.96 FALSE
12 GTEx Esophagus Muscularis DNAJC18 0.22 0.10 lasso 6 0.13 3.2e-08 4.6 5.8 4.8e-09 0.40 0.56 0.10 FALSE
13 GTEx Esophagus Muscularis TMEM173 0.24 0.00 lasso 6 0.06 1.5e-04 4.6 -5.7 1.6e-08 -0.40 0.75 0.08 FALSE
14 GTEx Nerve Tibial HARS 0.07 0.01 enet 16 0.04 1.1e-03 -4.7 5.8 5.0e-09 -0.03 0.10 0.83 TRUE
15 GTEx Skin Sun Exposed Lower leg WDR55 0.04 0.01 enet 10 0.01 2.8e-02 -4.6 -5.6 2.7e-08 -0.02 0.10 0.79 FALSE
16 GTEx Spleen DNAJC18 0.30 0.13 lasso 5 0.20 6.5e-06 4.6 5.7 1.3e-08 0.47 0.14 0.53 FALSE
17 GTEx Vagina PURA 0.52 0.05 enet 51 0.09 3.6e-03 5.2 -6.0 1.7e-09 -0.44 0.06 0.10 FALSE
18 ROSMAP Brain Pre-frontal Cortex WNT8A 0.05 0.01 blup 300 0.03 1.0e-04 -1.9 -6.5 7.9e-11 0.05 0.10 0.84 TRUE
19 ROSMAP Brain Pre-frontal Cortex KDM3B 0.07 0.01 blup 307 0.03 1.0e-04 4.8 -5.3 1.4e-07 -0.03 0.12 0.81 FALSE
20 ROSMAP Brain Pre-frontal Cortex PROB1 0.12 0.09 lasso 6 0.10 7.7e-13 4.6 -5.3 1.3e-07 -0.39 1.00 0.00 FALSE
21 YFS Blood CXXC5 0.01 0.00 bslmm 244 0.01 2.6e-03 8.5 -6.7 1.6e-11 -0.67 0.00 0.94 FALSE
22 YFS Blood TMCO6 0.01 0.00 blup 329 0.01 4.1e-03 -4.8 -5.6 2.2e-08 -0.03 0.10 0.87 FALSE
23 The Cancer Genome Atlas Breast Invasive Carcinoma CD14 0.01 0.01 blup 38 0.00 3.5e-02 4.7 -5.2 1.9e-07 -0.07 0.01 0.38 FALSE
24 The Cancer Genome Atlas Breast Invasive Carcinoma TMEM173 0.02 0.03 blup 7 0.03 4.6e-07 4.5 -5.5 4.5e-08 -0.40 0.07 0.92 FALSE
25 The Cancer Genome Atlas Breast Invasive Carcinoma WDR55 0.10 0.03 enet 8 0.04 3.3e-09 -4.9 -5.2 2.3e-07 0.01 0.02 0.98 FALSE
26 The Cancer Genome Atlas Colon Adenocarcinoma WDR55 0.09 0.08 enet 12 0.12 1.5e-07 -4.9 -5.4 8.3e-08 -0.05 0.02 0.97 FALSE
27 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma UBE2D2 0.05 0.02 enet 6 0.03 4.4e-04 5.2 7.6 4.1e-14 0.76 0.01 0.97 TRUE
28 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma BRD8 0.12 0.07 lasso 4 0.05 1.2e-03 6.4 -6.1 1.3e-09 0.03 0.00 0.98 FALSE
29 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma DNAJC18 0.06 0.02 blup 23 0.02 9.5e-03 4.6 5.1 2.7e-07 0.37 0.02 0.46 FALSE
30 The Cancer Genome Atlas Prostate Adenocarcinoma WDR55 0.07 0.06 blup 44 0.06 1.7e-06 -4.9 -5.2 1.7e-07 -0.05 0.02 0.97 FALSE
31 The Cancer Genome Atlas Thyroid Carcinoma SLC4A9 0.07 0.02 blup 30 0.06 3.1e-06 4.2 -5.2 1.7e-07 -0.03 0.08 0.77 FALSE